Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation

Leukemia

Volumn 26, Issue 9, 2012, Pages 2039-2051

  Sprussel A ^a   Schulte, J H ^a   Weber, S ^a   Necke, M ^a   Handschke K ^a   Thor, T ^a   Pajtler, K W ^a   Schramm, A ^a   Konig K ^b   Diehl, L ^c   Mestdagh, P ^d   Vandesompele, J ^d   Speleman, F ^d   Jastrow, H ^a   Heukamp, L C ^b   Schule R ^e   Duhrsen U ^a   Buettner, R ^b   Eggert, A ^a   Gothert J R ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^c UNIVERSITY HOSPITAL BONN   (Germany)

^d GHENT UNIVERSITY HOSPITAL   (Belgium)

^e UNIVERSITY OF FREIBURG   (Germany)

Author keywords

hematopoiesis; inhibited terminal differentiation; LSD1 KDM1A; progenitor expansion

Indexed keywords

FIBRINOGEN RECEPTOR; GFI1B PROTEIN; LYSINE SPECIFIC DEMETHYLASE 1; MEIS1 PROTEIN; PROTEIN; TRANSCRIPTION FACTOR HOXA9; UNCLASSIFIED DRUG; UNCLASSIFIED ENZYME;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOREGULATION; CELL ACTIVITY; CELL COUNT; CELL DIFFERENTIATION; CELL EXPANSION; CELL PROLIFERATION; CONTROLLED STUDY; ERYTHROID CELL; ERYTHROPOIESIS; EXTRAMEDULLARY HEMATOPOIESIS; GENE SILENCING; GRANULOCYTE; GRANULOCYTOPENIA; GRANULOPOIESIS; HEMATOPOIETIC STEM CELL; IN VIVO STUDY; MALE; MEGAKARYOCYTE; MONOCYTOSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TERMINAL DIFFERENTIATION; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL PROLIFERATION; ERYTHROPOIESIS; FEMALE; FLOW CYTOMETRY; GRANULOCYTES; HEMATOPOIESIS; HUMANS; INTEGRASES; MALE; MEGAKARYOCYTES; MICE; MICE, TRANSGENIC; OXIDOREDUCTASES, N-DEMETHYLATING; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; STEM CELLS;

EID: 84865864630     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2012.157     Document Type: Article

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