MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer and in response to pomegranate extracts consumption: Critical issues to discern between modulatory effects and potential artefacts

Molecular Nutrition and Food Research

Volumn 59, Issue 10, 2015, Pages 1973-1986

  Nuñez Sánchez, María A ^a   Dávalos, Alberto ^b   González Sarrías, Antonio ^a   Casas Agustench, Patricia ^b   Visioli, Francesco ^b   Monedero Saiz, Tamara ^a,c   García Talavera, Noelia V ^c   Gómez Sánchez, María B ^c   Sánchez Álvarez, Carmen ^c   García Albert, Ana M ^c   Rodríguez Gil, Francisco J ^c   Ruiz Marín, Miguel ^c   Pastor Quirante, Francisco A ^c   Martínez Díaz, Francisco ^c   Tomás Barberán, Francisco A ^a   García Conesa, María Teresa ^a   Espín, Juan Carlos ^a  

^a RESEARCH GROUP ON QUALITY   (Spain)

^b IMDEA FOOD INSTITUTE   (Spain)

^c HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

Author keywords

Clinical trials; Colon cancer; MicroRNA; Pomegranate; Urolithins

Indexed keywords

MICRORNA; PLANT EXTRACT; TUMOR MARKER;

AGED; COLON; COLORECTAL NEOPLASMS; CONTROLLED STUDY; DIET THERAPY; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LYTHRACEAE; MALE; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; PREOPERATIVE CARE; RANDOMIZED CONTROLLED TRIAL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BIOMARKERS, TUMOR; COLON; COLORECTAL NEOPLASMS; DOUBLE-BLIND METHOD; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICRORNAS; MIDDLE AGED; PLANT EXTRACTS; PREOPERATIVE CARE; PUNICACEAE;

EID: 84942834606     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201500357     Document Type: Article

References (50)

