Targeting histone methylation for cancer therapy: Enzymes, inhibitors, biological activity and perspectives

Journal of Hematology and Oncology

Volumn 9, Issue 1, 2016, Pages

  Song, Yongcheng ^a   Wu, Fangrui ^a   Wu, Jingyu ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cancer therapeutics; Enzyme inhibitor; Histone demethylase; Histone lysine methyltransferase; Histone methylation; Protein arginine methyltransferase

Indexed keywords

1 [3 [[5 (4 AMINO 5 BROMO 7H PYRROLO[2,3 D]PYRIMIDIN 7 YL) 3,4 DIHYDROXYTETRAHYDRO 2 FURFURYL](ISOPROPYL)AMINO]PROPYL] 3 (4 TERT BUTYLPHENYL)UREA; ARGININE; ENASIDENIB; EPZ 004777; GSK 126; GSK 2879552; GSK 690; HISTONE; HISTONE DEACETYLASE INHIBITOR; HISTONE LYSINE METHYLTRANSFERASE; HISTONE LYSINE METHYLTRANSFERASE INHIBITOR; HISTONE METHYLTRANSFERASE; ISOCITRATE DEHYDROGENASE; LYSINE; LYSINE SPECIFIC DEMETHYLASE 1; MIXED LINEAGE LEUKEMIA PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN INHIBITOR; MONOAMINE OXIDASE INHIBITOR; N (1 BENZYL 4 PIPERIDINYL) 2 (HEXAHYDRO 4 METHYL 1H 1,4 DIAZEPIN 1 YL) 6,7 DIMETHOXY 4 QUINAZOLINAMINE; N CYCLOPROPYL 4 (3 THIENYL) 3 [[[[3 (TRIFLUOROMETHYL)PHENYL]AMINO]CARBONYL]AMINO]BENZENESULFONAMIDE; N [2 CYCLOHEXYLAMINO 1 (2 METHYLPHENYL) 2 OXOETHYL] N (3 FLUOROPHENYL) 2 METHYL 1H IMIDAZOLE 1 ACETAMIDE; OXYGENASE; PINOMETOSTAT; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN INHIBITOR; SP 2509; TAZEMETOSTAT; TRANYLCYPROMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZPI 169; ENZYME INHIBITOR; METHYLTRANSFERASE;

ACUTE MYELOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; BIOCHEMISTRY; CARCINOGENESIS; CONTINUOUS INFUSION; DIARRHEA; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG POTENTIATION; DRUG RESEARCH; DRUG SAFETY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; ENZYME STRUCTURE; EPIGENETICS; FATIGUE; GENE CONTROL; GENE MUTATION; GENE OVEREXPRESSION; GENE TRANSLOCATION; GLIOMA; HISTONE METHYLATION; HUMAN; HYPERBILIRUBINEMIA; HYPOMAGNESEMIA; LEUKEMIA; LEUKOCYTOSIS; MALIGNANT NEOPLASTIC DISEASE; MIXED LINEAGE LEUKEMIA; MYELODYSPLASTIC SYNDROME; NAUSEA; NONHODGKIN LYMPHOMA; NONHUMAN; PROTEIN PROCESSING; REVIEW; SMALL CELL LUNG CANCER; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; DNA METHYLATION; DRUG EFFECTS; GENETIC EPIGENESIS; GENETICS; METABOLISM; NEOPLASM;

DNA METHYLATION; ENZYME INHIBITORS; EPIGENESIS, GENETIC; HISTONES; METHYLTRANSFERASES; NEOPLASMS;

EID: 84975789841     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/s13045-016-0279-9     Document Type: Review

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