The gut microbiota ellagic acid-derived metabolite urolithin a and its sulfate conjugate are substrates for the drug efflux transporter breast cancer resistance protein (ABCG2/BCRP)

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 18, 2013, Pages 4352-4359

  González Sarrías, Antonio ^a   Miguel, Verónica ^b   Merino, Gracia ^b   Lucas, Ricardo ^c   Morales, Juan C ^c   Tomás Barberán, Francisco ^a   Álvarez, Ana I ^b   Espín, Juan C ^a  

^a RESEARCH GROUP ON QUALITY   (Spain)

^b UNIVERSITY OF LEÓN   (Spain)

^c UNIVERSITY OF SEVILLE   (Spain)

Author keywords

ABCG2 BCRP transporters; Bcrp1 MDCKII cells; ellagic acid; gut microbiota; urolithin

Indexed keywords

ABCG2/BCRP TRANSPORTERS; ANTI-INFLAMMATORIES; ANTINEOPLASTIC AGENTS; BREAST CANCER RESISTANCE PROTEINS; DOSE-DEPENDENT MANNER; GUT MICROBIOTA; TOXICOLOGICAL PROPERTIES; UROLITHIN;

BIOMOLECULES; DISEASES; ELLAGIC ACID; FLOW CYTOMETRY; METABOLITES; PROTEINS; SULFUR COMPOUNDS;

SUBSTRATES;

3 (6 ISOBUTYL 9 METHOXY 1,4 DIOXO 1,2,3,4,6,7,12,12A OCTAHYDROPYRAZINO(1',2' 1,6)PYRIDO(3,4 B)INDOL 3 YL)PROPIONIC ACID TERT BUTYL ESTER; 3,8 DIHYDROXY 6H DIBENZO(B,D)PYRAN 6 ONE; 3,8-DIHYDROXY-6H-DIBENZO(B,D)PYRAN-6-ONE; 3-(6-ISOBUTYL-9-METHOXY-1,4-DIOXO-1,2,3,4,6,7,12,12A-OCTAHYDROPYRAZINO(1',2'-1,6)PYRIDO(3,4-B)INDOL-3-YL)PROPIONIC ACID TERT-BUTYL ESTER; ABC TRANSPORTER; ABCG2 PROTEIN, HUMAN; ADENOSINE; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; COUMARIN DERIVATIVE; DRUG DERIVATIVE; ELLAGIC ACID; GLUCURONIDE; MITOXANTRONE; SULFATE; TANNIN; TUMOR PROTEIN;

ANIMAL; ARTICLE; BREAST TUMOR; CATTLE; DOG; FEMALE; GENETICS; HUMAN; MDCK CELL; METABOLISM; MICROFLORA; MOUSE; SHEEP; TUMOR CELL LINE;

ADENOSINE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BREAST NEOPLASMS; CATTLE; CELL LINE, TUMOR; COUMARINS; DOGS; ELLAGIC ACID; FEMALE; GLUCURONIDES; HUMANS; HYDROLYZABLE TANNINS; MADIN DARBY CANINE KIDNEY CELLS; MICE; MICROBIOTA; MITOXANTRONE; NEOPLASM PROTEINS; SHEEP; SULFATES;

EID: 84877295491     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf4007505     Document Type: Article

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