Role of actin cytoskeleton in dendritic spine morphogenesis

Neurochemistry International

Volumn 51, Issue 2-4 SPEC. ISS., 2007, Pages 92-104

  Sekino, Yuko ^a,b,c   Kojima, Nobuhiko ^a   Shirao, Tomoaki ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Actin; Actin binding protein; Actin myosin interaction; Drebrin; Spine formation; Spine morphology; Synaptic activity

Indexed keywords

ACTIN; ADDUCIN; DREBRIN; F ACTIN; FASCIN; G ACTIN; GELSOLIN; GLUTAMATE RECEPTOR; GUANOSINE TRIPHOSPHATASE; MYOSIN; MYOSIN II; PROFILIN; SPINOPHILIN;

CYTOSKELETON; DENDRITIC SPINE; FILOPODIUM; MORPHOGENESIS; NERVE CELL; NERVE CELL PLASTICITY; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; REVIEW; SYNAPTOGENESIS;

ACTINS; ANIMALS; DENDRITIC SPINES; HUMANS; MICROFILAMENT PROTEINS; MICROFILAMENTS; MONOMERIC GTP-BINDING PROTEINS; NEURONAL PLASTICITY; NEUROPEPTIDES; SYNAPSES;

EID: 34547488455     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2007.04.029     Document Type: Review

References (160)

1. Abe M., Takahashi K., and Hiwada K. Effect of calponin on actin-activated myosin ATPase activity. J. Biochem. (Tokyo) 108 (1990) 835-838
2. Ackermann M., and Matus A. Activity-induced targeting of profilin and stabilization of dendritic spine morphology. Nat. Neurosci. 6 (2003) 1194-1200
3. Adelstein R.S., Conti M.A., and Anderson Jr. W. Phosphorylation of human platelet myosin. Proc. Natl. Acad. Sci. U.S.A. 70 (1973) 3115-3119
4. Agassandian C., Plantier M., Fattoum A., Represa A., and der Terrossian E. Subcellular distribution of calponin and caldesmon in rat hippocampus. Brain Res. 887 (2000) 444-449
5. Allen P.B., Ouimet C.C., and Greengard P. Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 9956-9961
6. Allison D.W., Gelfand V.I., Spector I., and Craig A.M. Role of actin in anchoring postsynaptic receptors in cultured hippocampal neurons: differential attachment of NMDA versus AMPA receptors. J. Neurosci. 18 (1998) 2423-2436
7. Allison D.W., Chervin A.S., Gelfand V.I., and Craig A.M. Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules. J. Neurosci. 20 (2000) 4545-4554
8. Aoki C., Sekino Y., Hanamura K., Fujisawa S., Mahadomrongkul V., Ren Y., and Shirao T. Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses. J. Comp. Neurol. 483 (2005) 383-402
9. Bamburg J.R., Harris H.E., and Weeds A.G. Partial purification and characterization of an actin depolymerizing factor from brain. FEBS Lett. 121 (1980) 178-182
10. Blanchard A., Ohanian V., and Critchley D. The structure and function of alpha-actinin. J. Muscle Res. Cell. Motil. 10 (1989) 280-289
11. Bridgman P.C. Myosin-dependent transport in neurons. J. Neurobiol. 58 (2004) 164-174
12. Bryan J., and Kane R.E. Separation and interaction of the major components of sea urchin actin gel. J. Mol. Biol. 125 (1978) 207-224
13. Butkevich E., Hulsmann S., Wenzel D., Shirao T., Duden R., and Majoul I. Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton. Curr. Biol. 14 (2004) 650-658
14. Calon F., Lim G.P., Yang F., Morihara T., Teter B., Ubeda O., Rostaing P., Triller A., Salem Jr. N., Ashe K.H., Frautschy S.A., and Cole G.M. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron 43 (2004) 633-645
15. Carlier M.F., and Pantaloni D. Control of actin dynamics in cell motility. J. Mol. Biol. 269 (1997) 459-467
16. Carlier M.F., Laurent V., Santolini J., Melki R., Didry D., Xia G.X., Hong Y., Chua N.H., and Pantaloni D. Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: implication in actin-based motility. J. Cell Biol. 136 (1997) 1307-1322
