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Volumn 11, Issue , 2016, Pages 47-76

Cancer Stem Cells: Basic Concepts and Therapeutic Implications

Author keywords

Cancer; Cancer stem cells; Epithelial to mesenchymal transition; Resistance to therapy; Tumor heterogeneity; Tumor microenvironment

Indexed keywords

ARTICLE; CANCER RECURRENCE; CANCER STEM CELL; CELL RENEWAL; CELL SUBPOPULATION; CLONAL EVOLUTION; EPITHELIAL MESENCHYMAL TRANSITION; GENE MUTATION; GENETIC HETEROGENEITY; HUMAN; NONHUMAN; PRIMARY TUMOR; PRIORITY JOURNAL; SOLID TUMOR; TUMOR MICROENVIRONMENT; ANIMAL; DRUG EFFECTS; NEOPLASMS; PATHOLOGY;

EID: 84971254606     PISSN: 15534006     EISSN: 15534014     Source Type: Book Series    
DOI: 10.1146/annurev-pathol-012615-044438     Document Type: Article
Times cited : (627)

References (216)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D,Weinberg RA. 2011. Hallmarks of cancer: The next generation. Cell 144:646-74
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 0021242388 scopus 로고
    • Tumor heterogeneity
    • Heppner GH. 1984. Tumor heterogeneity. Cancer Res. 44:2259-65
    • (1984) Cancer Res. , vol.44 , pp. 2259-2265
    • Heppner, G.H.1
  • 5
    • 84896125494 scopus 로고    scopus 로고
    • Evolution of the cancer stem cell model
    • Kreso A, Dick JE. 2014. Evolution of the cancer stem cell model. Cell Stem Cell 14:275-91
    • (2014) Cell Stem Cell , vol.14 , pp. 275-291
    • Kreso, A.1    Dick, J.E.2
  • 7
    • 84884377472 scopus 로고    scopus 로고
    • Tumour heterogeneity and cancer cell plasticity
    • Meacham CE, Morrison SJ. 2013. Tumour heterogeneity and cancer cell plasticity. Nature 501:328-37
    • (2013) Nature , vol.501 , pp. 328-337
    • Meacham, C.E.1    Morrison, S.J.2
  • 8
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC. 1976. The clonal evolution of tumor cell populations. Science 194:23-28
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 13
    • 84885735554 scopus 로고    scopus 로고
    • Mutational landscape and significance across 12 major cancer types
    • Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, et al. 2013. Mutational landscape and significance across 12 major cancer types. Nature 502:333-39
    • (2013) Nature , vol.502 , pp. 333-339
    • Kandoth, C.1    McLellan, M.D.2    Vandin, F.3    Ye, K.4    Niu, B.5
  • 14
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • GerlingerM, Rowan AJ, Horswell S, Larkin J, Endesfelder D, et al. 2012. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N. Engl. J. Med. 366:883-92
    • (2012) N. Engl. J. Med. , vol.366 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3    Larkin, J.4    Endesfelder, D.5
  • 15
    • 84895876130 scopus 로고    scopus 로고
    • Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
    • GerlingerM,Horswell S, Larkin J, Rowan AJ, Salm MP, et al. 2014. Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing. Nat. Genet. 46:225-33
    • (2014) Nat. Genet. , vol.46 , pp. 225-233
    • Gerlinger, M.1    Horswell, S.2    Larkin, J.3    Rowan, A.J.4    Salm, M.P.5
  • 16
    • 84907855592 scopus 로고    scopus 로고
    • Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
    • de Bruin EC, McGranahan N, Mitter R, Salm M, Wedge DC, et al. 2014. Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. Science 346:251-56
    • (2014) Science , vol.346 , pp. 251-256
    • De Bruin, E.C.1    McGranahan, N.2    Mitter, R.3    Salm, M.4    Wedge, D.C.5
  • 17
    • 84907808265 scopus 로고    scopus 로고
    • Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing
    • Zhang J, Fujimoto J, Zhang J, Wedge DC, Song X, et al. 2014. Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing. Science 346:256-59
    • (2014) Science , vol.346 , pp. 256-259
    • Zhang, J.1    Fujimoto, J.2    Zhang, J.3    Wedge, D.C.4    Song, X.5
  • 19
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves M, Maley CC. 2012. Clonal evolution in cancer. Nature 481:306-13
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 20
    • 79953766940 scopus 로고    scopus 로고
    • Tumour evolution inferred by single-cell sequencing
    • NavinN,Kendall J, Troge J, Andrews P, Rodgers L, et al. 2011. Tumour evolution inferred by single-cell sequencing. Nature 472:90-94
    • (2011) Nature , vol.472 , pp. 90-94
    • Navin, N.1    Kendall, J.2    Troge, J.3    Andrews, P.4    Rodgers, L.5
  • 21
    • 84925229458 scopus 로고    scopus 로고
    • Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution
    • Eirew P, Steif A, Khattra J, Ha G, Yap D, et al. 2015. Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution. Nature 518:422-26
    • (2015) Nature , vol.518 , pp. 422-426
    • Eirew, P.1    Steif, A.2    Khattra, J.3    Ha, G.4    Yap, D.5
  • 22
    • 84863229772 scopus 로고    scopus 로고
    • Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm
    • Hou Y, Song L, Zhu P, Zhang B, Tao Y, et al. 2012. Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell 148:873-85
    • (2012) Cell , vol.148 , pp. 873-885
    • Hou, Y.1    Song, L.2    Zhu, P.3    Zhang, B.4    Tao, Y.5
  • 24
    • 84897482887 scopus 로고    scopus 로고
    • Tumour cell heterogeneity maintained by cooperating subclones inWnt-driven mammary cancers
    • Cleary AS, Leonard TL, Gestl SA, Gunther EJ. 2014. Tumour cell heterogeneity maintained by cooperating subclones inWnt-driven mammary cancers. Nature 508:113-17
    • (2014) Nature , vol.508 , pp. 113-117
    • Cleary, A.S.1    Leonard, T.L.2    Gestl, S.A.3    Gunther, E.J.4
  • 25
    • 84902603107 scopus 로고    scopus 로고
    • Plasticity of epithelial stem cells in tissue regeneration
    • Blanpain C, Fuchs E. 2014. Plasticity of epithelial stem cells in tissue regeneration. Science 344:1242281
    • (2014) Science , vol.344 , pp. 1242281
    • Blanpain, C.1    Fuchs, E.2
  • 26
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • Lapidot T, Sirard C, Vormoor J, Murdoch B,Hoang T, et al. 1994. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367:645-48
    • (1994) Nature , vol.367 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3    Murdoch, B.4    Hoang, T.5
  • 27
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. 1997. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3:730-37
    • (1997) Nat. Med. , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 28
    • 80052468964 scopus 로고    scopus 로고
    • Stem cell gene expression programs influence clinical outcome in human leukemia
    • Eppert K, Takenaka K, Lechman ER, Waldron L, Nilsson B, et al. 2011. Stem cell gene expression programs influence clinical outcome in human leukemia. Nat. Med. 17:1086-93
    • (2011) Nat. Med. , vol.17 , pp. 1086-1093
    • Eppert, K.1    Takenaka, K.2    Lechman, E.R.3    Waldron, L.4    Nilsson, B.5
  • 30
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, et al. 2007. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1:555-67
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1    Hur, M.H.2    Charafe-Jauffret, E.3    Monville, F.4    Dutcher, J.5
  • 31
    • 74949129868 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 1-positive cancer stem cells mediatemetastasis and poor clinical outcome in inflammatory breast cancer
    • Charafe-Jauffret E, Ginestier C, Iovino F, Tarpin C, Diebel M, et al. 2010. Aldehyde dehydrogenase 1-positive cancer stem cells mediatemetastasis and poor clinical outcome in inflammatory breast cancer. Clin. Cancer Res. 16:45-55
    • (2010) Clin. Cancer Res. , vol.16 , pp. 45-55
    • Charafe-Jauffret, E.1    Ginestier, C.2    Iovino, F.3    Tarpin, C.4    Diebel, M.5
  • 33
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O'Brien CA, Pollett A, Gallinger S, Dick JE. 2007. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445:106-10
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 34
  • 36
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, et al. 2007. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1:313-23
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3    Aicher, A.4    Ellwart, J.W.5
  • 37
    • 33846512398 scopus 로고    scopus 로고
    • Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
    • Prince ME, Sivanandan R, Kaczorowski A, Wolf GT, Kaplan MJ, et al. 2007. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. PNAS 104:973-78
    • (2007) PNAS , vol.104 , pp. 973-978
    • Prince, M.E.1    Sivanandan, R.2    Kaczorowski, A.3    Wolf, G.T.4    Kaplan, M.J.5
  • 38
    • 51649111430 scopus 로고    scopus 로고
    • Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity
    • Vermeulen L, Todaro M, de Sousa Mello F, Sprick MR, Kemper K, et al. 2008. Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. PNAS 105:13427-32
    • (2008) PNAS , vol.105 , pp. 13427-13432
    • Vermeulen, L.1    Todaro, M.2    De Sousa Mello, F.3    Sprick, M.R.4    Kemper, K.5
  • 40
    • 77954238710 scopus 로고    scopus 로고
    • Human melanomainitiating cells express neural crest nerve growth factor receptor CD271
    • Boiko AD, Razorenova OV, van de Rijn M, Swetter SM, Johnson DL, et al. 2010. Human melanomainitiating cells express neural crest nerve growth factor receptor CD271. Nature 466:133-37
    • (2010) Nature , vol.466 , pp. 133-137
    • Boiko, A.D.1    Razorenova, O.V.2    Van De Rijn, M.3    Swetter, S.M.4    Johnson, D.L.5
  • 41
    • 79954617310 scopus 로고    scopus 로고
    • Human CD271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth
    • Civenni G, Walter A, Kobert N, Mihic-Probst D, Zipser M, et al. 2011. Human CD271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth. Cancer Res. 71:3098-109
    • (2011) Cancer Res. , vol.71 , pp. 3098-3109
    • Civenni, G.1    Walter, A.2    Kobert, N.3    Mihic-Probst, D.4    Zipser, M.5
  • 44
    • 84871003153 scopus 로고    scopus 로고
    • Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness
    • LapougeG, Beck B,NassarD,Dubois C,Dekoninck S, Blanpain C. 2012. Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness. EMBO J. 31:4563-75
    • (2012) EMBO J. , vol.31 , pp. 4563-4575
    • Lapouge, G.1    Beck, B.2    Nassar, D.3    Dubois, C.4    Dekoninck, S.5    Blanpain, C.6
  • 45
    • 84857028067 scopus 로고    scopus 로고
    • Tumorigenic cells are common in mouseMPNSTs but their frequency depends upon tumor genotype and assay conditions
    • Buchstaller J,McKeever PE,Morrison SJ. 2012. Tumorigenic cells are common in mouseMPNSTs but their frequency depends upon tumor genotype and assay conditions. Cancer Cell 21:240-52
    • (2012) Cancer Cell , vol.21 , pp. 240-252
    • Buchstaller, J.1    McKeever, P.E.2    Morrison, S.J.3
  • 46
    • 45849102392 scopus 로고    scopus 로고
    • In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties
    • le Viseur C,HotfilderM, Bomken S,Wilson K, Rottgers S, et al. 2008. In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties. Cancer Cell 14:47-58
    • (2008) Cancer Cell , vol.14 , pp. 47-58
    • Le Viseur, C.1    Hotfilder, M.2    Bomken, S.3    Wilson, K.4    Rottgers, S.5
  • 48
    • 79955711142 scopus 로고    scopus 로고
    • Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse
    • Clappier E, Gerby B, Sigaux F, DelordM, Touzri F, et al. 2011. Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse. J. Exp. Med. 208:653-61
    • (2011) J. Exp. Med. , vol.208 , pp. 653-661
    • Clappier, E.1    Gerby, B.2    Sigaux, F.3    Delord, M.4    Touzri, F.5
  • 49
    • 84963966189 scopus 로고    scopus 로고
    • Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance
    • Nowak D, Liem NL, Mossner M, Klaumunzer M, Papa RA, et al. 2015. Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance. Exp. Hematol. 43:32-43.e35
    • (2015) Exp. Hematol. , vol.43 , pp. 32e35-43e35
    • Nowak, D.1    Liem, N.L.2    Mossner, M.3    Klaumunzer, M.4    Papa, R.A.5
  • 50
    • 4444290010 scopus 로고    scopus 로고
    • Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche
    • Blanpain C, Lowry WE, Geoghegan A, Polak L, Fuchs E. 2004. Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell 118:635-48
    • (2004) Cell , vol.118 , pp. 635-648
    • Blanpain, C.1    Lowry, W.E.2    Geoghegan, A.3    Polak, L.4    Fuchs, E.5
  • 51
    • 41649089525 scopus 로고    scopus 로고
    • Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
    • Malanchi I, Peinado H, Kassen D, Hussenet T, Metzger D, et al. 2008. Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature 452:650-53
    • (2008) Nature , vol.452 , pp. 650-653
    • Malanchi, I.1    Peinado, H.2    Kassen, D.3    Hussenet, T.4    Metzger, D.5
  • 52
    • 80055003796 scopus 로고    scopus 로고
    • A vascular niche and a VEGFNrp1 loop regulate the initiation and stemness of skin tumours
    • Beck B, Driessens G, Goossens S, Youssef KK, Kuchnio A, et al. 2011. A vascular niche and a VEGFNrp1 loop regulate the initiation and stemness of skin tumours. Nature 478:399-403
    • (2011) Nature , vol.478 , pp. 399-403
    • Beck, B.1    Driessens, G.2    Goossens, S.3    Youssef, K.K.4    Kuchnio, A.5
  • 53
    • 84904246245 scopus 로고    scopus 로고
    • SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma
    • Boumahdi S, Driessens G, Lapouge G, Rorive S,Nassar D, et al. 2014. SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma. Nature 511:246-50
    • (2014) Nature , vol.511 , pp. 246-250
    • Boumahdi, S.1    Driessens, G.2    Lapouge, G.3    Rorive, S.4    Nassar, D.5
  • 54
    • 77957676330 scopus 로고    scopus 로고
    • Primary tumor genotype is an important determinant in identification of lung cancer propagating cells
    • Curtis SJ, SinkeviciusKW,Li D, LauAN, Roach RR, et al. 2010. Primary tumor genotype is an important determinant in identification of lung cancer propagating cells. Cell Stem Cell 7:127-33
    • (2010) Cell Stem Cell , vol.7 , pp. 127-133
    • Curtis, S.J.1    Sinkevicius, K.W.2    Li, D.3    Lau, A.N.4    Roach, R.R.5
  • 55
    • 58649111264 scopus 로고    scopus 로고
    • Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma
    • Read TA, Fogarty MP, Markant SL, McLendon RE, Wei Z, et al. 2009. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell 15:135-47
    • (2009) Cancer Cell , vol.15 , pp. 135-147
    • Read, T.A.1    Fogarty, M.P.2    Markant, S.L.3    McLendon, R.E.4    Wei, Z.5
  • 56
    • 54249086214 scopus 로고    scopus 로고
    • The mammary progenitor marker CD61/β3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis
    • Vaillant F, Asselin-Labat ML, ShackletonM, Forrest NC, Lindeman GJ, Visvader JE. 2008. The mammary progenitor marker CD61/β3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res. 68:7711-17
    • (2008) Cancer Res. , vol.68 , pp. 7711-7717
    • Vaillant, F.1    Asselin-Labat, M.L.2    Shackleton, M.3    Forrest, N.C.4    Lindeman, G.J.5    Visvader, J.E.6
  • 57
    • 84880794274 scopus 로고    scopus 로고
    • Unravelling stem cell dynamics by lineage tracing
    • Blanpain C, Simons BD. 2013. Unravelling stem cell dynamics by lineage tracing. Nat. Rev. Mol. Cell Biol. 14:489-502
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 489-502
    • Blanpain, C.1    Simons, B.D.2
  • 59
    • 28644451449 scopus 로고    scopus 로고
    • Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis
    • Ito M, Liu Y, Yang Z, Nguyen J, Liang F, et al. 2005. Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat. Med. 11:1351-54
    • (2005) Nat. Med. , vol.11 , pp. 1351-1354
    • Ito, M.1    Liu, Y.2    Yang, Z.3    Nguyen, J.4    Liang, F.5
  • 60
    • 30144432901 scopus 로고    scopus 로고
    • Purification and unique properties of mammary epithelial stem cells
    • Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, et al. 2006. Purification and unique properties of mammary epithelial stem cells. Nature 439:993-97
    • (2006) Nature , vol.439 , pp. 993-997
    • Stingl, J.1    Eirew, P.2    Ricketson, I.3    Shackleton, M.4    Vaillant, F.5
  • 61
    • 80855130470 scopus 로고    scopus 로고
    • Distinct stem cells contribute to mammary gland development and maintenance
    • Van Keymeulen A, Rocha AS, Ousset M, Beck B, Bouvencourt G, et al. 2011. Distinct stem cells contribute to mammary gland development and maintenance. Nature 479:189-93
    • (2011) Nature , vol.479 , pp. 189-193
    • Van Keymeulen, A.1    Rocha, A.S.2    Ousset, M.3    Beck, B.4    Bouvencourt, G.5
  • 65
    • 84866147372 scopus 로고    scopus 로고
    • Distinct contribution of stem and progenitor cells to epidermal maintenance
    • Mascre G, Dekoninck S, Drogat B, Youssef KK, Brohee S, et al. 2012. Distinct contribution of stem and progenitor cells to epidermal maintenance. Nature 489:257-62
    • (2012) Nature , vol.489 , pp. 257-262
    • Mascre, G.1    Dekoninck, S.2    Drogat, B.3    Youssef, K.K.4    Brohee, S.5
  • 66
  • 67
    • 85027924783 scopus 로고    scopus 로고
    • Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas
    • Kozar S, Morrissey E, Nicholson AM, van der Heijden M, Zecchini HI, et al. 2013. Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas. Cell Stem Cell 13:626-33
