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Volumn 41, Issue 3, 2011, Pages 175-186

Using mode of action information to improve regulatory decision-making: An ECETOC/ILSI RF/HESI workshop overview

Author keywords

Biological pathways; chemical categories; chemical risk assessment; human relevance; key events; mode modes of action (MOA MOAs); read across

Indexed keywords

4 HYDROXYPHENYLPYRUVATE DIOXYGENASE; CHOLINESTERASE INHIBITOR; FORMALDEHYDE; PHENOBARBITAL; VINYL ACETATE;

EID: 79952583383     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408444.2010.541225     Document Type: Review
Times cited : (46)

References (50)
  • 1
    • 66849113471 scopus 로고    scopus 로고
    • Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries: The National Cancer Institute Cohort
    • Beane Freeman LE, Blair A, Lubin JH, Stewart PA, Hayes RB, Hoover RN, Hauptmann M. (2009). Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries: The National Cancer Institute Cohort. J Natl Ccaner Inst 101:751-761.
    • (2009) J Natl Ccaner Inst , vol.101 , pp. 751-761
    • Beane Freeman, L.E.1    Blair, A.2    Lubin, J.H.3    Stewart, P.A.4    Hayes, R.B.5    Hoover, R.N.6    Hauptmann, M.7
  • 4
    • 33646086476 scopus 로고    scopus 로고
    • A classifcation framework and practical guidance for establishing a mode of action for chemical carcinogens
    • Butterworth BE. (2006). A classifcation framework and practical guidance for establishing a mode of action for chemical carcinogens. Regul Toxicol Pharmacol 45:9-23.
    • (2006) Regul Toxicol Pharmacol , vol.45 , pp. 9-23
    • Butterworth, B.E.1
  • 5
    • 26944445839 scopus 로고    scopus 로고
    • A risk assessment perspective: Application of mode of action and human relevance frameworks to the analysis of rodent tumor data
    • DOI 10.1093/toxsci/kfi133
    • Dellarco VL, Baetcke K. (2005). A risk assessment perspective: Application of mode of action and human relevance frameworks to the analysis of rodent tumor data. Toxicol Sci 86:1-3. (Pubitemid 41511342)
    • (2005) Toxicological Sciences , vol.86 , Issue.1 , pp. 1-3
    • Dellarco, V.L.1    Baetcke, K.2
  • 6
    • 76949101415 scopus 로고    scopus 로고
    • Toxicological modes of action: Relevance for human risk assessment
    • Brussels: European Centre for Ecotoxicology and Toxicology of Chemicals; July 2006
    • ECETOC. (2006). Toxicological Modes of Action: Relevance for Human Risk Assessment. Technical Report No. 99. Brussels: European Centre for Ecotoxicology and Toxicology of Chemicals; July 2006.
    • (2006) ECETOC Technical Report No. 99
  • 7
    • 79952596568 scopus 로고    scopus 로고
    • Cyanides of hydrogen, sodium and potassium, and acetone cyanohydrin
    • ECETOC Brussels: European Centre for Ecotoxicology and Toxicology of Chemicals; September 2007
    • ECETOC. (2007). Cyanides of Hydrogen, Sodium and Potassium, and Acetone Cyanohydrin. JACC Report No. 53. Brussels: European Centre for Ecotoxicology and Toxicology of Chemicals; September 2007.
    • (2007) JACC Report No. 53
  • 8
    • 84888444579 scopus 로고    scopus 로고
    • EU. (2006). Directive 2006/121/ec of the European Parliament and of the Council of 18 December 2006 amending Council Directive 67/548/EEC on the approximation of laws regulations and administrative provisions relating to the classifcation packaging and labelling of dangerous substances in order to adapt it to Regulation (EC) No. 1907/2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) and establishing a European Chemicals Agency
    • EU. (2006). Directive 2006/121/ec of the European Parliament and of the Council of 18 December 2006 amending Council Directive 67/548/EEC on the approximation of laws regulations and administrative provisions relating to the classifcation packaging and labelling of dangerous substances in order to adapt it to Regulation (EC) No. 1907/2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) and establishing a European Chemicals Agency.