17. Carlsson L., Nystrom L.E., Sundkvist I., Markey F., and Lindberg U. Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells. J. Mol. Biol. 115 (1977) 465-483
18. Cheng X.T., Hayashi K., and Shirao T. Non-muscle myosin IIB-like immunoreactivity is present at the drebrin-binding cytoskeleton in neurons. Neurosci. Res. 36 (2000) 167-173
19. Cho K.O., Hunt C.A., and Kennedy M.B. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron 9 (1992) 929-942
20. Cohen I., Kaminski E., and De Vries A. Actin-linked regulation of the human platelet contractile system. FEBS Lett. 34 (1973) 315-317
21. Cohen R.S., Chung S.K., and Pfaff D.W. Immunocytochemical localization of actin in dendritic spines of the cerebral cortex using colloidal gold as a probe. Cell. Mol. Neurobiol. 5 (1985) 271-284
22. Counts S.E., Nadeem M., Lad S.P., Wuu J., and Mufson E.J. Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment. J. Neuropathol. Exp. Neurol. 65 (2006) 592-601
23. Dailey M.E., and Smith S.J. The dynamics of dendritic structure in developing hippocampal slices. J. Neurosci. 16 (1996) 2983-2994
24. Dunaevsky A., Tashiro A., Majewska A., Mason C., and Yuste R. Developmental regulation of spine motility in the mammalian central nervous system. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 13438-13443
25. Ebashi S., and Endo M. Calcium ion and muscle contraction. Prog. Biophys. Mol. Biol. 18 (1968) 123-183
26. Edelstein-Keshet L., and Ermentrout G.B. Models for spatial polymerization dynamics of rod-like polymers. J. Math. Biol. 40 (2000) 64-96
27. Edwards R.A., and Bryan J. Fascins, a family of actin bundling proteins. Cell Motil. Cytoskeleton 32 (1995) 1-9
28. Ethell I.M., and Pasquale E.B. Molecular mechanisms of dendritic spine development and remodeling. Prog. Neurobiol. 75 (2005) 161-205
29. Feng J., Yan Z., Ferreira A., Tomizawa K., Liauw J.A., Zhuo M., Allen P.B., Ouimet C.C., and Greengard P. Spinophilin regulates the formation and function of dendritic spines. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 9287-9292
30. Ferhat L., Esclapez M., Represa A., Fattoum A., Shirao T., and Ben-Ari Y. Increased levels of acidic calponin during dendritic spine plasticity after pilocarpine-induced seizures. Hippocampus 13 (2003) 845-858
31. Fiala J.C., Feinberg M., Popov V., and Harris K.M. Synaptogenesis via dendritic filopodia in developing hippocampal area CA1. J. Neurosci. 18 (1998) 8900-8911
32. Fischer M., Kaech S., Knutti D., and Matus A. Rapid actin-based plasticity in dendritic spines. Neuron 20 (1998) 847-854
33. Fischer M., Kaech S., Wagner U., Brinkhaus H., and Matus A. Glutamate receptors regulate actin-based plasticity in dendritic spines. Nat. Neurosci. 3 (2000) 887-894
34. Friedman H.V., Bresler T., Garner C.C., and Ziv N.E. Assembly of new individual excitatory synapses: time course and temporal order of synaptic molecule recruitment. Neuron 27 (2000) 57-69
35. Fujisawa S., Shirao T., and Aoki C. In vivo, competitive blockade of n-methyl-d-aspartate receptors induces rapid changes in filamentous actin and drebrin a distributions within dendritic spines of adult rat cortex. Neuroscience 140 (2006) 1177-1187
36. Fukazawa Y., Saitoh Y., Ozawa F., Ohta Y., Mizuno K., and Inokuchi K. Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo. Neuron 38 (2003) 447-460
37. Furuyashiki T., Arakawa Y., Takemoto-Kimura S., Bito H., and Narumiya S. Multiple spatiotemporal modes of actin reorganization by NMDA receptors and voltage-gated Ca2+ channels. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 14458-14463
38. Gardner K., and Bennett V. Modulation of spectrin-actin assembly by erythrocyte adducin. Nature 328 (1987) 359-362