    • (2013) Cell Stem Cell , vol.13 , pp. 626-633
    • Kozar, S.1    Morrissey, E.2    Nicholson, A.M.3    Van Der Heijden, M.4    Zecchini, H.I.5
  • 69
    • 84908356441 scopus 로고    scopus 로고
    • Quantification of crypt and stem cell evolution in the normal and neoplastic human colon
    • Baker AM, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, et al. 2014. Quantification of crypt and stem cell evolution in the normal and neoplastic human colon. Cell Rep. 8:940-47
    • (2014) Cell Rep. , vol.8 , pp. 940-947
    • Baker, A.M.1    Cereser, B.2    Melton, S.3    Fletcher, A.G.4    Rodriguez-Justo, M.5
  • 70
    • 84879736910 scopus 로고    scopus 로고
    • Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution
    • Humphries A, Cereser B, Gay LJ, Miller DS, Das B, et al. 2013. Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution. PNAS 110:E2490-99
    • (2013) PNAS , vol.110 , pp. E2490-E2499
    • Humphries, A.1    Cereser, B.2    Gay, L.J.3    Miller, D.S.4    Das, B.5
  • 71
    • 84873084388 scopus 로고    scopus 로고
    • Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer
    • Kreso A, O'Brien CA, van Galen P, Gan OI, Notta F, et al. 2013. Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science 339:543-48
    • (2013) Science , vol.339 , pp. 543-548
    • Kreso, A.1    O'Brien, C.A.2    Van Galen, P.3    Gan, O.I.4    Notta, F.5
  • 72
    • 77950981309 scopus 로고    scopus 로고
    • Cellular barcoding tool for clonal analysis in the hematopoietic system
    • Gerrits A, Dykstra B, Kalmykowa OJ, Klauke K, Verovskaya E, et al. 2010. Cellular barcoding tool for clonal analysis in the hematopoietic system. Blood 115:2610-18
    • (2010) Blood , vol.115 , pp. 2610-2618
    • Gerrits, A.1    Dykstra, B.2    Kalmykowa, O.J.3    Klauke, K.4    Verovskaya, E.5
  • 73
    • 84893732797 scopus 로고    scopus 로고
    • Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells
    • Nguyen LV, Makarem M, Carles A, Moksa M, Kannan N, et al. 2014. Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells. Cell Stem Cell 14:253-63
    • (2014) Cell Stem Cell , vol.14 , pp. 253-263
    • Nguyen, L.V.1    Makarem, M.2    Carles, A.3    Moksa, M.4    Kannan, N.5
  • 74
    • 84942906239 scopus 로고    scopus 로고
    • DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts
    • Nguyen LV, Cox CL, Eirew P, Knapp DJ, Pellacani D, et al. 2014. DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts. Nat. Commun. 5:5871
    • (2014) Nat. Commun. , vol.5 , pp. 5871
    • Nguyen, L.V.1    Cox, C.L.2    Eirew, P.3    Knapp, D.J.4    Pellacani, D.5
  • 75
    • 84928391898 scopus 로고    scopus 로고
    • A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis
    • Wagenblast E, Soto M, Gutierrez-Angel S, Hartl CA, Gable AL, et al. 2015. A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis. Nature 520:358-62
    • (2015) Nature , vol.520 , pp. 358-362
    • Wagenblast, E.1    Soto, M.2    Gutierrez-Angel, S.3    Hartl, C.A.4    Gable, A.L.5
  • 76
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • Chen J, Li Y, Yu TS, McKay RM, Burns DK, et al. 2012. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488:522-26
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.S.3    McKay, R.M.4    Burns, D.K.5
  • 77
    • 85027944761 scopus 로고    scopus 로고
    • Dclk1 distinguishes between tumor and normal stem cells in the intestine
    • Nakanishi Y, Seno H, Fukuoka A, Ueo T, Yamaga Y, et al. 2013. Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat. Genet. 45:98-103
    • (2013) Nat. Genet. , vol.45 , pp. 98-103
    • Nakanishi, Y.1    Seno, H.2    Fukuoka, A.3    Ueo, T.4    Yamaga, Y.5
  • 78
    • 84872046078 scopus 로고    scopus 로고
    • The sox family of transcription factors: Versatile regulators of stem and progenitor cell fate
    • Sarkar A, Hochedlinger K. 2013. The sox family of transcription factors: versatile regulators of stem and progenitor cell fate. Cell Stem Cell 12:15-30
    • (2013) Cell Stem Cell , vol.12 , pp. 15-30
    • Sarkar, A.1    Hochedlinger, K.2
  • 79
    • 80054041585 scopus 로고    scopus 로고
    • A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
    • Tian H, Biehs B,Warming S, Leong KG, Rangell L, et al. 2011. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 478:255-59
    • (2011) Nature , vol.478 , pp. 255-259
    • Tian, H.1    Biehs, B.2    Warming, S.3    Leong, K.G.4    Rangell, L.5
  • 82
    • 84893768750 scopus 로고    scopus 로고
    • Lgr5+ stem cells are indispensable for radiationinduced intestinal regeneration
    • MetcalfeC, Kljavin NM, Ybarra R, de Sauvage FJ. 2014. Lgr5+ stem cells are indispensable for radiationinduced intestinal regeneration. Cell Stem Cell 14:149-59
    • (2014) Cell Stem Cell , vol.14 , pp. 149-159
    • Metcalfe, C.1    Kljavin, N.M.2    Ybarra, R.3    De Sauvage, F.J.4
  • 83
    • 84873406827 scopus 로고    scopus 로고
    • Tracing the cellular origin of cancer
    • Blanpain C. 2013. Tracing the cellular origin of cancer. Nat. Cell Biol. 15:126-34
    • (2013) Nat. Cell Biol. , vol.15 , pp. 126-134
    • Blanpain, C.1
  • 84
    • 79956317899 scopus 로고    scopus 로고
    • Identifying the cellular origin of squamous skin tumors
    • Lapouge G, Youssef KK, Vokaer B, Achouri Y, Michaux C, et al. 2011. Identifying the cellular origin of squamous skin tumors. PNAS 108:7431-36
    • (2011) PNAS , vol.108 , pp. 7431-7436
    • Lapouge, G.1    Youssef, K.K.2    Vokaer, B.3    Achouri, Y.4    Michaux, C.5
  • 85
    • 79956317166 scopus 로고    scopus 로고
    • Defining the origins of Ras/p53-mediated squamous cell carcinoma
    • White AC, Tran K, Khuu J, Dang C, Cui Y, et al. 2011. Defining the origins of Ras/p53-mediated squamous cell carcinoma. PNAS 108:7425-30
    • (2011) PNAS , vol.108 , pp. 7425-7430
    • White, A.C.1    Tran, K.2    Khuu, J.3    Dang, C.4    Cui, Y.5
  • 87
    • 84872600554 scopus 로고    scopus 로고
    • Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
    • Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Goktuna SI, et al. 2013. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell 152:25-38
    • (2013) Cell , vol.152 , pp. 25-38
    • Schwitalla, S.1    Fingerle, A.A.2    Cammareri, P.3    Nebelsiek, T.4    Goktuna, S.I.5
  • 88
    • 84884558125 scopus 로고    scopus 로고
    • Unravelling cancer stem cell potential
    • Beck B, Blanpain C. 2013. Unravelling cancer stem cell potential. Nat. Rev. Cancer 13:727-38
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 727-738
    • Beck, B.1    Blanpain, C.2
  • 89
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • Gupta PB, Fillmore CM, Jiang G, Shapira SD, Tao K, et al. 2011. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 146:633-44
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3    Shapira, S.D.4    Tao, K.5
  • 90
    • 78249250559 scopus 로고    scopus 로고
    • Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized
    • Quintana E, Shackleton M, Foster HR, Fullen DR, Sabel MS, et al. 2010. Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell 18:510-23
    • (2010) Cancer Cell , vol.18 , pp. 510-523
    • Quintana, E.1    Shackleton, M.2    Foster, H.R.3    Fullen, D.R.4    Sabel, M.S.5
  • 91
    • 79960573076 scopus 로고    scopus 로고
    • Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-βand integrin/focal adhesion kinase (FAK) signaling
    • Schober M, Fuchs E. 2011. Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-βand integrin/focal adhesion kinase (FAK) signaling. PNAS 108:10544-49
    • (2011) PNAS , vol.108 , pp. 10544-10549
    • Schober, M.1    Fuchs, E.2
  • 92
    • 77952502408 scopus 로고    scopus 로고
    • A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
    • Roesch A, Fukunaga-Kalabis M, Schmidt EC, Zabierowski SE, Brafford PA, et al. 2010. A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell 141:583-94
    • (2010) Cell , vol.141 , pp. 583-594
    • Roesch, A.1    Fukunaga-Kalabis, M.2    Schmidt, E.C.3    Zabierowski, S.E.4    Brafford, P.A.5
  • 93
    • 84879983245 scopus 로고    scopus 로고
    • Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity
    • Chaffer CL, Marjanovic ND, Lee T, Bell G, Kleer CG, et al. 2013. Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell 154:61-74
    • (2013) Cell , vol.154 , pp. 61-74
    • Chaffer, C.L.1    Marjanovic, N.D.2    Lee, T.3    Bell, G.4    Kleer, C.G.5
  • 94
    • 84887273608 scopus 로고    scopus 로고
