Absorption, metabolism, and effects at transcriptome level of a standardized french oak wood extract, Robuvit, in healthy volunteers: Pilot study

Journal of Agricultural and Food Chemistry

Volumn 62, Issue 2, 2014, Pages 443-453

  Natella, Fausta ^a   Leoni, Guido ^a   Maldini, Mariateresa ^a   Natarelli, Lucia ^a   Comitato, Raffaella ^a   Schonlau, Frank ^b   Virgili, Fabio ^a   Canali, Raffaella ^a  

^a ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

^b Horphag Research UK Ltd   (United Kingdom)

Author keywords

ellagitannins; gene array; human study; Quercus robur; roburins

Indexed keywords

ELLAGITANNINS; GENE ARRAYS; HUMAN STUDY; QUERCUS ROBUR; ROBURINS;

BIOACTIVITY; BIOMOLECULES; CELL CULTURE; ELLAGIC ACID; GENE EXPRESSION; METABOLITES; WATER ABSORPTION; BIOCHEMISTRY; GENES;

PLASMAS; WATER ABSORPTION;

CATALPA LONGISSIMA; QUERCUS ROBUR;

3,8-DIHYDROXY-6H-DIBENZO(B,D)PYRAN-6-ONE GLUCURONIDE; ANTIOXIDANT; COUMARIN DERIVATIVE; ELLAGIC ACID; GLUCURONIDE; PHENOL DERIVATIVE; PLANT EXTRACT; ROBUVIT; TANNIN; TRANSCRIPTOME;

BLOOD; CELL CYCLE; CHEMISTRY; DIET SUPPLEMENTATION; DRUG EFFECTS; FRANCE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; OAK; PILOT STUDY; RIBOSOME; SPLICEOSOME;

ANTIOXIDANTS; CELL CYCLE; COUMARINS; DIETARY SUPPLEMENTS; ELLAGIC ACID; FRANCE; GENE EXPRESSION REGULATION; GLUCURONIDES; HUMANS; HYDROLYZABLE TANNINS; PHENOLS; PILOT PROJECTS; PLANT EXTRACTS; QUERCUS; RIBOSOMES; SPLICEOSOMES; TRANSCRIPTOME;

EID: 84892770341     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf403493a     Document Type: Article

References (42)