39. Goldschmidt-Clermont P.J., Furman M.I., Wachsstock D., Safer D., Nachmias V.T., and Pollard T.D. The control of actin nucleotide exchange by thymosin beta 4 and profiling. A potential regulatory mechanism for actin polymerization in cells. Mol. Biol. Cell 3 (1992) 1015-1024
40. Hall A. Rho GTPases and the actin cytoskeleton. Science 279 (1998) 509-514
41. Halpain S., Hipolito A., and Saffer L. Regulation of F-actin stability in dendritic spines by glutamate receptors and calcineurin. J. Neurosci. 18 (1998) 9835-9844
42. Harigaya Y., Shoji M., Shirao T., and Hirai S. Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease. J. Neurosci. Res. 43 (1996) 87-92
43. Harris K.M., and Kater S.B. Dendritic spines: cellular specializations imparting both stability and flexibility to synaptic function. Annu. Rev. Neurosci. 17 (1994) 341-371
44. Hatanpaa K., Isaacs K.R., Shirao T., Brady D.R., and Rapoport S.I. Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease. J. Neuropathol. Exp. Neurol. 58 (1999) 637-643
45. Hayashi K., and Shirao T. Change in the shape of dendritic spines caused by overexpression of drebrin in cultured cortical neurons. J. Neurosci. 19 (1999) 3918-3925
46. Hayashi K., Ishikawa R., Kawai-Hirai R., Takagi T., Taketomi A., and Shirao T. Domain analysis of the actin-binding and actin-remodeling activities of drebrin. Exp. Cell Res. 253 (1999) 673-680
47. Hayashi K., Ishikawa R., Ye L.H., He X.L., Takata K., Kohama K., and Shirao T. Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex. J. Neurosci. 16 (1996) 7161-7170
48. Hering H., and Sheng M. Activity-dependent redistribution and essential role of cortactin in dendritic spine morphogenesis. J. Neurosci. 23 (2003) 11759-11769
49. Ikeda K., Shirao T., Toda M., Asada H., Toya S., and Uyemura K. Effect of a neuron-specific actin-binding protein, drebrin A, on cell-substratum adhesion. Neurosci. Lett. 194 (1995) 197-200
50. Ikeda K., Kaub P.A., Asada H., Uyemura K., Toya S., and Shirao T. Stabilization of adhesion plaques by the expression of drebrin A in fibroblasts. Dev. Brain Res. 91 (1996) 227-236
51. Irwin S.A., Galvez R., and Greenough W.T. Dendritic spine structural anomalies in fragile-X mental retardation syndrome. Cereb. Cortex 10 (2000) 1038-1044
52. Ishikawa R., Yamashiro S., and Matsumura F. Differential modulation of actin-severing activity of gelsolin by multiple isoforms of cultured rat cell tropomyosin. Potentiation of protective ability of tropomyosins by 83 kDa nonmuscle caldesmon. J. Biol. Chem. 264 (1989) 7490-7497
53. 2+. Potentiation of the annealing process by caldesmon. J. Biol. Chem. 264 (1989) 16764-16770
54. Ishikawa R., Sasaki Y., Nakamura A., Takagi T., and Kohama K. Purification of an ATP-dependent actin-binding protein from a lower eukaryote, Physarum polycephalum. Biochem. Biophys. Res. Commun. 212 (1995) 347-352
55. Ishikawa R., Sakamoto T., Ando T., Higashi-Fujime S., and Kohama K. Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro. J. Neurochem. 87 (2003) 676-685
56. Ishikawa R., Hayashi K., Shirao T., Xue Y., Takagi T., Sasaki Y., and Kohama K. Drebrin, a development-associated brain protein from rat embryo, causes the dissociation of tropomyosin from actin filaments. J. Biol. Chem. 269 (1994) 29928-29933
57. Janmey P.A., and Stossel T.P. Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate. Nature 325 (1987) 362-364
58. Janmey P.A., Chaponnier C., Lind S.E., Zaner K.S., Stossel T.P., and Yin H.L. Interactions of gelsolin and gelsolin-actin complexes with actin. Effects of calcium on actin nucleation, filament severing, and end blocking. Biochemistry 24 (1985) 3714-3723
