-
1
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D,Weinberg RA. 2011. Hallmarks of cancer: The next generation. Cell 144:646-74
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
4
-
-
0021242388
-
Tumor heterogeneity
-
Heppner GH. 1984. Tumor heterogeneity. Cancer Res. 44:2259-65
-
(1984)
Cancer Res.
, vol.44
, pp. 2259-2265
-
-
Heppner, G.H.1
-
5
-
-
84896125494
-
Evolution of the cancer stem cell model
-
Kreso A, Dick JE. 2014. Evolution of the cancer stem cell model. Cell Stem Cell 14:275-91
-
(2014)
Cell Stem Cell
, vol.14
, pp. 275-291
-
-
Kreso, A.1
Dick, J.E.2
-
7
-
-
84884377472
-
Tumour heterogeneity and cancer cell plasticity
-
Meacham CE, Morrison SJ. 2013. Tumour heterogeneity and cancer cell plasticity. Nature 501:328-37
-
(2013)
Nature
, vol.501
, pp. 328-337
-
-
Meacham, C.E.1
Morrison, S.J.2
-
8
-
-
0017167185
-
The clonal evolution of tumor cell populations
-
Nowell PC. 1976. The clonal evolution of tumor cell populations. Science 194:23-28
-
(1976)
Science
, vol.194
, pp. 23-28
-
-
Nowell, P.C.1
-
10
-
-
84875490185
-
Cancer genome landscapes
-
Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA Jr, Kinzler KW. 2013. Cancer genome landscapes. Science 339:1546-58
-
(2013)
Science
, vol.339
, pp. 1546-1558
-
-
Vogelstein, B.1
Papadopoulos, N.2
Velculescu, V.E.3
Zhou, S.4
Diaz, L.A.5
Kinzler, K.W.6
-
11
-
-
84913590602
-
Cancer: Evolution within a lifetime
-
Gerlinger M, McGranahan N, Dewhurst SM, Burrell RA, Tomlinson I, Swanton C. 2014. Cancer: evolution within a lifetime. Annu. Rev. Genet. 48:215-36
-
(2014)
Annu. Rev. Genet.
, vol.48
, pp. 215-236
-
-
Gerlinger, M.1
McGranahan, N.2
Dewhurst, S.M.3
Burrell, R.A.4
Tomlinson, I.5
Swanton, C.6
-
12
-
-
74449093973
-
A comprehensive catalogue of somatic mutations from a human cancer genome
-
Pleasance ED, Cheetham RK, Stephens PJ, McBride DJ, Humphray SJ, et al. 2010. A comprehensive catalogue of somatic mutations from a human cancer genome. Nature 463:191-96
-
(2010)
Nature
, vol.463
, pp. 191-196
-
-
Pleasance, E.D.1
Cheetham, R.K.2
Stephens, P.J.3
McBride, D.J.4
Humphray, S.J.5
-
13
-
-
84885735554
-
Mutational landscape and significance across 12 major cancer types
-
Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, et al. 2013. Mutational landscape and significance across 12 major cancer types. Nature 502:333-39
-
(2013)
Nature
, vol.502
, pp. 333-339
-
-
Kandoth, C.1
McLellan, M.D.2
Vandin, F.3
Ye, K.4
Niu, B.5
-
14
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
GerlingerM, Rowan AJ, Horswell S, Larkin J, Endesfelder D, et al. 2012. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N. Engl. J. Med. 366:883-92
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
Larkin, J.4
Endesfelder, D.5
-
15
-
-
84895876130
-
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
-
GerlingerM,Horswell S, Larkin J, Rowan AJ, Salm MP, et al. 2014. Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing. Nat. Genet. 46:225-33
-
(2014)
Nat. Genet.
, vol.46
, pp. 225-233
-
-
Gerlinger, M.1
Horswell, S.2
Larkin, J.3
Rowan, A.J.4
Salm, M.P.5
-
16
-
-
84907855592
-
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
-
de Bruin EC, McGranahan N, Mitter R, Salm M, Wedge DC, et al. 2014. Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. Science 346:251-56
-
(2014)
Science
, vol.346
, pp. 251-256
-
-
De Bruin, E.C.1
McGranahan, N.2
Mitter, R.3
Salm, M.4
Wedge, D.C.5
-
17
-
-
84907808265
-
Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing
-
Zhang J, Fujimoto J, Zhang J, Wedge DC, Song X, et al. 2014. Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing. Science 346:256-59
-
(2014)
Science
, vol.346
, pp. 256-259
-
-
Zhang, J.1
Fujimoto, J.2
Zhang, J.3
Wedge, D.C.4
Song, X.5
-
18
-
-
84861541343
-
Mutational processes molding the genomes of 21 breast cancers
-
Nik-Zainal S, Alexandrov LB,Wedge DC, Van Loo P,Greenman CD, et al. 2012. Mutational processes molding the genomes of 21 breast cancers. Cell 149:979-93
-
(2012)
Cell
, vol.149
, pp. 979-993
-
-
Nik-Zainal, S.1
Alexandrov, L.B.2
Wedge, D.C.3
Van Loo, P.4
Greenman, C.D.5
-
19
-
-
84856013431
-
Clonal evolution in cancer
-
Greaves M, Maley CC. 2012. Clonal evolution in cancer. Nature 481:306-13
-
(2012)
Nature
, vol.481
, pp. 306-313
-
-
Greaves, M.1
Maley, C.C.2
-
20
-
-
79953766940
-
Tumour evolution inferred by single-cell sequencing
-
NavinN,Kendall J, Troge J, Andrews P, Rodgers L, et al. 2011. Tumour evolution inferred by single-cell sequencing. Nature 472:90-94
-
(2011)
Nature
, vol.472
, pp. 90-94
-
-
Navin, N.1
Kendall, J.2
Troge, J.3
Andrews, P.4
Rodgers, L.5
-
21
-
-
84925229458
-
Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution
-
Eirew P, Steif A, Khattra J, Ha G, Yap D, et al. 2015. Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution. Nature 518:422-26
-
(2015)
Nature
, vol.518
, pp. 422-426
-
-
Eirew, P.1
Steif, A.2
Khattra, J.3
Ha, G.4
Yap, D.5
-
22
-
-
84863229772
-
Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm
-
Hou Y, Song L, Zhu P, Zhang B, Tao Y, et al. 2012. Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell 148:873-85
-
(2012)
Cell
, vol.148
, pp. 873-885
-
-
Hou, Y.1
Song, L.2
Zhu, P.3
Zhang, B.4
Tao, Y.5
-
23
-
-
84908032167
-
Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity
-
Marusyk A, Tabassum DP, Altrock PM, Almendro V, Michor F, Polyak K. 2014. Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity. Nature 514:54-58
-
(2014)
Nature
, vol.514
, pp. 54-58
-
-
Marusyk, A.1
Tabassum, D.P.2
Altrock, P.M.3
Almendro, V.4
Michor, F.5
Polyak, K.6
-
24
-
-
84897482887
-
Tumour cell heterogeneity maintained by cooperating subclones inWnt-driven mammary cancers
-
Cleary AS, Leonard TL, Gestl SA, Gunther EJ. 2014. Tumour cell heterogeneity maintained by cooperating subclones inWnt-driven mammary cancers. Nature 508:113-17
-
(2014)
Nature
, vol.508
, pp. 113-117
-
-
Cleary, A.S.1
Leonard, T.L.2
Gestl, S.A.3
Gunther, E.J.4
-
25
-
-
84902603107
-
Plasticity of epithelial stem cells in tissue regeneration
-
Blanpain C, Fuchs E. 2014. Plasticity of epithelial stem cells in tissue regeneration. Science 344:1242281
-
(2014)
Science
, vol.344
, pp. 1242281
-
-
Blanpain, C.1
Fuchs, E.2
-
26
-
-
0028091194
-
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
-
Lapidot T, Sirard C, Vormoor J, Murdoch B,Hoang T, et al. 1994. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367:645-48
-
(1994)
Nature
, vol.367
, pp. 645-648
-
-
Lapidot, T.1
Sirard, C.2
Vormoor, J.3
Murdoch, B.4
Hoang, T.5
-
27
-
-
0030789242
-
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
-
Bonnet D, Dick JE. 1997. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3:730-37
-
(1997)
Nat. Med.
, vol.3
, pp. 730-737
-
-
Bonnet, D.1
Dick, J.E.2
-
28
-
-
80052468964
-
Stem cell gene expression programs influence clinical outcome in human leukemia
-
Eppert K, Takenaka K, Lechman ER, Waldron L, Nilsson B, et al. 2011. Stem cell gene expression programs influence clinical outcome in human leukemia. Nat. Med. 17:1086-93
-
(2011)
Nat. Med.
, vol.17
, pp. 1086-1093
-
-
Eppert, K.1
Takenaka, K.2
Lechman, E.R.3
Waldron, L.4
Nilsson, B.5
-
29
-
-
0037388204
-
Prospective identification of tumorigenic breast cancer cells
-
Al-Hajj M, WichaMS, Benito-Hernandez A,Morrison SJ, Clarke MF. 2003. Prospective identification of tumorigenic breast cancer cells. PNAS 100:3983-88
-
(2003)
PNAS
, vol.100
, pp. 3983-3988
-
-
Al-Hajj, M.1
Wicha, M.S.2
Benito-Hernandez, A.3
Morrison, S.J.4
Clarke, M.F.5
-
30
-
-
35848955428
-
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
-
Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, et al. 2007. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1:555-67
-
(2007)
Cell Stem Cell
, vol.1
, pp. 555-567
-
-
Ginestier, C.1
Hur, M.H.2
Charafe-Jauffret, E.3
Monville, F.4
Dutcher, J.5
-
31
-
-
74949129868
-
Aldehyde dehydrogenase 1-positive cancer stem cells mediatemetastasis and poor clinical outcome in inflammatory breast cancer
-
Charafe-Jauffret E, Ginestier C, Iovino F, Tarpin C, Diebel M, et al. 2010. Aldehyde dehydrogenase 1-positive cancer stem cells mediatemetastasis and poor clinical outcome in inflammatory breast cancer. Clin. Cancer Res. 16:45-55
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 45-55
-
-
Charafe-Jauffret, E.1
Ginestier, C.2
Iovino, F.3
Tarpin, C.4
Diebel, M.5
-
32
-
-
9244241576
-
Identification of human brain tumour initiating cells
-
Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, et al. 2004. Identification of human brain tumour initiating cells. Nature 432:396-401
-
(2004)
Nature
, vol.432
, pp. 396-401
-
-
Singh, S.K.1
Hawkins, C.2
Clarke, I.D.3
Squire, J.A.4
Bayani, J.5
-
33
-
-
33846100356
-
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
-
O'Brien CA, Pollett A, Gallinger S, Dick JE. 2007. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445:106-10
-
(2007)
Nature
, vol.445
, pp. 106-110
-
-
O'Brien, C.A.1
Pollett, A.2
Gallinger, S.3
Dick, J.E.4
-
34
-
-
33846095137
-
Identification and expansion of human colon-cancer-initiating cells
-
Ricci-Vitiani L, Lombardi DG, Pilozzi E, BiffoniM, Todaro M, et al. 2007. Identification and expansion of human colon-cancer-initiating cells. Nature 445:111-15
-
(2007)
Nature
, vol.445
, pp. 111-115
-
-
Ricci-Vitiani, L.1
Lombardi, D.G.2
Pilozzi, E.3
Biffoni, M.4
Todaro, M.5
-
35
-
-
33847052127
-
Identification of pancreatic cancer stem cells
-
Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, et al. 2007. Identification of pancreatic cancer stem cells. Cancer Res. 67:1030-37
-
(2007)
Cancer Res.
