메뉴 건너뛰기




Volumn 5, Issue 8, 2013, Pages 1196-1212

The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance

Author keywords

Brain; Cancer stem cell; EMT; Glioma; Xenograft

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MICRORNA 200; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; PEPTIDES AND PROTEINS; PROTEIN C MYB; PROTEIN ROBO1; TEMOZOLOMIDE; TRANSCRIPTION FACTOR ZEB1; UNCLASSIFIED DRUG;

EID: 84881540768     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201302827     Document Type: Article
Times cited : (322)

References (68)
  • 5
    • 77956230322 scopus 로고    scopus 로고
    • The ZEB/miR-200 feedback loop - A motor of cellular plasticity in development and cancer
    • Brabletz S, Brabletz T (2010) The ZEB/miR-200 feedback loop - A motor of cellular plasticity in development and cancer? EMBO Rep 11: 670-677
    • (2010) EMBO Rep , vol.11 , pp. 670-677
    • Brabletz, S.1    Brabletz, T.2
  • 6
    • 70849122697 scopus 로고    scopus 로고
    • Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
    • Brennan C, Momota H, Hambardzumyan D, Ozawa T, Tandon A, Pedraza A, Holland E (2009) Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS ONE 4: e7752
    • (2009) PLoS ONE , vol.4
    • Brennan, C.1    Momota, H.2    Hambardzumyan, D.3    Ozawa, T.4    Tandon, A.5    Pedraza, A.6    Holland, E.7
  • 7
    • 82855170853 scopus 로고    scopus 로고
    • TGFbeta-induced c-Myb affects the expression of EMT-associated genes and promotes invasion of ER+ breast cancer cells
    • Cesi V, Casciati A, Sesti F, Tanno B, Calabretta B, Raschella G (2011) TGFbeta-induced c-Myb affects the expression of EMT-associated genes and promotes invasion of ER+ breast cancer cells. Cell Cycle 10: 4149-4161
    • (2011) Cell Cycle , vol.10 , pp. 4149-4161
    • Cesi, V.1    Casciati, A.2    Sesti, F.3    Tanno, B.4    Calabretta, B.5    Raschella, G.6
  • 8
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer CL, Weinberg RA (2011) A perspective on cancer cell metastasis. Science 331: 1559-1564
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 10
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • Chen J, Li Y, Yu TS, McKay RM, Burns DK, Kernie SG, Parada LF (2012) A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488: 522-526
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.S.3    McKay, R.M.4    Burns, D.K.5    Kernie, S.G.6    Parada, L.F.7
  • 12
    • 0023854984 scopus 로고
    • Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation
    • Clarke MF, Kukowska-Latallo JF, Westin E, Smith M, Prochownik EV (1988) Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation. Mol Cell Biol 8: 884-892
    • (1988) Mol Cell Biol , vol.8 , pp. 884-892
    • Clarke, M.F.1    Kukowska-Latallo, J.F.2    Westin, E.3    Smith, M.4    Prochownik, E.V.5
  • 14
    • 0034756371 scopus 로고    scopus 로고
    • Glioma migration: clues from the biology of neural progenitor cells and embryonic CNS cell migration
    • Dirks PB (2001) Glioma migration: clues from the biology of neural progenitor cells and embryonic CNS cell migration. J Neuro-Oncol 53: 203-212
    • (2001) J Neuro-Oncol , vol.53 , pp. 203-212
    • Dirks, P.B.1
  • 16
    • 77955381770 scopus 로고    scopus 로고
    • BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery
    • Facchino S, Abdouh M, Chatoo W, Bernier G (2010) BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery. J Neurosci 30: 10096-10111
    • (2010) J Neurosci , vol.30 , pp. 10096-10111
    • Facchino, S.1    Abdouh, M.2    Chatoo, W.3    Bernier, G.4
  • 18
    • 1942469956 scopus 로고    scopus 로고
    • MGMT: its role in cancer aetiology and cancer therapeutics