59. Jin M., Tanaka S., Sekino Y., Ren Y., Yamazaki H., Kawai-Hirai R., Kojima N., and Shirao T. A novel, brain-specific mouse drebrin: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization. Genomics 79 (2002) 686-692
60. Jordan B.A., Fernholz B.D., Boussac M., Xu C., Grigorean G., Ziff E.B., and Neubert T.A. Identification and verification of novel rodent postsynaptic density proteins. Mol. Cell. Proteomics 3 (2004) 857-871
61. Kaech S., Fischer M., Doll T., and Matus A. Isoform specificity in the relationship of actin to dendritic spines. J. Neurosci. 17 (1997) 9565-9572
62. Kaech S., Parmar H., Roelandse M., Bornmann C., and Matus A. Cytoskeletal microdifferentiation: a mechanism for organizing morphological plasticity in dendrites. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 7086-7092
63. Kamm K.E., and Stull J.T. The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. Annu. Rev. Pharmacol. Toxicol. 25 (1985) 593-620
64. Katoh H., Hiramoto K., and Negishi M. Activation of Rac1 by RhoG regulates cell migration. J. Cell Sci. 119 (2006) 56-65
65. Kawamoto S., and Adelstein R.S. Chicken nonmuscle myosin heavy chains: differential expression of two mRNAs and evidence for two different polypeptides. J. Cell Biol. 112 (1991) 915-924
66. Kennedy M.B. The postsynaptic density at glutamatergic synapses. Trends Neurosci. 20 (1997) 264-268
67. Kiehart D.P. Molecular genetic dissection of myosin heavy chain function. Cell 60 (1990) 347-350
68. + channels by interaction with a family of membrane-associated guanylate kinases. Nature 378 (1995) 85-88
69. Kim Y., Sung J.Y., Ceglia I., Lee K.W., Ahn J.H., Halford J.M., Kim A.M., Kwak S.P., Park J.B., Ho Ryu S., Schenck A., Bardoni B., Scott J.D., Nairn A.C., and Greengard P. Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. Nature 442 (2006) 814-817
70. Kistner U., Wenzel B.M., Veh R.W., Cases-Langhoff C., Garner A.M., Appeltauer U., Voss B., Gundelfinger E.D., and Garner C.C. SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A. J. Biol. Chem. 268 (1993) 4580-4583
71. Kojima N., Kato Y., Shirao T., and Obata K. Nucleotide sequences of two embryonic drebrins, developmentally regulated brain proteins, and developmental change in their mRNAs. Brain Res. 464 (1988) 207-215
72. Kojima N., Shirao T., and Obata K. Molecular cloning of a developmentally regulated brain protein, chicken drebrin A and its expression by alternative splicing of the drebrin gene. Mol. Brain Res. 19 (1993) 101-114
73. Kojima N., and Shirao T. Synaptic dysfunction and disruption of postsynaptic drebrin-actin complex: a study of neurological disorders accompanied by cognitive deficits. Neurosci. Res. 58 (2007) 1-5
74. Koss R., Diefenbach T.J., Kuang S., Doran S.A., and Goldberg J.I. Coordinated development of identified serotonergic neurons and their target ciliary cells in Helisoma trivolvis embryos. J. Comp. Neurol. 457 (2003) 313-325
75. Kovar D.R., Harris E.S., Mahaffy R., Higgs H.N., and Pollard T.D. Control of the assembly of ATP- and ADP-actin by formins and profilin. Cell 124 (2006) 423-435
76. Krupp J.J., Vissel B., Thomas C.G., Heinemann S.F., and Westbrook G.L. Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2+-dependent inactivation of NMDA receptors. J. Neurosci. 19 (1999) 1165-1178
77. Kuhlman P.A., Hughes C.A., Bennett V., and Fowler V.M. A new function for adducing. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments. J. Biol. Chem. 271 (1996) 7986-7991
78. Lacor P.N., Buniel M.C., Furlow P.W., Clemente A.S., Velasco P.T., Wood M., Viola K.L., and Klein W.L. Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J. Neurosci. 27 (2007) 796-807