1. Arts, I. C.; Hollman, P. C. Polyphenols and disease risk in epidemiologic studies Am. J. Clin. Nutr. 2005, 81, 317S-325S
2. Queen, B. L.; Tollefsbol, T. O. Polyphenols and aging Curr. Aging Sci. 2010, 3, 34-42
3. Forman, H. J.; Davies, K. J.; Ursini, F. How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo Free Radical Biol. Med. 2013, 10.1016/j.freeradbiomed.2013.05.045
4. Larrosa, M.; Gonzalez-Sarrias, A.; Yanez-Gascon, M. J.; Selma, M. V.; Azorin-Ortuno, M.; Toti, S.; Tomas-Barberan, F.; Dolara, P.; Espin, J. C. Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism J. Nutr. Biochem. 2010, 21, 717-725
5. Wu, S. B.; Dastmalchi, K.; Long, C.; Kennelly, E. J. Metabolite profiling of jaboticaba (Myrciaria cauliflora) and other dark-colored fruit juices J. Agric. Food Chem. 2012, 60, 7513-7525
6. Mayer, W.; Gabler, W.; Riester, A.; Korger, H. On tannins compounds from the wood of chestnut and oak wood-IIs. Isolation of castalagin, vescalagin, castalin and vescaline Liebigs Ann. Chem. 1967, 707, 177-181
7. García-Estévez, I.; Escribano-Bailón, M. T.; Rivas-Gonzalo, J. C.; Alcalde-Eon, C. Development of a fractionation method for the detection and identification of oak ellagitannins in red wines Anal. Chim. Acta 2010, 660, 171-176
8. Glabasnia, A.; Hofmann, T. Sensory-directed identification of taste-active ellagitannins in American (Quercus alba L.) and European oak wood (Quercus robur L.) and quantitative analysis in bourbon whiskey and oak-matured red wines J. Agric. Food Chem. 2006, 54, 3380-3390
9. Seeram, N. P.; Henning, S. M.; Zhang, Y.; Suchard, M.; Li, Z.; Heber, D. Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 h J. Nutr. 2006, 136, 2481-2485
10. Espín, J. C.; González-Barrio, R.; Cerdá, B.; López-Bote, C.; Rey, A. I.; Tomás-Barberán, F. A. Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans J. Agric. Food Chem. 2007, 55, 10476-10485
11. Cerda, B.; Tomas-Barberan, F. A.; Espin, J. C. Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability J. Agric. Food Chem. 2005, 53, 227-235
12. Gonzalez-Barrio, R.; Borges, G.; Mullen, W.; Crozier, A. Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy J. Agric. Food Chem. 2010, 58, 3933-3939
13. Serafini, M.; Maiani, G.; Ferro-Luzzi, A. Alcohol-free red wine enhances plasma antioxidant capacity in humans J. Nutr. 1998, 128, 1003-1007
14. Prior, R. L.; Hoang, H.; Gu, L.; Wu, X.; Bacchiocca, M.; Howard, L.; Hampsch-Woodill, M.; Huang, D.; Ou, B.; Jacob, R. Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC(FL))) of plasma and other biological and food samples J. Agric. Food Chem. 2003, 51, 3273-3279
15. Huang, D.; Ou, B.; Hampsch-Woodill, M.; Flanagan, J. A.; Prior, R. L. High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format J. Agric. Food Chem. 2002, 50, 4437-4444
16. Sanges, R.; Cordero, F.; Calogero, R. A. oneChannelGUI: a graphical interface to Bioconductor tools, designed for life scientists who are not familiar with R language Bioinformatics 2007, 23, 3406-3408
17. Huang da, W.; Sherman, B. T.; Tan, Q.; Kir, J.; Liu, D.; Bryant, D.; Guo, Y.; Stephens, R.; Baseler, M. W.; Lane, H. C.; Lempicki, R. A. DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists Nucleic Acids Res. 2007, 35, W169-175
18. D'Andrea, D.; Grassi, L.; Mazzapioda, M.; Tramontano, A. FIDEA: a server for the functional interpretation of differential expression analysis Nucleic Acids Res. 2013, 41, W84-88
19. Canali, R.; Ambra, R.; Stelitano, C.; Mattivi, F.; Scaccini, C.; Virgili, F. A novel model to study the biological effects of red wine at the molecular level Br. J. Nutr. 2007, 97, 1053-1058
20. Shahrzad, S.; Aoyagi, K.; Winter, A.; Koyama, A.; Bitsch, I. Pharmacokinetics of gallic acid and its relative bioavailability from tea in healthy humans J. Nutr. 2001, 131, 1207-1210
21. Manach, C.; Williamson, G.; Morand, C.; Scalbert, A.; Remesy, C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies Am. J. Clin. Nutr. 2005, 81, 230S-242S
22. Shor, D.; Sathyapalan, T.; Atkin, S. L.; Thatcher, N. J. Does equol production determine soy endocrine effects? Eur. J. Nutr. 2012, 51, 389-398
23. Cerda, B.; Periago, P.; Espin, J. C.; Tomas-Barberan, F. A. Identification of urolithin a as a metabolite produced by human colon microflora from ellagic acid and related compounds J. Agric. Food Chem. 2005, 53, 5571-5576