1. Brenner, H., Kloor, M., Pox, C. P., Colorectal cancer. Lancet 2014, 383, 1490-1502.
2. Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S. et al., Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer 2015, 136, E359-E386.
3. Binefa, G., Rodríguez-Moranta, F., Teule, A., Medina-Hayas, M., Colorectal cancer: from prevention to personalized medicine. World J. Gastroenterol. 2014, 20, 6786-6808.
4. Ye, J. J., Cao, J., MicroRNAs in colorectal cancer as markers and targets: recent advances. World J. Gastroenterol. 2014, 20, 4288-4299.
5. Kong, Y. W., Ferland-McCollough, D., Jackson, T. J., Bushell, M., microRNAs in cancer management. Lancet Oncol. 2012, 13, 249-258.
6. Schwingshackl, L., Hoffmann, G., Adherence to Mediterranean diet and risk of cancer: a systematic review and meta-analysis of observational studies. Int. J. Cancer 2014, 135, 1884-1897.
7. Bradbury, K. E., Appleby, P. N., Key, T. J., Fruit, vegetable, and fiber intake in relation to cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC). Am. J. Clin. Nutr. 2014, 100, 394S-398S.
8. Núñez-Sánchez, M. A., González-Sarrías, A., Romo-Vaquero, M., García-Villalba, R. et al., Dietary phenolics against colorectal cancer-from promising preclinical results to poor translation into clinical trials: pitfalls and future needs. Mol. Nutr. Food Res. 2015, 59, 1274-1291.
9. Milenkovic, D., Jude, B., Morand, C., miRNA as molecular target of polyphenols underlying their biological effects. Free Radic. Biol. Med. 2013, 64, 40-51.
10. Wang, L. S., Burke, C. A., Hasson, H., Kuo, C. T. et al., A phase Ib study of the effects of black raspberries on rectal polyps in patients with familial adenomatous polyposis. Cancer Prev. Res. 2014, 7, 666-674.
11. Núñez-Sánchez, M. A., García-Villalba, R., Monedero-Saiz, T., García-Talavera, N. V. et al., Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients. Mol. Nutr. Food Res. 2014, 58, 1199-1211.
12. Schroeder, A., Mueller, O., Stocker, S., Salowsky, R. et al., The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol. Biol. 2006, 7, 3.
13. Dweep, H., Sticht, C., Pandey, P., Gretz, H., miRWalk-database: prediction of possible miRNA binding sites by "walking" the genes of three genomes. J. Biomed. Inform. 2011, 44, 839-847.
14. Hsu, S. D., Lin, F. M., Wu, W. Y., Liang, C. et al., miRTarBase: a database curates experimentally validated microRNA-target interactions. Nucleic Acids Res. 2011, 39 (database issue), D163-D169.
15. Tabas-Madrid, D., Nogales-Cadenas, R., Pascual-Montano, A., GeneCodis3: a non-redundant and modular enrichment analysis tool for functional genomics. Nucleic Acids Res. 2012, 40 (web server issue), W478-W483.
16. Meijer, H. A., Smith, E. M., Bushell, M., Regulation of miRNA strand selection: follow the leader? Biochem. Soc. Trans. 2014, 42, 1135-1140.
17. Bustin, S. A., Murphy, J., RNA biomarkers in colorectal cancer. Methods 2013, 59, 116-125.
18. Wu, X., Xu, X., Li, S., Wu, S. et al., Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma. PLoS One 2015, 10, e0120024.
19. Gattolliat, C. H., Uguen, A., Pesson, M., Trillet, K. et al., MicroRNA and targeted mRNA expression profiling analysis in human colorectal adenomas and adenocarcinomas. Eur. J. Cancer 2015, 51, 409-420.
20. Borgan, E., Navon, R., Vollan, H. K., Schlichting, E. et al., Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue. Mol. Oncol. 2011, 5, 564-576.
21. Kent, O. A., McCall, M. N., Cornish, T. C., Halushka, M. K., Lessons from miR-143/145: the importance of cell-type localization of miRNAs. Nucleic Acids Res. 2014, 42, 7528-7538.
22. Slattery, M. L., Wolff, E., Hoffman, M. D., Pellatt, D. F. et al., MicroRNAs and colon and rectal cancer: differential expression by tumor location and subtype. Genes Chromosomes Cancer 2011, 50, 196-206.
23. Motoyama, K., Inoue, H., Takatsuno, Y., Tanaka, F. et al., Over- and under-expressed microRNAs in human colorectal cancer. Int. J. Oncol. 2009, 34, 1069-1075.
24. Aslam, M. I., Hussein, S., West, K., Singh, B. et al., MicroRNAs associated with initiation and progression of colonic polyp: a feasibility study. Int. J. Surg. 2015, 13, 272-279.
25. Brunet Vega, A., Pericay, C., Moya, I., Ferrer, A. et al., microRNA expression profile in stage III colorectal cancer: circulating miR-18a and miR-29a as promising biomarkers. Oncol. Rep. 2013, 30, 320-326.
26. Wang, L., Yu, J., Xu, J., Zheng, C. et al., The analysis of microRNA-34 family expression in human cancer studies comparing cancer tissues with corresponding pericarcinous tissues. Gene 2015, 554, 1-8.
27. Goedeke, L., Vales-Lara, F. M., Fenstermaker, M., Cirera-Salinas, D. et al., A regulatory role for microRNA 33 in controlling lipid metabolism gene expression. Mol. Cell Biol. 2013, 33, 2339-2352.
