Molecular target sequence similarity as a basis for species extrapolation to assess the ecological risk of chemicals with known modes of action

Aquatic Toxicology

Volumn 144-145, Issue , 2013, Pages 141-154

  LaLone, Carlie A ^a   Villeneuve, Daniel L ^a   Burgoon, Lyle D ^b   Russom, Christine L ^a   Helgen, Henry W ^c   Berninger, Jason P ^d   Tietge, Joseph E ^a   Severson, Megan N ^a   Cavallin, Jenna E ^a   Ankley, Gerald T ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c North American Public Sector ^*  (United States)

^d NATIONAL RESEARCH COUNCIL   (United States)

Author keywords

Conserved functional domains; Molecular target; Predictive toxicology; Protein sequence similarity; Relative intrinsic susceptibility

Indexed keywords

AMINO ACID; ETHINYLESTRADIOL; PERMETHRIN; TRENBOLONE; VOLTAGE GATED SODIUM CHANNEL;

BIOINFORMATICS; CHEMICAL POLLUTANT; ECOTOXICOLOGY; ENVIRONMENTAL RISK; PREDICTION; RISK ASSESSMENT; TOXICITY;

AEDES AEGYPTI; AMINO ACID SEQUENCE; ARTICLE; BIOINFORMATICS; GENETIC SIMILARITY; MOLECULAR ECOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; PROTEIN DATABASE; PROTEIN TARGETING; RISK ASSESSMENT; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SPECIES EXTRAPOLATION; SPECIES IDENTIFICATION;

17Β-TRB; 17Β-TRENBOLONE; ADVERSE OUTCOME PATHWAY; AGS; ANDROGEN RECEPTOR; AOP; AQUATIC LIFE GUIDELINES; AR; BASIC LOCAL ALIGNMENT SEARCH TOOL FOR PROTEINS; BLASTP; CDD; CONSERVED DOMAIN DATABASE; CONSERVED FUNCTIONAL DOMAINS; E-VALUE; EC(50); EE2; ER; ESTROGEN RECEPTOR; ETHINYLESTRADIOL; EXPECT VALUE; LC(50); LOEC; LOWEST OBSERVABLE EFFECTS CONCENTRATION; MIE; MOA; MODE OF ACTION; MOLECULAR INITIATING EVENT; MOLECULAR TARGET; NATIONAL CENTER FOR BIOTECHNOLOGY INFORMATION; NCBI; NO OBSERVABLE EFFECTS CONCENTRATION; NOEC; PREDICTIVE TOXICOLOGY; PROTEIN SEQUENCE SIMILARITY; RBH; RECIPROCAL BEST HIT; RELATIVE INTRINSIC SUSCEPTIBILITY; SPECIES SENSITIVITY DISTRIBUTIONS; SSDS; THE MEDIAN EFFECTS CONCENTRATION; THE MEDIAN LETHAL CONCENTRATION; US ENVIRONMENTAL PROTECTION AGENCY; US EPA; US FDA; US FOOD AND DRUG ADMINISTRATION; VETERINARY SUBSTANCES DATABASE; VGSC; VOLTAGE-GATED PARA-LIKE SODIUM CHANNEL; VSDB;

ANIMALS; DRUG DELIVERY SYSTEMS; RISK ASSESSMENT; SEQUENCE HOMOLOGY, NUCLEIC ACID; TOXICOLOGY; WATER POLLUTANTS, CHEMICAL;

EID: 84886797600     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2013.09.004     Document Type: Article

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