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Volumn 19, Issue , 2015, Pages 225-235

Identifying the limits for ellagic acid bioavailability: A crossover pharmacokinetic study in healthy volunteers after consumption of pomegranate extracts

Author keywords

Bioavailability; Ellagic acid; Pharmacokinetics; Pomegranate; Punicalagin; Urolithins

Indexed keywords


EID: 84946397477     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2015.09.019     Document Type: Article
Times cited : (133)

References (33)
  • 4
    • 0025895019 scopus 로고
    • The effects of pH and rat intestinal contents on the liberation of ellagic acid from purified and crude ellagitannins
    • Daniel E.M., Ratnayake S., Kinstle T., Stoner G.D. The effects of pH and rat intestinal contents on the liberation of ellagic acid from purified and crude ellagitannins. Journal of Natural Products 1991, 54:946-952.
    • (1991) Journal of Natural Products , vol.54 , pp. 946-952
    • Daniel, E.M.1    Ratnayake, S.2    Kinstle, T.3    Stoner, G.D.4
  • 5
    • 84905127274 scopus 로고    scopus 로고
    • Dietary ellagic acid improves oxidant-induced endothelial dysfunction and atherosclerosis: Role of Nrf2 activation
    • Ding Y., Zhang B., Zhou K., Chen M., Wang M., Jia Y., Song Y., Li Y., Wen A. Dietary ellagic acid improves oxidant-induced endothelial dysfunction and atherosclerosis: Role of Nrf2 activation. International Journal of Cardiology 2014, 175:508-514.
    • (2014) International Journal of Cardiology , vol.175 , pp. 508-514
    • Ding, Y.1    Zhang, B.2    Zhou, K.3    Chen, M.4    Wang, M.5    Jia, Y.6    Song, Y.7    Li, Y.8    Wen, A.9
  • 10
    • 70349925317 scopus 로고    scopus 로고
    • A citrus extract containing flavanones represses plasminogen activator inhibitor-1 (PAI-1) expression and regulates multiple inflammatory, tissue repair, and fibrosis genes in human colon fibroblasts
    • Giménez-Bastida J.A., Martínez-Florensa M., Espín J.C., Tomás-Barberán F.A., García-Conesa M.T. A citrus extract containing flavanones represses plasminogen activator inhibitor-1 (PAI-1) expression and regulates multiple inflammatory, tissue repair, and fibrosis genes in human colon fibroblasts. Journal of Agricultural and Food Chemistry 2009, 57:9305-9315.
    • (2009) Journal of Agricultural and Food Chemistry , vol.57 , pp. 9305-9315
    • Giménez-Bastida, J.A.1    Martínez-Florensa, M.2    Espín, J.C.3    Tomás-Barberán, F.A.4    García-Conesa, M.T.5
  • 13
    • 84906792059 scopus 로고    scopus 로고
    • Unravelling of the health effects of polyphenols is a complex puzzle complicated by metabolism
    • Hollman P.C. Unravelling of the health effects of polyphenols is a complex puzzle complicated by metabolism. Archives of Biochemistry and Biophysics 2014, 559:100-105.
    • (2014) Archives of Biochemistry and Biophysics , vol.559 , pp. 100-105
    • Hollman, P.C.1
  • 14
    • 84870201265 scopus 로고    scopus 로고
    • Stability and solubility enhancement of ellagic acid in cellulose ester solid dispersions
    • Li B., Harich K., Wegiel L., Taylor L.S., Edgara K.J. Stability and solubility enhancement of ellagic acid in cellulose ester solid dispersions. Carbohydrate Polymers 2013, 92:1443-1450.
    • (2013) Carbohydrate Polymers , vol.92 , pp. 1443-1450
    • Li, B.1    Harich, K.2    Wegiel, L.3    Taylor, L.S.4    Edgara, K.J.5
  • 16
    • 84898607793 scopus 로고    scopus 로고
    • Quality and chemical composition of ten red raspberry (Rubus idaeus L.) genotypes during three harvest seasons
    • Mazur S.P., Nes A., Wold A.B., Remberg S.F., Aaby K. Quality and chemical composition of ten red raspberry (Rubus idaeus L.) genotypes during three harvest seasons. Food Chemistry 2014, 160:233-240.
    • (2014) Food Chemistry , vol.160 , pp. 233-240
    • Mazur, S.P.1    Nes, A.2    Wold, A.B.3    Remberg, S.F.4    Aaby, K.5
  • 17
    • 33751260936 scopus 로고    scopus 로고
    • Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers
    • Mertens-Talcott S.U., Jilma-Stohlawetz P., Rios J., Hingorani L., Derendorf H. Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers. Journal of Agricultural and Food Chemistry 2006, 54:8956-8961.
    • (2006) Journal of Agricultural and Food Chemistry , vol.54 , pp. 8956-8961
    • Mertens-Talcott, S.U.1    Jilma-Stohlawetz, P.2    Rios, J.3    Hingorani, L.4    Derendorf, H.5
  • 18
    • 84923316600 scopus 로고    scopus 로고
    • Ellagic acid, a component of pomegranate fruit juice, suppresses androgen-dependent prostate carcinogenesis via induction of apoptosis
    • Naiki-Ito A., Chewonarin T., Tang M., Pitchakarn P., Kuno T., Ogawa K., Asamoto M., Shirai T., Takahashi S. Ellagic acid, a component of pomegranate fruit juice, suppresses androgen-dependent prostate carcinogenesis via induction of apoptosis. The Prostate 2015, 75:151-160.
    • (2015) The Prostate , vol.75 , pp. 151-160