, vol.67
, pp. 1030-1037
-
-
Li, C.1
Heidt, D.G.2
Dalerba, P.3
Burant, C.F.4
Zhang, L.5
-
36
-
-
34548455927
-
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
-
Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, et al. 2007. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1:313-23
-
(2007)
Cell Stem Cell
, vol.1
, pp. 313-323
-
-
Hermann, P.C.1
Huber, S.L.2
Herrler, T.3
Aicher, A.4
Ellwart, J.W.5
-
37
-
-
33846512398
-
Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
-
Prince ME, Sivanandan R, Kaczorowski A, Wolf GT, Kaplan MJ, et al. 2007. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. PNAS 104:973-78
-
(2007)
PNAS
, vol.104
, pp. 973-978
-
-
Prince, M.E.1
Sivanandan, R.2
Kaczorowski, A.3
Wolf, G.T.4
Kaplan, M.J.5
-
38
-
-
51649111430
-
Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity
-
Vermeulen L, Todaro M, de Sousa Mello F, Sprick MR, Kemper K, et al. 2008. Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. PNAS 105:13427-32
-
(2008)
PNAS
, vol.105
, pp. 13427-13432
-
-
Vermeulen, L.1
Todaro, M.2
De Sousa Mello, F.3
Sprick, M.R.4
Kemper, K.5
-
39
-
-
38349165576
-
Identification of cells initiating human melanomas
-
Schatton T, Murphy GF, Frank NY, Yamaura K,Waaga-Gasser AM, et al. 2008. Identification of cells initiating human melanomas. Nature 451:345-49
-
(2008)
Nature
, vol.451
, pp. 345-349
-
-
Schatton, T.1
Murphy, G.F.2
Frank, N.Y.3
Yamaura, K.4
Waaga-Gasser, A.M.5
-
40
-
-
77954238710
-
Human melanomainitiating cells express neural crest nerve growth factor receptor CD271
-
Boiko AD, Razorenova OV, van de Rijn M, Swetter SM, Johnson DL, et al. 2010. Human melanomainitiating cells express neural crest nerve growth factor receptor CD271. Nature 466:133-37
-
(2010)
Nature
, vol.466
, pp. 133-137
-
-
Boiko, A.D.1
Razorenova, O.V.2
Van De Rijn, M.3
Swetter, S.M.4
Johnson, D.L.5
-
41
-
-
79954617310
-
Human CD271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth
-
Civenni G, Walter A, Kobert N, Mihic-Probst D, Zipser M, et al. 2011. Human CD271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth. Cancer Res. 71:3098-109
-
(2011)
Cancer Res.
, vol.71
, pp. 3098-3109
-
-
Civenni, G.1
Walter, A.2
Kobert, N.3
Mihic-Probst, D.4
Zipser, M.5
-
42
-
-
77956214387
-
Tumor-initiating cells are rare in many human tumors
-
Ishizawa K, Rasheed ZA, Karisch R, Wang Q, Kowalski J, et al. 2010. Tumor-initiating cells are rare in many human tumors. Cell Stem Cell 7:279-82
-
(2010)
Cell Stem Cell
, vol.7
, pp. 279-282
-
-
Ishizawa, K.1
Rasheed, Z.A.2
Karisch, R.3
Wang, Q.4
Kowalski, J.5
-
43
-
-
57349143739
-
Efficient tumour formation by single human melanoma cells
-
Quintana E, Shackleton M, Sabel MS, Fullen DR, Johnson TM, Morrison SJ. 2008. Efficient tumour formation by single human melanoma cells. Nature 456:593-98
-
(2008)
Nature
, vol.456
, pp. 593-598
-
-
Quintana, E.1
Shackleton, M.2
Sabel, M.S.3
Fullen, D.R.4
Johnson, T.M.5
Morrison, S.J.6
-
44
-
-
84871003153
-
Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness
-
LapougeG, Beck B,NassarD,Dubois C,Dekoninck S, Blanpain C. 2012. Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness. EMBO J. 31:4563-75
-
(2012)
EMBO J.
, vol.31
, pp. 4563-4575
-
-
Lapouge, G.1
Beck, B.2
Nassar, D.3
Dubois, C.4
Dekoninck, S.5
Blanpain, C.6
-
45
-
-
84857028067
-
Tumorigenic cells are common in mouseMPNSTs but their frequency depends upon tumor genotype and assay conditions
-
Buchstaller J,McKeever PE,Morrison SJ. 2012. Tumorigenic cells are common in mouseMPNSTs but their frequency depends upon tumor genotype and assay conditions. Cancer Cell 21:240-52
-
(2012)
Cancer Cell
, vol.21
, pp. 240-252
-
-
Buchstaller, J.1
McKeever, P.E.2
Morrison, S.J.3
-
46
-
-
45849102392
-
In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties
-
le Viseur C,HotfilderM, Bomken S,Wilson K, Rottgers S, et al. 2008. In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties. Cancer Cell 14:47-58
-
(2008)
Cancer Cell
, vol.14
, pp. 47-58
-
-
Le Viseur, C.1
Hotfilder, M.2
Bomken, S.3
Wilson, K.4
Rottgers, S.5
-
47
-
-
77950502115
-
A hierarchy of selfrenewing tumor-initiating cell types in glioblastoma
-
Chen R, Nishimura MC, Bumbaca SM, Kharbanda S, Forrest WF, et al. 2010. A hierarchy of selfrenewing tumor-initiating cell types in glioblastoma. Cancer Cell 17:362-75
-
(2010)
Cancer Cell
, vol.17
, pp. 362-375
-
-
Chen, R.1
Nishimura, M.C.2
Bumbaca, S.M.3
Kharbanda, S.4
Forrest, W.F.5
-
48
-
-
79955711142
-
Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse
-
Clappier E, Gerby B, Sigaux F, DelordM, Touzri F, et al. 2011. Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse. J. Exp. Med. 208:653-61
-
(2011)
J. Exp. Med.
, vol.208
, pp. 653-661
-
-
Clappier, E.1
Gerby, B.2
Sigaux, F.3
Delord, M.4
Touzri, F.5
-
49
-
-
84963966189
-
Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance
-
Nowak D, Liem NL, Mossner M, Klaumunzer M, Papa RA, et al. 2015. Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance. Exp. Hematol. 43:32-43.e35
-
(2015)
Exp. Hematol.
, vol.43
, pp. 32e35-43e35
-
-
Nowak, D.1
Liem, N.L.2
Mossner, M.3
Klaumunzer, M.4
Papa, R.A.5
-
50
-
-
4444290010
-
Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche
-
Blanpain C, Lowry WE, Geoghegan A, Polak L, Fuchs E. 2004. Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell 118:635-48
-
(2004)
Cell
, vol.118
, pp. 635-648
-
-
Blanpain, C.1
Lowry, W.E.2
Geoghegan, A.3
Polak, L.4
Fuchs, E.5
-
51
-
-
41649089525
-
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
-
Malanchi I, Peinado H, Kassen D, Hussenet T, Metzger D, et al. 2008. Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature 452:650-53
-
(2008)
Nature
, vol.452
, pp. 650-653
-
-
Malanchi, I.1
Peinado, H.2
Kassen, D.3
Hussenet, T.4
Metzger, D.5
-
52
-
-
80055003796
-
A vascular niche and a VEGFNrp1 loop regulate the initiation and stemness of skin tumours
-
Beck B, Driessens G, Goossens S, Youssef KK, Kuchnio A, et al. 2011. A vascular niche and a VEGFNrp1 loop regulate the initiation and stemness of skin tumours. Nature 478:399-403
-
(2011)
Nature
, vol.478
, pp. 399-403
-
-
Beck, B.1
Driessens, G.2
Goossens, S.3
Youssef, K.K.4
Kuchnio, A.5
-
53
-
-
84904246245
-
SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma
-
Boumahdi S, Driessens G, Lapouge G, Rorive S,Nassar D, et al. 2014. SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma. Nature 511:246-50
-
(2014)
Nature
, vol.511
, pp. 246-250
-
-
Boumahdi, S.1
Driessens, G.2
Lapouge, G.3
Rorive, S.4
Nassar, D.5
-
54
-
-
77957676330
-
Primary tumor genotype is an important determinant in identification of lung cancer propagating cells
-
Curtis SJ, SinkeviciusKW,Li D, LauAN, Roach RR, et al. 2010. Primary tumor genotype is an important determinant in identification of lung cancer propagating cells. Cell Stem Cell 7:127-33
-
(2010)
Cell Stem Cell
, vol.7
, pp. 127-133
-
-
Curtis, S.J.1
Sinkevicius, K.W.2
Li, D.3
Lau, A.N.4
Roach, R.R.5
-
55
-
-
58649111264
-
Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma
-
Read TA, Fogarty MP, Markant SL, McLendon RE, Wei Z, et al. 2009. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell 15:135-47
-
(2009)
Cancer Cell
, vol.15
, pp. 135-147
-
-
Read, T.A.1
Fogarty, M.P.2
Markant, S.L.3
McLendon, R.E.4
Wei, Z.5
-
56
-
-
54249086214
-
The mammary progenitor marker CD61/β3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis
-
Vaillant F, Asselin-Labat ML, ShackletonM, Forrest NC, Lindeman GJ, Visvader JE. 2008. The mammary progenitor marker CD61/β3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res. 68:7711-17
-
(2008)
Cancer Res.
, vol.68
, pp. 7711-7717
-
-
Vaillant, F.1
Asselin-Labat, M.L.2
Shackleton, M.3
Forrest, N.C.4
Lindeman, G.J.5
Visvader, J.E.6
-
57
-
-
84880794274
-
Unravelling stem cell dynamics by lineage tracing
-
Blanpain C, Simons BD. 2013. Unravelling stem cell dynamics by lineage tracing. Nat. Rev. Mol. Cell Biol. 14:489-502
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 489-502
-
-
Blanpain, C.1
Simons, B.D.2
-
58
-
-
1842529559
-
Capturing and profiling adult hair follicle stem cells
-
Morris RJ, Liu Y, Marles L, Yang Z, Trempus C, et al. 2004. Capturing and profiling adult hair follicle stem cells. Nat. Biotechnol. 22:411-17
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 411-417
-
-
Morris, R.J.1
Liu, Y.2
Marles, L.3
Yang, Z.4
Trempus, C.5
-
59
-
-
28644451449
-
Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis
-
Ito M, Liu Y, Yang Z, Nguyen J, Liang F, et al. 2005. Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat. Med. 11:1351-54
-
(2005)
Nat. Med.