    • Epithelial plasticity: A common theme in embryonic and cancer cells
    • Nieto MA. 2013. Epithelial plasticity: A common theme in embryonic and cancer cells. Science 342:1234850
    • (2013) Science , vol.342 , pp. 1234850
    • Nieto, M.A.1
  • 95
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, NietoMA. 2009. Epithelial-mesenchymal transitions in development and disease. Cell 139:871-90
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 96
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer CL, Weinberg RA. 2011. A perspective on cancer cell metastasis. Science 331:1559-64
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 97
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA. 2009. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat. Rev. Cancer 9:265-73
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 98
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, et al. 2008. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133:704-15
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5
  • 99
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • Morel AP, Lievre M, Thomas C, Hinkal G, Ansieau S, Puisieux A. 2008. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLOS ONE 3:e2888
    • (2008) PLOS ONE , vol.3 , pp. e2888
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3    Hinkal, G.4    Ansieau, S.5    Puisieux, A.6
  • 100
    • 84901787644 scopus 로고    scopus 로고
    • Oncogenic roles of EMT-inducing transcription factors
    • Puisieux A, Brabletz T, Caramel J. 2014. Oncogenic roles of EMT-inducing transcription factors. Nat. Cell Biol. 16:488-94
    • (2014) Nat. Cell Biol. , vol.16 , pp. 488-494
    • Puisieux, A.1    Brabletz, T.2    Caramel, J.3
  • 101
    • 84920942890 scopus 로고    scopus 로고
    • Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation
    • Schmidt JM, Panzilius E, Bartsch HS, Irmler M, Beckers J, et al. 2015. Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation. Cell Rep. 10:131-39
    • (2015) Cell Rep. , vol.10 , pp. 131-139
    • Schmidt, J.M.1    Panzilius, E.2    Bartsch, H.S.3    Irmler, M.4    Beckers, J.5
  • 102
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelialmesenchymal transition is essential for squamous cell carcinoma metastasis
    • Tsai JH, Donaher JL, Murphy DA, Chau S, Yang J. 2012. Spatiotemporal regulation of epithelialmesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 22:725-36
    • (2012) Cancer Cell , vol.22 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 103
    • 84860578009 scopus 로고    scopus 로고
    • Epithelialmesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
    • Celià-Terrassa T, Meca-Cortés O, Mateo F, Martínez de Paz A, Rubio N, et al. 2012. Epithelialmesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J. Clin. Investig. 122:1849-68
    • (2012) J. Clin. Investig. , vol.122 , pp. 1849-1868
    • Celià-Terrassa, T.1    Meca-Cortés, O.2    Mateo, F.3    Martínez De Paz, A.4    Rubio, N.5
  • 104
    • 45849087087 scopus 로고    scopus 로고
    • Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence
    • Ansieau S, Bastid J, Doreau A, Morel AP, Bouchet BP, et al. 2008. Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell 14:79-89
    • (2008) Cancer Cell , vol.14 , pp. 79-89
    • Ansieau, S.1    Bastid, J.2    Doreau, A.3    Morel, A.P.4    Bouchet, B.P.5
  • 105
    • 84863650416 scopus 로고    scopus 로고
    • EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice
    • Morel AP, Hinkal GW, Thomas C, Fauvet F, Courtois-Cox S, et al. 2012. EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice. PLOS Genet. 8:e1002723
    • (2012) PLOS Genet. , vol.8 , pp. e1002723
    • Morel, A.P.1    Hinkal, G.W.2    Thomas, C.3    Fauvet, F.4    Courtois-Cox, S.5
  • 106
    • 84920733761 scopus 로고    scopus 로고
    • Different levels of Twist1 regulate skin tumor initiation, stemness, and progression
    • Beck B, Lapouge G, Rorive S, Drogat B, Desaedelaere K, et al. 2015. Different levels of Twist1 regulate skin tumor initiation, stemness, and progression. Cell Stem Cell 16:67-79
    • (2015) Cell Stem Cell , vol.16 , pp. 67-79
    • Beck, B.1    Lapouge, G.2    Rorive, S.3    Drogat, B.4    Desaedelaere, K.5
  • 107
    • 84858126071 scopus 로고    scopus 로고
    • MicroRNA dysregulation in cancer: Diagnostics, monitoring and therapeutics. A comprehensive review
    • IorioMV, Croce CM. 2012. MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol. Med. 4:143-59
    • (2012) EMBO Mol. Med. , vol.4 , pp. 143-159
    • Iorio, M.V.1    Croce, C.M.2
  • 108
    • 85028133025 scopus 로고    scopus 로고
    • MicroRNAs and cancer stem cells: The sword and the shield
    • Sun X, Jiao X, Pestell TG, Fan C, Qin S, et al. 2014. MicroRNAs and cancer stem cells: The sword and the shield. Oncogene 33:4967-77
    • (2014) Oncogene , vol.33 , pp. 4967-4977
    • Sun, X.1    Jiao, X.2    Pestell, T.G.3    Fan, C.4    Qin, S.5
  • 109
    • 41649091906 scopus 로고    scopus 로고
    • ThemiR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • Park SM,GaurAB, Lengyel E, PeterME. 2008. ThemiR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 22:894-907
    • (2008) Genes Dev. , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 110
    • 43049103824 scopus 로고    scopus 로고
    • The MIR-200 family and MIR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    • Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, et al. 2008. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat. Cell Biol. 10:593-601
    • (2008) Nat. Cell Biol. , vol.10 , pp. 593-601
    • Gregory, P.A.1    Bert, A.G.2    Paterson, E.L.3    Barry, S.C.4    Tsykin, A.5
  • 111
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between ZEB1 and members of the MIR-200 family promotes EMT and invasion in cancer cells
    • Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, et al. 2008. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 9:582-89
    • (2008) EMBO Rep. , vol.9 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Wellner, U.3    Schmalhofer, O.4    Vincan, E.5
  • 112
    • 68049114782 scopus 로고    scopus 로고
    • Downregulation ofmiRNA-200c links breast cancer stem cells with normal stem cells
    • Shimono Y, Zabala M, Cho RW, Lobo N, Dalerba P, et al. 2009. Downregulation ofmiRNA-200c links breast cancer stem cells with normal stem cells. Cell 138:592-603
    • (2009) Cell , vol.138 , pp. 592-603
    • Shimono, Y.1    Zabala, M.2    Cho, R.W.3    Lobo, N.4    Dalerba, P.5
  • 113
    • 79952283482 scopus 로고    scopus 로고
    • P53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs
    • Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, et al. 2011. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat. Cell Biol. 13:317-23
    • (2011) Nat. Cell Biol. , vol.13 , pp. 317-323
    • Chang, C.J.1    Chao, C.H.2    Xia, W.3    Yang, J.Y.4    Xiong, Y.5
  • 114
    • 79956143950 scopus 로고    scopus 로고
    • P53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
    • Kim T, Veronese A, Pichiorri F, Lee TJ, Jeon YJ, et al. 2011. p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J. Exp. Med. 208:875-83
    • (2011) J. Exp. Med. , vol.208 , pp. 875-883
    • Kim, T.1    Veronese, A.2    Pichiorri, F.3    Lee, T.J.4    Jeon, Y.J.5
  • 115
    • 84855729906 scopus 로고    scopus 로고
    • A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition
    • Kim NH, Kim HS, LiXY, Lee I,ChoiHS, et al. 2011. A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J. Cell Biol. 195:417-33
    • (2011) J. Cell Biol. , vol.195 , pp. 417-433
    • Kim, N.H.1    Kim, H.S.2    Li, X.Y.3    Lee, I.4    Choi, H.S.5
  • 116
    • 80455149978 scopus 로고    scopus 로고
    • MIR-34 miRNAs provide a barrier for somatic cell reprogramming
    • Choi YJ, Lin CP, Ho JJ, He X, Okada N, et al. 2011. miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat. Cell Biol. 13:1353-60
    • (2011) Nat. Cell Biol. , vol.13 , pp. 1353-1360
    • Choi, Y.J.1    Lin, C.P.2    Ho, J.J.3    He, X.4    Okada, N.5
  • 118
    • 77957583439 scopus 로고    scopus 로고
    • Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition
    • Yang MH, Hsu DS, Wang HW, Wang HJ, Lan HY, et al. 2010. Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat. Cell Biol. 12:982-92
    • (2010) Nat. Cell Biol. , vol.12 , pp. 982-992
    • Yang, M.H.1    Hsu, D.S.2    Wang, H.W.3    Wang, H.J.4    Lan, H.Y.5
  • 119
    • 84865589321 scopus 로고    scopus 로고
    • How does Lin28 let-7 control development and disease?