  • 9
    • 84888467952 scopus 로고    scopus 로고
    • EC (2008). Regulation (EC) No. 1272/ 2008 of the European Parliament and of the Council of 16 December 2008 on classifcation, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC and amending Regulation (EC) No 1907/ 2006.
    • EC (2008). Regulation (EC) No. 1272/ 2008 of the European Parliament and of the Council of 16 December 2008 on classifcation, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC and amending Regulation (EC) No 1907/ 2006.
  • 11
    • 79952610452 scopus 로고    scopus 로고
    • ECB CAS-No.: 108-05-4 EINECS-No.: 203- 545-4
    • ECB (2008). Risk Assessment Vinyl Acetate, CAS-No.: 108-05-4 EINECS-No.: 203- 545-4.
    • (2008) Risk Assessment Vinyl Acetate
  • 12
    • 84888473059 scopus 로고    scopus 로고
    • Ispra, Italy: European Chemicals Bureau, Institute for Health and Consumer Protection, European Commission Joint Research Centre
    • Ispra, Italy: European Chemicals Bureau, Institute for Health and Consumer Protection, European Commission Joint Research Centre. Luxembourg: Ofce for Ofcial Publications of the European Communities. Available at: http://ecb.jrc.ec.europa.eu/esis/.
    • Luxembourg: Ofce for Ofcial Publications of the European Communities
  • 13
    • 56649086859 scopus 로고    scopus 로고
    • Systems biology and mode of action based risk assessment
    • Edwards SW, Preston RJ. (2008). Systems biology and mode of action based risk assessment. Toxicol Sci 106:312-318.
    • (2008) Toxicol Sci , vol.106 , pp. 312-318
    • Edwards, S.W.1    Preston, R.J.2
  • 17
    • 0034836917 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of NTBC (2-(2-nitro-4- fluoromethylbenzoyl)-1,3-cyclohexanedione) and mesotrione, inhibitors of 4-hydroxyphenyl pyruvate dioxygenase (HPPD) following a single dose to healthy male volunteers
    • DOI 10.1046/j.0306-5251.2001.01421.x
    • Hall MG, Wilks MF, Provan WM, Eksborg S, Lumholtz B. (2001). Pharmacokinetcs and pharmacodynamics of NTBC (2-(2-nitro-4-fuoromethylbenzoyl)- 1,3-cyclohexanedione) and mesotrione, inhibitors of 4-hydroxyphenyl pyruvate dioxygenase (HPPD) following a single dose to healthy male volunteers. Br J Clin Pharmacol 52:169-177. (Pubitemid 32863075)
    • (2001) British Journal of Clinical Pharmacology , vol.52 , Issue.2 , pp. 169-177
    • Hall, M.G.1    Wilks, M.F.2    McLean Provan, W.3    Eksborg, S.4    Lumholt, B.5
  • 18
    • 60549084518 scopus 로고    scopus 로고
    • A preliminary operational classifcation system for nonmutagenic modes of action for carcinogenesis
    • Hattis D, Chu M, Rahmioglu N, Goble R, Verma P, Hartman K, Kozlak M. (2009). A preliminary operational classifcation system for nonmutagenic modes of action for carcinogenesis. Crit Rev Toxicol 39:97-138.
    • (2009) Crit Rev Toxicol , vol.39 , pp. 97-138
    • Hattis, D.1    Chu, M.2    Rahmioglu, N.3    Goble, R.4    Verma, P.5    Hartman, K.6    Kozlak, M.7
  • 19
    • 31844443695 scopus 로고
    • The environment and disease: Association or causation?
    • Hill AB. (1965). The environment and disease: Association or causation? Proc R Soc Med 58:295-300.
    • (1965) Proc R Soc Med , vol.58 , pp. 295-300
    • Hill, A.B.1
  • 20
    • 79952613308 scopus 로고
    • Monographs on the evaluation of the carcinogenic risk of chemicals to humans
    • IARC International Agency for Research on Cancer Some Chlorinated Solvents and Other Industrial Chemicals Vinyl Acetate. Lyon, France: IARC
    • IARC. (1995). International Agency for Research on Cancer. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Dry Cleaning, Some Chlorinated Solvents and Other Industrial Chemicals. 63: Vinyl Acetate. Lyon, France: IARC.