, vol.11
, pp. 1351-1354
-
-
Ito, M.1
Liu, Y.2
Yang, Z.3
Nguyen, J.4
Liang, F.5
-
60
-
-
30144432901
-
Purification and unique properties of mammary epithelial stem cells
-
Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, et al. 2006. Purification and unique properties of mammary epithelial stem cells. Nature 439:993-97
-
(2006)
Nature
, vol.439
, pp. 993-997
-
-
Stingl, J.1
Eirew, P.2
Ricketson, I.3
Shackleton, M.4
Vaillant, F.5
-
61
-
-
80855130470
-
Distinct stem cells contribute to mammary gland development and maintenance
-
Van Keymeulen A, Rocha AS, Ousset M, Beck B, Bouvencourt G, et al. 2011. Distinct stem cells contribute to mammary gland development and maintenance. Nature 479:189-93
-
(2011)
Nature
, vol.479
, pp. 189-193
-
-
Van Keymeulen, A.1
Rocha, A.S.2
Ousset, M.3
Beck, B.4
Bouvencourt, G.5
-
62
-
-
84922019806
-
Mammary stem cells have myoepithelial cell properties
-
Prater MD, Petit V, Russell IA, Giraddi RR, Shehata M, et al. 2014. Mammary stem cells have myoepithelial cell properties. Nat. Cell Biol. 16:942-50
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 942-950
-
-
Prater, M.D.1
Petit, V.2
Russell, I.A.3
Giraddi, R.R.4
Shehata, M.5
-
63
-
-
84865222310
-
Defining the mode of tumour growth by clonal analysis
-
Driessens G, Beck B, Caauwe A, Simons BD, Blanpain C. 2012. Defining the mode of tumour growth by clonal analysis. Nature 488:527-30
-
(2012)
Nature
, vol.488
, pp. 527-530
-
-
Driessens, G.1
Beck, B.2
Caauwe, A.3
Simons, B.D.4
Blanpain, C.5
-
64
-
-
33947104197
-
A single type of progenitor cell maintains normal epidermis
-
Clayton E, Doupe DP, Klein AM,Winton DJ, Simons BD, Jones PH. 2007. A single type of progenitor cell maintains normal epidermis. Nature 446:185-89
-
(2007)
Nature
, vol.446
, pp. 185-189
-
-
Clayton, E.1
Doupe, D.P.2
Klein, A.M.3
Winton, D.J.4
Simons, B.D.5
Jones, P.H.6
-
65
-
-
84866147372
-
Distinct contribution of stem and progenitor cells to epidermal maintenance
-
Mascre G, Dekoninck S, Drogat B, Youssef KK, Brohee S, et al. 2012. Distinct contribution of stem and progenitor cells to epidermal maintenance. Nature 489:257-62
-
(2012)
Nature
, vol.489
, pp. 257-262
-
-
Mascre, G.1
Dekoninck, S.2
Drogat, B.3
Youssef, K.K.4
Brohee, S.5
-
66
-
-
84864854371
-
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas
-
Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, et al. 2012. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science 337:730-35
-
(2012)
Science
, vol.337
, pp. 730-735
-
-
Schepers, A.G.1
Snippert, H.J.2
Stange, D.E.3
Van Den Born, M.4
Van Es, J.H.5
-
67
-
-
85027924783
-
Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas
-
Kozar S, Morrissey E, Nicholson AM, van der Heijden M, Zecchini HI, et al. 2013. Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas. Cell Stem Cell 13:626-33
-
(2013)
Cell Stem Cell
, vol.13
, pp. 626-633
-
-
Kozar, S.1
Morrissey, E.2
Nicholson, A.M.3
Van Der Heijden, M.4
Zecchini, H.I.5
-
68
-
-
84874866571
-
Intravital imaging of cancer stem cell plasticity in mammary tumors
-
Zomer A, Ellenbroek SI, Ritsma L, Beerling E, Vrisekoop N, Van Rheenen J. 2013. Intravital imaging of cancer stem cell plasticity in mammary tumors. Stem Cells 31:602-6
-
(2013)
Stem Cells
, vol.31
, pp. 602-606
-
-
Zomer, A.1
Ellenbroek, S.I.2
Ritsma, L.3
Beerling, E.4
Vrisekoop, N.5
Van Rheenen, J.6
-
69
-
-
84908356441
-
Quantification of crypt and stem cell evolution in the normal and neoplastic human colon
-
Baker AM, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, et al. 2014. Quantification of crypt and stem cell evolution in the normal and neoplastic human colon. Cell Rep. 8:940-47
-
(2014)
Cell Rep.
, vol.8
, pp. 940-947
-
-
Baker, A.M.1
Cereser, B.2
Melton, S.3
Fletcher, A.G.4
Rodriguez-Justo, M.5
-
70
-
-
84879736910
-
Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution
-
Humphries A, Cereser B, Gay LJ, Miller DS, Das B, et al. 2013. Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution. PNAS 110:E2490-99
-
(2013)
PNAS
, vol.110
, pp. E2490-E2499
-
-
Humphries, A.1
Cereser, B.2
Gay, L.J.3
Miller, D.S.4
Das, B.5
-
71
-
-
84873084388
-
Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer
-
Kreso A, O'Brien CA, van Galen P, Gan OI, Notta F, et al. 2013. Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science 339:543-48
-
(2013)
Science
, vol.339
, pp. 543-548
-
-
Kreso, A.1
O'Brien, C.A.2
Van Galen, P.3
Gan, O.I.4
Notta, F.5
-
72
-
-
77950981309
-
Cellular barcoding tool for clonal analysis in the hematopoietic system
-
Gerrits A, Dykstra B, Kalmykowa OJ, Klauke K, Verovskaya E, et al. 2010. Cellular barcoding tool for clonal analysis in the hematopoietic system. Blood 115:2610-18
-
(2010)
Blood
, vol.115
, pp. 2610-2618
-
-
Gerrits, A.1
Dykstra, B.2
Kalmykowa, O.J.3
Klauke, K.4
Verovskaya, E.5
-
73
-
-
84893732797
-
Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells
-
Nguyen LV, Makarem M, Carles A, Moksa M, Kannan N, et al. 2014. Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells. Cell Stem Cell 14:253-63
-
(2014)
Cell Stem Cell
, vol.14
, pp. 253-263
-
-
Nguyen, L.V.1
Makarem, M.2
Carles, A.3
Moksa, M.4
Kannan, N.5
-
74
-
-
84942906239
-
DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts
-
Nguyen LV, Cox CL, Eirew P, Knapp DJ, Pellacani D, et al. 2014. DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts. Nat. Commun. 5:5871
-
(2014)
Nat. Commun.
, vol.5
, pp. 5871
-
-
Nguyen, L.V.1
Cox, C.L.2
Eirew, P.3
Knapp, D.J.4
Pellacani, D.5
-
75
-
-
84928391898
-
A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis
-
Wagenblast E, Soto M, Gutierrez-Angel S, Hartl CA, Gable AL, et al. 2015. A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis. Nature 520:358-62
-
(2015)
Nature
, vol.520
, pp. 358-362
-
-
Wagenblast, E.1
Soto, M.2
Gutierrez-Angel, S.3
Hartl, C.A.4
Gable, A.L.5
-
76
-
-
84865203983
-
A restricted cell population propagates glioblastoma growth after chemotherapy
-
Chen J, Li Y, Yu TS, McKay RM, Burns DK, et al. 2012. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488:522-26
-
(2012)
Nature
, vol.488
, pp. 522-526
-
-
Chen, J.1
Li, Y.2
Yu, T.S.3
McKay, R.M.4
Burns, D.K.5
-
77
-
-
85027944761
-
Dclk1 distinguishes between tumor and normal stem cells in the intestine
-
Nakanishi Y, Seno H, Fukuoka A, Ueo T, Yamaga Y, et al. 2013. Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat. Genet. 45:98-103
-
(2013)
Nat. Genet.
