Pomegranate's Neuroprotective Effects against Alzheimer's Disease Are Mediated by Urolithins, Its Ellagitannin-Gut Microbial Derived Metabolites

ACS Chemical Neuroscience

Volumn 7, Issue 1, 2016, Pages 26-33

  Yuan, Tao ^a   Ma, Hang ^a   Liu, Weixi ^a   Niesen, Daniel B ^a   Shah, Nishan ^a   Crews, Rebecca ^b   Rose, Kenneth N ^a   Vattem, Dhiraj A ^b   Seeram, Navindra P ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b TEXAS STATE UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; blood brain barrier; ellagitannins; microbial metabolites; Pomegranate; urolithins

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; ELLAGITANNIN; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); COUMARIN DERIVATIVE; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT; TANNIN; UROLITHIN B;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE FLORA; METABOLITE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PARALYSIS; POMEGRANATE; PRIORITY JOURNAL; AGE; ANIMAL; BIOLOGICAL MODEL; BIOPHYSICS; CHEMISTRY; COMPUTER SIMULATION; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; HUMAN; LIQUID CHROMATOGRAPHY; LYTHRACEAE; MASS SPECTROMETRY; METABOLISM; TRANSGENIC ANIMAL;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BIOPHYSICS; BLOOD-BRAIN BARRIER; CAENORHABDITIS ELEGANS; CHROMATOGRAPHY, LIQUID; COMPUTER SIMULATION; COUMARINS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROLYZABLE TANNINS; MASS SPECTROMETRY; MODELS, BIOLOGICAL; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; PUNICACEAE;

EID: 84955570396     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.5b00260     Document Type: Article

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