    • (1995) Dry Cleaning , vol.63
  • 21
    • 79952601787 scopus 로고    scopus 로고
    • Monographs on the evaluation of the carcinogenic risk of chemicals to humans
    • IARC International Agency for Research on Cancer Formaldehyde. Lyon, France: IARC
    • IARC. (2006). International Agency for Research on Cancer. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Formaldehyde, 2-Butoxyethanol and 1-tert-Butoxypropan-2-ol. 88: Formaldehyde. Lyon, France: IARC.
    • (2006) Formaldehyde, 2-Butoxyethanol and 1-tert-Butoxypropan-2-ol , vol.88
  • 22
    • 79952614009 scopus 로고    scopus 로고
    • ICH The Non-Clinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals. Guideline S7B, May 2005.
    • ICH. (2005). International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. The Non-Clinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals. Guideline S7B. May 2005.
    • (2005) International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use
  • 23
    • 79952593004 scopus 로고    scopus 로고
    • International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use
    • ICH October 2009
    • ICH. (2009). International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. Addendum to ICH S6: Preclinical Safety Evaluation of Biotechnology-Derived Pharmaceuticals S6(R1). October 2009.
    • (2009) Addendum to ICH S6: Preclinical Safety Evaluation of Biotechnology- Derived Pharmaceuticals S6(R1)
  • 25
    • 34548095431 scopus 로고    scopus 로고
    • Chemical-specifc adjustment factors for interspecies diferences and human variability: Guidance document for use of data in dose/concentration-response assessment
    • IPCS (International Programme on Chemical Safety) Geneva: World Health Organization
    • IPCS (International Programme on Chemical Safety). (2005). Chemical-Specifc Adjustment Factors for Interspecies Diferences and Human Variability: Guidance Document for Use of Data in Dose/Concentration-Response Assessment. Harmonization Project Document No. 2. Geneva: World Health Organization.
    • (2005) Harmonization Project Document No. 2
  • 26
    • 0014468454 scopus 로고
    • A phosphorylation site in brain and the delayed neurotoxic efect of some organophosphorus compounds
    • Johnson MK. (1969). A phosphorylation site in brain and the delayed neurotoxic efect of some organophosphorus compounds. Biochem J 111:487-495.
    • (1969) Biochem J , vol.111 , pp. 487-495
    • Johnson, M.K.1
  • 27
    • 69849101419 scopus 로고    scopus 로고
    • The key events dose-response framework: A cross-disciplinary mode-of-action based approach to examining dose-response and thresholds
    • Julien E, Boobis AR, Olin SS. (2009). The Key Events Dose-Response Framework: A cross-disciplinary mode-of-action based approach to examining dose-response and thresholds. Crit Rev Food Sci Nutr 49:682-689.
    • (2009) Crit Rev Food Sci Nutr , vol.49 , pp. 682-689
    • Julien, E.1    Boobis, A.R.2    Olin, S.S.3
  • 28
    • 36048999438 scopus 로고    scopus 로고
    • Mode of action as a determining factor in additivity models for chemical mixture risk assessment
    • DOI 10.1016/j.yrtph.2007.07.002, PII S0273230007001006
    • Lambert JC, Lipscomb JC. (2007). Mode of action as a determining factor in additivity models for chemical mixture risk assessment. Regul Toxicol Pharmacol 49:183-194. (Pubitemid 350087394)
    • (2007) Regulatory Toxicology and Pharmacology , vol.49 , Issue.3 , pp. 183-194
    • Lambert, J.C.1    Lipscomb, J.C.2
  • 29
    • 43549114744 scopus 로고    scopus 로고
    • Alternative methods to safety studies in experimental animals: Role in risk assessment of chemicals under the new European Chemicals Legislation (REACH)
    • Lilienblum W, Dekant W, Foth H, Gebel T, Hengstler JG, Kahl R, Kramer P-J, Schweinfurth H, Wollin K-M. (2008). Alternative methods to safety studies in experimental animals: Role in risk assessment of chemicals under the new European Chemicals Legislation (REACH). Arch Toxicol 82:211-236.