    • Gerson SL (2004) MGMT: its role in cancer aetiology and cancer therapeutics. Nat Rev Cancer 4: 296-307
    • (2004) Nat Rev Cancer , vol.4 , pp. 296-307
    • Gerson, S.L.1
  • 19
    • 0033978588 scopus 로고    scopus 로고
    • Object-oriented transcription factors database (ooTFD)
    • Ghosh D (2000) Object-oriented transcription factors database (ooTFD). Nucl Acid Res 28: 308-310
    • (2000) Nucl Acid Res , vol.28 , pp. 308-310
    • Ghosh, D.1
  • 23
    • 36048994736 scopus 로고    scopus 로고
    • Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment
    • Hoelzinger DB, Demuth T, Berens ME (2007) Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment. J Natl Cancer Inst 99: 1583-1593
    • (2007) J Natl Cancer Inst , vol.99 , pp. 1583-1593
    • Hoelzinger, D.B.1    Demuth, T.2    Berens, M.E.3
  • 25
    • 79957905986 scopus 로고    scopus 로고
    • Molecular subclassification of diffuse gliomas: seeing order in the chaos
    • Huse JT, Phillips HS, Brennan CW (2011) Molecular subclassification of diffuse gliomas: seeing order in the chaos. Glia 59: 1190-1199
    • (2011) Glia , vol.59 , pp. 1190-1199
    • Huse, J.T.1    Phillips, H.S.2    Brennan, C.W.3
  • 26
    • 0036737914 scopus 로고    scopus 로고
    • Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro
    • Ignatova TN, Kukekov VG, Laywell ED, Suslov ON, Vrionis FD, Steindler DA (2002) Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia 39: 193-206
    • (2002) Glia , vol.39 , pp. 193-206
    • Ignatova, T.N.1    Kukekov, V.G.2    Laywell, E.D.3    Suslov, O.N.4    Vrionis, F.D.5    Steindler, D.A.6
  • 27
    • 0027992876 scopus 로고
    • Intracellular localization and function of DNA repair methyltransferase in human cells
    • Ishibashi T, Nakabeppu Y, Kawate H, Sakumi K, Hayakawa H, Sekiguchi M (1994) Intracellular localization and function of DNA repair methyltransferase in human cells. Mutat Res 315: 199-212
    • (1994) Mutat Res , vol.315 , pp. 199-212
    • Ishibashi, T.1    Nakabeppu, Y.2    Kawate, H.3    Sakumi, K.4    Hayakawa, H.5    Sekiguchi, M.6
  • 29
    • 84865302520 scopus 로고    scopus 로고
    • Activation of canonical WNT/beta-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition
    • Kahlert UD, Maciaczyk D, Doostkam S, Orr BA, Simons B, Bogiel T, Reithmeier T, Prinz M, Schubert J, Niedermann G, et al (2012) Activation of canonical WNT/beta-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition. Cancer Lett 325: 42-53
    • (2012) Cancer Lett , vol.325 , pp. 42-53
    • Kahlert, U.D.1    Maciaczyk, D.2    Doostkam, S.3    Orr, B.A.4    Simons, B.5    Bogiel, T.6    Reithmeier, T.7    Prinz, M.8    Schubert, J.9    Niedermann, G.10
  • 30
    • 79955702339 scopus 로고    scopus 로고
    • Deadly teamwork: neural cancer stem cells and the tumor microenvironment
    • Lathia JD, Heddleston JM, Venere M, Rich JN (2011) Deadly teamwork: neural cancer stem cells and the tumor microenvironment. Cell Stem Cell 8: 482-485
    • (2011) Cell Stem Cell , vol.8 , pp. 482-485
    • Lathia, J.D.1    Heddleston, J.M.2    Venere, M.3    Rich, J.N.4
  • 31
    • 17144398831 scopus 로고    scopus 로고
    • Possible future issues in the treatment of glioblastomas: special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis
    • Lefranc F, Brotchi J, Kiss R (2005) Possible future issues in the treatment of glioblastomas: special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis. J Clin Oncol 23: 2411-2422
    • (2005) J Clin Oncol , vol.23 , pp. 2411-2422
    • Lefranc, F.1    Brotchi, J.2    Kiss, R.3
  • 33
    • 84869875206 scopus 로고    scopus 로고
    • IL-1beta promotes stemness and invasiveness of colon cancer cells through Zeb1 activation