24. Cerda, B.; Espin, J. C.; Parra, S.; Martinez, P.; Tomas-Barberan, F. A. The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6 H -dibenzopyran-6-one derivatives by the colonic microflora of healthy humans Eur. J. Nutr. 2004, 43, 205-220
25. Seeram, N. P.; Lee, R.; Heber, D. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice Clin. Chim. Acta 2004, 348, 63-68
26. Mertens-Talcott, S. U.; Jilma-Stohlawetz, P.; Rios, J.; Hingorani, L.; Derendorf, H. Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum L.) polyphenols after ingestion of a standardized extract in healthy human volunteers J. Agric. Food Chem. 2006, 54, 8956-8961
27. Cerda, B.; Soto, C.; Albaladejo, M. D.; Martinez, P.; Sanchez-Gascon, F.; Tomas-Barberan, F.; Espin, J. C. Pomegranate juice supplementation in chronic obstructive pulmonary disease: a 5-week randomized, double-blind, placebo-controlled trial Eur. J. Clin. Nutr. 2006, 60, 245-253
28. Gonzalez-Sarrias, A.; Gimenez-Bastida, J. A.; Garcia-Conesa, M. T.; Gomez-Sanchez, M. B.; Garcia-Talavera, N. V.; Gil-Izquierdo, A.; Sanchez-Alvarez, C.; Fontana-Compiano, L. O.; Morga-Egea, J. P.; Pastor-Quirante, F. A.; Martinez-Diaz, F.; Tomas-Barberan, F. A.; Espin, J. C. Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice Mol. Nutr. Food Res. 2010, 54, 311-322
29. Stoner, G. D.; Sardo, C.; Apseloff, G.; Mullet, D.; Wargo, W.; Pound, V.; Singh, A.; Sanders, J.; Aziz, R.; Casto, B.; Sun, X. Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days J. Clin. Pharmacol. 2005, 45, 1153-1164
30. Cerda, B.; Llorach, R.; Ceron, J. J.; Espin, J. C.; Tomas-Barberan, F. A. Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice Eur. J. Nutr. 2003, 42, 18-28
31. Robbins, R. J.; Kwik-Uribe, C.; Hammerstone, J. F.; Schmitz, H. H. Analysis of flavanols in foods: what methods are required to enable meaningful health recommendations? J. Cardiovasc. Pharmacol. 2006, 47, S110-S121
32. Bialonska, D.; Kasimsetty, S. G.; Khan, S. I.; Ferreira, D. Urolithins, intestinal microbial metabolites of pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay J. Agric. Food Chem. 2009, 57, 10181-10186
33. Ito, H.; Iguchi, A.; Hatano, T. Identification of urinary and intestinal bacterial metabolites of ellagitannin geraniin in rats J. Agric. Food Chem. 2008, 56, 393-400
34. Qiu, Z.; Zhou, B.; Jin, L.; Yu, H.; Liu, L.; Liu, Y.; Qin, C.; Xie, S.; Zhu, F. In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells Food Chem. Toxicol. 2013, 59, 428-437
35. Losso, J. N.; Bansode, R. R.; Trappey, A., 2nd; Bawadi, H. A.; Truax, R. In vitro anti-proliferative activities of ellagic acid J. Nutr. Biochem. 2004, 15, 672-678
36. Vidya Priyadarsini, R.; Kumar, N.; Khan, I.; Thiyagarajan, P.; Kondaiah, P.; Nagini, S. Gene expression signature of DMBA-induced hamster buccal pouch carcinomas: modulation by chlorophyllin and ellagic acid PLoS One 2012, 7, e34628
37. Gimenez-Bastida, J. A.; Gonzalez-Sarrias, A.; Larrosa, M.; Tomas-Barberan, F.; Espin, J. C.; Garcia-Conesa, M. T. Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-alpha-induced inflammation and associated molecular markers in human aortic endothelial cells Mol. Nutr. Food Res. 2012, 56, 784-796
38. Gonzalez-Sarrias, A.; Azorin-Ortuno, M.; Yanez-Gascon, M. J.; Tomas-Barberan, F. A.; Garcia-Conesa, M. T.; Espin, J. C. Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytochrome P450 1A1 J. Agric. Food Chem. 2009, 57, 5623-5632
39. Ho, H. H.; Chang, C. S.; Ho, W. C.; Liao, S. Y.; Lin, W. L.; Wang, C. J. Gallic acid inhibits gastric cancer cells metastasis and invasive growth via increased expression of RhoB, downregulation of AKT/small GTPase signals and inhibition of NF-kappaB activity Toxicol. Appl. Pharmacol. 2013, 266, 76-85
40. Yeh, R. D.; Chen, J. C.; Lai, T. Y.; Yang, J. S.; Yu, C. S.; Chiang, J. H.; Lu, C. C.; Yang, S. T.; Yu, C. C.; Chang, S. J.; Lin, H. Y.; Chung, J. G. Gallic acid induces G(0)/G(1) phase arrest and apoptosis in human leukemia HL-60 cells through inhibiting cyclin D and E, and activating mitochondria-dependent pathway Anticancer Res. 2011, 31, 2821-2832
41. Verma, S.; Singh, A.; Mishra, A. Gallic acid: molecular rival of cancer Environ. Toxicol. Pharmacol. 2013, 35, 473-485
42. Al-Halabi, R.; Bou Chedid, M.; Abou Merhi, R.; El-Hajj, H.; Zahr, H.; Schneider-Stock, R.; Bazarbachi, A.; Gali-Muhtasib, H. Gallotannin inhibits NFkB signaling and growth of human colon cancer xenografts Cancer Biol. Ther. 2011, 12, 59-68