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Volumn 48, Issue , 2014, Pages 215-236

Cancer: Evolution within a lifetime

Author keywords

cancer evolution; drug resistance; genome instability; intratumor heterogeneity; precision medicine

Indexed keywords

ARTICLE; CANCER CELL; CANCER STEM CELL; CARCINOGENESIS; CHROMOSOME REARRANGEMENT; EVOLUTION; GENE MUTATION; GENETIC HETEROGENEITY; GENOME; GENOMIC INSTABILITY; HUMAN; LIFESPAN; MUTATION RATE; NEOPLASM; NONHUMAN; TUMOR BIOPSY; CHROMOSOME ABERRATION; GENETICS; MOLECULAR EVOLUTION; MUTATION; NEOPLASMS;

EID: 84913590602     PISSN: 00664197     EISSN: 15452948     Source Type: Book Series    
DOI: 10.1146/annurev-genet-120213-092314     Document Type: Article
Times cited : (162)

References (154)
  • 1
  • 4
    • 0003397692 scopus 로고    scopus 로고
    • Am. Cancer Soc. Atlanta, GA: Am. Cancer Soc
    • Am. Cancer Soc. 2012. Cancer Facts&Figures 2012. Atlanta, GA: Am. Cancer Soc. http://www. Cancer. org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-031941. pdf
    • (2012) Cancer Facts&Figures 2012
  • 5
    • 78751644099 scopus 로고    scopus 로고
    • Genetic variegation of clonal architecture and propagating cells in leukaemia
    • Anderson K, Lutz C, van Delft FW, Bateman CM, Guo Y, et al. 2011. Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature 469:356-61
    • (2011) Nature , vol.469 , pp. 356-361
    • Anderson, K.1    Lutz, C.2    Van Delft, F.W.3    Bateman, C.M.4    Guo, Y.5
  • 6
    • 84965187257 scopus 로고
    • The age distribution of cancer and a multi-stage theory of carcinogenesis
    • Armitage P, Doll R. 1954. The age distribution of cancer and a multi-stage theory of carcinogenesis. Br. J. Cancer 8:1-12
    • (1954) Br. J. Cancer , vol.8 , pp. 1-12
    • Armitage, P.1    Doll, R.2
  • 7
    • 84891701184 scopus 로고    scopus 로고
    • Acquired resistance to crizotinib from a mutation in CD74-ROS1
    • Awad MM, Engelman JA, Shaw AT. 2013. Acquired resistance to crizotinib from a mutation in CD74-ROS1. N. Engl. J. Med. 369:1173
    • (2013) N. Engl. J. Med. , vol.369 , pp. 1173
    • Awad, M.M.1    Engelman, J.A.2    Shaw, A.T.3
  • 9
    • 84861581164 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
    • Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, et al. 2012. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat. Genet. 44:685-89
    • (2012) Nat. Genet. , vol.44 , pp. 685-689
    • Barbieri, C.E.1    Baca, S.C.2    Lawrence, M.S.3    Demichelis, F.4    Blattner, M.5
  • 10
    • 79959858471 scopus 로고    scopus 로고
    • Two-phase resolution of polyploidy in the Arabidopsis metabolic network gives rise to relative and absolute dosage constraints
    • Bekaert M, Edger PP, Pires JC, Conant GC. 2011. Two-phase resolution of polyploidy in the Arabidopsis metabolic network gives rise to relative and absolute dosage constraints. Plant Cell 23:1719-28
    • (2011) Plant Cell , vol.23 , pp. 1719-1728
    • Bekaert, M.1    Edger, P.P.2    Pires, J.C.3    Conant, G.C.4
  • 12
    • 79956160582 scopus 로고    scopus 로고
    • Paradoxical relationship between chromosomal instability and survival outcome in cancer
    • Birkbak NJ, Eklund AC, Li Q, McClelland SE, Endesfelder D, et al. 2011. Paradoxical relationship between chromosomal instability and survival outcome in cancer. Cancer Res. 71:3447-52
    • (2011) Cancer Res. , vol.71 , pp. 3447-3452
    • Birkbak, N.J.1    Eklund, A.C.2    Li, Q.3    McClelland, S.E.4    Endesfelder, D.5
  • 13
    • 0029075933 scopus 로고
    • Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression
    • Boland CR, Sato J, Appelman HD, Bresalier RS, Feinberg AP. 1995. Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression. Nat. Med. 1:902-9
    • (1995) Nat. Med. , vol.1 , pp. 902-909
    • Boland, C.R.1    Sato, J.2    Appelman, H.D.3    Bresalier, R.S.4    Feinberg, A.P.5
  • 14
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. 1997. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3:730-37
    • (1997) Nat. Med. , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 15
    • 84899836282 scopus 로고    scopus 로고
    • Neo-Antigens predicted by tumor genome meta-Analysis correlate with increased patient survival
    • Brown SD, Warren RL, Gibb EA, Martin SD, Spinelli JJ, et al. 2014. Neo-Antigens predicted by tumor genome meta-Analysis correlate with increased patient survival. Genome Res. 24:743-50
    • (2014) Genome Res. , vol.24 , pp. 743-750
    • Brown, S.D.1    Warren, R.L.2    Gibb, E.A.3    Martin, S.D.4    Spinelli, J.J.5
  • 16
    • 84884365015 scopus 로고    scopus 로고
    • The causes and consequences of genetic heterogeneity in cancer evolution
    • Burrell RA, McGranahan N, Bartek J, Swanton C. 2013. The causes and consequences of genetic heterogeneity in cancer evolution. Nature 501:338-45
    • (2013) Nature , vol.501 , pp. 338-345
    • Burrell, R.A.1    McGranahan, N.2    Bartek, J.3    Swanton, C.4
  • 18
    • 78049380554 scopus 로고    scopus 로고
    • The patterns and dynamics of genomic instability in metastatic pancreatic cancer
    • Campbell PJ, Yachida S, Mudie LJ, Stephens PJ, Pleasance ED, et al. 2010. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature 467:1109-13
    • (2010) Nature , vol.467 , pp. 1109-1113
    • Campbell, P.J.1    Yachida, S.2    Mudie, L.J.3    Stephens, P.J.4    Pleasance, E.D.5
  • 19
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • Cancer Genome Atlas Netw