79. Landis D.M., and Reese T.S. Cytoplasmic organization in cerebellar dendritic spines. J. Cell Biol. 97 (1983) 1169-1178
80. Lappalainen P., Kessels M.M., Cope M.J., and Drubin D.G. The ADF homology (ADF-H) domain: a highly exploited actin-binding module. Mol. Biol. Cell 9 (1998) 1951-1959
81. Lazarides E. Actin, alpha-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells. J. Cell Biol. 68 (1976) 202-219
82. Luo L., Hensch T.K., Ackerman L., Barbel S., Jan L.Y., and Jan Y.N. Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines. Nature 379 (1996) 837-840
83. Machesky L.M., and Way M. Actin branches out. Nature 394 (1998) 125-126
84. Maciver S.K., Zot H.G., and Pollard T.D. Characterization of actin filament severing by actophorin from Acanthamoeba castellanii. J. Cell Biol. 115 (1991) 1611-1620
85. Mahadomrongkul V., Huerta P.T., Shirao T., and Aoki C. Stability of the distribution of spines containing drebrin A in the sensory cortex layer I of mice expressing mutated APP and PS1 genes. Brain Res. 1064 (2005) 66-74
86. Masaki T., Endo M., and Ebashi S. Localization of 6S component of a alpha-actinin at Z-band. J. Biochem. (Tokyo) 62 (1967) 630-632
87. Matus A. Postsynaptic actin and neuronal plasticity. Curr. Opin. Neurobiol. 9 (1999) 561-565
88. Matus A., Ackermann M., Pehling G., Byers H.R., and Fujiwara K. High actin concentrations in brain dendritic spines and postsynaptic densities. Proc. Natl. Acad. Sci. U.S.A. 79 (1982) 7590-7594
89. Medeiros N.A., Burnette D.T., and Forscher P. Myosin II functions in actin-bundle turnover in neuronal growth cones. Nat. Cell Biol. 8 (2006) 215-226
90. Migaud M., Charlesworth P., Dempster M., Webster L.C., Watabe A.M., Makhinson M., He Y., Ramsay M.F., Morris R.G., Morrison J.H., O'Dell T.J., and Grant S.G. Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein. Nature 396 (1998) 433-439
91. Mische S.M., Mooseker M.S., and Morrow J.S. Erythrocyte adducin: a calmodulin-regulated actin-bundling protein that stimulates spectrin-actin binding. J. Cell Biol. 105 (1987) 2837-2845
92. Mizui T., Takahashi H., Sekino Y., and Shirao T. Overexpression of drebrin A in immature neurons induces the accumulation of F-actin and PSD-95 into dendritic filopodia, and the formation of large abnormal protrusions. Mol. Cell. Neurosci. 30 (2005) 630-638
93. Morales M., and Fifkova E. In situ localization of myosin and actin in dendritic spines with the immunogold technique. J. Comp. Neurol. 279 (1989) 666-674
94. Moussavi R.S., Kelley C.A., and Adelstein R.S. Phosphorylation of vertebrate nonmuscle and smooth muscle myosin heavy chains and light chains. Mol. Cell. Biochem. 127/128 (1993) 219-227
95. Mullins R.D., Heuser J.A., and Pollard T.D. The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 6181-6186
96. Nakanishi H., Obaishi H., Satoh A., Wada M., Mandai K., Satoh K., Nishioka H., Matsuura Y., Mizoguchi A., and Takai Y. Neurabin: a novel neural tissue-specific actin filament-binding protein involved in neurite formation. J. Cell Biol. 139 (1997) 951-961
97. Nishida E., Maekawa S., and Sakai H. Cofilin, a protein in porcine brain that binds to actin filaments and inhibits their interactions with myosin and tropomyosin. Biochemistry 23 (1984) 5307-5313
98. Okabe S., Miwa A., and Okado H. Spine formation and correlated assembly of presynaptic and postsynaptic molecules. J. Neurosci. 21 (2001) 6105-6114
99. Okamoto K., Nagai T., Miyawaki A., and Hayashi Y. Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity. Nat. Neurosci. 7 (2004) 1104-1112