, vol.45
, pp. 98-103
-
-
Nakanishi, Y.1
Seno, H.2
Fukuoka, A.3
Ueo, T.4
Yamaga, Y.5
-
78
-
-
84872046078
-
The sox family of transcription factors: Versatile regulators of stem and progenitor cell fate
-
Sarkar A, Hochedlinger K. 2013. The sox family of transcription factors: versatile regulators of stem and progenitor cell fate. Cell Stem Cell 12:15-30
-
(2013)
Cell Stem Cell
, vol.12
, pp. 15-30
-
-
Sarkar, A.1
Hochedlinger, K.2
-
79
-
-
80054041585
-
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
-
Tian H, Biehs B,Warming S, Leong KG, Rangell L, et al. 2011. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 478:255-59
-
(2011)
Nature
, vol.478
, pp. 255-259
-
-
Tian, H.1
Biehs, B.2
Warming, S.3
Leong, K.G.4
Rangell, L.5
-
80
-
-
84867097416
-
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
-
van Es JH, Sato T, van deWetering M, Lyubimova A, Nee AN, et al. 2012. Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nat. Cell Biol. 14:1099-104
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 1099-1104
-
-
Van Es, J.H.1
Sato, T.2
Van Dewetering, M.3
Lyubimova, A.4
Nee, A.N.5
-
81
-
-
84874730918
-
Intestinal label-retaining cells are secretory precursors expressing Lgr5
-
Buczacki SJ, Zecchini HI, Nicholson AM, Russell R, Vermeulen L, et al. 2013. Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature 495:65-69
-
(2013)
Nature
, vol.495
, pp. 65-69
-
-
Buczacki, S.J.1
Zecchini, H.I.2
Nicholson, A.M.3
Russell, R.4
Vermeulen, L.5
-
82
-
-
84893768750
-
Lgr5+ stem cells are indispensable for radiationinduced intestinal regeneration
-
MetcalfeC, Kljavin NM, Ybarra R, de Sauvage FJ. 2014. Lgr5+ stem cells are indispensable for radiationinduced intestinal regeneration. Cell Stem Cell 14:149-59
-
(2014)
Cell Stem Cell
, vol.14
, pp. 149-159
-
-
Metcalfe, C.1
Kljavin, N.M.2
Ybarra, R.3
De Sauvage, F.J.4
-
83
-
-
84873406827
-
Tracing the cellular origin of cancer
-
Blanpain C. 2013. Tracing the cellular origin of cancer. Nat. Cell Biol. 15:126-34
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 126-134
-
-
Blanpain, C.1
-
84
-
-
79956317899
-
Identifying the cellular origin of squamous skin tumors
-
Lapouge G, Youssef KK, Vokaer B, Achouri Y, Michaux C, et al. 2011. Identifying the cellular origin of squamous skin tumors. PNAS 108:7431-36
-
(2011)
PNAS
, vol.108
, pp. 7431-7436
-
-
Lapouge, G.1
Youssef, K.K.2
Vokaer, B.3
Achouri, Y.4
Michaux, C.5
-
85
-
-
79956317166
-
Defining the origins of Ras/p53-mediated squamous cell carcinoma
-
White AC, Tran K, Khuu J, Dang C, Cui Y, et al. 2011. Defining the origins of Ras/p53-mediated squamous cell carcinoma. PNAS 108:7425-30
-
(2011)
PNAS
, vol.108
, pp. 7425-7430
-
-
White, A.C.1
Tran, K.2
Khuu, J.3
Dang, C.4
Cui, Y.5
-
86
-
-
59049106578
-
Crypt stem cells as the cells-of-origin of intestinal cancer
-
Barker N, Ridgway RA, van Es JH, van deWetering M, Begthel H, et al. 2009. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457:608-11
-
(2009)
Nature
, vol.457
, pp. 608-611
-
-
Barker, N.1
Ridgway, R.A.2
Van Es, J.H.3
Van Dewetering, M.4
Begthel, H.5
-
87
-
-
84872600554
-
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
-
Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Goktuna SI, et al. 2013. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell 152:25-38
-
(2013)
Cell
, vol.152
, pp. 25-38
-
-
Schwitalla, S.1
Fingerle, A.A.2
Cammareri, P.3
Nebelsiek, T.4
Goktuna, S.I.5
-
88
-
-
84884558125
-
Unravelling cancer stem cell potential
-
Beck B, Blanpain C. 2013. Unravelling cancer stem cell potential. Nat. Rev. Cancer 13:727-38
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 727-738
-
-
Beck, B.1
Blanpain, C.2
-
89
-
-
80051967505
-
Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
-
Gupta PB, Fillmore CM, Jiang G, Shapira SD, Tao K, et al. 2011. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 146:633-44
-
(2011)
Cell
, vol.146
, pp. 633-644
-
-
Gupta, P.B.1
Fillmore, C.M.2
Jiang, G.3
Shapira, S.D.4
Tao, K.5
-
90
-
-
78249250559
-
Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized
-
Quintana E, Shackleton M, Foster HR, Fullen DR, Sabel MS, et al. 2010. Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell 18:510-23
-
(2010)
Cancer Cell
, vol.18
, pp. 510-523
-
-
Quintana, E.1
Shackleton, M.2
Foster, H.R.3
Fullen, D.R.4
Sabel, M.S.5
-
91
-
-
79960573076
-
Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-βand integrin/focal adhesion kinase (FAK) signaling
-
Schober M, Fuchs E. 2011. Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-βand integrin/focal adhesion kinase (FAK) signaling. PNAS 108:10544-49
-
(2011)
PNAS
, vol.108
, pp. 10544-10549
-
-
Schober, M.1
Fuchs, E.2
-
92
-
-
77952502408
-
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
-
Roesch A, Fukunaga-Kalabis M, Schmidt EC, Zabierowski SE, Brafford PA, et al. 2010. A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell 141:583-94
-
(2010)
Cell
, vol.141
, pp. 583-594
-
-
Roesch, A.1
Fukunaga-Kalabis, M.2
Schmidt, E.C.3
Zabierowski, S.E.4
Brafford, P.A.5
-
93
-
-
84879983245
-
Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity
-
Chaffer CL, Marjanovic ND, Lee T, Bell G, Kleer CG, et al. 2013. Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell 154:61-74
-
(2013)
Cell
, vol.154
, pp. 61-74
-
-
Chaffer, C.L.1
Marjanovic, N.D.2
Lee, T.3
Bell, G.4
Kleer, C.G.5
-
94
-
-
84887273608
-
Epithelial plasticity: A common theme in embryonic and cancer cells
-
Nieto MA. 2013. Epithelial plasticity: A common theme in embryonic and cancer cells. Science 342:1234850
-
(2013)
Science
, vol.342
, pp. 1234850
-
-
Nieto, M.A.1
-
95
-
-
70450198396
-
Epithelial-mesenchymal transitions in development and disease
-
Thiery JP, Acloque H, Huang RY, NietoMA. 2009. Epithelial-mesenchymal transitions in development and disease. Cell 139:871-90
-
(2009)
Cell
, vol.139
, pp. 871-890
-
-
Thiery, J.P.1
Acloque, H.2
Huang, R.Y.3
Nieto, M.A.4
-
96
-
-
79953147370
-
A perspective on cancer cell metastasis
-
Chaffer CL, Weinberg RA. 2011. A perspective on cancer cell metastasis. Science 331:1559-64
-
(2011)
Science
, vol.331
, pp. 1559-1564
-
-
Chaffer, C.L.1
Weinberg, R.A.2
-
97
-
-
63049123066
-
Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
-
Polyak K, Weinberg RA. 2009. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat. Rev. Cancer 9:265-73
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 265-273
-
-
Polyak, K.1
Weinberg, R.A.2
-
98
-
-
43049165453
-
The epithelial-mesenchymal transition generates cells with properties of stem cells
-
Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, et al. 2008. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133:704-15
-
(2008)
Cell
, vol.133
, pp. 704-715
-
-
Mani, S.A.1
Guo, W.2
Liao, M.J.3
Eaton, E.N.4
Ayyanan, A.5
-
99
-
-
51449085561
-
Generation of breast cancer stem cells through epithelial-mesenchymal transition
-
Morel AP, Lievre M, Thomas C, Hinkal G, Ansieau S, Puisieux A. 2008. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLOS ONE 3:e2888
-
(2008)
PLOS ONE
, vol.3
, pp. e2888
-
-
Morel, A.P.1
Lievre, M.2
Thomas, C.3
Hinkal, G.4
Ansieau, S.5
Puisieux, A.6
-
100
-
-
84901787644
-
Oncogenic roles of EMT-inducing transcription factors
-
Puisieux A, Brabletz T, Caramel J. 2014. Oncogenic roles of EMT-inducing transcription factors. Nat. Cell Biol. 16:488-94
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 488-494
-
-
Puisieux, A.1
Brabletz, T.2
Caramel, J.3
-
101
-
-
84920942890
-
Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation
-
Schmidt JM, Panzilius E, Bartsch HS, Irmler M, Beckers J, et al. 2015. Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation. Cell Rep. 10:131-39
-
(2015)
Cell Rep.
, vol.10
, pp. 131-139
-
-
Schmidt, J.M.1
Panzilius, E.2
Bartsch, H.S.3
Irmler, M.4
Beckers, J.5
-
102
-
-
84870845421
-
Spatiotemporal regulation of epithelialmesenchymal transition is essential for squamous cell carcinoma metastasis
-
Tsai JH, Donaher JL, Murphy DA, Chau S, Yang J. 2012. Spatiotemporal regulation of epithelialmesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 22:725-36
-
(2012)
Cancer Cell
, vol.22
, pp. 725-736
-
-
Tsai, J.H.1
Donaher, J.L.2
Murphy, D.A.3
Chau, S.4
Yang, J.5
-
103
-
-
84860578009
-
Epithelialmesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
-
Celià-Terrassa T, Meca-Cortés O, Mateo F, Martínez de Paz A, Rubio N, et al. 2012. Epithelialmesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J. Clin. Investig. 122:1849-68
-
(2012)
J. Clin. Investig.
, vol.122
, pp. 1849-1868
-
-
Celià-Terrassa, T.1
Meca-Cortés, O.2
Mateo, F.3
Martínez De Paz, A.4
Rubio, N.5
-
104
-
-
45849087087
-
Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence
-
Ansieau S, Bastid J, Doreau A, Morel AP, Bouchet BP, et al. 2008. Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell 14:79-89
-
(2008)
Cancer Cell
, vol.14
, pp. 79-89
-
-
Ansieau, S.1
Bastid, J.2
Doreau, A.3
Morel, A.P.4
Bouchet, B.P.5
-
105
-
-
84863650416
-
EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice
-
Morel AP, Hinkal GW, Thomas C, Fauvet F, Courtois-Cox S, et al. 2012. EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice. PLOS Genet. 8:e1002723
-
(2012)
PLOS Genet.
, vol.8
, pp. e1002723
-
-
Morel, A.P.1
Hinkal, G.W.2
Thomas, C.3
Fauvet, F.4
Courtois-Cox, S.5
-
106
-
-
84920733761
-
Different levels of Twist1 regulate skin tumor initiation, stemness, and progression
-
Beck B, Lapouge G, Rorive S, Drogat B, Desaedelaere K, et al. 2015. Different levels of Twist1 regulate skin tumor initiation, stemness, and progression. Cell Stem Cell 16:67-79
-
(2015)
Cell Stem Cell
, vol.16
, pp. 67-79
-
-
Beck, B.1
Lapouge, G.2
Rorive, S.3
Drogat, B.4
Desaedelaere, K.5
-
107
-
-
84858126071
-
MicroRNA dysregulation in cancer: Diagnostics, monitoring and therapeutics. A comprehensive review
-
IorioMV, Croce CM. 2012. MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol. Med. 4:143-59
-
(2012)
EMBO Mol. Med.
, vol.4
, pp. 143-159
-
-
Iorio, M.V.1
Croce, C.M.2
-
108
-
-
85028133025
-
MicroRNAs and cancer stem cells: The sword and the shield
-
Sun X, Jiao X, Pestell TG, Fan C, Qin S, et al. 2014. MicroRNAs and cancer stem cells: The sword and the shield. Oncogene 33:4967-77
-
(2014)
Oncogene
, vol.33
, pp. 4967-4977
-
-
Sun, X.1
Jiao, X.2
Pestell, T.G.3
Fan, C.4
Qin, S.5
-
109
-
-
41649091906
-
ThemiR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
-
Park SM,GaurAB, Lengyel E, PeterME. 2008. ThemiR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 22:894-907
-
(2008)
Genes Dev.
, vol.22
, pp. 894-907
-
-
Park, S.M.1
Gaur, A.B.2
Lengyel, E.3
Peter, M.E.4
-
110
-
-
43049103824
-
The MIR-200 family and MIR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
-
Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, et al. 2008. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat. Cell Biol. 10:593-601
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 593-601
-
-
Gregory, P.A.1
Bert, A.G.2
Paterson, E.L.3
Barry, S.C.4
Tsykin, A.5
-
111
-
-
44649163918
-
A reciprocal repression between ZEB1 and members of the MIR-200 family promotes EMT and invasion in cancer cells
-
Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, et al. 2008. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 9:582-89
-
(2008)
EMBO Rep.
