Mammary stem cells have myoepithelial cell properties

Nature Cell Biology

Volumn 16, Issue 10, 2014, Pages 942-950

  Prater, Michael D ^a   Petit, Valérie ^b,c   Alasdair Russell, I ^a   Giraddi, Rajshekhar R ^a   Shehata, Mona ^a   Menon, Suraj ^a   Schulte, Reiner ^a   Kalajzic, Ivo ^d   Rath, Nicola ^e   Olson, Michael F ^e   Metzger, Daniel ^f   Faraldo, Marisa M ^b,c   Deugnier, Marie Ange ^b,c   Glukhova, Marina A ^b,c   Stingl, John ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b INSTITUT CURIE   (France)

^c CNRS   (France)

^d UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^e BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^f UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; TRANSFORMING GROWTH FACTOR BETA; 1,3 DIOXOLANE DERIVATIVE; 4-(5-BENZO(1,3)DIOXOL-5-YL-4-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE; ACTIN; BENZAMIDE DERIVATIVE; GREEN FLUORESCENT PROTEIN; IL2RG PROTEIN, MOUSE; INTERLEUKIN 2 RECEPTOR GAMMA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASAL CELL; BREAST CELL; CELL CULTURE; CELL EXPANSION; CELL FUNCTION; CELL LINEAGE; CELL PROLIFERATION; CELL SELECTION; CELLULAR PARAMETERS; COLONY FORMATION; CONTROLLED STUDY; CYTOSKELETON; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MAMMARY REPOPULATING UNIT; MAMMARY STEM CELL; MOUSE; MYOEPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; STEM CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CBA MOUSE; CYTOLOGY; DEFICIENCY; DNA MICROARRAY; DRUG EFFECTS; EPITHELIUM CELL; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; NONOBESE DIABETIC MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; SMOOTH MUSCLE FIBER; TRANSGENIC MOUSE; UDDER;

ACTINS; ANIMALS; BENZAMIDES; CELL PROLIFERATION; CELLS, CULTURED; DIOXOLES; EPITHELIAL CELLS; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GREEN FLUORESCENT PROTEINS; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; MAMMARY GLANDS, ANIMAL; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, INBRED NOD; MICE, SCID; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MYOCYTES, SMOOTH MUSCLE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS;

EID: 84922019806     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3025     Document Type: Article

References (35)

1. Franke, W. W. et al. Intermediate-sized filaments of the prekeratin type in myoepithelial cells. J. Cell Biol. 84, 633-654 (1980).
2. Lazard, D. et al. Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue. Proc. Natl Acad. Sci. USA 90, 999-1003 (1993).
3. Chepko, G. et al. Differential alteration of stem and other cell populations in ducts and lobules of TGF[α] and c-Myc transgenic mouse mammary epithelium. Tissue Cell 37, 393-412 (2005).
4. Smith, G. H. & Medina, D. A morphologically distinct candidate for an epithelial stem cell in mouse mammary gland. J. Cell Sci. 90, 173-183 (1988).
5. Stingl, J. et al. Purification and unique properties of mammary epithelial stem cells. Nature 439, 993-997 (2006).
6. Shackleton, M. et al. Generation of a functional mammary gland from a single stem cell. Nature 439, 84-88 (2006).
7. Sleeman, K. E. et al. Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland. J. Cell Biol. 176, 19-26 (2007).
8. van Keymeulen, A. et al. Distinct stem cells contribute to mammary gland development and maintenance. Nature 479, 189-193 (2011).
9. van Amerongen, R., Bowman, A. N. & Nusse, R. Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland. Cell Stem Cell 11, 387-400 (2012).
10. Taddei, I. et al. β1 Integrin deletion from the basal compartment of the mammary epithelium affects stem cells. Nat. Cell Biol. 10, 716-722 (2008).
11. Rios, A. C., Fu, N. Y., Lindeman, G. J. & Visvader, J. E. In situ identification of bipotent stem cells in the mammary gland. Nature 506, 322-327 (2014).
12. Shehata, M. et al. Phenotypic and functional characterization of the luminal cell hierarchy of the mammary gland. Breast Cancer Res. 14, R134 (2012).
13. Gottlieb, C., Raju, U. & Greenwald, K. A. Myoepithelial cells in the differential diagnosis of complex benign and malignant breast lesions: an immunohistochemical study. Mod. Pathol. 3, 135-140 (1990).
14. Wu, Y-J. et al. The mesothelial keratins: a new family of cytoskeletal proteins identified in cultured mesothelial cells and nonkeratinizing epithelia. Cell 31, 693-703 (1982).
15. Inman, G. J. et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 62, 65-74 (2002).
16. Flanagan, M. D. & Lin, S. Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin. J. Biol. Chem. 255, 835-838 (1980).
17. Spector, I., Shochet, N., Kashman, Y. & Groweiss, A. Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells. Science 219, 493-495 (1983).
18. Bubb, M. R., Senderowicz, A. M., Sausville, E. A., Duncan, K. L. & Korn, E. D. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J. Biol. Chem. 269, 14869-14871 (1994).
19. Ikenoya, M. et al. Inhibition of Rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J. Neurochem. 81, 9-16 (2002).
20. Chen, G., Hou, Z., Gulbranson, D. R. & Thomson, J. A. Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells. Cell Stem Cell 7, 240-248 (2010).
21. Ohgushi, M. et al. Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. Cell Stem Cell 7, 225-239 (2010).
22. Straight, A. F. et al. Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299, 1743-1747 (2003).
23. Haaksma, C. J., Schwartz, R. J. & Tomasek, J. J. Myoepithelial cell contraction and milk ejection are impaired in mammary glands of mice lacking smooth muscle alpha-actin. Biol. Reprod. 85, 13-21 (2011).
24. Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L. & Luo, L. A global double-fluorescent Cre reporter mouse. Genesis 45, 593-605 (2007).
25. Chepko, G. & Smith, G. H. Three division-competent, structurally-distinct cell populations contribute to murine mammary epithelial renewal. Tissue Cell 29, 239-253 (1997).
26. Joshi, P. A. et al. Progesterone induces adult mammary stem cell expansion. Nature 465, 803-807 (2010).
27. Yokota, T. et al. Bone marrow lacks a transplantable progenitor for smooth muscle type α-actin-expressing cells. Stem Cells 24, 13-22 (2006).
28. Wendling, O., Bornert, J. M., Chambon, P. & Metzger, D. Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse. Genesis 47, 14-18 (2009).
29. Soriano, P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21, 70-71 (1999).
30. Young, L. J. T. in Methods in Mammary Gland Biology and Breast Cancer Research (eds Ip, M. M. & Asch, B. B.) 67-74 (Kluwer/Plenum, 2000).
31. Gentleman, R. et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5, R80 (2004).
32. Cairns, J. M., Dunning, M. J., Ritchie, M. E., Russell, R. & Lynch, A. G. BASH: a tool for managing BeadArray spatial artefacts. Bioinformatics 24, 2921-2922 (2008).
33. Dunning, M. J., Smith, M. L., Ritchie, M. E. & Tavaré, S. beadarray: R classes and methods for Illumina bead-based data. Bioinformatics 23, 2183-2184 (2007).
34. Smyth, G. K. in Bioinformatics and Computational Biology Solutions using R and Bioconductor (eds Gentleman, R. et al.) 397-420 (Springer, 2005).
35. Hu, Y. & Smyth, G. K. ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. J. Immunol. Methods 347, 70-78 (2009).