    • Cancer Genome Atlas Netw. 2011. Integrated genomic analyses of ovarian carcinoma. Nature 474:609-15
    • (2011) Nature , vol.474 , pp. 609-615
  • 20
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas Netw
    • Cancer Genome Atlas Netw. 2012. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487:330-37
    • (2012) Nature , vol.487 , pp. 330-337
  • 22
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • Chen J, Li Y, Yu TS, McKay RM, Burns DK, et al. 2012. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488:522-26
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.S.3    McKay, R.M.4    Burns, D.K.5
  • 23
    • 84877747678 scopus 로고    scopus 로고
    • DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer
    • Church DN, Briggs SE, Palles C, Domingo E, Kearsey SJ, et al. 2013. DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer. Hum. Mol. Genet. 22:2820-28
    • (2013) Hum. Mol. Genet. , vol.22 , pp. 2820-2828
    • Church, D.N.1    Briggs, S.E.2    Palles, C.3    Domingo, E.4    Kearsey, S.J.5
  • 25
    • 84897482887 scopus 로고    scopus 로고
    • Tumour cell heterogeneity maintained by cooperating subclones inWnt-driven mammary cancers
    • Cleary AS, Leonard TL, Gestl SA, Gunther EJ. 2014. Tumour cell heterogeneity maintained by cooperating subclones inWnt-driven mammary cancers. Nature 508:113-18
    • (2014) Nature , vol.508 , pp. 113-118
    • Cleary, A.S.1    Leonard, T.L.2    Gestl, S.A.3    Gunther, E.J.4
  • 27
    • 80054029091 scopus 로고    scopus 로고
    • The causes and consequences of polyploidy in normal development and cancer
    • Davoli T, de Lange T. 2011. The causes and consequences of polyploidy in normal development and cancer. Annu. Rev. Cell Dev. Biol. 27:585-610
    • (2011) Annu. Rev. Cell Dev. Biol. , vol.27 , pp. 585-610
    • Davoli, T.1    De Lange, T.2
  • 28
    • 77950932096 scopus 로고    scopus 로고
    • Persistent telomere damage induces bypass of mitosis and tetraploidy
    • Davoli T, Denchi EL, de Lange T. 2010. Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell 141:81-93
    • (2010) Cell , vol.141 , pp. 81-93
    • Davoli, T.1    Denchi, E.L.2    De T, L.3
  • 29
    • 84888087317 scopus 로고    scopus 로고
    • Intra-tumor heterogeneity: Lessons from microbial evolution and clinical implications
    • de Bruin EC, Taylor TB, Swanton C. 2013. Intra-tumor heterogeneity: lessons from microbial evolution and clinical implications. Genome Med. 5:101
    • (2013) Genome Med. , vol.5 , pp. 101
    • De Ec, B.1    Taylor, T.B.2    Swanton, C.3
  • 30
    • 84896711553 scopus 로고    scopus 로고
    • Tolerance of wholegenome doubling propagates chromosomal instability and accelerates cancer genome evolution
    • Dewhurst SM, McGranahan N, Burrell RA, Rowan AJ, Gronroos E, et al. 2014. Tolerance of wholegenome doubling propagates chromosomal instability and accelerates cancer genome evolution. Cancer Discov. 4:175-85
    • (2014) Cancer Discov. , vol.4 , pp. 175-185
    • Dewhurst, S.M.1    McGranahan, N.2    Burrell, R.A.3    Rowan, A.J.4    Gronroos, E.5
  • 31
    • 84863000299 scopus 로고    scopus 로고
    • The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
    • Diaz LA Jr, Williams RT, Wu J, Kinde I, Hecht JR, et al. 2012. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486:537-40
    • (2012) Nature , vol.486 , pp. 537-540
    • Diaz, L.A.1    Williams, R.T.2    Wu, J.3    Kinde, I.4    Hecht, J.R.5
  • 32
    • 77951139631 scopus 로고    scopus 로고
    • Genome remodelling in a basal-like breast cancer metastasis and xenograft
    • Ding L, Ellis MJ, Li S, Larson DE, Chen K, et al. 2010. Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature 464:999-1005
    • (2010) Nature , vol.464 , pp. 999-1005
    • Ding, L.1    Ellis, M.J.2    Li, S.3    Larson, D.E.4    Chen, K.5
  • 33
    • 84862776906 scopus 로고    scopus 로고
    • Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
    • Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, et al. 2012. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature 481:506-10
    • (2012) Nature , vol.481 , pp. 506-510
    • Ding, L.1    Ley, T.J.2    Larson, D.E.3    Miller, C.A.4    Koboldt, D.C.5
  • 35
    • 0035949485 scopus 로고    scopus 로고
    • Origin of multidrug resistance in cells with and without multidrug resistance genes: Chromosome reassortments catalyzed by aneuploidy
    • Duesberg P, Stindl R, Hehlmann R. 2001. Origin of multidrug resistance in cells with and without multidrug resistance genes: chromosome reassortments catalyzed by aneuploidy. Proc. Natl. Acad. Sci. USA 98:11283-88
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 11283-11288
    • Duesberg, P.1    Stindl, R.2    Hehlmann, R.3
  • 37
    • 77958004840 scopus 로고    scopus 로고
    • The ploidy conveyor of mature hepatocytes as a source of genetic variation
    • Duncan AW, Taylor MH, Hickey RD, Hanlon Newell AE, Lenzi ML, et al. 2010. The ploidy conveyor of mature hepatocytes as a source of genetic variation. Nature 467:707-10
    • (2010) Nature , vol.467 , pp. 707-710
    • Duncan, A.W.1    Taylor, M.H.2    Hickey, R.D.3    Hanlon Newell, A.E.4    Lenzi, M.L.5
  • 38
    • 84862584058 scopus 로고    scopus 로고
    • Whole-genome analysis informs breast cancer response to aromatase inhibition
    • Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, et al. 2012. Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature 486:353-60