    • Li Y, Wang L, Pappan L, Galliher-Beckley A, Shi J (2012) IL-1beta promotes stemness and invasiveness of colon cancer cells through Zeb1 activation. Mol Cancer 11: 87
    • (2012) Mol Cancer , vol.11 , pp. 87
    • Li, Y.1    Wang, L.2    Pappan, L.3    Galliher-Beckley, A.4    Shi, J.5
  • 39
    • 46449115281 scopus 로고    scopus 로고
    • Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma
    • Murat A, Migliavacca E, Gorlia T, Lambiv WL, Shay T, Hamou MF, de Tribolet N, Regli L, Wick W, Kouwenhoven MC, et al (2008) Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma. J Clin Oncol 26: 3015-3024
    • (2008) J Clin Oncol , vol.26 , pp. 3015-3024
    • Murat, A.1    Migliavacca, E.2    Gorlia, T.3    Lambiv, W.L.4    Shay, T.5    Hamou, M.F.6    de Tribolet, N.7    Regli, L.8    Wick, W.9    Kouwenhoven, M.C.10
  • 41
    • 77952830726 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors
    • Ohashi S, Natsuizaka M, Wong GS, Michaylira CZ, Grugan KD, Stairs DB, Kalabis J, Vega ME, Kalman RA, Nakagawa M, et al (2010) Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors. Cancer Res 70: 4174-4184
    • (2010) Cancer Res , vol.70 , pp. 4174-4184
    • Ohashi, S.1    Natsuizaka, M.2    Wong, G.S.3    Michaylira, C.Z.4    Grugan, K.D.5    Stairs, D.B.6    Kalabis, J.7    Vega, M.E.8    Kalman, R.A.9    Nakagawa, M.10
  • 42
    • 78651336469 scopus 로고    scopus 로고
    • MethylViewer: computational analysis and editing for bisulfite sequencing and methyltransferase accessibility protocol for individual templates (MAPit) projects
    • Pardo CE, Carr IM, Hoffman CJ, Darst RP, Markham AF, Bonthron DT, Kladde MP (2011) MethylViewer: computational analysis and editing for bisulfite sequencing and methyltransferase accessibility protocol for individual templates (MAPit) projects. Nucl Acids Res 39: e5
    • (2011) Nucl Acids Res , vol.39
    • Pardo, C.E.1    Carr, I.M.2    Hoffman, C.J.3    Darst, R.P.4    Markham, A.F.5    Bonthron, D.T.6    Kladde, M.P.7
  • 45
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9: 265-273
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 46
    • 0041737535 scopus 로고    scopus 로고
    • Molecular mechanisms of glioma invasiveness: the role of proteases
    • Rao JS (2003) Molecular mechanisms of glioma invasiveness: the role of proteases. Nat Rev Cancer 3: 489-501
    • (2003) Nat Rev Cancer , vol.3 , pp. 489-501
    • Rao, J.S.1
  • 48
    • 0036800124 scopus 로고    scopus 로고
    • Activation of the repulsive receptor roundabout inhibits N-cadherin-mediated cell adhesion
    • Rhee J, Mahfooz NS, Arregui C, Lilien J, Balsamo J, VanBerkum MF (2002) Activation of the repulsive receptor roundabout inhibits N-cadherin-mediated cell adhesion. Nat Cell Biol 4: 798-805
    • (2002) Nat Cell Biol , vol.4 , pp. 798-805
    • Rhee, J.1    Mahfooz, N.S.2    Arregui, C.3    Lilien, J.4    Balsamo, J.5    VanBerkum, M.F.6
  • 49
    • 68549106083 scopus 로고    scopus 로고
    • E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    • Schmalhofer O, Brabletz S, Brabletz T (2009) E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer. Cancer Metastasis Rev 28: 151-166
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 151-166
    • Schmalhofer, O.1    Brabletz, S.2    Brabletz, T.3
  • 53
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
    • Singh A, Settleman J (2010) EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 29: 4741-4751
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 55
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • The Cancer Genome Atlas Research Network
    • The Cancer Genome Atlas Research Network (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455: 1061-1068
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 56
