Epigenetic targets and drug discovery: Part 1: Histone methylation

Pharmacology and Therapeutics

Volumn 143, Issue 3, 2014, Pages 275-294

  Liu, Yanli ^a,b   Liu, Ke ^a,b   Qin, Su ^b   Xu, Chao ^b   Min, Jinrong ^a,b,c  

^a CENTRAL CHINA NORMAL UNIVERSITY   (China)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cancer; Chemical probe; Epigenetics; Histone methylation; Inhibitor

Indexed keywords

1 [3 [[5 (4 AMINO 5 BROMO 7H PYRROLO[2,3 D]PYRIMIDIN 7 YL) 3,4 DIHYDROXYTETRAHYDRO 2 FURFURYL](ISOPROPYL)AMINO]PROPYL] 3 (4 TERT BUTYLPHENYL)UREA; 2 (6 AMINO 9H PURIN 9 YL) 5 [[[3 [2 (5 TERT BUTYL 1H BENZIMIDAZOL 2 YL)ETHYL]CYCLOBUTYL](ISOPROPYL)AMINO]METHYL]TETRAHYDROFURAN 3,4 DIOL; 2 CYCLOHEXYL N (1 ISOPROPYL 4 PIPERIDINYL) 6 METHOXY 7 [3 (1 PYRROLIDINYL)PROPOXY] 4 QUINAZOLINAMINE; 3 DEAZANEPLANOCIN A; 4 [2 (4 ISOPROPYLBENZAMIDO)ETHOXY]BENZOIC ACID; 7 [3 (DIMETHYLAMINO)PROPOXY] 2 (HEXAHYDRO 4 METHYL 1H 1,4 DIAZEPIN 1 YL) 6 METHOXY N (1 METHYL 4 PIPERIDINYL) 4 QUINAZOLINAMINE; A 36; A 366; A 9145C; AMI 1; AMI 2; AMI 3; AMI 4; AMI 5; AMI 6; AMI 7; AMI 8; AMI 9; AZ 505; BIX 01337; BIX 01338; BRD 9539; CCT 021895; CYPROHEPTADINE; E 67; E 70; E 72; EBI 099; EBI 435; EBI 455; EI 1; EPZ 000004; EPZ 004777; EPZ 005687; EPZ 6438; FED 1; FED 2; GSK 126; GSK 343; HISTONE METHYLTRANSFERASE; IA 9; K 15; MM 101; MM 102; MM 103; MM 401; MM 402; N (1 BENZYL 4 PIPERIDINYL) 2 (HEXAHYDRO 4 METHYL 1H 1,4 DIAZEPIN 1 YL) 6,7 DIMETHOXY 4 QUINAZOLINAMINE; NP 7; NS 2; ON 6; PROTEIN; PROTEIN G9A; PROTEIN GLP; PROTEIN SUV39H1; S ADENOSYLHOMOCYSTEINE; SGC 0947; SINEFUNGIN; SPIRO[CYCLOBUTANE 1,3' INDOL] 2' AMINE; TRANSCRIPTION FACTOR EZH2; TT 8; UNC 0321; UNC 0642; UNC 0925; UNC 0965; UNC 1021; UNC 1079; UNC 1215; UNC 1999; UNC 2533; UNC 280; UNC 669; UNC 928; UNCLASSIFIED DRUG; WDR 50101; WDR 50102; WDR 50103; CARRIER PROTEIN; HISTONE; HISTONE LYSINE METHYLTRANSFERASE;

ACETYLATION; ARTICLE; CHROMATIN STRUCTURE; COMPLEX FORMATION; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; EPIGENETICS; HISTONE METHYLATION; HUMAN; METHYLATION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; STRUCTURE ACTIVITY RELATION; DRUG DEVELOPMENT; GENETIC EPIGENESIS; METABOLISM; PROTEIN TERTIARY STRUCTURE;

CARRIER PROTEINS; DRUG DISCOVERY; EPIGENESIS, GENETIC; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; METHYLATION; PROTEIN STRUCTURE, TERTIARY;

EID: 84905254858     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2014.03.007     Document Type: Review

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