100. Ooe N., Saito K., Mikami N., Nakatuka I., and Kaneko H. Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. Mol. Cell. Biol. 24 (2004) 608-616
101. Osterweil E., Wells D.G., and Mooseker M.S. A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis. J. Cell Biol. 168 (2005) 329-338
102. Ouimet C.C., da Cruz e Silva E.F., and Greengard P. The alpha and gamma 1 isoforms of protein phosphatase 1 are highly and specifically concentrated in dendritic spines. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 3396-3400
103. Pak D.T., and Sheng M. Targeted protein degradation and synapse remodeling by an inducible protein kinase. Science 302 (2003) 1368-1373
104. Peitsch W.K., Grund C., Kuhn C., Schnolzer M., Spring H., Schmelz M., and Franke W.W. Drebrin is a widespread actin-associating protein enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells. Eur. J. Cell Biol. 78 (1999) 767-778
105. Peng J., Kim M.J., Cheng D., Duong D.M., Gygi S.P., and Sheng M. Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry. J. Biol. Chem. 279 (2004) 21003-21011
106. Pollard T.D. Rate constants for the reactions of ATP- and ADP-actin with the ends of actin filaments. J. Cell Biol. 103 (1986) 2747-2754
107. Portera-Cailliau C., Pan D.T., and Yuste R. Activity-regulated dynamic behavior of early dendritic protrusions: evidence for different types of dendritic filopodia. J. Neurosci. 23 (2003) 7129-7142
108. Purpura D.P., Bodick N., Suzuki K., Rapin I., and Wurzelmann S. Microtubule disarray in cortical dendrites and neurobehavioral failure. I. Golgi and electron microscopic studies. Brain Res. 281 (1982) 287-297
109. Rabenstein R.L., Addy N.A., Caldarone B.J., Asaka Y., Gruenbaum L.M., Peters L.L., Gilligan D.M., Fitzsimonds R.M., and Picciotto M.R. Impaired synaptic plasticity and learning in mice lacking beta-adducin, an actin-regulating protein. J. Neurosci. 25 (2005) 2138-2145
110. Rami G., Caillard O., Medina I., Pellegrino C., Fattoum A., Ben-Ari Y., and Ferhat L. Change in the shape and density of dendritic spines caused by overexpression of acidic calponin in cultured hippocampal neurons. Hippocampus 16 (2006) 183-197
111. Rao A., and Craig A.M. Signaling between the actin cytoskeleton and the postsynaptic density of dendritic spines. Hippocampus 10 (2000) 527-541
112. Ryu J., Liu L., Wong T.P., Wu D.C., Burette A., Weinberg R., Wang Y.T., and Sheng M. A critical role for myosin IIb in dendritic spine morphology and synaptic function. Neuron 49 (2006) 175-182
113. Safer D., and Nachmias V.T. Beta thymosins as actin binding peptides. Bioessays 16 (1994) 590
114. Safer D., Golla R., and Nachmias V.T. Isolation of a 5-kDa actin-sequestering peptide from human blood platelets. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 2536-2540
115. Sasaki Y., Hayashi K., Shirao T., Ishikawa R., and Kohama K. Inhibition by drebrin of the actin-bundling activity of brain fascin, a protein localized in filopodia of growth cones. J. Neurochem. 66 (1996) 980-988
116. Satoh A., Nakanishi H., Obaishi H., Wada M., Takahashi K., Satoh K., Hirao K., Nishioka H., Hata Y., Mizoguchi A., and Takai Y. Neurabin-II/spinophilin. An actin filament-binding protein with one pdz domain localized at cadherin-based cell-cell adhesion sites. J. Biol. Chem. 273 (1998) 3470-3475
117. Schubert V., Da Silva J.S., and Dotti C.G. Localized recruitment and activation of RhoA underlies dendritic spine morphology in a glutamate receptor-dependent manner. J. Cell Biol. 172 (2006) 453-467
118. Sekino Y., Tanaka S., Hanamura K., Yamazaki H., Sasagawa Y., Xue Y., Hayashi K., and Shirao T. Activation of N-methyl-d-aspartate receptor induces a shift of drebrin distribution: disappearance from dendritic spines and appearance in dendritic shafts. Mol. Cell. Neurosci. 31 (2006) 493-504