28. Almeida, M. I., Nicoloso, M. S., Zeng, L., Ivan, C. et al., Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells. Gastroenterology 2012, 142, 886-896.
29. Choo, K. B., Soon, Y. L., Nguyen, P. N., Hiew, M. S. et al., MicroRNA-5p and -3p co-expression and cross-targeting in colon cancer cells. J. Biomed. Sci. 2014, 21, 95.
30. Xi, Y., Formentini, A., Chien, M., Weir, D. B. et al., Prognostic values of microRNAs in colorectal cancer. Biomark. Insights 2006, 2, 113-121.
31. Fu, J., Tang, W., Du, P., Wang, G. et al., Identifying microRNA-mRNA regulatory network in colorectal cancer by a combination of expression profile and bioinformatics analysis. BMC Syst. Biol. 2012, 6, 68.
32. Chen, W. S., Chen, T. W., Yang, T. H., Hu, L. Y. et al., Co-modulated behavior and effects of differentially expressed miRNA in colorectal cancer. BMC Genomics 2013, 14, S12.
33. Kumazaki, M., Noguchi, S., Yasui, Y., Iwasaki, J. et al., Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells. J. Nutr. Biochem. 2013, 24, 1849-1858.
34. Del Follo-Martinez, A., Banerjee, N., Li, X., Safe, S. et al., Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a. Nutr. Cancer 2013, 65, 494-504.
35. Banerjee, N., Kim, H., Talcott, S., Mertens-Talcott, S., Pomegranate polyphenolics suppressed azoxymethane-induced colorectal aberrant crypt foci and inflammation: possible role of miR-126/VCAM-1 and miR-126/PI3K/AKT/mTOR. Carcinogenesis 2013, 34, 2814-2822.
36. Saud, S. M., Li, W., Morris, N. L., Matter, M. S. et al., Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic KRAS expression. Carcinogenesis 2014, 35, 2778-2786.
37. Tomás-Barberán, F. A., García-Villalba, R., González-Sarrías, A., Selma, M. V. et al., Ellagic acid metabolism by human gut microbiota: consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and health status. J. Agric. Food Chem. 2014, 62, 6535-6538.
38. Slattery, M. L., Herrick, J. S., Mullany, L. E., Valeri, N. et al., An evaluation and replication of miRNAs with disease stage and colorectal cancer-specific mortality. Int. J. Cancer 2015, 137, 428-438.
39. Ngalame, N. N., Tokar, E. J., Person, R. J., Xu, Y. et al., Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic. Toxicol. Sci. 2014, 138, 268-277.
40. Pichler, M., Winter, E., Ress, A. L., Bauernhofer, T. et al., miR-181a is associated with poor clinical outcome in patients with colorectal cancer treated with EGFR inhibitor. J. Clin. Pathol. 2014, 67, 198-203.
41. Wotschofsky, Z., Busch, J., Jung, M., Kempkensteffen, C. et al., Diagnostic and prognostic potential of differentially expressed miRNAs between metastatic and non-metastatic renal cell carcinoma at the time of nephrectomy. Clin. Chim. Acta 2013, 416, 5-10.
42. Xu, J., Tian, S., Yin, Z., Wu, S. et al., MicroRNA-binding site SNPs in deregulated genes are associated with clinical outcome of non-small cell lung cancer. Lung Cancer 2014, 85, 442-448.
43. Zhu, H., Miao, M. H., Ji, X. Q., Xue, J. et al., miR-664 negatively regulates PLP2 and promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia. Biochem. Biophys. Res. Commun. 2015, 459, 340-345.
44. Venkatachalam, R., Verwiel, E. T., Kamping, E. J., Hoenselaar, E. et al., Identification of candidate predisposing copy number variants in familial and early-onset colorectal cancer patients. Int. J. Cancer 2011, 129, 1635-1642.
45. Della Vittoria Scarpati, G., Falcetta, F., Carlomagno, C., Ubezio, P. et al., A specific miRNA signature correlates with complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 2012, 83, 1113-1119.
46. Kou, Y., Qiao, L., Wang, Q., Identification of core miRNA based on small RNA-seq and RNA-seq for colorectal cancer by bioinformatics Tumour Biol. 2014, 36, 2249-2255.
47. Okumura, T., Shimada, Y., Omura, T., Hirano, K. et al., MicroRNA profiles to predict postoperative prognosis in patients with small cell carcinoma of the esophagus. Anticancer Res. 2015, 35, 719-727.
48. Castell-Auví, A., Cedó, L., Movassat, J., Portha, B. et al., Procyanidins modulate microRNA expression in pancreatic islets. J. Agric. Food Chem. 2013, 61, 355-363.
49. Alvarado, S., Wyglinski, J., Suderman, M., Andrews, S. A. et al., Methylated DNA binding domain protein 2 (MBD2) coordinately silences gene expression through activation of the microRNA hsa-mir-496 promoter in breast cancer cell line. PLoS One 2013, 8, e74009.
50. Skawran, B., Steinemann, D., Becker, T., Buurman, R. et al., Loss of 13q is associated with genes involved in cell cycle and proliferation in dedifferentiated hepatocellularcarcinoma. Mod. Pathol. 2008, 21, 1479-1489.