, vol.9
, pp. 582-589
-
-
Burk, U.1
Schubert, J.2
Wellner, U.3
Schmalhofer, O.4
Vincan, E.5
-
112
-
-
68049114782
-
Downregulation ofmiRNA-200c links breast cancer stem cells with normal stem cells
-
Shimono Y, Zabala M, Cho RW, Lobo N, Dalerba P, et al. 2009. Downregulation ofmiRNA-200c links breast cancer stem cells with normal stem cells. Cell 138:592-603
-
(2009)
Cell
, vol.138
, pp. 592-603
-
-
Shimono, Y.1
Zabala, M.2
Cho, R.W.3
Lobo, N.4
Dalerba, P.5
-
113
-
-
79952283482
-
P53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs
-
Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, et al. 2011. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat. Cell Biol. 13:317-23
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 317-323
-
-
Chang, C.J.1
Chao, C.H.2
Xia, W.3
Yang, J.Y.4
Xiong, Y.5
-
114
-
-
79956143950
-
P53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
-
Kim T, Veronese A, Pichiorri F, Lee TJ, Jeon YJ, et al. 2011. p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J. Exp. Med. 208:875-83
-
(2011)
J. Exp. Med.
, vol.208
, pp. 875-883
-
-
Kim, T.1
Veronese, A.2
Pichiorri, F.3
Lee, T.J.4
Jeon, Y.J.5
-
115
-
-
84855729906
-
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition
-
Kim NH, Kim HS, LiXY, Lee I,ChoiHS, et al. 2011. A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J. Cell Biol. 195:417-33
-
(2011)
J. Cell Biol.
, vol.195
, pp. 417-433
-
-
Kim, N.H.1
Kim, H.S.2
Li, X.Y.3
Lee, I.4
Choi, H.S.5
-
116
-
-
80455149978
-
MIR-34 miRNAs provide a barrier for somatic cell reprogramming
-
Choi YJ, Lin CP, Ho JJ, He X, Okada N, et al. 2011. miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat. Cell Biol. 13:1353-60
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 1353-1360
-
-
Choi, Y.J.1
Lin, C.P.2
Ho, J.J.3
He, X.4
Okada, N.5
-
117
-
-
84891852738
-
Self-renewal as a therapeutic target in human colorectal cancer
-
Kreso A, van Galen P, PedleyNM, Lima-Fernandes E, Frelin C, et al. 2014. Self-renewal as a therapeutic target in human colorectal cancer. Nat. Med. 20:29-36
-
(2014)
Nat. Med.
, vol.20
, pp. 29-36
-
-
Kreso, A.1
Van Galen, P.2
Pedley, N.M.3
Lima-Fernandes, E.4
Frelin, C.5
-
118
-
-
77957583439
-
Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition
-
Yang MH, Hsu DS, Wang HW, Wang HJ, Lan HY, et al. 2010. Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat. Cell Biol. 12:982-92
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 982-992
-
-
Yang, M.H.1
Hsu, D.S.2
Wang, H.W.3
Wang, H.J.4
Lan, H.Y.5
-
119
-
-
84865589321
-
How does Lin28 let-7 control development and disease?
-
Thornton JE, Gregory RI. 2012. How does Lin28 let-7 control development and disease? Trends Cell Biol. 22:474-82
-
(2012)
Trends Cell Biol.
, vol.22
, pp. 474-482
-
-
Thornton, J.E.1
Gregory, R.I.2
-
120
-
-
36849078711
-
Let-7 regulates self renewal and tumorigenicity of breast cancer cells
-
Yu F, Yao H, Zhu P, Zhang X, Pan Q, et al. 2007. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131:1109-23
-
(2007)
Cell
, vol.131
, pp. 1109-1123
-
-
Yu, F.1
Yao, H.2
Zhu, P.3
Zhang, X.4
Pan, Q.5
-
121
-
-
40849108663
-
Selective blockade of microRNA processing by Lin28
-
Viswanathan SR, Daley GQ, Gregory RI. 2008. Selective blockade of microRNA processing by Lin28. Science 320:97-100
-
(2008)
Science
, vol.320
, pp. 97-100
-
-
Viswanathan, S.R.1
Daley, G.Q.2
Gregory, R.I.3
-
122
-
-
67649881121
-
Lin28 promotes transformation and is associated with advanced human malignancies
-
Viswanathan SR, Powers JT, EinhornW,HoshidaY,NgTL, et al. 2009. Lin28 promotes transformation and is associated with advanced human malignancies. Nat. Genet. 41:843-48
-
(2009)
Nat. Genet.
, vol.41
, pp. 843-848
-
-
Viswanathan, S.R.1
Powers, J.T.2
Einhorn, W.3
Hoshida, Y.4
Ng, T.L.5
-
123
-
-
84875933577
-
Lin28: Primal regulator of growth and metabolism in stem cells
-
Shyh-Chang N, Daley GQ. 2013. Lin28: primal regulator of growth and metabolism in stem cells. Cell Stem Cell 12:395-406
-
(2013)
Cell Stem Cell
, vol.12
, pp. 395-406
-
-
Shyh-Chang, N.1
Daley, G.Q.2
-
124
-
-
84938659491
-
Lin28b/Let-7 regulates expression of Oct4 and Sox2 and reprograms oral squamous cell carcinoma cells to a stem-like state
-
Chien CS, Wang ML, Chu PY, Chang YL, Liu WH, et al. 2015. Lin28b/Let-7 regulates expression of Oct4 and Sox2 and reprograms oral squamous cell carcinoma cells to a stem-like state. Cancer Res. 75(12):2553-65
-
(2015)
Cancer Res.
, vol.75
, Issue.12
, pp. 2553-2565
-
-
Chien, C.S.1
Wang, M.L.2
Chu, P.Y.3
Chang, Y.L.4
Liu, W.H.5
-
125
-
-
84887456252
-
The epigenetics of epithelial-mesenchymal plasticity in cancer
-
Tam WL, Weinberg RA. 2013. The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat. Med. 19:1438-49
-
(2013)
Nat. Med.
, vol.19
, pp. 1438-1449
-
-
Tam, W.L.1
Weinberg, R.A.2
-
126
-
-
79961023271
-
Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition
-
McDonald OG, Wu H, Timp W, Doi A, Feinberg AP. 2011. Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat. Struct. Mol. Biol. 18:867-74
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 867-874
-
-
McDonald, O.G.1
Wu, H.2
Timp, W.3
Doi, A.4
Feinberg, A.P.5
-
127
-
-
78649328949
-
Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells
-
Ke XS, Qu Y, Cheng Y, LiWC, Rotter V, et al. 2010. Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells. BMC Genomics 11:669
-
(2010)
BMC Genomics
, vol.11
, pp. 669
-
-
Ke, X.S.1
Qu, Y.2
Cheng, Y.3
Li, W.C.4
Rotter, V.5
-
128
-
-
84859837026
-
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
-
HarrisWJ, Huang X, Lynch JT, Spencer GJ, Hitchin JR, et al. 2012. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell 21:473-87
-
(2012)
Cancer Cell
, vol.21
, pp. 473-487
-
-
Harris, W.J.1
Huang, X.2
Lynch, J.T.3
Spencer, G.J.4
Hitchin, J.R.5
-
129
-
-
57649124289
-
Repression of E-cadherin by the polycomb group protein EZH2 in cancer
-
Cao Q, Yu J, Dhanasekaran SM, Kim JH,ManiRS, et al. 2008. Repression of E-cadherin by the polycomb group protein EZH2 in cancer. Oncogene 27:7274-84
-
(2008)
Oncogene
, vol.27
, pp. 7274-7284
-
-
Cao, Q.1
Yu, J.2
Dhanasekaran, S.M.3
Kim, J.H.4
Mani, R.S.5
-
130
-
-
47949125993
-
Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor
-
Herranz N, Pasini D, Diaz VM, Franci C, Gutierrez A, et al. 2008. Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol. Cell. Biol. 28:4772-81
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 4772-4781
-
-
Herranz, N.1
Pasini, D.2
Diaz, V.M.3
Franci, C.4
Gutierrez, A.5
-
131
-
-
73649102464
-
EZH2 is essential for glioblastoma cancer stem cell maintenance
-
Suva ML, Riggi N, JaniszewskaM, Radovanovic I, Provero P, et al. 2009. EZH2 is essential for glioblastoma cancer stem cell maintenance. Cancer Res. 69:9211-18
-
(2009)
Cancer Res.
, vol.69
, pp. 9211-9218
-
-
Suva, M.L.1
Riggi, N.2
Janiszewska, M.3
Radovanovic, I.4
Provero, P.5
-
132
-
-
84922574009
-
EZH2 protects glioma stem cells from radiation-induced cell death in a MELK/FOXM1-dependent manner
-
Kim SH, Joshi K, Ezhilarasan R, Myers TR, Siu J, et al. 2015. EZH2 protects glioma stem cells from radiation-induced cell death in a MELK/FOXM1-dependent manner. Stem Cell Rep. 4:226-38
-
(2015)
Stem Cell Rep.
, vol.4
, pp. 226-238
-
-
Kim, S.H.1
Joshi, K.2
Ezhilarasan, R.3
Myers, T.R.4
Siu, J.5
-
133
-
-
84927547043
-
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors
-
Fillmore CM, Xu C, Desai PT, Berry JM, Rowbotham SP, et al. 2015. EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors. Nature 520:239-42
-
(2015)
Nature
, vol.520
, pp. 239-242
-
-
Fillmore, C.M.1
Xu, C.2
Desai, P.T.3
Berry, J.M.4
Rowbotham, S.P.5
-
134
-
-
77956547097
-
Loss of MIR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells
-
Iliopoulos D, Lindahl-AllenM,Polytarchou C, Hirsch HA,Tsichlis PN, StruhlK. 2010. Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol. Cell 39:761-72
-
(2010)
Mol. Cell
, vol.39
, pp. 761-772
-
-
Iliopoulos, D.1
Lindahl-Allen, M.2
Polytarchou, C.3
Hirsch, H.A.4
Tsichlis, P.N.5
Struhl, K.6
-
135
-
-
77952105211
-
Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate
-
Zhang B, Strauss AC, Chu S, Li M, Ho Y, et al. 2010. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell 17:427-42
-
(2010)
Cancer Cell
, vol.17
, pp. 427-442
-
-
Zhang, B.1
Strauss, A.C.2
Chu, S.3
Li, M.4
Ho, Y.5
-
136
-
-
84890434613
-
HDAC inhibitor confers radiosensitivity to prostate stem-like cells
-
Frame FM, Pellacani D, Collins AT, Simms MS, Mann VM, et al. 2013. HDAC inhibitor confers radiosensitivity to prostate stem-like cells. Br. J. Cancer 109:3023-33
-
(2013)
Br. J. Cancer
, vol.109
, pp. 3023-3033
-
-
Frame, F.M.1
Pellacani, D.2
Collins, A.T.3
Simms, M.S.4
Mann, V.M.5
-
137
-
-
79958719758
-
HDACinhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ERBB receptor expression and reverting EMT
-
Bruzzese F, Leone A, Rocco M, Carbone C, PiroG, et al. 2011.HDACinhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ErbB receptor expression and reverting EMT. J. Cell. Physiol. 226:2378-90
-
(2011)
J. Cell. Physiol.
, vol.226
, pp. 2378-2390
-
-
Bruzzese, F.1
Leone, A.2
Rocco, M.3
Carbone, C.4
Piro, G.5
-
138
-
-
84902185617
-
Chromatin repressive complexes in stem cells, development, and cancer
-
Laugesen A, Helin K. 2014. Chromatin repressive complexes in stem cells, development, and cancer. Cell Stem Cell 14:735-51
-
(2014)
Cell Stem Cell
, vol.14
, pp. 735-751
-
-
Laugesen, A.1
Helin, K.2
-
139
-
-
54449085718
-
Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basallike breast cancers
-
Dumont N, Wilson MB, Crawford YG, Reynolds PA, Sigaroudinia M, Tlsty TD. 2008. Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basallike breast cancers. PNAS 105:14867-72
-
(2008)
PNAS
, vol.105
, pp. 14867-14872
-
-
Dumont, N.1
Wilson, M.B.2
Crawford, Y.G.3
Reynolds, P.A.4
Sigaroudinia, M.5
Tlsty, T.D.6
-
140
-
-
84907562669
-
A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition
-
Carmona FJ, Davalos V, Vidal E, Gomez A, Heyn H, et al. 2014. A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition. Cancer Res. 74:5608-19
-
(2014)
Cancer Res.
