IPCS framework for analyzing the relevance of a cancer mode of action for humans

Critical Reviews in Toxicology

Volumn 36, Issue 10, 2006, Pages 781-792

  Boobis, Alan R ^a   Cohen, Samuel M ^b   Dellarco, Vicki ^c   McGregor, Douglas ^d   Meek, M E ^e   Vickers, Carolyn ^f   Willcocks, Deborah ^g   Farland, William ^c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d Toxicity Evaluation Consultants   (United Kingdom)

^e HEALTH CANADA   (Canada)

^f WORLD HEALTH ORGANIZATION   (Switzerland)

^g National Industry Chemicals Notification and Assessment Scheme   (Australia)

Author keywords

Animal Human Concordance; Carcinogens; DNA Reactive; Human Relevance Framework for Cancer; Key Events; Mode of Action; Risk Assessment

Indexed keywords

CARCINOGEN;

AGE DISTRIBUTION; CANCER RISK; CAUSAL ATTRIBUTION; CHEMICAL CARCINOGENESIS; DOSE RESPONSE; GENETIC DIFFERENCE; HEALTH PROGRAM; HUMAN; INTERNATIONAL COOPERATION; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REVIEW; RISK ASSESSMENT; SAFETY; STATISTICAL SIGNIFICANCE;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; GUIDELINES; HUMANS; NEOPLASMS; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; RISK ASSESSMENT;

ANIMALIA;

EID: 33751283298     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.1080/10408440600977677     Document Type: Review

References (15)

1. Cohen, M., Meek, M.E., Klaunig, J.E., Patton, D.E., and Fenner-Crisp, P.A. (2003). The human relevance of information on carcinogenic modes of action: an overview. Crit. Rev. Toxicol. 33:581-589.
2. Committee on Carcinogenicity. (2004). Guidance on a Strategy for the Risk Assessment of Chemical Carcinogens, London, United Kingdom: Department of Health.
3. Cortopassi, G.A., and Wang, E. (1996). There is substantial agreement among interspecies estimates of DNA repair activity. Mech. Ageing Dev. 91:211-218.
4. Hanawalt, P.C. (2001). Revisiting the rodent repairadox. Environ. Mol. Mutagen. 38:89-96.
5. Holsapple, M.P., Pitot, H.C., Cohen, S.M., Boobis, A.R., Klaunig, J.E., Pastoor, T., Dellarco, V.L., and Dragan, Y.P. (2006). Mode of action in relevance of rodent liver tumors to human cancer risk. Toxicol. Sci. 89:51-56.
6. IPCS. (2000). Scoping meeting to address the human relevance of animal modes of action in assessing cancer risk, Carshalton, United Kingdom, 8-10 November 2000. Geneva, World Health Organization, International Programme on Chemical Safety. http://www.who.int/ipcs/methods/harmonization/areas/cancer/en/ index.html
7. IPCS. (2004). Report of the first meeting of the Cancer Working Group, Arlington, Virginia, USA, 3-5 March 2004. Geneva, World Health Organization, International Programme on Chemical Safety. http://www.who.int/ipcs/methods/ harmonization/areas/ cancer/en/index.html
8. IPCS. (2005). Record of the Cancer Framework Workshop, Bradford, United Kingdom, 21-23 April 2005. Geneva, World Health Organization, International Programme on Chemical Safety. http://www. who.int/ipcs/methods/harmonization/ areas/cancer/en/index.html
9. National Research Council. (1983). Risk Assessment in the Federal Government. Managing the Process. National Academy Press, Washington, DC.
10. Meek, M.E., Bucher, J.R., Cohen, S.M., Dellarco, V., Hill, R.N., Lehman-McKeeman, L.D., Longfellow, D.G., Pastoor, T., Seed, J., and Patton, D.E. (2003). A framework for human relevance analysis of information on carcinogenic modes of action. Crit. Rev. Toxicol. 33:591-653.
11. Preston, J.R., and Williams, G.M. (2005). DNA-reactive carcinogens: Mode of action and human cancer hazard. Crit. Rev. Toxicol. 35:673-683.
12. Slikker, W., Jr., Andersen, M.E., Bogdanffy, M.S., Bus, J.S., Cohen, S.D., Conolly, R.B., David, R.M., Doerrer, N.G., Dorman, D.C., Gaylor, D.W., Hattis, D., Rogers, J.M., Setzer, R.W., Swenberg, J.A., and Wallace, K. (2004). Dose-dependent transitions in mechanisms of toxicity: Case studies. Toxicol. Appl. Pharmacol. 20:226-294.
13. Sonich-Mullin, C., Fielder, R., Wiltse, J., Baetcke, K., Dempsey, J., Fenner-Crisp, P., Grant, D., Hartley, M., Knaap, A., Kroese, D., Mangelsdorf, I., Meek, E., Rice, J., and Younes, M. (2001). IPCS Conceptual framework for evaluating a mode of action for chemical carcinogenesis. Regul. Toxicol. Pharmacol. 34:146-152.
14. U.S. Environmental Protection Agency. (1999). Guidelines for Carcinogen Risk Assessment (Review Draft). Risk Assessment Forum, Washington, DC. NCEA-F-0644.
15. U.S. Environmental Protection Agency. (2005). Guidelines for Carcinogen Risk Assessment. Risk Assessment Forum, Washington, DC. EPA/639/P-03/001F.