    • Naiki-Ito, A.1    Chewonarin, T.2    Tang, M.3    Pitchakarn, P.4    Kuno, T.5    Ogawa, K.6    Asamoto, M.7    Shirai, T.8    Takahashi, S.9
  • 20
    • 84926252843 scopus 로고    scopus 로고
    • Ellagic acid modulates lipid accumulation in primary human adipocytes and human hepatoma Huh7 cells via discrete mechanisms
    • Okla M., Kang I., da Kim M., Gourineni V., Shay N., Gu L., Chung S. Ellagic acid modulates lipid accumulation in primary human adipocytes and human hepatoma Huh7 cells via discrete mechanisms. The Journal of Nutritional Biochemistry 2015, 26:82-90.
    • (2015) The Journal of Nutritional Biochemistry , vol.26 , pp. 82-90
    • Okla, M.1    Kang, I.2    da Kim, M.3    Gourineni, V.4    Shay, N.5    Gu, L.6    Chung, S.7
  • 22
    • 33749494522 scopus 로고    scopus 로고
    • Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours
    • Seeram N.P., Henning S.M., Zhang Y., Suchard M., Li Z., Heber D. Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. The Journal of Nutrition 2006, 136:2481-2485.
    • (2006) The Journal of Nutrition , vol.136 , pp. 2481-2485
    • Seeram, N.P.1    Henning, S.M.2    Zhang, Y.3    Suchard, M.4    Li, Z.5    Heber, D.6
  • 23
    • 4444365417 scopus 로고    scopus 로고
    • Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice
    • Seeram N.P., Lee R., Heber D. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clinica Chimica Acta 2004, 348:63-68.
    • (2004) Clinica Chimica Acta , vol.348 , pp. 63-68
    • Seeram, N.P.1    Lee, R.2    Heber, D.3
  • 25
    • 84946491882 scopus 로고    scopus 로고
    • Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effects: A review
    • Shahidi F., Ambigaipalan P. Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effects: A review. Journal of Functional Foods 2015, 10.1016/j.jff.2015.06.018.
    • (2015) Journal of Functional Foods
    • Shahidi, F.1    Ambigaipalan, P.2
  • 27
    • 84898053516 scopus 로고    scopus 로고
    • Common delivery systems for enhancing in vivo bioavailability and biological efficacy of nutraceuticals
    • Ting Y., Jiang Y., Ho C.T., Huang Q. Common delivery systems for enhancing in vivo bioavailability and biological efficacy of nutraceuticals. Journal of Functional Foods 2014, 7:112-128.
    • (2014) Journal of Functional Foods , vol.7 , pp. 112-128
    • Ting, Y.1    Jiang, Y.2    Ho, C.T.3    Huang, Q.4
  • 29
    • 84904437984 scopus 로고    scopus 로고
    • Ellagic acid metabolism by human gut microbiota: Consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and health status
    • Tomás-Barberán F.A., García-Villalba R., González-Sarrías A., Selma M.V., Espín J.C. Ellagic acid metabolism by human gut microbiota: Consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and health status. Journal of Agricultural and Food Chemistry 2014, 62:6535-6538.
    • (2014) Journal of Agricultural and Food Chemistry , vol.62 , pp. 6535-6538
    • Tomás-Barberán, F.A.1    García-Villalba, R.2    González-Sarrías, A.3    Selma, M.V.4    Espín, J.C.5
  • 30
    • 0042762851 scopus 로고    scopus 로고
    • Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid-extensive binding to protein and DNA
    • Whitley A.C., Stoner G.D., Darby M.V., Walle T. Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid-extensive binding to protein and DNA. Biochemical Pharmacology 2003, 66:907-915.
    • (2003) Biochemical Pharmacology , vol.66 , pp. 907-915
    • Whitley, A.C.1    Stoner, G.D.2    Darby, M.V.3    Walle, T.4
  • 31
    • 22944481531 scopus 로고    scopus 로고
    • The dietary polyphenol ellagic acid is a potent inhibitor of hOAT1
    • Whitley A.C., Sweet D.H., Walle T. The dietary polyphenol ellagic acid is a potent inhibitor of hOAT1. Drug Metabolism and Disposition 2005, 33:1097-1100.
    • (2005) Drug Metabolism and Disposition , vol.33 , pp. 1097-1100
    • Whitley, A.C.1    Sweet, D.H.2    Walle, T.3
  • 32
    • 33748296179 scopus 로고    scopus 로고
    • Site-specific accumulation of the cancer preventive dietary polyphenol ellagic acid in epithelial cells of the aerodigestive tract
    • Whitley A.C., Sweet D.H., Walle T. Site-specific accumulation of the cancer preventive dietary polyphenol ellagic acid in epithelial cells of the aerodigestive tract. The Journal of Pharmacy and Pharmacology 2006, 58:1201-1209.
    • (2006) The Journal of Pharmacy and Pharmacology , vol.58 , pp. 1201-1209
    • Whitley, A.C.1    Sweet, D.H.2    Walle, T.3
  • 33
    • 84938834045 scopus 로고    scopus 로고
    • Regulations and protection for functional food products in the United States
    • Wong A.Y.T., Lai J.M.C., Chan A.W.K. Regulations and protection for functional food products in the United States. Journal of Functional Foods 2015, 17:540-551.
    • (2015) Journal of Functional Foods , vol.17 , pp. 540-551
    • Wong, A.Y.T.1    Lai, J.M.C.2    Chan, A.W.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.