, vol.74
, pp. 5608-5619
-
-
Carmona, F.J.1
Davalos, V.2
Vidal, E.3
Gomez, A.4
Heyn, H.5
-
141
-
-
84884368877
-
Influence of tumour micro-environment heterogeneity on therapeutic response
-
Junttila MR, de Sauvage FJ. 2013. Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 501:346-54
-
(2013)
Nature
, vol.501
, pp. 346-354
-
-
Junttila, M.R.1
De Sauvage, F.J.2
-
142
-
-
33846029123
-
A perivascular niche for brain tumor stem cells
-
Calabrese C, Poppleton H, Kocak M, Hogg TL, Fuller C, et al. 2007. A perivascular niche for brain tumor stem cells. Cancer Cell 11:69-82
-
(2007)
Cancer Cell
, vol.11
, pp. 69-82
-
-
Calabrese, C.1
Poppleton, H.2
Kocak, M.3
Hogg, T.L.4
Fuller, C.5
-
143
-
-
74549133965
-
Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development
-
Lichtenberger BM, Tan PK, Niederleithner H, Ferrara N, Petzelbauer P, Sibilia M. 2010. Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development. Cell 140:268-79
-
(2010)
Cell
, vol.140
, pp. 268-279
-
-
Lichtenberger, B.M.1
Tan, P.K.2
Niederleithner, H.3
Ferrara, N.4
Petzelbauer, P.5
Sibilia, M.6
-
144
-
-
84860356630
-
Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth
-
Hamerlik P, Lathia JD, Rasmussen R, Wu Q, Bartkova J, et al. 2012. Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. J. Exp. Med. 209:507-20
-
(2012)
J. Exp. Med.
, vol.209
, pp. 507-520
-
-
Hamerlik, P.1
Lathia, J.D.2
Rasmussen, R.3
Wu, Q.4
Bartkova, J.5
-
145
-
-
84901267967
-
Endothelial cell-secreted EGF induces epithelial to mesenchymal transition and endows head and neck cancer cells with stem-like phenotype
-
Zhang Z,Dong Z, Lauxen IS, FilhoMS, Nor JE. 2014. Endothelial cell-secreted EGF induces epithelial to mesenchymal transition and endows head and neck cancer cells with stem-like phenotype. Cancer Res. 74:2869-81
-
(2014)
Cancer Res.
, vol.74
, pp. 2869-2881
-
-
Zhang, Z.1
Dong, Z.2
Lauxen, I.S.3
Filho, M.S.4
Nor, J.E.5
-
146
-
-
75349091751
-
Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells
-
CharlesN,OzawaT, SquatritoM, Bleau AM, BrennanCW,et al. 2010. Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells. Cell Stem Cell 6:141-52
-
(2010)
Cell Stem Cell
, vol.6
, pp. 141-152
-
-
Charles, N.1
Ozawa, T.2
Squatrito, M.3
Bleau, A.M.4
Brennan, C.W.5
-
147
-
-
84890254301
-
Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche
-
Infanger DW, Cho Y, Lopez BS, Mohanan S, Liu SC, et al. 2013. Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche. Cancer Res. 73:7079-89
-
(2013)
Cancer Res.
, vol.73
, pp. 7079-7089
-
-
Infanger, D.W.1
Cho, Y.2
Lopez, B.S.3
Mohanan, S.4
Liu, S.C.5
-
148
-
-
84899047394
-
Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bonemarrow niche
-
Krause DS, Lazarides K, Lewis JB, von Andrian UH, Van Etten RA. 2014. Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bonemarrow niche. Blood 123:1361-71
-
(2014)
Blood
, vol.123
, pp. 1361-1371
-
-
Krause, D.S.1
Lazarides, K.2
Lewis, J.B.3
Von Andrian, U.H.4
Van Etten, R.A.5
-
149
-
-
84896098492
-
Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance
-
Cao Z, Ding BS, Guo P, Lee SB, Butler JM, et al. 2014. Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance. Cancer Cell 25:350-65
-
(2014)
Cancer Cell
, vol.25
, pp. 350-365
-
-
Cao, Z.1
Ding, B.S.2
Guo, P.3
Lee, S.B.4
Butler, J.M.5
-
150
-
-
84896107633
-
Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth
-
Pietras A, Katz AM, Ekstrom EJ, Wee B, Halliday JJ, et al. 2014. Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth. Cell Stem Cell 14:357-69
-
(2014)
Cell Stem Cell
, vol.14
, pp. 357-369
-
-
Pietras, A.1
Katz, A.M.2
Ekstrom, E.J.3
Wee, B.4
Halliday, J.J.5
-
151
-
-
34247527730
-
Hypoxia-inducible factors, stem cells, and cancer
-
Keith B, Simon MC. 2007. Hypoxia-inducible factors, stem cells, and cancer. Cell 129:465-72
-
(2007)
Cell
, vol.129
, pp. 465-472
-
-
Keith, B.1
Simon, M.C.2
-
152
-
-
54249151684
-
Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction
-
Das B, Tsuchida R,Malkin D, Koren G, Baruchel S, Yeger H. 2008. Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction. Stem Cells 26:1818-30
-
(2008)
Stem Cells
, vol.26
, pp. 1818-1830
-
-
Das, B.1
Tsuchida, R.2
Malkin, D.3
Koren, G.4
Baruchel, S.5
Yeger, H.6
-
153
-
-
65749106405
-
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
-
Li Z, Bao S, Wu Q, Wang H, Eyler C, et al. 2009. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15:501-13
-
(2009)
Cancer Cell
, vol.15
, pp. 501-513
-
-
Li, Z.1
Bao, S.2
Wu, Q.3
Wang, H.4
Eyler, C.5
-
154
-
-
70449687092
-
Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α
-
Soeda A, ParkM, Lee D, Mintz A, Androutsellis-Theotokis A, et al. 2009. Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α. Oncogene 28:3949-59
-
(2009)
Oncogene
, vol.28
, pp. 3949-3959
-
-
Soeda, A.1
Park, M.2
Lee, D.3
Mintz, A.4
Androutsellis-Theotokis, A.5
-
155
-
-
79953870540
-
Targeting HIF1α eliminates cancer stem cells in hematological malignancies
-
Wang Y, Liu Y, Malek SN, Zheng P, Liu Y. 2011. Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 8:399-411
-
(2011)
Cell Stem Cell
, vol.8
, pp. 399-411
-
-
Wang, Y.1
Liu, Y.2
Malek, S.N.3
Zheng, P.4
Liu, Y.5
-
156
-
-
84903146712
-
Physiologic hypoxia promotes maintenance of CMLstem cells despite effective BCR-ABL1 inhibition
-
Ng KP,Manjeri A, LeeKL. 2014. Physiologic hypoxia promotes maintenance of CMLstem cells despite effective BCR-ABL1 inhibition. Blood 123:3316-26
-
(2014)
Blood
, vol.123
, pp. 3316-3326
-
-
Ng, K.P.1
Manjeri, A.2
Lee, K.L.3
-
157
-
-
84918530536
-
Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells
-
Samanta D, Gilkes DM, Chaturvedi P, Xiang L, Semenza GL. 2014. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. PNAS 111:E5429-38
-
(2014)
PNAS
, vol.111
, pp. E5429-E5438
-
-
Samanta, D.1
Gilkes, D.M.2
Chaturvedi, P.3
Xiang, L.4
Semenza, G.L.5
-
158
-
-
84923289688
-
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
-
van den Beucken T, Koch E, Chu K, Rupaimoole R, Prickaerts P, et al. 2014. Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER. Nat. Commun. 5:5203
-
(2014)
Nat. Commun.
, vol.5
, pp. 5203
-
-
Van Den Beucken, T.1
Koch, E.2
Chu, K.3
Rupaimoole, R.4
Prickaerts, P.5
-
159
-
-
84924249260
-
The cancer stem cell niche: How essential is the niche in regulating stemness of tumor cells?
-
Plaks V, Kong N, Werb Z. 2015. The cancer stem cell niche: How essential is the niche in regulating stemness of tumor cells? Cell Stem Cell 16:225-38
-
(2015)
Cell Stem Cell
, vol.16
, pp. 225-238
-
-
Plaks, V.1
Kong, N.2
Werb, Z.3
-
160
-
-
84856088337
-
EMT and dissemination precede pancreatic tumor formation
-
Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, et al. 2012. EMT and dissemination precede pancreatic tumor formation. Cell 148:349-61
-
(2012)
Cell
, vol.148
, pp. 349-361
-
-
Rhim, A.D.1
Mirek, E.T.2
Aiello, N.M.3
Maitra, A.4
Bailey, J.M.5
-
161
-
-
84908485098
-
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages
-
Lu H, Clauser KR, Tam WL, Frose J, Ye X, et al. 2014. A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat. Cell Biol. 16:1105-17
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 1105-1117
-
-
Lu, H.1
Clauser, K.R.2
Tam, W.L.3
Frose, J.4
Ye, X.5
-
162
-
-
84897561550
-
IL-6R/STAT3/MIR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
-
Rokavec M, Oner MG, Li H, Jackstadt R, Jiang L, et al. 2014. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J. Clin. Investig. 124:1853-67
-
(2014)