119. Sellers J.R. Myosins: a diverse superfamily. Biochim. Biophys. Acta 1496 (2000) 3-22
120. Settleman J. Rho GTPases in development. Prog. Mol. Subcell. Biol. 22 (1999) 201-229
121. Shim K.S., and Lubec G. Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. Neurosci. Lett. 324 (2002) 209-212
122. Shirao T. The roles of microfilament-associated proteins, drebrins, in brain morphogenesis: a review. J. Biochem. (Tokyo) 117 (1995) 231-236
123. Shirao T., and Obata K. Two acidic proteins associated with brain development in chick embryo. J. Neurochem. 44 (1985) 1210-1216
124. Shirao T., and Obata K. Immunochemical homology of 3 developmentally regulated brain proteins and their developmental change in neuronal distribution. Brain Res. 394 (1986) 233-244
125. Shirao T., and Sekino Y. Clustering and anchoring mechanisms of molecular constituents of postsynaptic scaffolds in dendritic spines. Neurosci. Res. 40 (2001) 1-7
126. Shirao T., Inoue H.K., Kano Y., and Obata K. Localization of a developmentally regulated neuron-specific protein S54 in dendrites as revealed by immunoelectron microscopy. Brain Res. 413 (1987) 374-378
127. Shirao T., Kojima N., Kato Y., and Obata K. Molecular cloning of a cDNA for the developmentally regulated brain protein, drebrin. Brain Res. 464 (1988) 71-74
128. Shirao T., Kojima N., Nabeta Y., and Obata K. Two forms of drebrins, developmentally regulated brain proteins, in rat. Proc. Jpn. Acad. 65 (1989) 169-172
129. Shirao T., Kojima N., and Obata K. Cloning of drebrin A and induction of neurite-like processes in drebrin-transfected cells. Neuroreport 3 (1992) 109-112
130. Shirao T., Kojima N., Terada S., and Obata K. Expression of three drebrin isoforms in the developing nervous system. Neurosci. Res. Suppl. 13 (1990) S106-S111
131. Shirao T., Hayashi K., Ishikawa R., Isa K., Asada H., Ikeda K., and Uyemura K. Formation of thick, curving bundles of actin by drebrin A expressed in fibroblasts. Exp. Cell Res. 215 (1994) 145-153
132. Small J.V., Herzog M., and Anderson K. Actin filament organization in the fish keratocyte lamellipodium. J. Cell Biol. 129 (1995) 1275-1286
133. Small J.V., Stradal T., Vignal E., and Rottner K. The lamellipodium: where motility begins. Trends Cell Biol. 12 (2002) 112-120
134. Star E.N., Kwiatkowski D.J., and Murthy V.N. Rapid turnover of actin in dendritic spines and its regulation by activity. Nat. Neurosci. 5 (2002) 239-246
135. Svitkina T.M., and Borisy G.G. Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia. J. Cell Biol. 145 (1999) 1009-1026
136. Takahashi H., Mizui T., and Shirao T. Down-regulation of drebrin A expression suppresses synaptic targeting of NMDA receptors in developing hippocampal neurones. J. Neurochem. 97 Suppl. 1 (2006) 110-115
137. Takahashi H., Sekino Y., Tanaka S., Mizui T., Kishi S., and Shirao T. Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis. J. Neurosci. 23 (2003) 6586-6595
138. Takahashi K., Hiwada K., and Kokubu T. Isolation and characterization of a 34,000 Da calmodulin- and F-actin-binding protein from chicken gizzard smooth muscle. Biochem. Biophys. Res. Commun. 141 (1986) 20-26
139. Tanaka S., Sekino Y., and Shirao T. The effects of neurotrophin-3 and brain-derived neurotrophic factor on cerebellar granule cell movement and neurite extension in vitro. Neuroscience 97 (2000) 727-734
140. Theriot J.A., and Mitchison T.J. Actin microfilament dynamics in locomoting cells. Nature 352 (1991) 126-131