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 57
    • 80052428699 scopus 로고    scopus 로고
    • The social aspects of EMT-MET plasticity
    • Thompson EW, Haviv I (2011) The social aspects of EMT-MET plasticity. Nat Med 17: 1048-1049
    • (2011) Nat Med , vol.17 , pp. 1048-1049
    • Thompson, E.W.1    Haviv, I.2
  • 58
    • 0035990052 scopus 로고    scopus 로고
    • Relationship between the expression of E-, N-cadherins and beta-catenin and tumor grade in astrocytomas
    • Utsuki S, Sato Y, Oka H, Tsuchiya B, Suzuki S, Fujii K (2002) Relationship between the expression of E-, N-cadherins and beta-catenin and tumor grade in astrocytomas. J Neuro-Oncol 57: 187-192
    • (2002) J Neuro-Oncol , vol.57 , pp. 187-192
    • Utsuki, S.1    Sato, Y.2    Oka, H.3    Tsuchiya, B.4    Suzuki, S.5    Fujii, K.6
  • 59
    • 79957928264 scopus 로고    scopus 로고
    • Cancer stem cells in gliomas: identifying and understanding the apex cell in cancer's hierarchy
    • Venere M, Fine HA, Dirks PB, Rich JN (2011) Cancer stem cells in gliomas: identifying and understanding the apex cell in cancer's hierarchy. Glia 59: 1148-1154
    • (2011) Glia , vol.59 , pp. 1148-1154
    • Venere, M.1    Fine, H.A.2    Dirks, P.B.3    Rich, J.N.4
  • 60
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, Miller CR, Ding L, Golub T, Mesirov JP, et al (2010) Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17: 98-110
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6    Miller, C.R.7    Ding, L.8    Golub, T.9    Mesirov, J.P.10
  • 62
    • 65549141305 scopus 로고    scopus 로고
    • Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway
    • Wang Z, Li Y, Kong D, Banerjee S, Ahmad A, Azmi AS, Ali S, Abbruzzese JL, Gallick GE, Sarkar FH (2009) Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res 69: 2400-2407
    • (2009) Cancer Res , vol.69 , pp. 2400-2407
    • Wang, Z.1    Li, Y.2    Kong, D.3    Banerjee, S.4    Ahmad, A.5    Azmi, A.S.6    Ali, S.7    Abbruzzese, J.L.8    Gallick, G.E.9    Sarkar, F.H.10
  • 64
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen PY, Kesari S (2008) Malignant gliomas in adults. N Engl J Med 359: 492-507
    • (2008) N Engl J Med , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 66
    • 0026461785 scopus 로고
    • Glioblastoma: the past, the present, and the future
    • Wilson CB (1992) Glioblastoma: the past, the present, and the future. Clin Neurosurg 38: 32-48
    • (1992) Clin Neurosurg , vol.38 , pp. 32-48
    • Wilson, C.B.1
  • 67
    • 33748471285 scopus 로고    scopus 로고
    • Neurogenic astrocytes transplanted into the adult mouse lateral ventricle contribute to olfactory neurogenesis, and reveal a novel intrinsic subependymal neuron
    • Zheng T, Marshall GP, II, Laywell ED, Steindler DA (2006) Neurogenic astrocytes transplanted into the adult mouse lateral ventricle contribute to olfactory neurogenesis, and reveal a novel intrinsic subependymal neuron. Neuroscience 142: 175-185
    • (2006) Neuroscience , vol.142 , pp. 175-185
    • Zheng, T.1    Marshall II, G.P.2    Laywell, E.D.3    Steindler, D.A.4
  • 68
    • 34547132048 scopus 로고    scopus 로고
    • Predicting human tumor drug concentrations from a preclinical pharmacokinetic model of temozolomide brain disposition
    • Zhou Q, Guo P, Kruh GD, Vicini P, Wang X, Gallo JM (2007) Predicting human tumor drug concentrations from a preclinical pharmacokinetic model of temozolomide brain disposition. Clin Cancer Res 13: 4271-4279
    • (2007) Clin Cancer Res , vol.13 , pp. 4271-4279
    • Zhou, Q.1    Guo, P.2    Kruh, G.D.3    Vicini, P.4    Wang, X.5    Gallo, J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.