Comparative human and rat "neurosphere assay" for developmental neurotoxicity testing

Current Protocols in Toxicology

Volumn 1, Issue SUPPL.59, 2014, Pages

  Baumann, Jenny ^a   Barenys, Marta ^a   Gassmann, Kathrin ^a   Fritsche, Ellen ^a  

^a IUF LEIBNIZ RESEARCH INSTITUTE FOR ENVIRONMENTAL MEDICINE   (Germany)

Author keywords

Brain development; Developmental neurotoxicity; In vitro; Neural progenitor cell; Species differences

Indexed keywords

APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CYTOTOXICITY; DEVELOPMENTAL TOXICITY; HUMAN; NEURAL STEM CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; SPECIES DIFFERENCE; TOXICITY TESTING; ANIMAL; COMPARATIVE STUDY; DRUG EFFECTS; RAT;

ANIMALS; HUMANS; NEURAL STEM CELLS; RATS; TOXICITY TESTS;

EID: 84902479918     PISSN: 19349254     EISSN: 19349262     Source Type: Journal    
DOI: 10.1002/0471140856.tx1221s59     Document Type: Article

References (31)

1. Ayuso-Sacido, A., Moliterno, J.A., Kratovac, S., Kapoor, G.S., O'Rourke, D.M., Holland, E.C., García-Verdugo, J.M., Roy, N.S., and Boockvar, J.A. 2010. Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells. J. Neurooncol. 97:323-337.
2. Bal-Price, A.K., Coecke, S., Costa, L., Crofton, K.M., Fritsche, E., Goldberg, A., Grandjean, P., Lein, P.J., Li, A., Lucchini, R., Mundy, W.R., Padilla, S., Persico, A.M., Seiler, A.E., and Kreysa, J. 2012. Advancing the science of developmental neurotoxicity (DNT): Testing for better safety evaluation. ALTEX 29:202-215.
3. Bal-Price, A.K., Crofton, K., Shafer, T.J., Behl, M., Forsby, A., Hargreaves, A., Landesmann, B., Paini, A., Lein, P.J., Louisse, J., Sachana, M., Schrattenholz, A., Suñol, C., Tschudi-Monnet, F., Van Thriel, C., Whelan, M., and Fritsche, E. 2013. Workshop report: Adverse outcome pathways (AOPs) relevant for neurotoxicity. Crit. Rev. Toxicol. In press.
4. Breier, J.M., Gassmann, K., Kayser, R., Stegeman, H., De Groot, D., Fritsche, E., and Shafer, T.J. 2010. Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: state of the science. Neurotoxicol. Teratol. 32:4-15.
5. Camarillo, C. and Miranda, R.C. 2008. Ethanol exposure during neurogenesis induces persistent effects on neural maturation: Evidence from an ex vivo model of fetal cerebral cortical neuroepithelial progenitor maturation. Gene Exp. 14:159-171.
6. Campos, L.S. 2004. Neurospheres: Insights into neural stem cell biology. J. Neurosci. Res. 78:761-769.
7. Carpenter, M.K., Cui, X., Hu, Z.Y., Jackson, J., Sherman, S., Seiger, A., and Wahlberg, L.U. 1999. In vitro expansion of a multipotent population of human neural progenitor cells. Exp. Neurol. 158:265-278.
8. Coecke, S., Goldberg, A.M., Allen, S., Buzanska, L., Calamandrei, G., Crofton, K., Hareng, L., Hartung, T., Knaut, H., Honegger, P., Jacobs, M., Lein, P., Li, A., Mundy, W., Owen, D., Schneider, S., Silbergeld, E., Reum, T., Trnovec, T., Monnet-Tschudi, F., and Bal-Price, A. 2007. Workgroup report: Incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies. Environ. Health Perspect. 115:924-931.
9. Elliott, N.T. and Yuan, F. 2011. A review of threedimensional in vitro tissue models for drug discovery and transport studies. J. Pharm. Sci. 100:59-74.
10. Fritsche, E., Cline, J.E., Nguyen, N.H., Scanlan, T.S., and Abel, J. 2005. Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: Clue for involvement of thyroid hormone receptors. Environ. Health Perspect. 113:871-876.
11. Fritsche, E., Gassmann, K., and Schreiber, T. 2011. Neurospheres as a model for developmental neurotoxicity testing. In Handbook of Methods in Molecular Biology, Vol. 758: In Vitro Neurotoxicology (L.G. Costa, G. Giordano, and M. Guizzetti, eds.) pp. 99-120. Springer Science, New York.
12. Gassmann, K., Abel, J., Bothe, H., Haarmann-Stemmann, T., Merk, H.F., Quasthoff, K.N., Rockel, T.D., Schreiber, T., and Fritsche, E. 2010. Species-specific differential AhR expression protects human neural progenitor cells against developmental neurotoxicity of PAHs. Environ. Health Perspect. 118:1571-1577.