141. Van Aelst L., and D'Souza-Schorey C. Rho GTPases and signaling networks. Genes Dev. 11 (1997) 2295-2322
142. Vignjevic D., Kojima S., Aratyn Y., Danciu O., Svitkina T., and Borisy G.G. Role of fascin in filopodial protrusion. J. Cell Biol. 174 (2006) 863-875
143. Wachsstock D.H., Schwartz W.H., and Pollard T.D. Affinity of alpha-actinin for actin determines the structure and mechanical properties of actin filament gels. Biophys. J. 65 (1993) 205-214
144. Weber A., Pennise C.R., and Fowler V.M. Tropomodulin increases the critical concentration of barbed end-capped actin filaments by converting ADP.P(i)-actin to ADP-actin at all pointed filament ends. J. Biol. Chem. 274 (1999) 34637-34645
145. Wegner A. Treadmilling of actin at physiological salt concentrations. An analysis of the critical concentrations of actin filaments. J. Mol. Biol. 161 (1982) 607-615
146. Welch M.D., Rosenblatt J., Skoble J., Portnoy D.A., and Mitchison T.J. Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation. Science 281 (1998) 105-108
147. Wills F.L., McCubbin W.D., Gimona M., Strasser P., and Kay C.M. Two domains of interaction with calcium binding proteins can be mapped using fragments of calponin. Protein Sci. 3 (1994) 2311-2321
148. Wisniewski K.E., Segan S.M., Miezejeski C.M., Sersen E.A., and Rudelli R.D. The Fra(X) syndrome: neurological, electrophysiological, and neuropathological abnormalities. Am. J. Med. Genet. 38 (1991) 476-480
149. Woodrum D.T., Rich S.A., and Pollard T.D. Evidence for biased bidirectional polymerization of actin filaments using heavy meromyosin prepared by an improved method. J. Cell Biol. 67 (1975) 231-237
150. Wyszynski M., Kharazia V., Shanghvi R., Rao A., Beggs A.H., Craig A.M., Weinberg R., and Sheng M. Differential regional expression and ultrastructural localization of alpha-actinin-2, a putative NMDA receptor-anchoring protein, in rat brain. J. Neurosci. 18 (1998) 1383-1392
151. Xu W., and Stamnes M. The actin-depolymerizing factor homology and charged/helical domains of drebrin and mAbp1 direct membrane binding and localization via distinct interactions with actin. J. Biol. Chem. 281 (2006) 11826-11833
152. Yamashiro-Matsumura S., and Matsumura F. Purification and characterization of an F-actin-bundling 55 kDa protein from HeLa cells. J. Biol. Chem. 260 (1985) 5087-5097
153. Yamashiro-Matsumura S., and Matsumura F. Intracellular localization of the 55-kDa actin-bundling protein in cultured cells: spatial relationships with actin, alpha-actinin, tropomyosin, and fimbrin. J. Cell Biol. 103 (1986) 631-640
154. Yonezawa N., Nishida E., and Sakai H. pH control of actin polymerization by cofilin. J. Biol. Chem. 260 (1985) 14410-14412
155. Yoshimura A., Fujii R., Watanabe Y., Okabe S., Fukui K., and Takumi T. Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines. Curr. Biol. 16 (2006) 2345-2351
156. Zhang H., Webb D.J., Asmussen H., Niu S., and Horwitz A.F. A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC. J. Neurosci. 25 (2005) 3379-3388
157. Zhang W., and Benson D.L. Stages of synapse development defined by dependence on F-actin. J. Neurosci. 21 (2001) 5169-5181
158. Zhao L., Ma Q.L., Calon F., Harris-White M.E., Yang F., Lim G.P., Morihara T., Ubeda O.J., Ambegaokar S., Hansen J.E., Weisbart R.H., Teter B., Frautschy S.A., and Cole G.M. Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nat. Neurosci. 9 (2006) 234-242
159. Zigmond S.H. Recent quantitative studies of actin filament turnover during cell locomotion. Cell Motil. Cytoskeleton 25 (1993) 309-316
160. Ziv N.E., and Smith S.J. Evidence for a role of dendritic filopodia in synaptogenesis and spine formation. Neuron 17 (1996) 91-102