    • (2012) Nature , vol.486 , pp. 353-360
    • Ellis, M.J.1    Ding, L.2    Shen, D.3    Luo, J.4    Suman, V.J.5
  • 39
    • 83455171954 scopus 로고    scopus 로고
    • Many tumors in one: A daunting therapeutic prospect
    • Ene CI, Fine HA. 2011. Many tumors in one: a daunting therapeutic prospect. Cancer Cell 20:695-97
    • (2011) Cancer Cell , vol.20 , pp. 695-697
    • Ene, C.I.1    Fine, H.A.2
  • 40
    • 0028887597 scopus 로고
    • Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer
    • Eshleman JR, Lang EZ, Bowerfind GK, Parsons R, Vogelstein B, et al. 1995. Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer. Oncogene 10:33-37
    • (1995) Oncogene , vol.10 , pp. 33-37
    • Eshleman, J.R.1    Lang, E.Z.2    Bowerfind, G.K.3    Parsons, R.4    Vogelstein, B.5
  • 41
    • 78649491016 scopus 로고    scopus 로고
    • Stage-specific sensitivity to p53 restoration during lung cancer progression
    • Feldser DM, Kostova KK, Winslow MM, Taylor SE, Cashman C, et al. 2010. Stage-specific sensitivity to p53 restoration during lung cancer progression. Nature 468:572-75
    • (2010) Nature , vol.468 , pp. 572-575
    • Feldser, D.M.1    Kostova, K.K.2    Winslow, M.M.3    Taylor, S.E.4    Cashman, C.5
  • 42
    • 0028153397 scopus 로고
    • Hybridization and origins of polyploidy
    • France D, Hebert PDN. 1994. Hybridization and origins of polyploidy. Proc. R. Soc. Lond. Ser. B 258(1352):141-46
    • (1994) Proc. R. Soc. Lond. Ser. B , vol.258 , Issue.1352 , pp. 141-146
    • France, D.1    Hebert, P.D.N.2
  • 43
    • 74949090309 scopus 로고    scopus 로고
    • The therapeutic promise of the cancer stem cell concept
    • Frank NY, Schatton T, Frank MH. 2010. The therapeutic promise of the cancer stem cell concept. J. Clin. Investig. 120:41-50
    • (2010) J. Clin. Investig. , vol.120 , pp. 41-50
    • Frank, N.Y.1    Schatton, T.2    Frank, M.H.3
  • 44
    • 27144507868 scopus 로고    scopus 로고
    • Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
    • Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, Pellman D. 2005. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 437:1043-47
    • (2005) Nature , vol.437 , pp. 1043-1047
    • Fujiwara, T.1    Bandi, M.2    Nitta, M.3    Ivanova, E.V.4    Bronson, R.T.5    Pellman, D.6
  • 45
    • 0030013170 scopus 로고    scopus 로고
    • 17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus
    • Galipeau PC, Cowan DS, Sanchez CA, Barrett MT, Emond MJ, et al. 1996. 17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus. Proc. Natl. Acad. Sci. USA 93:7081-84
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7081-7084
    • Galipeau, P.C.1    Cowan, D.S.2    Sanchez, C.A.3    Barrett, M.T.4    Emond, M.J.5
  • 47
    • 84895876130 scopus 로고    scopus 로고
    • Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
    • Gerlinger M, Horswell S, Larkin J, Rowan AJ, Salm MP, et al. 2014. Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing. Nat. Genet. 46:225-33
    • (2014) Nat. Genet. , vol.46 , pp. 225-233
    • Gerlinger, M.1    Horswell, S.2    Larkin, J.3    Rowan, A.J.4    Salm, M.P.5
  • 48
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, et al. 2012. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N. Engl. J. Med. 366:883-92
    • (2012) N. Engl. J. Med. , vol.366 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3    Larkin, J.4    Endesfelder, D.5
  • 49
    • 77958014613 scopus 로고    scopus 로고
    • How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine
    • Gerlinger M, Swanton C. 2010. How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine. Br. J. Cancer 103:1139-43
    • (2010) Br. J. Cancer , vol.103 , pp. 1139-1143
    • Gerlinger, M.1    Swanton, C.2
  • 50
    • 0019281223 scopus 로고
    • Chromosome-breakage syndromes: Different genes, different treatments, different cancers
    • German J. 1980. Chromosome-breakage syndromes: different genes, different treatments, different cancers. Basic Life Sci. 15:429-39
    • (1980) Basic Life Sci. , vol.15 , pp. 429-439
    • German, J.1
  • 51
    • 0014945242 scopus 로고
    • Fitness of an Escherichia coli mutator gene
    • Gibson TC, Scheppe ML, Cox EC. 1970. Fitness of an Escherichia coli mutator gene. Science 169:686-88
    • (1970) Science , vol.169 , pp. 686-688
    • Gibson, T.C.1    Scheppe, M.L.2    Cox, E.C.3
  • 53
    • 0034851729 scopus 로고    scopus 로고
    • Polyploidy associated with oxidative injury attenuates proliferative potential of cells
    • Gorla GR, Malhi H, Gupta S. 2001. Polyploidy associated with oxidative injury attenuates proliferative potential of cells. J. Cell Sci. 114:2943-51
    • (2001) J. Cell Sci. , vol.114 , pp. 2943-2951
    • Gorla, G.R.1    Malhi, H.2    Gupta, S.3
  • 54
    • 84866434919 scopus 로고    scopus 로고
    • Genomic landscape of non-small cell lung cancer in smokers and never-smokers
    • Govindan R, Ding L, Griffith M, Subramanian J, Dees ND, et al. 2012. Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell 150:1121-34
    • (2012) Cell , vol.150 , pp. 1121-1134
    • Govindan, R.1    Ding, L.2    Griffith, M.3    Subramanian, J.4    Dees, N.D.5
  • 55
    • 84863723010 scopus 로고    scopus 로고
    • The mutational landscape of lethal castration-resistant prostate cancer
    • Grasso CS, Wu YM, Robinson DR, Cao X, Dhanasekaran SM, et al. 2012. The mutational landscape of lethal castration-resistant prostate cancer. Nature 487:239-43
    • (2012) Nature , vol.487 , pp. 239-243