J. Clin. Investig.
, vol.124
, pp. 1853-1867
-
-
Rokavec, M.1
Oner, M.G.2
Li, H.3
Jackstadt, R.4
Jiang, L.5
-
163
-
-
70350778443
-
An epigenetic switch involving NF-κB, Lin28, let-7 microRNA, and IL6 links inflammation to cell transformation
-
Iliopoulos D, Hirsch HA, Struhl K. 2009. An epigenetic switch involving NF-κB, Lin28, let-7 microRNA, and IL6 links inflammation to cell transformation. Cell 139:693-706
-
(2009)
Cell
, vol.139
, pp. 693-706
-
-
Iliopoulos, D.1
Hirsch, H.A.2
Struhl, K.3
-
164
-
-
84862806829
-
IL6-mediated suppression of MIR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis
-
Rokavec M,WuW, Luo JL. 2012. IL6-mediated suppression of miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis. Mol. Cell 45:777-89
-
(2012)
Mol. Cell
, vol.45
, pp. 777-789
-
-
Rokavec, M.1
Wu, W.2
Luo, J.L.3
-
165
-
-
73049110243
-
TheEMT-activatorZEB1promotes tumorigenicity by repressing stemness-inhibiting microRNAs
-
Wellner U, Schubert J, BurkUC,Schmalhofer O, ZhuF, et al. 2009. TheEMT-activatorZEB1promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat. Cell Biol. 11:1487-95
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1487-1495
-
-
Wellner, U.1
Schubert, J.2
Burk, U.C.3
Schmalhofer, O.4
Zhu, F.5
-
166
-
-
79961074770
-
Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells
-
JinushiM, Chiba S, YoshiyamaH,Masutomi K, Kinoshita I, et al. 2011. Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells. PNAS 108:12425-30
-
(2011)
PNAS
, vol.108
, pp. 12425-12430
-
-
Jinushi, M.1
Chiba, S.2
Yoshiyama, H.3
Masutomi, K.4
Kinoshita, I.5
-
167
-
-
84869239093
-
Epithelial-mesenchymal-transitionlike and TGFβpathways associated with autochthonous inflammatory melanoma development in mice
-
WehbeM, Soudja SM, Mas A,ChassonL,Guinamard R, et al. 2012. Epithelial-mesenchymal-transitionlike and TGFβpathways associated with autochthonous inflammatory melanoma development in mice. PLOS ONE 7:e49419
-
(2012)
PLOS ONE
, vol.7
, pp. e49419
-
-
Wehbe, M.1
Soudja, S.M.2
Mas, A.3
Chasson, L.4
Guinamard, R.5
-
168
-
-
84861344069
-
Tissue transglutaminase links TGF-β, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer
-
Cao L, Shao M, Schilder J, Guise T, Mohammad KS, Matei D. 2012. Tissue transglutaminase links TGF-β, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer. Oncogene 31:2521-34
-
(2012)
Oncogene
, vol.31
, pp. 2521-2534
-
-
Cao, L.1
Shao, M.2
Schilder, J.3
Guise, T.4
Mohammad, K.S.5
Matei, D.6
-
169
-
-
79959863770
-
TGFβ/TNFα-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype
-
Asiedu MK, Ingle JN, Behrens MD, Radisky DC, Knutson KL. 2011. TGFβ/TNFα-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype. Cancer Res. 71:4707-19
-
(2011)
Cancer Res.
, vol.71
, pp. 4707-4719
-
-
Asiedu, M.K.1
Ingle, J.N.2
Behrens, M.D.3
Radisky, D.C.4
Knutson, K.L.5
-
170
-
-
79958265710
-
Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
-
Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, et al. 2011. Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 145:926-40
-
(2011)
Cell
, vol.145
, pp. 926-940
-
-
Scheel, C.1
Eaton, E.N.2
Li, S.H.3
Chaffer, C.L.4
Reinhardt, F.5
-
171
-
-
84866334922
-
TGF-β-induced epithelial-mesenchymal transition: A link between cancer and inflammation
-
Fuxe J, Karlsson MC. 2012. TGF-β-induced epithelial-mesenchymal transition: A link between cancer and inflammation. Semin. Cancer Biol. 22:455-61
-
(2012)
Semin. Cancer Biol.
, vol.22
, pp. 455-461
-
-
Fuxe, J.1
Karlsson, M.C.2
-
172
-
-
84923329516
-
TGF-βpromotes heterogeneity and drug resistance in squamous cell carcinoma
-
OshimoriN,Oristian D, FuchsE. 2015.TGF-βpromotes heterogeneity and drug resistance in squamous cell carcinoma. Cell 160:963-76
-
(2015)
Cell
, vol.160
, pp. 963-976
-
-
Oshimori, N.1
Oristian, D.2
Fuchs, E.3
-
173
-
-
84905103883
-
Fibroblast heterogeneity in the cancer wound
-
Ohlund D, Elyada E, Tuveson D. 2014. Fibroblast heterogeneity in the cancer wound. J. Exp. Med. 211:1503-23
-
(2014)
J. Exp. Med.
, vol.211
, pp. 1503-1523
-
-
Ohlund, D.1
Elyada, E.2
Tuveson, D.3
-
174
-
-
84902469661
-
Depletion of carcinomaassociated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
-
Ozdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X,Wu CC, et al. 2014. Depletion of carcinomaassociated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 25:719-34
-
(2014)
Cancer Cell
, vol.25
, pp. 719-734
-
-
Ozdemir, B.C.1
Pentcheva-Hoang, T.2
Carstens, J.L.3
Zheng, X.4
Wu, C.C.5
-
175
-
-
77956280130
-
Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness
-
Giannoni E, Bianchini F, Masieri L, Serni S, Torre E, et al. 2010. Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. Cancer Res. 70:6945-56
-
(2010)
Cancer Res.
, vol.70
, pp. 6945-6956
-
-
Giannoni, E.1
Bianchini, F.2
Masieri, L.3
Serni, S.4
Torre, E.5
-
176
-
-
84906899235
-
Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state
-
Shimoda M, Principe S, Jackson HW, Luga V, Fang H, et al. 2014. Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state. Nat. Cell Biol. 16:889-901
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 889-901
-
-
Shimoda, M.1
Principe, S.2
Jackson, H.W.3
Luga, V.4
Fang, H.5
-
177
-
-
84861986053
-
Wnt/β-catenin signaling and disease
-
Clevers H, Nusse R. 2012. Wnt/β-catenin signaling and disease. Cell 149:1192-205
-
(2012)
Cell
, vol.149
, pp. 1192-1205
-
-
Clevers, H.1
Nusse, R.2
-
178
-
-
77951975325
-
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
-
Vermeulen L, De Sousa EMF, van der Heijden M, Cameron K, de Jong JH, et al. 2010. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat. Cell Biol. 12:468-76
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 468-476
-
-
Vermeulen, L.1
De Sousa, E.M.F.2
Van Der Heijden, M.3
Cameron, K.4
De Jong, J.H.5
-
179
-
-
84922481750
-
Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity
-
Yasuda K, Torigoe T,Mariya T, Asano T, Kuroda T, et al. 2014. Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity. Lab. Investig. 94:1355-69
-
(2014)
Lab. Investig.
, vol.94
, pp. 1355-1369
-
-
Yasuda, K.1
Torigoe, T.2
Mariya, T.3
Asano, T.4
Kuroda, T.5
-
180
-
-
84861882582
-
CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells
-
Tsuyada A, Chow A,Wu J, Somlo G, Chu P, et al. 2012. CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res. 72:2768-79
-
(2012)
Cancer Res.
, vol.72
, pp. 2768-2779
-
-
Tsuyada, A.1
Chow, A.2
Wu, J.3
Somlo, G.4
Chu, P.5
-
181
-
-
84899480372
-
CAF-secreted annexin A1 induces prostate cancer cells to gain stem cell-like features
-
Geary LA, Nash KA, Adisetiyo H, Liang M, Liao CP, et al. 2014. CAF-secreted annexin A1 induces prostate cancer cells to gain stem cell-like features. Mol. Cancer Res. 12:607-21
-
(2014)
Mol. Cancer Res.
, vol.12
, pp. 607-621
-
-
Geary, L.A.1
Nash, K.A.2
Adisetiyo, H.3
Liang, M.4
Liao, C.P.5
-
182
-
-
84897058262
-
Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling
-
Chen WJ, Ho CC, Chang YL, Chen HY, Lin CA, et al. 2014. Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling. Nat. Commun. 5:3472
-
(2014)
Nat. Commun.
, vol.5
, pp. 3472
-
-
Chen, W.J.1
Ho, C.C.2
Chang, Y.L.3
Chen, H.Y.4
Lin, C.A.5
-
183
-
-
84866307571
-
Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling
-
Li HJ, Reinhardt F, Herschman HR, Weinberg RA. 2012. Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling. Cancer Discov. 2:840-55
-
(2012)
Cancer Discov.
, vol.2
, pp. 840-855
-
-
Li, H.J.1
Reinhardt, F.2
Herschman, H.R.3
Weinberg, R.A.4
-
184
-
-
84890812467
-
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
-
Lotti F, Jarrar AM, Pai RK, Hitomi M, Lathia J, et al. 2013. Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A. J. Exp. Med. 210:2851-72
-
(2013)
J. Exp. Med.
, vol.210
, pp. 2851-2872
-
-
Lotti, F.1
Jarrar, A.M.2
Pai, R.K.3
Hitomi, M.4
Lathia, J.5
-
185
-
-
84896113460
-
Metastatic stem cells: Sources, niches, and vital pathways
-
Oskarsson T, Batlle E, Massagué J. 2014. Metastatic stem cells: sources, niches, and vital pathways. Cell Stem Cell 14:306-21
-
(2014)
Cell Stem Cell
, vol.14
, pp. 306-321
-
-
Oskarsson, T.1
Batlle, E.2
Massagué, J.3
-
186
-
-
78049398107
-
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
-
Yachida S, Jones S, Bozic I, Antal T, Leary R, et al. 2010. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467:1114-17
-
(2010)
Nature
, vol.467
, pp. 1114-1117
-
-
Yachida, S.1
Jones, S.2
Bozic, I.3
Antal, T.4
Leary, R.5
-
187
-
-
84928405167
-
The evolutionary history of lethal metastatic prostate cancer
-
Gundem G, Van Loo P, Kremeyer B, Alexandrov LB, Tubio JM, et al. 2015. The evolutionary history of lethal metastatic prostate cancer. Nature 520:353-57
-
(2015)
Nature
, vol.520
, pp. 353-357
-
-
Gundem, G.1
Van Loo, P.2
Kremeyer, B.3
Alexandrov, L.B.4
Tubio, J.M.5
-
188
-
-
80053904142
-
Distinct types of tumor-initiating cells form human colon cancer tumors and metastases
-
Dieter SM, Ball CR,HoffmannCM, Nowrouzi A,Herbst F, et al. 2011. Distinct types of tumor-initiating cells form human colon cancer tumors and metastases. Cell Stem Cell 9:357-65
-
(2011)
Cell Stem Cell
, vol.9
, pp. 357-365
-
-
Dieter, S.M.1
Ball, C.R.2
Hoffmann, C.M.3
Nowrouzi, A.4
Herbst, F.5
-
189
-
-
84872080485
-
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer
-
Vanharanta S, Shu W, Brenet F, Hakimi AA, Heguy A, et al. 2013. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nat. Med. 19:50-56
-
(2013)
Nat. Med.
, vol.19
, pp. 50-56
-
-
Vanharanta, S.1
Shu, W.2
Brenet, F.3
Hakimi, A.A.4
Heguy, A.5
-
190
-
-
77956641496
-
A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer
-
Pang R, LawWL, Chu AC, Poon JT, Lam CS, et al. 2010. A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer. Cell Stem Cell 6:603-15
-
(2010)
Cell Stem Cell
, vol.6
, pp. 603-615
-
-
Pang, R.1
Law, W.L.2
Chu, A.C.3
Poon, J.T.4
Lam, C.S.5
-
191
-
-
84925300542
-
Biology, detection, and clinical implications of circulating tumor cells
-
Joosse SA,GorgesTM, Pantel K. 2015. Biology, detection, and clinical implications of circulating tumor cells. EMBO Mol. Med. 7:1-11
-
(2015)
EMBO Mol. Med.
