Stem-cell-like properties and epithelial plasticity arise as stable traits after transient twist1 activation

Cell Reports

Volumn 10, Issue 2, 2015, Pages 131-139

  Schmidt, Johanna M ^a   Panzilius, Elena ^a   Bartsch, Harald S ^b   Irmler, Martin ^a   Beckers, Johannes ^a,d   Kari, Vijayalakshmi ^c   Linnemann, Jelena R ^a   Dragoi, Diana ^a   Hirschi, Benjamin ^a   Kloos, Uwe J ^a   Sass, Steffen ^a   Theis, Fabian ^a,d   Kahlert, Steffen ^b   Johnsen, Steven A ^c   Sotlar, Karl ^b   Scheel, Christina H ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SNAIL1; TRANSCRIPTION FACTOR TWIST1; UNCLASSIFIED DRUG; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; NUCLEAR PROTEIN; SNAIL FAMILY TRANSCRIPTION FACTORS; TAMOXIFEN; TRANSCRIPTION FACTOR TWIST; TWIST1 PROTEIN, HUMAN;

ARTICLE; BREAST EPITHELIUM CELL; CANCER STEM CELL; CELL INVASION; CONTROLLED STUDY; DISSEMINATED CANCER; DISTANT METASTASIS; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; HUMAN; HUMAN CELL; METASTASIS; PLASTICITY; STEM CELL; TUMOR INVASION; BREAST TUMOR; CELL LINE; CELL MOTION; CELL PROLIFERATION; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; FEMALE; GENETICS; METABOLISM; PATHOLOGY;

ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; CELL CULTURE TECHNIQUES; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; NUCLEAR PROTEINS; STEM CELLS; TAMOXIFEN; TRANSCRIPTION FACTORS; TWIST TRANSCRIPTION FACTOR;

EID: 84920942890     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.12.032     Document Type: Article

References (29)

1. Ansieau S. EMT in breast cancer stem cell generation. Cancer Lett. 2013, 338:63-68.
2. Bedi U., Mishra V.K., Wasilewski D., Scheel C., Johnsen S.A. Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer. Oncotarget 2014, 5:2016-2029.
3. Bergethon K., Shaw A.T., Ou S.-H.I., Katayama R., Lovly C.M., McDonald N.T., Massion P.P., Siwak-Tapp C., Gonzalez A., Fang R., et al. ROS1 rearrangements define a unique molecular class of lung cancers. J.Clin. Oncol. 2012, 30:863-870.
4. Casas E., Kim J., Bendesky A., Ohno-Machado L., Wolfe C.J., Yang J. Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis. Cancer Res. 2011, 71:245-254.
5. Celià-Terrassa T., Meca-Cortés O., Mateo F., de Paz A.M., Rubio N., Arnal-Estapé A., Ell B.J., Bermudo R., Díaz A., Guerra-Rebollo M., et al. Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J.Clin. Invest. 2012, 122:1849-1868.
6. Chaffer C.L., Brennan J.P., Slavin J.L., Blick T., Thompson E.W., Williams E.D. Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2. Cancer Res. 2006, 66:11271-11278.
7. Dontu G., Abdallah W.M., Foley J.M., Jackson K.W., Clarke M.F., Kawamura M.J., Wicha M.S. Invitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev. 2003, 17:1253-1270.
8. Elenbaas B., Spirio L., Koerner F., Fleming M.D., Zimonjic D.B., Donaher J.L., Popescu N.C., Hahn W.C., Weinberg R.A. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev. 2001, 15:50-65.
9. Frisch S.M., Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J.Cell Biol. 1994, 124:619-626.
10. Gupta P.B., Onder T.T., Jiang G., Tao K., Kuperwasser C., Weinberg R.A., Lander E.S. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009, 138:645-659.
11. Korpal M., Ell B.J., Buffa F.M., Ibrahim T., Blanco M.A., Celià-Terrassa T., Mercatali L., Khan Z., Goodarzi H., Hua Y., et al. Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat. Med. 2011, 17:1101-1108.
12. Kowalski P.J., Rubin M.A., Kleer C.G. E-cadherin expression in primary carcinomas of the breast and its distant metastases. Breast Cancer Res. 2003, 5:R217-R222.
13. Lamouille S., Xu J., Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat. Rev. Mol. Cell Biol. 2014, 15:178-196.
14. Lim J., Thiery J.P. Epithelial-mesenchymal transitions: insights from development. Development 2012, 139:3471-3486.
15. Mani S.A., Guo W., Liao M.-J., Eaton E.N., Ayyanan A., Zhou A.Y., Brooks M., Reinhard F., Zhang C.C., Shipitsin M., et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133:704-715.
16. Morel A.-P., Lièvre M., Thomas C., Hinkal G., Ansieau S., Puisieux A. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS ONE 2008, 3:e2888.
17. Nieto M.A. The ins and outs of the epithelial to mesenchymal transition in health and disease. Annu. Rev. Cell Dev. Biol. 2011, 27:347-376.
18. Ocaña O.H., Córcoles R., Fabra A., Moreno-Bueno G., Acloque H., Vega S., Barrallo-Gimeno A., Cano A., Nieto M.A. Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell 2012, 22:709-724.
19. Puisieux A., Brabletz T., Caramel J. Oncogenic roles of EMT-inducing transcription factors. Nat. Cell Biol. 2014, 16:488-494.
20. Rossi A., Maione P., Sacco P.C., Sgambato A., Casaluce F., Ferrara M.L., Palazzolo G., Ciardiello F., Gridelli C. ALK inhibitors and advanced non-small cell lung cancer (review). Int. J. Oncol. 2014, 45:499-508.
21. Sarrio D., Franklin C.K., Mackay A., Reis-Filho J.S., Isacke C.M. Epithelial and mesenchymal subpopulations within normal basal breast cell lines exhibit distinct stem cell/progenitor properties. Stem Cells 2012, 30:292-303.
22. Scheel C., Weinberg R.A. Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin. Cancer Biol. 2012, 22:396-403.
23. Scheel C., Eaton E.N., Li S.H.-J., Chaffer C.L., Reinhardt F., Kah K.-J., Bell G., Guo W., Rubin J., Richardson A.L., Weinberg R.A. Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 2011, 145:926-940.
24. Shamir E.R., Pappalardo E., Jorgens D.M., Coutinho K., Tsai W.-T., Aziz K., Auer M., Tran P.T., Bader J.S., Ewald A.J. Twist1-induced dissemination preserves epithelial identity and requires E-cadherin. J.Cell Biol. 2014, 204:839-856.
25. Shi J., Wang Y., Zeng L., Wu Y., Deng J., Zhang Q., Lin Y., Li J., Kang T., Tao M., et al. Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer. Cancer Cell 2014, 25:210-225.
26. Stankic M., Pavlovic S., Chin Y., Brogi E., Padua D., Norton L., Massagué J., Benezra R. TGF-β-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition. Cell Rep. 2013, 5:1228-1242.
27. Tam W.L., Lu H., Buikhuisen J., Soh B.S., Lim E., Reinhardt F., Wu Z.J., Krall J.A., Bierie B., Guo W., et al. Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell 2013, 24:347-364.
28. Tran H.D., Luitel K., Kim M., Zhang K., Longmore G.D., Tran D.D. Transient SNAIL1 expression is necessary for metastatic competence in breast cancer. Cancer Res. 2014, 74:6330-6340.
29. Tsai J.H., Donaher J.L., Murphy D.A., Chau S., Yang J. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 2012, 22:725-736.