    • Grasso, C.S.1    Wu, Y.M.2    Robinson, D.R.3    Cao, X.4    Dhanasekaran, S.M.5
  • 56
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves M, Maley CC. 2012. Clonal evolution in cancer. Nature 481:306-13
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 57
    • 84872825418 scopus 로고    scopus 로고
    • Cancer stem cells as "units of selection
    • Greaves M. 2013. Cancer stem cells as "units of selection. " Evol. Appl. 6:102-8
    • (2013) Evol. Appl. , vol.6 , pp. 102-108
    • Greaves, M.1
  • 60
    • 73949088975 scopus 로고    scopus 로고
    • Life at the front of an expanding population
    • Hallatschek O, Nelson DR. 2010. Life at the front of an expanding population. Evolution 64:193-206
    • (2010) Evolution , vol.64 , pp. 193-206
    • Hallatschek, O.1    Nelson, D.R.2
  • 61
    • 77955886707 scopus 로고    scopus 로고
    • Somaticmutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer
    • Hennessy BT, Timms KM, Carey MS, Gutin A, Meyer LA, et al. 2010. Somaticmutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer. J. Clin. Oncol. 28:3570-76
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3570-3576
    • Hennessy, B.T.1    Timms, K.M.2    Carey, M.S.3    Gutin, A.4    Meyer, L.A.5
  • 62
    • 13144266670 scopus 로고    scopus 로고
    • Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
    • Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, et al. 1998. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc. Natl. Acad. Sci. USA 95:6870-75
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6870-6875
    • Herman, J.G.1    Umar, A.2    Polyak, K.3    Graff, J.R.4    Ahuja, N.5
  • 63
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, et al. 2005. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7:469-83
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1    Wang, L.2    Multani, A.S.3    Combs, C.4    Deramaudt, T.B.5
  • 65
    • 67649522162 scopus 로고    scopus 로고
    • Boveri revisited: Chromosomal instability, aneuploidy and tumorigenesis
    • Holland AJ, Cleveland DW. 2009. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat. Rev. Mol. Cell Biol. 10:478-87
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 478-487
    • Holland, A.J.1    Cleveland, D.W.2
  • 66
    • 84876704913 scopus 로고    scopus 로고
    • Polyploidy and the evolution of complex traits
    • Huminiecki L, Conant GC. 2012. Polyploidy and the evolution of complex traits. Int. J. Evol. Biol. 2012:292068
    • (2012) Int. J. Evol. Biol. , vol.2012 , pp. 292068
    • Huminiecki, L.1    Conant, G.C.2
  • 67
    • 33646256145 scopus 로고    scopus 로고
    • A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy
    • Hunter C, Smith R, Cahill DP, Stephens P, Stevens C, et al. 2006. A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. Cancer Res. 66:3987-91
    • (2006) Cancer Res. , vol.66 , pp. 3987-3991
    • Hunter, C.1    Smith, R.2    Cahill, D.P.3    Stephens, P.4    Stevens, C.5
  • 68
    • 77955911497 scopus 로고    scopus 로고
    • Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma
    • Inda MM, Bonavia R, Mukasa A, Narita Y, Sah DW, et al. 2010. Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev. 24:1731-45
    • (2010) Genes Dev. , vol.24 , pp. 1731-1745
    • Inda, M.M.1    Bonavia, R.2    Mukasa, A.3    Narita, Y.4    Sah, D.W.5
  • 69
    • 0035826732 scopus 로고    scopus 로고
    • Lessons from the past: Evolutionary impacts of mass extinctions
    • Jablonski D. 2001. Lessons from the past: evolutionary impacts of mass extinctions. Proc. Natl. Acad. Sci. USA 98:5393-98
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 5393-5398
    • Jablonski, D.1
  • 70
    • 84905370049 scopus 로고    scopus 로고
    • Tracking genomic cancer evolution for precision medicine: The lung TRACERx study
    • Jamal-Haniani M, Hackshaw A, Ngai Y, Shaw J, Dive C, et al. 2014. Tracking genomic cancer evolution for precision medicine: the lung TRACERx study. PLOS Biol. 12:e1001906
    • (2014) PLOS Biol. , vol.12 , pp. e1001906
    • Jamal-Haniani, M.1    Hackshaw, A.2    Ngai, Y.3    Shaw, J.4    Dive, C.5
  • 71
    • 84892373020 scopus 로고    scopus 로고
    • Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma
    • Johnson BE, Mazor T, Hong C, Barnes M, Aihara K, et al. 2014. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science 343:189-93
    • (2014) Science , vol.343 , pp. 189-193
    • Johnson, B.E.1    Mazor, T.2    Hong, C.3    Barnes, M.4    Aihara, K.5
  • 72
    • 35948974416 scopus 로고    scopus 로고
    • Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas
    • Jones AM, Thirlwell C, Howarth KM, Graham T, Chambers W, et al. 2007. Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas. J. Pathol. 213:249-56
    • (2007) J. Pathol. , vol.213 , pp. 249-256
    • Jones, A.M.1    Thirlwell, C.2    Howarth, K.M.3    Graham, T.4    Chambers, W.5
  • 74
    • 33947596504 scopus 로고    scopus 로고
    • Why is cancer drug discovery so difficult? Nat
    • Kamb A, Wee S, Lengauer C. 2007. Why is cancer drug discovery so difficult? Nat. Rev. Drug Discov. 6:115-20
    • (2007) Rev. Drug Discov. , vol.6 , pp. 115-120
    • Kamb, A.1    Wee, S.2    Lengauer, C.3
  • 75
    • 84861532638 scopus 로고    scopus 로고
    • Clonal competition with alternating dominance in multiple myeloma
    • Keats JJ, Chesi M, Egan JB, Garbitt VM, Palmer SE, et al. 2012. Clonal competition with alternating dominance in multiple myeloma. Blood 120:1067-76