, vol.7
, pp. 1-11
-
-
Joosse, S.A.1
Gorges, T.M.2
Pantel, K.3
-
192
-
-
84870816403
-
Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1
-
Ocana OH, Corcoles R, Fabra A, Moreno-Bueno G, Acloque H, et al. 2012. Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell 22:709-24
-
(2012)
Cancer Cell
, vol.22
, pp. 709-724
-
-
Ocana, O.H.1
Corcoles, R.2
Fabra, A.3
Moreno-Bueno, G.4
Acloque, H.5
-
193
-
-
84855425160
-
Interactions between cancer stem cells and their niche govern metastatic colonization
-
Malanchi I, Santamaria-Martinez A, Susanto E, Peng H, Lehr HA, et al. 2012. Interactions between cancer stem cells and their niche govern metastatic colonization. Nature 481:85-89
-
(2012)
Nature
, vol.481
, pp. 85-89
-
-
Malanchi, I.1
Santamaria-Martinez, A.2
Susanto, E.3
Peng, H.4
Lehr, H.A.5
-
194
-
-
84880332704
-
The perivascular niche regulates breast tumour dormancy
-
Ghajar CM, Peinado H, Mori H, Matei IR, Evason KJ, et al. 2013. The perivascular niche regulates breast tumour dormancy. Nat. Cell Biol. 15:807-17
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 807-817
-
-
Ghajar, C.M.1
Peinado, H.2
Mori, H.3
Matei, I.R.4
Evason, K.J.5
-
195
-
-
33845317573
-
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
-
Bao S,Wu Q, McLendon RE, Hao Y, Shi Q, et al. 2006. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756-60
-
(2006)
Nature
, vol.444
, pp. 756-760
-
-
Bao, S.1
Wu, Q.2
McLendon, R.E.3
Hao, Y.4
Shi, Q.5
-
196
-
-
64749093574
-
Association of reactive oxygen species levels and radioresistance in cancer stem cells
-
Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, et al. 2009. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 458:780-83
-
(2009)
Nature
, vol.458
, pp. 780-783
-
-
Diehn, M.1
Cho, R.W.2
Lobo, N.A.3
Kalisky, T.4
Dorie, M.J.5
-
197
-
-
84894245627
-
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
-
Shlush LI, Zandi S, Mitchell A, Chen WC, Brandwein JM, et al. 2014. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature 506:328-33
-
(2014)
Nature
, vol.506
, pp. 328-333
-
-
Shlush, L.I.1
Zandi, S.2
Mitchell, A.3
Chen, W.C.4
Brandwein, J.M.5
-
198
-
-
84877868296
-
Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells
-
Shien K, Toyooka S, Yamamoto H, Soh J, Jida M, et al. 2013. Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells. Cancer Res. 73:3051-61
-
(2013)
Cancer Res.
, vol.73
, pp. 3051-3061
-
-
Shien, K.1
Toyooka, S.2
Yamamoto, H.3
Soh, J.4
Jida, M.5
-
199
-
-
84902269863
-
Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy
-
Auffinger B, Tobias AL, Han Y, Lee G, GuoD, et al. 2014. Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy. Cell Death Differ. 21:1119-31
-
(2014)
Cell Death Differ.
, vol.21
, pp. 1119-1131
-
-
Auffinger, B.1
Tobias, A.L.2
Han, Y.3
Lee, G.4
Guo, D.5
-
200
-
-
77953121698
-
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death
-
Sotiropoulou PA, Candi A, Mascre G, De Clercq S, Youssef KK, et al. 2010. Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death. Nat. Cell Biol. 12:572-82
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 572-582
-
-
Sotiropoulou, P.A.1
Candi, A.2
Mascre, G.3
De Clercq, S.4
Youssef, K.K.5
-
201
-
-
84923248130
-
A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms
-
CojocM,Mabert K,Muders MH, Dubrovska A. 2015. A role for cancer stem cells in therapy resistance: cellular and molecular mechanisms. Semin. Cancer Biol. 31:16-27
-
(2015)
Semin. Cancer Biol.
, vol.31
, pp. 16-27
-
-
Cojoc, M.1
Mabert, K.2
Muders, M.H.3
Dubrovska, A.4
-
202
-
-
84881540768
-
The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance
-
Siebzehnrubl FA, Silver DJ, Tugertimur B, Deleyrolle LP, Siebzehnrubl D, et al. 2013. The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance. EMBO Mol. Med. 5:1196-212
-
(2013)
EMBO Mol. Med.
, vol.5
, pp. 1196-1212
-
-
Siebzehnrubl, F.A.1
Silver, D.J.2
Tugertimur, B.3
Deleyrolle, L.P.4
Siebzehnrubl, D.5
-
203
-
-
84930181902
-
ZEB1-associated drug resistance in cancer cells is reversed by the class i HDAC inhibitor mocetinostat
-
Meidhof S, Brabletz S, Lehmann W, Preca BT, Mock K, et al. 2015. ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat. EMBO Mol. Med. 7(6):831-47
-
(2015)
EMBO Mol. Med.
, vol.7
, Issue.6
, pp. 831-847
-
-
Meidhof, S.1
Brabletz, S.2
Lehmann, W.3
Preca, B.T.4
Mock, K.5
-
204
-
-
84923383604
-
MIR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13
-
Zhang P, Wang L, Rodriguez-Aguayo C, Yuan Y, Debeb BG, et al. 2014. miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13. Nat. Commun. 5:5671
-
(2014)
Nat. Commun.
, vol.5
, pp. 5671
-
-
Zhang, P.1
Wang, L.2
Rodriguez-Aguayo, C.3
Yuan, Y.4
Debeb, B.G.5
-
205
-
-
84908149021
-
ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1
-
Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, et al. 2014. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat. Cell Biol. 16:864-75
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 864-875
-
-
Zhang, P.1
Wei, Y.2
Wang, L.3
Debeb, B.G.4
Yuan, Y.5
-
206
-
-
84899582429
-
Knockdown of NANOG enhances chemosensitivity of liver cancer cells to doxorubicin by reducing MDR1 expression
-
Zhou JJ, Deng XG, He XY, Zhou Y, Yu M, et al. 2014. Knockdown of NANOG enhances chemosensitivity of liver cancer cells to doxorubicin by reducing MDR1 expression. Int. J. Oncol. 44:2034-40
-
(2014)
Int. J. Oncol.
, vol.44
, pp. 2034-2040
-
-
Zhou, J.J.1
Deng, X.G.2
He, X.Y.3
Zhou, Y.4
Yu, M.5
-
207
-
-
60849117508
-
PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
-
Bleau AM, Hambardzumyan D, Ozawa T, Fomchenko EI, Huse JT, et al. 2009. PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell 4:226-35
-
(2009)
Cell Stem Cell
, vol.4
, pp. 226-235
-
-
Bleau, A.M.1
Hambardzumyan, D.2
Ozawa, T.3
Fomchenko, E.I.4
Huse, J.T.5
-
208
-
-
84868496506
-
ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors
-
HuangCP, Tsai MF,Chang TH,TangWC, Chen SY, et al. 2013. ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors. Cancer Lett. 328:144-51
-
(2013)
Cancer Lett.
, vol.328
, pp. 144-151
-
-
Huang, C.P.1
Tsai, M.F.2
Chang, T.H.3
Tang, W.C.4
Chen, S.Y.5
-
209
-
-
84922388823
-
Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance
-
Kurtova AV, Xiao J, Mo Q, Pazhanisamy S, Krasnow R, et al. 2015. Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance. Nature 517:209-13
-
(2015)
Nature
, vol.517
, pp. 209-213
-
-
Kurtova, A.V.1
Xiao, J.2
Mo, Q.3
Pazhanisamy, S.4
Krasnow, R.5
-
210
-
-
84868633053
-
Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance throughWNT16B
-
Sun Y, Campisi J, Higano C, Beer TM, Porter P, et al. 2012. Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance throughWNT16B. Nat.Med. 18:1359-68
-
(2012)
Nat.Med.
, vol.18
, pp. 1359-1368
-
-
Sun, Y.1
Campisi, J.2
Higano, C.3
Beer, T.M.4
Porter, P.5
-
211
-
-
84896532797
-
MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors
-
Luraghi P, Reato G, Cipriano E, Sassi F, Orzan F, et al. 2014. MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors. Cancer Res. 74:1857-69
-
(2014)
Cancer Res.
, vol.74
, pp. 1857-1869
-
-
Luraghi, P.1
Reato, G.2
Cipriano, E.3
Sassi, F.4
Orzan, F.5
-
212
-
-
84901277245
-
Cancer stem-like cells derived from chemoresistant tumors have a unique capacity to prime tumorigenic myeloid cells
-
Yamashina T, Baghdadi M, Yoneda A, Kinoshita I, Suzu S, et al. 2014. Cancer stem-like cells derived from chemoresistant tumors have a unique capacity to prime tumorigenic myeloid cells. Cancer Res. 74:2698-709
-
(2014)
Cancer Res.
, vol.74
, pp. 2698-2709
-
-
Yamashina, T.1
Baghdadi, M.2
Yoneda, A.3
Kinoshita, I.4
Suzu, S.5
-
213
-
-
84900297049
-
Hypoxia increases gefitinibresistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor
-
Murakami A, Takahashi F,Nurwidya F,Kobayashi I,MinakataK, et al. 2014. Hypoxia increases gefitinibresistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor. PLOS ONE 9:e86459
-
(2014)
PLOS ONE
, vol.9
, pp. e86459
-
-
Murakami, A.1
Takahashi, F.2
Nurwidya, F.3
Kobayashi, I.4
Minakata, K.5
-
214
-
-
84862014301
-
Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment
-
Rausch V, Liu L, Apel A, Rettig T, Gladkich J, et al. 2012. Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment. J. Pathol. 227:325-35
-
(2012)
J. Pathol.
, vol.227
, pp. 325-335
-
-
Rausch, V.1
Liu, L.2
Apel, A.3
Rettig, T.4
Gladkich, J.5
-
215
-
-
84899860489
-
An integrin β3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition
-
Seguin L, Kato S, Franovic A, Camargo MF, Lesperance J, et al. 2014. An integrin β3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat. Cell Biol. 16:457-68
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 457-468
-
-
Seguin, L.1
Kato, S.2
Franovic, A.3
Camargo, M.F.4
Lesperance, J.5
-
216
-
-
84870020040
-
MED12 controls the response to multiple cancer drugs through regulation of TGF-βreceptor signaling
-
Huang S,HolzelM, Knijnenburg T, Schlicker A, Roepman P, et al. 2012. MED12 controls the response to multiple cancer drugs through regulation of TGF-βreceptor signaling. Cell 151:937-50
-
(2012)
Cell
, vol.151
, pp. 937-950
-
-
Huang, S.1
Holzel, M.2
Knijnenburg, T.3
Schlicker, A.4
Roepman, P.5
|