Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity

NeuroToxicology

Volumn 59, Issue , 2017, Pages 240-255

  Bal Price, Anna ^a   Lein, Pamela J ^b   Keil, Kimberly P ^b   Sethi, Sunjay ^b   Shafer, Timothy ^c   Barenys, Marta ^d   Fritsche, Ellen ^d   Sachana, Magdalini ^a  

^a JOINT RESEARCH CENTRE   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d IUF LEIBNIZ RESEARCH INSTITUTE FOR ENVIRONMENTAL MEDICINE   (Germany)

^e Bette)   (Canada)

Author keywords

Adverse outcome pathways; Mode of action; Neurotoxicity; Risk assessment

Indexed keywords

BETA1 INTEGRIN; BRAIN DERIVED NEUROTROPHIC FACTOR; GLUTAMIC ACID; INSECTICIDE; LAMININ; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RYANODINE RECEPTOR; VOLTAGE GATED SODIUM CHANNEL; NEUROTOXIN;

ADVERSE OUTCOME; APOPTOSIS; ARTICLE; BINDING SITE; CALCIUM TRANSPORT; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; HUMAN; LEARNING DISORDER; MEMORY DISORDER; NERVE CELL NETWORK; NEUROTOXICITY; NONHUMAN; PRESYNAPTIC POTENTIAL; RISK ASSESSMENT; SIGNAL TRANSDUCTION; SYNAPTOGENESIS; TOXICITY TESTING; ANIMAL; DRUG EFFECTS; NERVOUS SYSTEM; PATHOLOGY; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION; TOXICITY AND INTOXICATION;

ANIMALS; HUMANS; NERVOUS SYSTEM; NEUROTOXICITY SYNDROMES; NEUROTOXINS; RISK ASSESSMENT; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84973862422     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2016.05.010     Document Type: Article

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