    • (2012) Blood , vol.120 , pp. 1067-1076
    • Keats, J.J.1    Chesi, M.2    Egan, J.B.3    Garbitt, V.M.4    Palmer, S.E.5
  • 76
    • 84870341638 scopus 로고    scopus 로고
    • Why your new cancer biomarker may never work: Recurrent patterns and remarkable diversity in biomarker failures
    • Kern SE. 2012. Why your new cancer biomarker may never work: recurrent patterns and remarkable diversity in biomarker failures. Cancer Res. 72:6097-101
    • (2012) Cancer Res. , vol.72 , pp. 6097-6101
    • Kern, S.E.1
  • 78
    • 0028598147 scopus 로고
    • Evidence for multiple adaptive peaks from populations of bacteria evolving in a structured habitat
    • Korona R, Nakatsu CH, Forney LJ, Lenski RE. 1994. Evidence for multiple adaptive peaks from populations of bacteria evolving in a structured habitat. Proc. Natl. Acad. Sci. USA 91:9037-41
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 9037-9041
    • Korona, R.1    Nakatsu, C.H.2    Forney, L.J.3    Lenski, R.E.4
  • 80
    • 84874102335 scopus 로고    scopus 로고
    • Evolution and impact of subclonal mutations in chronic lymphocytic leukemia
    • Landau DA, Carter SL, Stojanov P, McKenna A, Stevenson K, et al. 2013. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell 152:714-26
    • (2013) Cell , vol.152 , pp. 714-726
    • Landau, D.A.1    Carter, S.L.2    Stojanov, P.3    McKenna, A.4    Stevenson, K.5
  • 81
  • 82
    • 84880507665 scopus 로고    scopus 로고
    • Mutational heterogeneity in cancer and the search for new cancer-Associated genes
    • Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, et al. 2013. Mutational heterogeneity in cancer and the search for new cancer-Associated genes. Nature 499:214-18
    • (2013) Nature , vol.499 , pp. 214-218
    • Lawrence, M.S.1    Stojanov, P.2    Polak, P.3    Kryukov, G.V.4    Cibulskis, K.5
  • 83
    • 0027145633 scopus 로고
    • Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
    • Leach FS, Nicolaides NC, Papadopoulos N, Liu B, Jen J, et al. 1993. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75:1215-25
    • (1993) Cell , vol.75 , pp. 1215-1225
    • Leach, F.S.1    Nicolaides, N.C.2    Papadopoulos, N.3    Liu, B.4    Jen, J.5
  • 85
    • 84864746573 scopus 로고    scopus 로고
    • A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers
    • Lee RS, Stewart C, Carter SL, Ambrogio L, Cibulskis K, et al. 2012. A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers. J. Clin. Investig. 122:2983-88
    • (2012) J. Clin. Investig. , vol.122 , pp. 2983-2988
    • Lee, R.S.1    Stewart, C.2    Carter, S.L.3    Ambrogio, L.4    Cibulskis, K.5
  • 86
    • 84863595550 scopus 로고    scopus 로고
    • The continuum model of selection in human tumors: General paradigm or niche product?
    • Leedham S, Tomlinson I. 2012. The continuum model of selection in human tumors: general paradigm or niche product? Cancer Res. 72:3131-34
    • (2012) Cancer Res. , vol.72 , pp. 3131-3134
    • Leedham, S.1    Tomlinson, I.2
  • 87
    • 0031004175 scopus 로고    scopus 로고
    • Genetic instability in colorectal cancers
    • Lengauer C, Kinzler KW, Vogelstein B. 1997. Genetic instability in colorectal cancers. Nature 386:623-27
    • (1997) Nature , vol.386 , pp. 623-627
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 88
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer C, Kinzler KW, Vogelstein B. 1998. Genetic instabilities in human cancers. Nature 396:643-49
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 89
    • 50249092801 scopus 로고    scopus 로고
    • Heterogeneity of kinase inhibitor resistance mechanisms in GIST
    • Liegl B, Kepten I, Le C, Zhu M, Demetri GD, et al. 2008. Heterogeneity of kinase inhibitor resistance mechanisms in GIST. J. Pathol. 216:64-74
    • (2008) J. Pathol. , vol.216 , pp. 64-74
    • Liegl, B.1    Kepten, I.2    Le Zhu C, M.3    Demetri, G.D.4
  • 90
    • 80052916562 scopus 로고    scopus 로고
    • Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements
    • Liu P, Erez A, Nagamani SC, Dhar SU, Kolodziejska KE, et al. 2011. Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements. Cell 146:889-903
    • (2011) Cell , vol.146 , pp. 889-903
    • Liu, P.1    Erez, A.2    Nagamani, S.C.3    Dhar, S.U.4    Kolodziejska, K.E.5
  • 91
    • 0025773554 scopus 로고
    • Mutator phenotype may be required for multistage carcinogenesis
    • Loeb LA. 1991. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 51:3075-79
    • (1991) Cancer Res. , vol.51 , pp. 3075-3079
    • Loeb, L.A.1
  • 92
    • 75749154085 scopus 로고    scopus 로고
    • Optimization of DNA polymerase mutation rates during bacterial evolution
    • Loh E, Salk JJ, Loeb LA. 2010. Optimization of DNA polymerase mutation rates during bacterial evolution. Proc. Natl. Acad. Sci. USA 107:1154-59
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 1154-1159
    • Loh, E.1    Salk, J.J.2    Loeb, L.A.3
  • 93
    • 84864540104 scopus 로고    scopus 로고
    • Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells
    • Lv L, Zhang T, Yi Q, Huang Y, Wang Z, et al. 2012. Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells. Cell Cycle 11:2864-75
    • (2012) Cell Cycle , vol.11 , pp. 2864-2875
    • Lv, L.1    Zhang, T.2    Yi, Q.3    Huang, Y.4    Wang, Z.5
  • 94
  • 97
    • 33645396945 scopus 로고    scopus 로고
    • Genetic clonal diversity predicts progression to esophageal adenocarcinoma