    • Thornton JE, Gregory RI. 2012. How does Lin28 let-7 control development and disease? Trends Cell Biol. 22:474-82
    • (2012) Trends Cell Biol. , vol.22 , pp. 474-482
    • Thornton, J.E.1    Gregory, R.I.2
  • 120
    • 36849078711 scopus 로고    scopus 로고
    • Let-7 regulates self renewal and tumorigenicity of breast cancer cells
    • Yu F, Yao H, Zhu P, Zhang X, Pan Q, et al. 2007. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131:1109-23
    • (2007) Cell , vol.131 , pp. 1109-1123
    • Yu, F.1    Yao, H.2    Zhu, P.3    Zhang, X.4    Pan, Q.5
  • 121
    • 40849108663 scopus 로고    scopus 로고
    • Selective blockade of microRNA processing by Lin28
    • Viswanathan SR, Daley GQ, Gregory RI. 2008. Selective blockade of microRNA processing by Lin28. Science 320:97-100
    • (2008) Science , vol.320 , pp. 97-100
    • Viswanathan, S.R.1    Daley, G.Q.2    Gregory, R.I.3
  • 122
    • 67649881121 scopus 로고    scopus 로고
    • Lin28 promotes transformation and is associated with advanced human malignancies
    • Viswanathan SR, Powers JT, EinhornW,HoshidaY,NgTL, et al. 2009. Lin28 promotes transformation and is associated with advanced human malignancies. Nat. Genet. 41:843-48
    • (2009) Nat. Genet. , vol.41 , pp. 843-848
    • Viswanathan, S.R.1    Powers, J.T.2    Einhorn, W.3    Hoshida, Y.4    Ng, T.L.5
  • 123
    • 84875933577 scopus 로고    scopus 로고
    • Lin28: Primal regulator of growth and metabolism in stem cells
    • Shyh-Chang N, Daley GQ. 2013. Lin28: primal regulator of growth and metabolism in stem cells. Cell Stem Cell 12:395-406
    • (2013) Cell Stem Cell , vol.12 , pp. 395-406
    • Shyh-Chang, N.1    Daley, G.Q.2
  • 124
    • 84938659491 scopus 로고    scopus 로고
    • Lin28b/Let-7 regulates expression of Oct4 and Sox2 and reprograms oral squamous cell carcinoma cells to a stem-like state
    • Chien CS, Wang ML, Chu PY, Chang YL, Liu WH, et al. 2015. Lin28b/Let-7 regulates expression of Oct4 and Sox2 and reprograms oral squamous cell carcinoma cells to a stem-like state. Cancer Res. 75(12):2553-65
    • (2015) Cancer Res. , vol.75 , Issue.12 , pp. 2553-2565
    • Chien, C.S.1    Wang, M.L.2    Chu, P.Y.3    Chang, Y.L.4    Liu, W.H.5
  • 125
    • 84887456252 scopus 로고    scopus 로고
    • The epigenetics of epithelial-mesenchymal plasticity in cancer
    • Tam WL, Weinberg RA. 2013. The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat. Med. 19:1438-49
    • (2013) Nat. Med. , vol.19 , pp. 1438-1449
    • Tam, W.L.1    Weinberg, R.A.2
  • 126
    • 79961023271 scopus 로고    scopus 로고
    • Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition
    • McDonald OG, Wu H, Timp W, Doi A, Feinberg AP. 2011. Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat. Struct. Mol. Biol. 18:867-74
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , pp. 867-874
    • McDonald, O.G.1    Wu, H.2    Timp, W.3    Doi, A.4    Feinberg, A.P.5
  • 127
    • 78649328949 scopus 로고    scopus 로고
    • Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells
    • Ke XS, Qu Y, Cheng Y, LiWC, Rotter V, et al. 2010. Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells. BMC Genomics 11:669
    • (2010) BMC Genomics , vol.11 , pp. 669
    • Ke, X.S.1    Qu, Y.2    Cheng, Y.3    Li, W.C.4    Rotter, V.5
  • 128
    • 84859837026 scopus 로고    scopus 로고
    • The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
    • HarrisWJ, Huang X, Lynch JT, Spencer GJ, Hitchin JR, et al. 2012. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell 21:473-87
    • (2012) Cancer Cell , vol.21 , pp. 473-487
    • Harris, W.J.1    Huang, X.2    Lynch, J.T.3    Spencer, G.J.4    Hitchin, J.R.5
  • 129
    • 57649124289 scopus 로고    scopus 로고
    • Repression of E-cadherin by the polycomb group protein EZH2 in cancer
    • Cao Q, Yu J, Dhanasekaran SM, Kim JH,ManiRS, et al. 2008. Repression of E-cadherin by the polycomb group protein EZH2 in cancer. Oncogene 27:7274-84
    • (2008) Oncogene , vol.27 , pp. 7274-7284
    • Cao, Q.1    Yu, J.2    Dhanasekaran, S.M.3    Kim, J.H.4    Mani, R.S.5
  • 130
    • 47949125993 scopus 로고    scopus 로고
    • Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor
    • Herranz N, Pasini D, Diaz VM, Franci C, Gutierrez A, et al. 2008. Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol. Cell. Biol. 28:4772-81
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 4772-4781
    • Herranz, N.1    Pasini, D.2    Diaz, V.M.3    Franci, C.4    Gutierrez, A.5
  • 132
    • 84922574009 scopus 로고    scopus 로고
    • EZH2 protects glioma stem cells from radiation-induced cell death in a MELK/FOXM1-dependent manner
    • Kim SH, Joshi K, Ezhilarasan R, Myers TR, Siu J, et al. 2015. EZH2 protects glioma stem cells from radiation-induced cell death in a MELK/FOXM1-dependent manner. Stem Cell Rep. 4:226-38
    • (2015) Stem Cell Rep. , vol.4 , pp. 226-238
    • Kim, S.H.1    Joshi, K.2    Ezhilarasan, R.3    Myers, T.R.4    Siu, J.5
  • 133
    • 84927547043 scopus 로고    scopus 로고
    • EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors
    • Fillmore CM, Xu C, Desai PT, Berry JM, Rowbotham SP, et al. 2015. EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors. Nature 520:239-42
    • (2015) Nature , vol.520 , pp. 239-242
    • Fillmore, C.M.1    Xu, C.2    Desai, P.T.3    Berry, J.M.4    Rowbotham, S.P.5
  • 134
    • 77956547097 scopus 로고    scopus 로고
    • Loss of MIR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells
    • Iliopoulos D, Lindahl-AllenM,Polytarchou C, Hirsch HA,Tsichlis PN, StruhlK. 2010. Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol. Cell 39:761-72
    • (2010) Mol. Cell , vol.39 , pp. 761-772
    • Iliopoulos, D.1    Lindahl-Allen, M.2    Polytarchou, C.3    Hirsch, H.A.4    Tsichlis, P.N.5    Struhl, K.6
  • 135
    • 77952105211 scopus 로고    scopus 로고
    • Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate
    • Zhang B, Strauss AC, Chu S, Li M, Ho Y, et al. 2010. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell 17:427-42
    • (2010) Cancer Cell , vol.17 , pp. 427-442
    • Zhang, B.1    Strauss, A.C.2    Chu, S.3    Li, M.4    Ho, Y.5
  • 137
    • 79958719758 scopus 로고    scopus 로고
    • HDACinhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ERBB receptor expression and reverting EMT
    • Bruzzese F, Leone A, Rocco M, Carbone C, PiroG, et al. 2011.HDACinhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ErbB receptor expression and reverting EMT. J. Cell. Physiol. 226:2378-90
    • (2011) J. Cell. Physiol. , vol.226 , pp. 2378-2390
    • Bruzzese, F.1    Leone, A.2    Rocco, M.3    Carbone, C.4    Piro, G.5
  • 138
    • 84902185617 scopus 로고    scopus 로고
    • Chromatin repressive complexes in stem cells, development, and cancer
    • Laugesen A, Helin K. 2014. Chromatin repressive complexes in stem cells, development, and cancer. Cell Stem Cell 14:735-51
    • (2014) Cell Stem Cell , vol.14 , pp. 735-751
    • Laugesen, A.1    Helin, K.2
  • 139
    • 54449085718 scopus 로고    scopus 로고
    • Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basallike breast cancers
    • Dumont N, Wilson MB, Crawford YG, Reynolds PA, Sigaroudinia M, Tlsty TD. 2008. Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basallike breast cancers. PNAS 105:14867-72
    • (2008) PNAS , vol.105 , pp. 14867-14872
    • Dumont, N.1    Wilson, M.B.2    Crawford, Y.G.3    Reynolds, P.A.4    Sigaroudinia, M.5    Tlsty, T.D.6
  • 140
    • 84907562669 scopus 로고    scopus 로고
    • A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition
    • Carmona FJ, Davalos V, Vidal E, Gomez A, Heyn H, et al. 2014. A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition. Cancer Res. 74:5608-19
    • (2014) Cancer Res. , vol.74 , pp. 5608-5619
    • Carmona, F.J.1    Davalos, V.2    Vidal, E.3    Gomez, A.4    Heyn, H.5
  • 141
    • 84884368877 scopus 로고    scopus 로고
    • Influence of tumour micro-environment heterogeneity on therapeutic response
    • Junttila MR, de Sauvage FJ. 2013. Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 501:346-54
    • (2013) Nature , vol.501 , pp. 346-354
    • Junttila, M.R.1    De Sauvage, F.J.2
  • 143
    • 74549133965 scopus 로고    scopus 로고
    • Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development
    • Lichtenberger BM, Tan PK, Niederleithner H, Ferrara N, Petzelbauer P, Sibilia M. 2010. Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development. Cell 140:268-79
    • (2010) Cell , vol.140 , pp. 268-279
    • Lichtenberger, B.M.1    Tan, P.K.2    Niederleithner, H.3    Ferrara, N.4    Petzelbauer, P.5    Sibilia, M.6
  • 144
    • 84860356630 scopus 로고    scopus 로고
    • Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth
    • Hamerlik P, Lathia JD, Rasmussen R, Wu Q, Bartkova J, et al. 2012. Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. J. Exp. Med. 209:507-20
    • (2012) J. Exp. Med. , vol.209 , pp. 507-520