    • (2008) Arch Toxicol , vol.82 , pp. 211-236
    • Lilienblum, W.1    Dekant, W.2    Foth, H.3    Gebel, T.4    Hengstler, J.G.5    Kahl, R.6    Kramer, P.-J.7    Schweinfurth, H.8    Wollin, K.-M.9
  • 30
    • 0030459545 scopus 로고    scopus 로고
    • Tissue distribution of 2-(2-nitro-4-trifluoromethylbenzoyl)cyclohexane-1, 3-dione (NTBC): Effect on enzymes involved in tyrosine catabolism and relevance to ocular toxicity in the rat
    • DOI 10.1006/taap.1996.0310
    • Lock EA, Gaskin P, Ellis M.K, Provan WM, Robinson M, Smith LL, Prisbylla MP, Mutter LC. (1996). Tissue distribution of 2-(2-nitro-4- trifuoromethylbenzoyl)cyclohexanedione (NTBC): Efect on enzymes involved in tyrosine catabolism and relevance to ocular toxicity in the rat. Toxicol Appl Pharmacol 141:439-447. (Pubitemid 27046370)
    • (1996) Toxicology and Applied Pharmacology , vol.141 , Issue.2 , pp. 439-447
    • Lock, E.A.1    Gaskin, P.2    Ellis, M.K.3    Provan, W.M.4    Robinson, M.5    Smith, L.L.6    Prisbylla, M.P.7    Mutter, L.C.8
  • 31
    • 0037432649 scopus 로고    scopus 로고
    • The role of mode of action studies in extrapolating to human risks in toxicology
    • DOI 10.1016/S0378-4274(03)00028-6
    • Lock EA, Smith LL. (2003) The role of mode of action studies in extrapolating to human risks in toxicology. Toxicol Lett 140-141:317-322. (Pubitemid 36378951)
    • (2003) Toxicology Letters , vol.140-141 , pp. 317-322
    • Lock, E.A.1    Smith, L.L.2
  • 32
    • 77955066854 scopus 로고    scopus 로고
    • Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia
    • Lu K, Collins LB, Ru H, Bermudez E, Swenberg JA. (2010). Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia. Toxicol Sci 116:441-451.
    • (2010) Toxicol Sci , vol.116 , pp. 441-451
    • Lu, K.1    Collins, L.B.2    Ru, H.3    Bermudez, E.4    Swenberg, J.A.5
  • 35
    • 35948959319 scopus 로고
    • NRC National Research Council: Risk Assessment in the Federal Government Washington, DC: National Academy Press
    • NRC. (1983). National Research Council: Risk Assessment in the Federal Government. Managing the Process. Washington, DC: National Academy Press.
    • (1983) Managing the Process
  • 36
    • 84888471838 scopus 로고    scopus 로고
    • Organisation for economic co-operation and development
    • OECD
    • OECD. (2009). Organisation for Economic Co-operation and Development. Guidance on Grouping of Chemicals: Chemical Categories and Read-Across. Available at: http://www.oecd.org/d ocument/6/03343en-2649-34379-43087494-1-1-1- 100.html.
    • (2009) Guidance on Grouping of Chemicals: Chemical Categories and Read-Across
  • 37
    • 79952577178 scopus 로고    scopus 로고
    • Organisation for economic co-operation and development. SIDS
    • OECD Paris: UNEP Publications
    • OECD. (2002). Organisation for Economic Co-operation and Development. SIDS. Initial Assessment Report: Formaldehyde. Paris: UNEP Publications.
    • (2002) Initial Assessment Report: Formaldehyde
  • 38
    • 84888447977 scopus 로고    scopus 로고
    • SCHER Scientifc Committee on Health and Environmental Risks Adopted November 17, 2008
    • SCHER. (2008). Scientifc Committee on Health and Environmental Risks. Risk assessment report on vinyl acetate, human health part. Adopted November 17, 2008. http://ec.europa.eu/health/archive/ph-risk/committees/04-scher/docs/ scher-o-108.pdf.
    • (2008) Risk Assessment Report on Vinyl Acetate, Human Health Part
  • 39
    • 77955084537 scopus 로고    scopus 로고
    • Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo
    • Ross J, Plummer SM, Rode A, Scheer N, Bower CC, Vogel O, Henderson CJ, Wolf CR, Elcombe CR. (2010). Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo. Toxicol Sci 116:452-466.