13. Gassmann, K., Baumann, J., Giersiefer, S., Schuwald, J., Schreiber, T., Merk, H.F., and Fritsche, E. 2012. Automated neurosphere sorting and plating by the COPAS large particle sorter is a suitable method for high-throughput 3D in vitro applications. Toxicol. In Vitro 26:993-1000.
14. Goldman, L.R. and Koduru, S. 2000. Chemicals in the environment and developmental toxicity to children: A public health and policy perspective. Environ. Health Perspect. 108:443-448.
15. Hitoshi, S., Tropepe, V., Ekker, M., and van der Kooy, D. 2002. Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain. Development 129:233-244.
16. Hoffman, G.E., Le, W.W., and Sita, L.V. 2008. The importance of titrating antibodies for immunocytochemical methods. Curr. Protoc. Neurosci. 45:2.12.1-2.12.26.
17. Klein, C., Butt, S.J., Machold, R.P., Johnson, J.E., and Fishell, G. 2005. Cerebellum-and forebrainderived stem cells possess intrinsic regional character. Development 132:4497-4508.
18. Kukekov, V.G., Laywell, E.D., Suslov, O., Davies, K., Scheffler, B., Thomas, L.B., O'Brien, T.F., Kusakabe, M., and Steindler, D.A. 1999. Multipotent stem/progenitor cells with similar properties arise from two neurogenic regions of adult human brain. Exp. Neurol. 156:333-344.
19. Lein, P., Silbergeld, E., Locke, P., and Goldberg, A. 2005. In vitro and other alternative approaches to developmental neurotoxicity testing (DNT). Environ. Toxicol. Pharmacol. 19:735-744.
20. Lein, P., Locke, P., and Goldberg, A. 2007. Meeting report: Alternatives for developmental neurotoxicity testing. Environ. Health Perspect. 115:764-768.
21. Moors, M., Cline, J.E., Abel, J., and Fritsche, E. 2007. ERK-dependent and-independent pathways trigger human neural progenitor cell migration. Toxicol. Appl. Pharmacol. 221:57-67.
22. Moors, M., Rockel, T.D., Abel, J., Cline, J.E., Gassmann, K., Schreiber, T., Schuwald, J., Weinmann, N., and Fritsche, E. 2009. Human neurospheres as three-dimensional cellular systems for developmental neurotoxicity testing. Environ. Health Perspect. 117:1131-1138.
23. National Research Council. 2007. Toxicity Testing in the 21st Century: A Vision and a Strategy. The National Academies Press, Washington, DC.
24. Ostenfeld, T., Joly, E., Tai, Y.T., Peters, A., Caldwell, M., Jauniaux, E., and Svendsen,C.N. 2002. Regional specification of rodent and human neurospheres. Brain Res. Dev. Brain Res. 134:43-55.
25. Parmar, M., Skogh, C., Bjorklund, A., and Campbell, K. 2002. Regional specification of neurosphere cultures derived from subregions of the embryonic telencephalon. Mol. Cell. Neurosci. 1:645-656.
26. Reynolds, B.A. and Weiss, S. 1992. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255:1707-1710.
27. Reynolds, B.A. and Rietze, R.L. 2005. Neural stem cells and neurospheres-re-evaluating the relationship. Nat. Methods 2:333-336.
28. Reynolds, B.A., Tetzlaff, W., and Weiss, S. 1992. A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. J. Neurosci. 12:4565-4574.
29. Schreiber, T., Gassmann, K., Götz, C., Hübenthal, U., Moors, M., Krause, G., Merk, H.F., Nguyen, N.H., Scanlan, T.S., Abel, J., Rose, C.R., and Fritsche, E. 2010. Polybrominated diphenyl ethers induce developmental neurotoxicity in a human in vitro model: Evidence for endocrine disruption. Environ. Health Perspect. 118:572-578.
30. Svendsen, C.N., ter Borg, M.G., Armstrong, R.J., Rosser, A.E., Chandran, S., Ostenfeld, T., and Caldwell, M.A. 1998. A new method for the rapid and long term growth of human neural precursor cells. J. Neurosci. Methods 85:141-152.
31. Zappone,M.V., Galli, R., Catena, R., Meani, N., De Biasi, S., Mattei, E., Tiveron, C., Vescovi, A.L., Lovell-Badge, R., Ottolenghi, S., and Nicolis, S.K. 2000. Sox2 regulatory sequences direct expression of a (beta)-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells. Development 127:2367-2382.