    • Hamerlik, P.1    Lathia, J.D.2    Rasmussen, R.3    Wu, Q.4    Bartkova, J.5
  • 145
    • 84901267967 scopus 로고    scopus 로고
    • Endothelial cell-secreted EGF induces epithelial to mesenchymal transition and endows head and neck cancer cells with stem-like phenotype
    • Zhang Z,Dong Z, Lauxen IS, FilhoMS, Nor JE. 2014. Endothelial cell-secreted EGF induces epithelial to mesenchymal transition and endows head and neck cancer cells with stem-like phenotype. Cancer Res. 74:2869-81
    • (2014) Cancer Res. , vol.74 , pp. 2869-2881
    • Zhang, Z.1    Dong, Z.2    Lauxen, I.S.3    Filho, M.S.4    Nor, J.E.5
  • 146
    • 75349091751 scopus 로고    scopus 로고
    • Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells
    • CharlesN,OzawaT, SquatritoM, Bleau AM, BrennanCW,et al. 2010. Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells. Cell Stem Cell 6:141-52
    • (2010) Cell Stem Cell , vol.6 , pp. 141-152
    • Charles, N.1    Ozawa, T.2    Squatrito, M.3    Bleau, A.M.4    Brennan, C.W.5
  • 147
    • 84890254301 scopus 로고    scopus 로고
    • Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche
    • Infanger DW, Cho Y, Lopez BS, Mohanan S, Liu SC, et al. 2013. Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche. Cancer Res. 73:7079-89
    • (2013) Cancer Res. , vol.73 , pp. 7079-7089
    • Infanger, D.W.1    Cho, Y.2    Lopez, B.S.3    Mohanan, S.4    Liu, S.C.5
  • 148
    • 84899047394 scopus 로고    scopus 로고
    • Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bonemarrow niche
    • Krause DS, Lazarides K, Lewis JB, von Andrian UH, Van Etten RA. 2014. Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bonemarrow niche. Blood 123:1361-71
    • (2014) Blood , vol.123 , pp. 1361-1371
    • Krause, D.S.1    Lazarides, K.2    Lewis, J.B.3    Von Andrian, U.H.4    Van Etten, R.A.5
  • 149
    • 84896098492 scopus 로고    scopus 로고
    • Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance
    • Cao Z, Ding BS, Guo P, Lee SB, Butler JM, et al. 2014. Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance. Cancer Cell 25:350-65
    • (2014) Cancer Cell , vol.25 , pp. 350-365
    • Cao, Z.1    Ding, B.S.2    Guo, P.3    Lee, S.B.4    Butler, J.M.5
  • 150
    • 84896107633 scopus 로고    scopus 로고
    • Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth
    • Pietras A, Katz AM, Ekstrom EJ, Wee B, Halliday JJ, et al. 2014. Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth. Cell Stem Cell 14:357-69
    • (2014) Cell Stem Cell , vol.14 , pp. 357-369
    • Pietras, A.1    Katz, A.M.2    Ekstrom, E.J.3    Wee, B.4    Halliday, J.J.5
  • 151
    • 34247527730 scopus 로고    scopus 로고
    • Hypoxia-inducible factors, stem cells, and cancer
    • Keith B, Simon MC. 2007. Hypoxia-inducible factors, stem cells, and cancer. Cell 129:465-72
    • (2007) Cell , vol.129 , pp. 465-472
    • Keith, B.1    Simon, M.C.2
  • 152
    • 54249151684 scopus 로고    scopus 로고
    • Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction
    • Das B, Tsuchida R,Malkin D, Koren G, Baruchel S, Yeger H. 2008. Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction. Stem Cells 26:1818-30
    • (2008) Stem Cells , vol.26 , pp. 1818-1830
    • Das, B.1    Tsuchida, R.2    Malkin, D.3    Koren, G.4    Baruchel, S.5    Yeger, H.6
  • 153
    • 65749106405 scopus 로고    scopus 로고
    • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    • Li Z, Bao S, Wu Q, Wang H, Eyler C, et al. 2009. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15:501-13
    • (2009) Cancer Cell , vol.15 , pp. 501-513
    • Li, Z.1    Bao, S.2    Wu, Q.3    Wang, H.4    Eyler, C.5
  • 154
    • 70449687092 scopus 로고    scopus 로고
    • Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α
    • Soeda A, ParkM, Lee D, Mintz A, Androutsellis-Theotokis A, et al. 2009. Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α. Oncogene 28:3949-59
    • (2009) Oncogene , vol.28 , pp. 3949-3959
    • Soeda, A.1    Park, M.2    Lee, D.3    Mintz, A.4    Androutsellis-Theotokis, A.5
  • 155
    • 79953870540 scopus 로고    scopus 로고
    • Targeting HIF1α eliminates cancer stem cells in hematological malignancies
    • Wang Y, Liu Y, Malek SN, Zheng P, Liu Y. 2011. Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 8:399-411
    • (2011) Cell Stem Cell , vol.8 , pp. 399-411
    • Wang, Y.1    Liu, Y.2    Malek, S.N.3    Zheng, P.4    Liu, Y.5
  • 156
    • 84903146712 scopus 로고    scopus 로고
    • Physiologic hypoxia promotes maintenance of CMLstem cells despite effective BCR-ABL1 inhibition
    • Ng KP,Manjeri A, LeeKL. 2014. Physiologic hypoxia promotes maintenance of CMLstem cells despite effective BCR-ABL1 inhibition. Blood 123:3316-26
    • (2014) Blood , vol.123 , pp. 3316-3326
    • Ng, K.P.1    Manjeri, A.2    Lee, K.L.3
  • 157
    • 84918530536 scopus 로고    scopus 로고
    • Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells
    • Samanta D, Gilkes DM, Chaturvedi P, Xiang L, Semenza GL. 2014. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. PNAS 111:E5429-38
    • (2014) PNAS , vol.111 , pp. E5429-E5438
    • Samanta, D.1    Gilkes, D.M.2    Chaturvedi, P.3    Xiang, L.4    Semenza, G.L.5
  • 158
    • 84923289688 scopus 로고    scopus 로고
    • Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
    • van den Beucken T, Koch E, Chu K, Rupaimoole R, Prickaerts P, et al. 2014. Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER. Nat. Commun. 5:5203
    • (2014) Nat. Commun. , vol.5 , pp. 5203
    • Van Den Beucken, T.1    Koch, E.2    Chu, K.3    Rupaimoole, R.4    Prickaerts, P.5
  • 159
    • 84924249260 scopus 로고    scopus 로고
    • The cancer stem cell niche: How essential is the niche in regulating stemness of tumor cells?
    • Plaks V, Kong N, Werb Z. 2015. The cancer stem cell niche: How essential is the niche in regulating stemness of tumor cells? Cell Stem Cell 16:225-38
    • (2015) Cell Stem Cell , vol.16 , pp. 225-238
    • Plaks, V.1    Kong, N.2    Werb, Z.3
  • 160
    • 84856088337 scopus 로고    scopus 로고
    • EMT and dissemination precede pancreatic tumor formation
    • Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, et al. 2012. EMT and dissemination precede pancreatic tumor formation. Cell 148:349-61
    • (2012) Cell , vol.148 , pp. 349-361
    • Rhim, A.D.1    Mirek, E.T.2    Aiello, N.M.3    Maitra, A.4    Bailey, J.M.5
  • 161
    • 84908485098 scopus 로고    scopus 로고
    • A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages
    • Lu H, Clauser KR, Tam WL, Frose J, Ye X, et al. 2014. A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat. Cell Biol. 16:1105-17
    • (2014) Nat. Cell Biol. , vol.16 , pp. 1105-1117
    • Lu, H.1    Clauser, K.R.2    Tam, W.L.3    Frose, J.4    Ye, X.5
  • 162
    • 84897561550 scopus 로고    scopus 로고
    • IL-6R/STAT3/MIR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
    • Rokavec M, Oner MG, Li H, Jackstadt R, Jiang L, et al. 2014. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J. Clin. Investig. 124:1853-67
    • (2014) J. Clin. Investig. , vol.124 , pp. 1853-1867
    • Rokavec, M.1    Oner, M.G.2    Li, H.3    Jackstadt, R.4    Jiang, L.5
  • 163
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NF-κB, Lin28, let-7 microRNA, and IL6 links inflammation to cell transformation
    • Iliopoulos D, Hirsch HA, Struhl K. 2009. An epigenetic switch involving NF-κB, Lin28, let-7 microRNA, and IL6 links inflammation to cell transformation. Cell 139:693-706
    • (2009) Cell , vol.139 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 164
    • 84862806829 scopus 로고    scopus 로고
    • IL6-mediated suppression of MIR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis
    • Rokavec M,WuW, Luo JL. 2012. IL6-mediated suppression of miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis. Mol. Cell 45:777-89
    • (2012) Mol. Cell , vol.45 , pp. 777-789
    • Rokavec, M.1    Wu, W.2    Luo, J.L.3
  • 165
    • 73049110243 scopus 로고    scopus 로고
    • TheEMT-activatorZEB1promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    • Wellner U, Schubert J, BurkUC,Schmalhofer O, ZhuF, et al. 2009. TheEMT-activatorZEB1promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat. Cell Biol. 11:1487-95
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1487-1495
    • Wellner, U.1    Schubert, J.2    Burk, U.C.3    Schmalhofer, O.4    Zhu, F.5
  • 166
    • 79961074770 scopus 로고    scopus 로고
    • Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells
    • JinushiM, Chiba S, YoshiyamaH,Masutomi K, Kinoshita I, et al. 2011. Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells. PNAS 108:12425-30
    • (2011) PNAS , vol.108 , pp. 12425-12430
    • Jinushi, M.1    Chiba, S.2    Yoshiyama, H.3    Masutomi, K.4    Kinoshita, I.5
  • 167
    • 84869239093 scopus 로고    scopus 로고
    • Epithelial-mesenchymal-transitionlike and TGFβpathways associated with autochthonous inflammatory melanoma development in mice