    • Maley CC, Galipeau PC, Finley JC, Wongsurawat VJ, Li X, et al. 2006. Genetic clonal diversity predicts progression to esophageal adenocarcinoma. Nat. Genet. 38:468-73
    • (2006) Nat. Genet. , vol.38 , pp. 468-473
    • Maley, C.C.1    Galipeau, P.C.2    Finley, J.C.3    Wongsurawat, V.J.4    Li, X.5
  • 98
    • 84866535011 scopus 로고    scopus 로고
    • Whole genome duplication affects evolvability of flowering time in an autotetraploid plant
    • Martin SL, Husband BC. 2012. Whole genome duplication affects evolvability of flowering time in an autotetraploid plant. PLOS ONE 7:e44784
    • (2012) PLOS ONE , vol.7 , pp. e44784
    • Martin, S.L.1    Husband, B.C.2
  • 99
    • 84861851519 scopus 로고    scopus 로고
    • Cancer chromosomal instability: Therapeutic and diagnostic challenges "exploring aneuploidy: The significance of chromosomal imbalance" review series
    • McGranahan N, Burrell RA, Endesfelder D, Novelli MR, Swanton C. 2012. Cancer chromosomal instability: therapeutic and diagnostic challenges. "Exploring aneuploidy: the significance of chromosomal imbalance" review series. EMBO Rep. 13:528-38
    • (2012) EMBO Rep. , vol.13 , pp. 528-538
    • McGranahan, N.1    Burrell, R.A.2    Endesfelder, D.3    Novelli, M.R.4    Swanton, C.5
  • 100
    • 84884377472 scopus 로고    scopus 로고
    • Tumour heterogeneity and cancer cell plasticity
    • Meacham CE, Morrison SJ. 2013. Tumour heterogeneity and cancer cell plasticity. Nature 501:328-37
    • (2013) Nature , vol.501 , pp. 328-337
    • Meacham, C.E.1    Morrison, S.J.2
  • 101
    • 76649116203 scopus 로고    scopus 로고
    • The role of genetic diversity in cancer
    • Merlo LM, Maley CC. 2010. The role of genetic diversity in cancer. J. Clin. Investig. 120:401-3
    • (2010) J. Clin. Investig. , vol.120 , pp. 401-403
    • Merlo, L.M.1    Maley, C.C.2
  • 102
    • 78649248733 scopus 로고    scopus 로고
    • A comprehensive survey of clonal diversity measures in Barrett's esophagus as biomarkers of progression to esophageal adenocarcinoma
    • Merlo LM, Shah NA, Li X, Blount PL, Vaughan TL, et al. 2010. A comprehensive survey of clonal diversity measures in Barrett's esophagus as biomarkers of progression to esophageal adenocarcinoma. Cancer Prev. Res. 3:1388-97
    • (2010) Cancer Prev. Res. , vol.3 , pp. 1388-1397
    • Merlo, L.M.1    Shah, N.A.2    Li, X.3    Blount, P.L.4    Vaughan, T.L.5
  • 103
    • 0019467329 scopus 로고
    • Mutation and cancer: Amodel for human carcinogenesis
    • Moolgavkar SH, Knudson AG Jr. 1981. Mutation and cancer: amodel for human carcinogenesis. J. Natl. Cancer Inst. 66:1037-52
    • (1981) J. Natl. Cancer Inst. , vol.66 , pp. 1037-1052
    • Moolgavkar, S.H.1    Knudson, A.G.2
  • 104
    • 50549201557 scopus 로고
    • The relation of recombination to mutational advance
    • Muller HJ. 1964. The relation of recombination to mutational advance. Mutat. Res. 106:2-9
    • (1964) Mutat. Res. , vol.106 , pp. 2-9
    • Muller, H.J.1
  • 105
    • 79953766940 scopus 로고    scopus 로고
    • Tumour evolution inferred by single-cell sequencing
    • Navin N, Kendall J, Troge J, Andrews P, Rodgers L, et al. 2011. Tumour evolution inferred by single-cell sequencing. Nature 472:90-94
    • (2011) Nature , vol.472 , pp. 90-94
    • Navin, N.1    Kendall, J.2    Troge, J.3    Andrews, P.4    Rodgers, L.5
  • 106
    • 74949101897 scopus 로고    scopus 로고
    • Inferring tumor progression from genomic heterogeneity
    • Navin N, Krasnitz A, Rodgers L, Cook K, Meth J, et al. 2010. Inferring tumor progression from genomic heterogeneity. Genome Res. 20:68-80
    • (2010) Genome Res. , vol.20 , pp. 68-80
    • Navin, N.1    Krasnitz, A.2    Rodgers, L.3    Cook, K.4    Meth, J.5
  • 108
    • 84870377034 scopus 로고    scopus 로고
    • A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas
    • Nikolaev SI, Sotiriou SK, Pateras IS, Santoni F, Sougioultzis S, et al. 2012. A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas. Cancer Res. 72:6279-89
    • (2012) Cancer Res. , vol.72 , pp. 6279-6289
    • Nikolaev, S.I.1    Sotiriou, S.K.2    Pateras, I.S.3    Santoni, F.4    Sougioultzis, S.5
  • 111
    • 78751661556 scopus 로고    scopus 로고
    • Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells
    • Notta F, Mullighan CG, Wang JC, Poeppl A, Doulatov S, et al. 2011. Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells. Nature 469:362-67
    • (2011) Nature , vol.469 , pp. 362-367
    • Notta, F.1    Mullighan, C.G.2    Wang, J.C.3    Poeppl, A.4    Doulatov, S.5
  • 112
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC. 1976. The clonal evolution of tumor cell populations. Science 194:23-28
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 114
    • 0034500239 scopus 로고    scopus 로고
    • Polyploid incidence and evolution
    • Otto SP, Whitton J. 2000. Polyploid incidence and evolution. Annu. Rev. Genet. 34:401-37
    • (2000) Annu. Rev. Genet. , vol.34 , pp. 401-437
    • Otto, S.P.1    Whitton, J.2
  • 115
    • 84873096362 scopus 로고    scopus 로고
    • Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
    • Palles C, Cazier JB, Howarth KM, Domingo E, Jones AM, et al. 2013. Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. Nat. Genet. 45:136-44
    • (2013) Nat. Genet. , vol.45 , pp. 136-144
    • Palles, C.1    Cazier, J.B.2    Howarth, K.M.3    Domingo, E.4    Jones, A.M.5
  • 116
    • 84888219405 scopus 로고    scopus 로고