    • (2010) Toxicol Sci , vol.116 , pp. 452-466
    • Ross, J.1    Plummer, S.M.2    Rode, A.3    Scheer, N.4    Bower, C.C.5    Vogel, O.6    Henderson, C.J.7    Wolf, C.R.8    Elcombe, C.R.9
  • 43
    • 67650245034 scopus 로고    scopus 로고
    • Inhalation of formaldehyde does not induce systemic genotoxic efects in rats
    • Speit G, Zeller J, Schmid O, Elhajouji A, Ma-Hock L, Neuss S. (2009). Inhalation of formaldehyde does not induce systemic genotoxic efects in rats. Mutat Res 677:76-85.
    • (2009) Mutat Res , vol.677 , pp. 76-85
    • Speit, G.1    Zeller, J.2    Schmid, O.3    Elhajouji, A.4    Ma-Hock, L.5    Neuss, S.6
  • 44
    • 0000060569 scopus 로고    scopus 로고
    • Proposed guidelines for carcinogen risk assessment
    • US EPA US Environmental Protection Agency
    • US EPA. (1996). US Environmental Protection Agency. Proposed guidelines for carcinogen risk assessment. Federal Register 61:17960-18011.
    • (1996) Federal Register , vol.61 , pp. 17960-18011
  • 45
    • 84888448624 scopus 로고    scopus 로고
    • Guidelines for carcinogen risk assessment
    • US EPA US Environmental Protection Agency
    • US EPA. (2005). US Environmental Protection Agency. Guidelines for carcinogen risk assessment. Washington, DC: Risk Assessment Forum. EPA/630/P-03001F. Available at: http://www.epa.gov/raf/publications/pdfs/CANCER- GUIDELINES-FINAL-3-25-05.
    • (2005) Washington, DC: Risk Assessment Forum. EPA/630/P-03001F
  • 47
    • 70349745441 scopus 로고    scopus 로고
    • Clear diferences in levels of a formaldehyde-DNA adduct in leukocytes of smokers and nonsmokers
    • Wang M, Cheng G, Balbo S, Carmella SG, Villalta PW, Hecht SS. (2009). Clear diferences in levels of a formaldehyde-DNA adduct in leukocytes of smokers and nonsmokers. Cancer Res 69:7170-774.
    • (2009) Cancer Res , vol.69 , pp. 7170-774
    • Wang, M.1    Cheng, G.2    Balbo, S.3    Carmella, S.G.4    Villalta, P.W.5    Hecht, S.S.6
  • 48
    • 48649110206 scopus 로고    scopus 로고
    • Application of mode-of-action considerations in human cancer risk assessment
    • Williams GM. (2008). Application of mode-of-action considerations in human cancer risk assessment. Toxicol Lett 180:75-80.
    • (2008) Toxicol Lett , vol.180 , pp. 75-80
    • Williams, G.M.1
  • 49
    • 5644295430 scopus 로고    scopus 로고
    • The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice
    • DOI 10.1158/0008-5472.CAN-04-1459
    • Yamamoto Y, Moore R, Goldsworthy TL, Negishi M, Maronpot RR. (2004). The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice. Cancer Res 64:7197-7200. (Pubitemid 39372050)
    • (2004) Cancer Research , vol.64 , Issue.20 , pp. 7197-7200
    • Yamamoto, Y.1    Moore, R.2    Goldsworthy, T.L.3    Negishi, M.4    Maronpot, R.R.5
  • 50
    • 59349084923 scopus 로고    scopus 로고
    • Formaldehyde exposure and leukemia: A new meta-analysis and potential mechanisms
    • Zhang L, Steinmaus C, Eastmond DA, Xin XK, Smith MT. (2009). Formaldehyde exposure and leukemia: A new meta-analysis and potential mechanisms. Mutat Res 681:150-168.
    • (2009) Mutat Res , vol.681 , pp. 150-168
    • Zhang, L.1    Steinmaus, C.2    Eastmond, D.A.3    Xin, X.K.4    Smith, M.T.5


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