    • WehbeM, Soudja SM, Mas A,ChassonL,Guinamard R, et al. 2012. Epithelial-mesenchymal-transitionlike and TGFβpathways associated with autochthonous inflammatory melanoma development in mice. PLOS ONE 7:e49419
    • (2012) PLOS ONE , vol.7 , pp. e49419
    • Wehbe, M.1    Soudja, S.M.2    Mas, A.3    Chasson, L.4    Guinamard, R.5
  • 168
    • 84861344069 scopus 로고    scopus 로고
    • Tissue transglutaminase links TGF-β, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer
    • Cao L, Shao M, Schilder J, Guise T, Mohammad KS, Matei D. 2012. Tissue transglutaminase links TGF-β, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer. Oncogene 31:2521-34
    • (2012) Oncogene , vol.31 , pp. 2521-2534
    • Cao, L.1    Shao, M.2    Schilder, J.3    Guise, T.4    Mohammad, K.S.5    Matei, D.6
  • 169
    • 79959863770 scopus 로고    scopus 로고
    • TGFβ/TNFα-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype
    • Asiedu MK, Ingle JN, Behrens MD, Radisky DC, Knutson KL. 2011. TGFβ/TNFα-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype. Cancer Res. 71:4707-19
    • (2011) Cancer Res. , vol.71 , pp. 4707-4719
    • Asiedu, M.K.1    Ingle, J.N.2    Behrens, M.D.3    Radisky, D.C.4    Knutson, K.L.5
  • 170
    • 79958265710 scopus 로고    scopus 로고
    • Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    • Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, et al. 2011. Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 145:926-40
    • (2011) Cell , vol.145 , pp. 926-940
    • Scheel, C.1    Eaton, E.N.2    Li, S.H.3    Chaffer, C.L.4    Reinhardt, F.5
  • 171
    • 84866334922 scopus 로고    scopus 로고
    • TGF-β-induced epithelial-mesenchymal transition: A link between cancer and inflammation
    • Fuxe J, Karlsson MC. 2012. TGF-β-induced epithelial-mesenchymal transition: A link between cancer and inflammation. Semin. Cancer Biol. 22:455-61
    • (2012) Semin. Cancer Biol. , vol.22 , pp. 455-461
    • Fuxe, J.1    Karlsson, M.C.2
  • 172
    • 84923329516 scopus 로고    scopus 로고
    • TGF-βpromotes heterogeneity and drug resistance in squamous cell carcinoma
    • OshimoriN,Oristian D, FuchsE. 2015.TGF-βpromotes heterogeneity and drug resistance in squamous cell carcinoma. Cell 160:963-76
    • (2015) Cell , vol.160 , pp. 963-976
    • Oshimori, N.1    Oristian, D.2    Fuchs, E.3
  • 173
    • 84905103883 scopus 로고    scopus 로고
    • Fibroblast heterogeneity in the cancer wound
    • Ohlund D, Elyada E, Tuveson D. 2014. Fibroblast heterogeneity in the cancer wound. J. Exp. Med. 211:1503-23
    • (2014) J. Exp. Med. , vol.211 , pp. 1503-1523
    • Ohlund, D.1    Elyada, E.2    Tuveson, D.3
  • 174
    • 84902469661 scopus 로고    scopus 로고
    • Depletion of carcinomaassociated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
    • Ozdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X,Wu CC, et al. 2014. Depletion of carcinomaassociated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 25:719-34
    • (2014) Cancer Cell , vol.25 , pp. 719-734
    • Ozdemir, B.C.1    Pentcheva-Hoang, T.2    Carstens, J.L.3    Zheng, X.4    Wu, C.C.5
  • 175
    • 77956280130 scopus 로고    scopus 로고
    • Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness
    • Giannoni E, Bianchini F, Masieri L, Serni S, Torre E, et al. 2010. Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. Cancer Res. 70:6945-56
    • (2010) Cancer Res. , vol.70 , pp. 6945-6956
    • Giannoni, E.1    Bianchini, F.2    Masieri, L.3    Serni, S.4    Torre, E.5
  • 176
    • 84906899235 scopus 로고    scopus 로고
    • Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state
    • Shimoda M, Principe S, Jackson HW, Luga V, Fang H, et al. 2014. Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state. Nat. Cell Biol. 16:889-901
    • (2014) Nat. Cell Biol. , vol.16 , pp. 889-901
    • Shimoda, M.1    Principe, S.2    Jackson, H.W.3    Luga, V.4    Fang, H.5
  • 177
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling and disease
    • Clevers H, Nusse R. 2012. Wnt/β-catenin signaling and disease. Cell 149:1192-205
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 179
    • 84922481750 scopus 로고    scopus 로고
    • Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity
    • Yasuda K, Torigoe T,Mariya T, Asano T, Kuroda T, et al. 2014. Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity. Lab. Investig. 94:1355-69
    • (2014) Lab. Investig. , vol.94 , pp. 1355-1369
    • Yasuda, K.1    Torigoe, T.2    Mariya, T.3    Asano, T.4    Kuroda, T.5
  • 180
    • 84861882582 scopus 로고    scopus 로고
    • CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells
    • Tsuyada A, Chow A,Wu J, Somlo G, Chu P, et al. 2012. CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res. 72:2768-79
    • (2012) Cancer Res. , vol.72 , pp. 2768-2779
    • Tsuyada, A.1    Chow, A.2    Wu, J.3    Somlo, G.4    Chu, P.5
  • 181
    • 84899480372 scopus 로고    scopus 로고
    • CAF-secreted annexin A1 induces prostate cancer cells to gain stem cell-like features
    • Geary LA, Nash KA, Adisetiyo H, Liang M, Liao CP, et al. 2014. CAF-secreted annexin A1 induces prostate cancer cells to gain stem cell-like features. Mol. Cancer Res. 12:607-21
    • (2014) Mol. Cancer Res. , vol.12 , pp. 607-621
    • Geary, L.A.1    Nash, K.A.2    Adisetiyo, H.3    Liang, M.4    Liao, C.P.5
  • 182
    • 84897058262 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling
    • Chen WJ, Ho CC, Chang YL, Chen HY, Lin CA, et al. 2014. Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling. Nat. Commun. 5:3472
    • (2014) Nat. Commun. , vol.5 , pp. 3472
    • Chen, W.J.1    Ho, C.C.2    Chang, Y.L.3    Chen, H.Y.4    Lin, C.A.5
  • 183
    • 84866307571 scopus 로고    scopus 로고
    • Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling
    • Li HJ, Reinhardt F, Herschman HR, Weinberg RA. 2012. Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling. Cancer Discov. 2:840-55
    • (2012) Cancer Discov. , vol.2 , pp. 840-855
    • Li, H.J.1    Reinhardt, F.2    Herschman, H.R.3    Weinberg, R.A.4
  • 184
    • 84890812467 scopus 로고    scopus 로고
    • Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
    • Lotti F, Jarrar AM, Pai RK, Hitomi M, Lathia J, et al. 2013. Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A. J. Exp. Med. 210:2851-72
    • (2013) J. Exp. Med. , vol.210 , pp. 2851-2872
    • Lotti, F.1    Jarrar, A.M.2    Pai, R.K.3    Hitomi, M.4    Lathia, J.5
  • 185
    • 84896113460 scopus 로고    scopus 로고
    • Metastatic stem cells: Sources, niches, and vital pathways
    • Oskarsson T, Batlle E, Massagué J. 2014. Metastatic stem cells: sources, niches, and vital pathways. Cell Stem Cell 14:306-21
    • (2014) Cell Stem Cell , vol.14 , pp. 306-321
    • Oskarsson, T.1    Batlle, E.2    Massagué, J.3
  • 186
    • 78049398107 scopus 로고    scopus 로고
    • Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    • Yachida S, Jones S, Bozic I, Antal T, Leary R, et al. 2010. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467:1114-17
    • (2010) Nature , vol.467 , pp. 1114-1117
    • Yachida, S.1    Jones, S.2    Bozic, I.3    Antal, T.4    Leary, R.5
  • 187
  • 188
    • 80053904142 scopus 로고    scopus 로고
    • Distinct types of tumor-initiating cells form human colon cancer tumors and metastases
    • Dieter SM, Ball CR,HoffmannCM, Nowrouzi A,Herbst F, et al. 2011. Distinct types of tumor-initiating cells form human colon cancer tumors and metastases. Cell Stem Cell 9:357-65
    • (2011) Cell Stem Cell , vol.9 , pp. 357-365
    • Dieter, S.M.1    Ball, C.R.2    Hoffmann, C.M.3    Nowrouzi, A.4    Herbst, F.5
  • 189
    • 84872080485 scopus 로고    scopus 로고
    • Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer
    • Vanharanta S, Shu W, Brenet F, Hakimi AA, Heguy A, et al. 2013. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nat. Med. 19:50-56
    • (2013) Nat. Med. , vol.19 , pp. 50-56
    • Vanharanta, S.1    Shu, W.2    Brenet, F.3    Hakimi, A.A.4    Heguy, A.5
  • 190
    • 77956641496 scopus 로고    scopus 로고
    • A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer
    • Pang R, LawWL, Chu AC, Poon JT, Lam CS, et al. 2010. A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer. Cell Stem Cell 6:603-15
    • (2010) Cell Stem Cell , vol.6 , pp. 603-615
    • Pang, R.1    Law, W.L.2    Chu, A.C.3    Poon, J.T.4    Lam, C.S.5
  • 191
    • 84925300542 scopus 로고    scopus 로고
    • Biology, detection, and clinical implications of circulating tumor cells
    • Joosse SA,GorgesTM, Pantel K. 2015. Biology, detection, and clinical implications of circulating tumor cells. EMBO Mol. Med. 7:1-11
    • (2015) EMBO Mol. Med. , vol.7 , pp. 1-11
    • Joosse, S.A.1    Gorges, T.M.2    Pantel, K.3
  • 192
    • 84870816403 scopus 로고    scopus 로고
    • Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1