    • Clinical and biological implications of driver mutations in myelodysplastic syndromes
    • Papaemmanuil E, Gerstung M, Malcovati L, Tauro S, Gundem G, et al. 2013. Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood 122:3616-27
    • (2013) Blood , vol.122 , pp. 3616-3627
    • Papaemmanuil, E.1    Gerstung, M.2    Malcovati, L.3    Tauro, S.4    Gundem, G.5
  • 117
    • 80053039210 scopus 로고    scopus 로고
    • Mutations in the p53 tumor suppressor gene: Important milestones at the various steps of tumorigenesis
    • Rivlin N, Brosh R, Oren M, Rotter V. 2011. Mutations in the p53 tumor suppressor gene: important milestones at the various steps of tumorigenesis. Genes Cancer 2:466-74
    • (2011) Genes Cancer , vol.2 , pp. 466-474
    • Rivlin, N.1    Brosh, R.2    Oren, M.3    Rotter, V.4
  • 118
    • 0036682481 scopus 로고    scopus 로고
    • Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
    • Roche-Lestienne C, Soenen-Cornu V, Grardel-Duflos N, Lai JL, Philippe N, et al. 2002. Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood 100:1014-18
    • (2002) Blood , vol.100 , pp. 1014-1018
    • Roche-Lestienne, C.1    Soenen-Cornu, V.2    Grardel-Duflos, N.3    Lai, J.L.4    Philippe, N.5
  • 119
    • 80053536086 scopus 로고    scopus 로고
    • Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer
    • Roylance R, Endesfelder D, Gorman P, Burrell RA, Sander J, et al. 2011. Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer. Cancer Epidemiol. Biomark. Prev. 20:2183-94
    • (2011) Cancer Epidemiol. Biomark. Prev. , vol.20 , pp. 2183-2194
    • Roylance, R.1    Endesfelder, D.2    Gorman, P.3    Burrell, R.A.4    Sander, J.5
  • 121
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah NP, Nicoll JM, Nagar B, Gorre ME, Paquette RL, et al. 2002. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2:117-25
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3    Gorre, M.E.4    Paquette, R.L.5
  • 122
    • 70349969478 scopus 로고    scopus 로고
    • Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
    • Shah SP, Morin RD, Khattra J, Prentice L, Pugh T, et al. 2009. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature 461:809-13
    • (2009) Nature , vol.461 , pp. 809-813
    • Shah, S.P.1    Morin, R.D.2    Khattra, J.3    Prentice, L.4    Pugh, T.5
  • 123
    • 84862526929 scopus 로고    scopus 로고
    • The clonal and mutational evolution spectrum of primary triple-negative breast cancers
    • Shah SP, Roth A, Goya R, Oloumi A, Ha G, et al. 2012. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature 486:395-99
    • (2012) Nature , vol.486 , pp. 395-399
    • Shah, S.P.1    Roth, A.2    Goya, R.3    Oloumi, A.4    Ha, G.5
  • 125
    • 83455176258 scopus 로고    scopus 로고
    • Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma
    • Snuderl M, Fazlollahi L, Le LP, Nitta M, Zhelyazkova BH, et al. 2011. Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma. Cancer Cell 20:810-17
    • (2011) Cancer Cell , vol.20 , pp. 810-817
    • Snuderl, M.1    Fazlollahi, L.2    Le Nitta, L.P.M.3    Zhelyazkova, B.H.4
  • 126
    • 79958103914 scopus 로고    scopus 로고
    • Modeling evolutionary dynamics of epigenetic mutations in hierarchically organized tumors
    • Sottoriva A, Vermeulen L, Tavare S. 2011. Modeling evolutionary dynamics of epigenetic mutations in hierarchically organized tumors. PLOS Comput. Biol. 7:e1001132
    • (2011) PLOS Comput. Biol. , vol.7 , pp. e1001132
    • Sottoriva, A.1    Vermeulen, L.2    Tavare, S.3
  • 128
    • 78650959663 scopus 로고    scopus 로고
    • Massive genomic rearrangement acquired in a single catastrophic event during cancer development
    • Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, et al. 2011. Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell 144:27-40
    • (2011) Cell , vol.144 , pp. 27-40
    • Stephens, P.J.1    Greenman, C.D.2    Fu, B.3    Yang, F.4    Bignell, G.R.5
  • 129
    • 84861576201 scopus 로고    scopus 로고
    • The landscape of cancer genes and mutational processes in breast cancer
    • Stephens PJ, Tarpey PS, Davies H, Van Loo P, Greenman C, et al. 2012. The landscape of cancer genes and mutational processes in breast cancer. Nature 486:400-4
    • (2012) Nature , vol.486 , pp. 400-404
    • Stephens, P.J.1    Tarpey, P.S.2    Davies, H.3    Van Loo, P.4    Greenman, C.5
  • 130
    • 84863011443 scopus 로고    scopus 로고
    • Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer
    • Su KY, Chen HY, Li KC, Kuo ML, Yang JC, et al. 2012. Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer. J. Clin. Oncol. 30:433-40
    • (2012) J. Clin. Oncol. , vol.30 , pp. 433-440
    • Su, K.Y.1    Chen, H.Y.2    Li, K.C.3    Kuo, M.L.4    Yang, J.C.5
  • 131
    • 84867121875 scopus 로고    scopus 로고
    • Intratumor heterogeneity: Evolution through space and time
    • Swanton C. 2012. Intratumor heterogeneity: evolution through space and time. Cancer Res. 72(19):4875-82
    • (2012) Cancer Res. , vol.72 , Issue.19 , pp. 4875-4882
    • Swanton, C.1
  • 134
    • 84873728334 scopus 로고    scopus 로고
    • Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance
    • Thakur MD, Salangsang F, Landman AS, Sellers WR, Pryer NK, et al. 2013. Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance. Nature 494(7436):251-55
    • (2013) Nature , vol.494 , Issue.7436 , pp. 251-255
    • Thakur, M.D.1    Salangsang, F.2    Landman, A.S.3    Sellers, W.R.4    Pryer, N.K.5
  • 135
    • 77949845433 scopus 로고    scopus 로고
    • Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas
    • Thirlwell C, Will OC, Domingo E, Graham TA, McDonald SA, et al. 2010. Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas. Gastroenterology 138:1441-54
    • (2010) Gastroenterology , vol.138 , pp. 1441-1454
    • Thirlwell, C.1    Will, O.C.2    Domingo, E.3    Graham, T.A.4    McDonald, S.A.5
  • 136
    • 33747153121 scopus 로고    scopus 로고
    • Ploidy controls the success of mutators and nature of mutations during budding yeast evolution
    • Thompson DA, Desai MM, Murray AW. 2006. Ploidy controls the success of mutators and nature of mutations during budding yeast evolution. Curr. Biol. 16:1581-90
    • (2006) Curr. Biol. , vol.16 , pp. 1581-1590
    • Thompson, D.A.1    Desai, M.M.2    Murray, A.W.3
  • 138
    • 84873441292 scopus 로고    scopus 로고
    • Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation
    • Tomasetti C, Vogelstein B, Parmigiani G. 2013. Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation. Proc. Natl. Acad. Sci. USA 110:1999-2004
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 1999-2004
    • Tomasetti, C.1    Vogelstein, B.2    Parmigiani, G.3
  • 141
    • 33646065584 scopus 로고
    • Ueber asymmetriche Zelltheilung in epithel Krebsen und deren biologische Bedeutung
    • von Hansemann D. 1890. Ueber asymmetriche Zelltheilung in epithel Krebsen und deren biologische Bedeutung. Virchow's Arch. Pathol. Anat. 119:299
    • (1890) Virchow's Arch. Pathol. Anat. , vol.119 , pp. 299
    • Von Hansemann, D.1
  • 142
    • 84864255882 scopus 로고    scopus 로고
    • The origin and evolution of mutations in acute myeloid leukemia
    • Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, et al. 2012. The origin and evolution of mutations in acute myeloid leukemia. Cell 150:264-78
    • (2012) Cell , vol.150 , pp. 264-278
    • Welch, J.S.1    Ley, T.J.2    Link, D.C.3    Miller, C.A.4    Larson, D.E.5
  • 143
    • 79959653996 scopus 로고    scopus 로고
    • SWI/SNF nucleosome remodellers and cancer
    • Wilson BG, Roberts CW. 2011. SWI/SNF nucleosome remodellers and cancer. Nat. Rev. Cancer 11:481-92
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 481-492
    • Wilson, B.G.1    Roberts, C.W.2
  • 144
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, et al. 2007. The genomic landscapes of human breast and colorectal cancers. Science 318:1108-13
    • (2007) Science , vol.318 , pp. 1108-1113
    • Wood, L.D.1    Parsons, D.W.2    Jones, S.3    Lin, J.4    Sjoblom, T.5
  • 145
    • 0035859859 scopus 로고    scopus 로고
    • SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway
    • Woodford-Richens KL, Rowan AJ, Gorman P, Halford S, Bicknell DC, et al. 2001. SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway. Proc. Natl. Acad. Sci. USA 98:9719-23
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9719-9723
    • Woodford-Richens, K.L.1    Rowan, A.J.2    Gorman, P.3    Halford, S.4    Bicknell, D.C.5
  • 146
    • 75749106942 scopus 로고    scopus 로고
    • Interaction between RasV12 and scribbled clones induces tumour growth and invasion
    • Wu M, Pastor-Pareja JC, Xu T. 2010. Interaction between RasV12 and scribbled clones induces tumour growth and invasion. Nature 463:545-48
    • (2010) Nature , vol.463 , pp. 545-548
    • Wu, M.1    Pastor-Pareja, J.C.2    Xu, T.3
  • 147
    • 84862776537 scopus 로고    scopus 로고
    • Clonal selection drives genetic divergence of metastatic medulloblastoma
    • Wu X, Northcott PA, Dubuc A, Dupuy AJ, Shih DJ, et al. 2012. Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature 482:529-33
    • (2012) Nature , vol.482 , pp. 529-533
    • Wu, X.1    Northcott, P.A.2    Dubuc, A.3    Dupuy, A.J.4    Shih, D.J.5
  • 148
    • 84863230091 scopus 로고    scopus 로고
    • Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor
    • Xu X, Hou Y, Yin X, Bao L, Tang A, et al. 2012. Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell 148:886-95
    • (2012) Cell , vol.148 , pp. 886-895
    • Xu, X.1    Hou, Y.2    Yin, X.3    Bao, L.4    Tang, A.5
  • 151
    • 62149092895 scopus 로고    scopus 로고
    • Genome based cell population heterogeneity promotes tumorigenicity: The evolutionary mechanism of cancer
    • Ye CJ, Stevens JB, Liu G, Bremer SW, Jaiswal AS, et al. 2009. Genome based cell population heterogeneity promotes tumorigenicity: the evolutionary mechanism of cancer. J. Cell. Physiol. 219:288-300
    • (2009) J. Cell. Physiol. , vol.219 , pp. 288-300
    • Ye, C.J.1    Stevens, J.B.2    Liu, G.3    Bremer, S.W.4    Jaiswal, A.S.5
  • 152
    • 68049095262 scopus 로고    scopus 로고
    • MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance
    • Yip S, Miao J, Cahill DP, Iafrate AJ, Aldape K, et al. 2009. MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance. Clin. Cancer Res. 15:4622-29
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4622-4629
    • Yip, S.1    Miao, J.2    Cahill, D.P.3    Iafrate, A.J.4    Aldape, K.5
  • 153
    • 0027452417 scopus 로고
    • Genomic instability occurs in colorectal carcinomas but not in adenomas
    • Young J, Leggett B, Gustafson C, Ward M, Searle J, et al. 1993. Genomic instability occurs in colorectal carcinomas but not in adenomas. Hum. Mutat. 2:351-54
    • (1993) Hum. Mutat. , vol.2 , pp. 351-354
    • Young, J.1    Leggett, B.2    Gustafson, C.3    Ward, M.4    Searle, J.5


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