    • Ocana OH, Corcoles R, Fabra A, Moreno-Bueno G, Acloque H, et al. 2012. Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell 22:709-24
    • (2012) Cancer Cell , vol.22 , pp. 709-724
    • Ocana, O.H.1    Corcoles, R.2    Fabra, A.3    Moreno-Bueno, G.4    Acloque, H.5
  • 193
    • 84855425160 scopus 로고    scopus 로고
    • Interactions between cancer stem cells and their niche govern metastatic colonization
    • Malanchi I, Santamaria-Martinez A, Susanto E, Peng H, Lehr HA, et al. 2012. Interactions between cancer stem cells and their niche govern metastatic colonization. Nature 481:85-89
    • (2012) Nature , vol.481 , pp. 85-89
    • Malanchi, I.1    Santamaria-Martinez, A.2    Susanto, E.3    Peng, H.4    Lehr, H.A.5
  • 195
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S,Wu Q, McLendon RE, Hao Y, Shi Q, et al. 2006. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756-60
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3    Hao, Y.4    Shi, Q.5
  • 196
    • 64749093574 scopus 로고    scopus 로고
    • Association of reactive oxygen species levels and radioresistance in cancer stem cells
    • Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, et al. 2009. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 458:780-83
    • (2009) Nature , vol.458 , pp. 780-783
    • Diehn, M.1    Cho, R.W.2    Lobo, N.A.3    Kalisky, T.4    Dorie, M.J.5
  • 197
    • 84894245627 scopus 로고    scopus 로고
    • Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
    • Shlush LI, Zandi S, Mitchell A, Chen WC, Brandwein JM, et al. 2014. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature 506:328-33
    • (2014) Nature , vol.506 , pp. 328-333
    • Shlush, L.I.1    Zandi, S.2    Mitchell, A.3    Chen, W.C.4    Brandwein, J.M.5
  • 198
    • 84877868296 scopus 로고    scopus 로고
    • Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells
    • Shien K, Toyooka S, Yamamoto H, Soh J, Jida M, et al. 2013. Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells. Cancer Res. 73:3051-61
    • (2013) Cancer Res. , vol.73 , pp. 3051-3061
    • Shien, K.1    Toyooka, S.2    Yamamoto, H.3    Soh, J.4    Jida, M.5
  • 199
    • 84902269863 scopus 로고    scopus 로고
    • Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy
    • Auffinger B, Tobias AL, Han Y, Lee G, GuoD, et al. 2014. Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy. Cell Death Differ. 21:1119-31
    • (2014) Cell Death Differ. , vol.21 , pp. 1119-1131
    • Auffinger, B.1    Tobias, A.L.2    Han, Y.3    Lee, G.4    Guo, D.5
  • 200
    • 77953121698 scopus 로고    scopus 로고
    • Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death
    • Sotiropoulou PA, Candi A, Mascre G, De Clercq S, Youssef KK, et al. 2010. Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death. Nat. Cell Biol. 12:572-82
    • (2010) Nat. Cell Biol. , vol.12 , pp. 572-582
    • Sotiropoulou, P.A.1    Candi, A.2    Mascre, G.3    De Clercq, S.4    Youssef, K.K.5
  • 201
    • 84923248130 scopus 로고    scopus 로고
    • A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms
    • CojocM,Mabert K,Muders MH, Dubrovska A. 2015. A role for cancer stem cells in therapy resistance: cellular and molecular mechanisms. Semin. Cancer Biol. 31:16-27
    • (2015) Semin. Cancer Biol. , vol.31 , pp. 16-27
    • Cojoc, M.1    Mabert, K.2    Muders, M.H.3    Dubrovska, A.4
  • 203
    • 84930181902 scopus 로고    scopus 로고
    • ZEB1-associated drug resistance in cancer cells is reversed by the class i HDAC inhibitor mocetinostat
    • Meidhof S, Brabletz S, Lehmann W, Preca BT, Mock K, et al. 2015. ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat. EMBO Mol. Med. 7(6):831-47
    • (2015) EMBO Mol. Med. , vol.7 , Issue.6 , pp. 831-847
    • Meidhof, S.1    Brabletz, S.2    Lehmann, W.3    Preca, B.T.4    Mock, K.5
  • 204
  • 205
    • 84908149021 scopus 로고    scopus 로고
    • ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1
    • Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, et al. 2014. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat. Cell Biol. 16:864-75
    • (2014) Nat. Cell Biol. , vol.16 , pp. 864-875
    • Zhang, P.1    Wei, Y.2    Wang, L.3    Debeb, B.G.4    Yuan, Y.5
  • 206
    • 84899582429 scopus 로고    scopus 로고
    • Knockdown of NANOG enhances chemosensitivity of liver cancer cells to doxorubicin by reducing MDR1 expression
    • Zhou JJ, Deng XG, He XY, Zhou Y, Yu M, et al. 2014. Knockdown of NANOG enhances chemosensitivity of liver cancer cells to doxorubicin by reducing MDR1 expression. Int. J. Oncol. 44:2034-40
    • (2014) Int. J. Oncol. , vol.44 , pp. 2034-2040
    • Zhou, J.J.1    Deng, X.G.2    He, X.Y.3    Zhou, Y.4    Yu, M.5
  • 207
    • 60849117508 scopus 로고    scopus 로고
    • PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
    • Bleau AM, Hambardzumyan D, Ozawa T, Fomchenko EI, Huse JT, et al. 2009. PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell 4:226-35
    • (2009) Cell Stem Cell , vol.4 , pp. 226-235
    • Bleau, A.M.1    Hambardzumyan, D.2    Ozawa, T.3    Fomchenko, E.I.4    Huse, J.T.5
  • 208
    • 84868496506 scopus 로고    scopus 로고
    • ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors
    • HuangCP, Tsai MF,Chang TH,TangWC, Chen SY, et al. 2013. ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors. Cancer Lett. 328:144-51
    • (2013) Cancer Lett. , vol.328 , pp. 144-151
    • Huang, C.P.1    Tsai, M.F.2    Chang, T.H.3    Tang, W.C.4    Chen, S.Y.5
  • 209
    • 84922388823 scopus 로고    scopus 로고
    • Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance
    • Kurtova AV, Xiao J, Mo Q, Pazhanisamy S, Krasnow R, et al. 2015. Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance. Nature 517:209-13
    • (2015) Nature , vol.517 , pp. 209-213
    • Kurtova, A.V.1    Xiao, J.2    Mo, Q.3    Pazhanisamy, S.4    Krasnow, R.5
  • 210
    • 84868633053 scopus 로고    scopus 로고
    • Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance throughWNT16B
    • Sun Y, Campisi J, Higano C, Beer TM, Porter P, et al. 2012. Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance throughWNT16B. Nat.Med. 18:1359-68
    • (2012) Nat.Med. , vol.18 , pp. 1359-1368
    • Sun, Y.1    Campisi, J.2    Higano, C.3    Beer, T.M.4    Porter, P.5
  • 211
    • 84896532797 scopus 로고    scopus 로고
    • MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors
    • Luraghi P, Reato G, Cipriano E, Sassi F, Orzan F, et al. 2014. MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors. Cancer Res. 74:1857-69
    • (2014) Cancer Res. , vol.74 , pp. 1857-1869
    • Luraghi, P.1    Reato, G.2    Cipriano, E.3    Sassi, F.4    Orzan, F.5
  • 212
    • 84901277245 scopus 로고    scopus 로고
    • Cancer stem-like cells derived from chemoresistant tumors have a unique capacity to prime tumorigenic myeloid cells
    • Yamashina T, Baghdadi M, Yoneda A, Kinoshita I, Suzu S, et al. 2014. Cancer stem-like cells derived from chemoresistant tumors have a unique capacity to prime tumorigenic myeloid cells. Cancer Res. 74:2698-709
    • (2014) Cancer Res. , vol.74 , pp. 2698-2709
    • Yamashina, T.1    Baghdadi, M.2    Yoneda, A.3    Kinoshita, I.4    Suzu, S.5
  • 213
    • 84900297049 scopus 로고    scopus 로고
    • Hypoxia increases gefitinibresistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor
    • Murakami A, Takahashi F,Nurwidya F,Kobayashi I,MinakataK, et al. 2014. Hypoxia increases gefitinibresistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor. PLOS ONE 9:e86459
    • (2014) PLOS ONE , vol.9 , pp. e86459
    • Murakami, A.1    Takahashi, F.2    Nurwidya, F.3    Kobayashi, I.4    Minakata, K.5
  • 214
    • 84862014301 scopus 로고    scopus 로고
    • Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment
    • Rausch V, Liu L, Apel A, Rettig T, Gladkich J, et al. 2012. Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment. J. Pathol. 227:325-35
    • (2012) J. Pathol. , vol.227 , pp. 325-335
    • Rausch, V.1    Liu, L.2    Apel, A.3    Rettig, T.4    Gladkich, J.5
  • 215
    • 84899860489 scopus 로고    scopus 로고
    • An integrin β3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition
    • Seguin L, Kato S, Franovic A, Camargo MF, Lesperance J, et al. 2014. An integrin β3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat. Cell Biol. 16:457-68
    • (2014) Nat. Cell Biol. , vol.16 , pp. 457-468
    • Seguin, L.1    Kato, S.2    Franovic, A.3    Camargo, M.F.4    Lesperance, J.5
  • 216
    • 84870020040 scopus 로고    scopus 로고
    • MED12 controls the response to multiple cancer drugs through regulation of TGF-βreceptor signaling
    • Huang S,HolzelM, Knijnenburg T, Schlicker A, Roepman P, et al. 2012. MED12 controls the response to multiple cancer drugs through regulation of TGF-βreceptor signaling. Cell 151:937-50
    • (2012) Cell , vol.151 , pp. 937-950
    • Huang, S.1    Holzel, M.2    Knijnenburg, T.3    Schlicker, A.4    Roepman, P.5


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