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Volumn 41, Issue , 2016, Pages 37-43

Structural and functional changes within the gut microbiota and susceptibility to Clostridium difficile infection

Author keywords

CDI; Clostridium difficile; Metabolome; Microbiome

Indexed keywords

AMINO ACID;

EID: 84969581211     PISSN: 10759964     EISSN: 10958274     Source Type: Journal    
DOI: 10.1016/j.anaerobe.2016.05.006     Document Type: Article
Times cited : (57)

References (145)
  • 1
    • 84897005978 scopus 로고    scopus 로고
    • Multistate point-prevalence survey of health care-associated infections
    • [1] Magill, S.S., et al. Multistate point-prevalence survey of health care-associated infections. N. Engl. J. Med. 370 (2014), 1198–1208.
    • (2014) N. Engl. J. Med. , vol.370 , pp. 1198-1208
    • Magill, S.S.1
  • 2
    • 55249105923 scopus 로고    scopus 로고
    • Clostridium difficile–more difficult than ever
    • [2] Kelly, C.P., LaMont, J.T., Clostridium difficile–more difficult than ever. N. Engl. J. Med. 359 (2008), 1932–1940.
    • (2008) N. Engl. J. Med. , vol.359 , pp. 1932-1940
    • Kelly, C.P.1    LaMont, J.T.2
  • 3
    • 84930809918 scopus 로고    scopus 로고
    • Burden of Clostridium difficile infection in the United States
    • [3] Lessa, F.C., Winston, L.G., McDonald, L.C., E. I. P. C. d. S. Team. Burden of Clostridium difficile infection in the United States. N. Engl. J. Med. 372 (2015), 2369–2370.
    • (2015) N. Engl. J. Med. , vol.372 , pp. 2369-2370
    • Lessa, F.C.1    Winston, L.G.2    McDonald, L.C.3
  • 4
    • 0031958706 scopus 로고    scopus 로고
    • Clostridium difficile infection
    • [4] Kelly, C.P., LaMont, J.T., Clostridium difficile infection. Annu. Rev. Med. 49 (1998), 375–390.
    • (1998) Annu. Rev. Med. , vol.49 , pp. 375-390
    • Kelly, C.P.1    LaMont, J.T.2
  • 5
    • 17444366186 scopus 로고    scopus 로고
    • Clostridium difficile toxins: mechanism of action and role in disease
    • [5] Voth, D.E., Ballard, J.D., Clostridium difficile toxins: mechanism of action and role in disease. Clin. Microbiol. Rev. 18 (2005), 247–263.
    • (2005) Clin. Microbiol. Rev. , vol.18 , pp. 247-263
    • Voth, D.E.1    Ballard, J.D.2
  • 6
    • 0029054398 scopus 로고
    • Glucosylation of Rho proteins by Clostridium difficile toxin B
    • [6] Just, I., et al. Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature 375 (1995), 500–503.
    • (1995) Nature , vol.375 , pp. 500-503
    • Just, I.1
  • 7
    • 0029011449 scopus 로고
    • The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins
    • [7] Just, I., et al. The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins. J. Biol. Chem. 270 (1995), 13932–13936.
    • (1995) J. Biol. Chem. , vol.270 , pp. 13932-13936
    • Just, I.1
  • 8
    • 84868203487 scopus 로고    scopus 로고
    • Immune responses to Clostridium difficile infection
    • [8] Madan, R., Petri, W.A. Jr., Immune responses to Clostridium difficile infection. Trends Mol. Med. 18 (2012), 658–666.
    • (2012) Trends Mol. Med. , vol.18 , pp. 658-666
    • Madan, R.1    Petri, W.A.2
  • 9
    • 0034628426 scopus 로고    scopus 로고
    • Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A
    • [9] Kyne, L., Warny, M., Qamar, A., Kelly, C.P., Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N. Engl. J. Med. 342 (2000), 390–397.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 390-397
    • Kyne, L.1    Warny, M.2    Qamar, A.3    Kelly, C.P.4
  • 10
    • 79960420811 scopus 로고    scopus 로고
    • The host immune response to Clostridium difficile
    • [10] Kelly, C.P., Kyne, L., The host immune response to Clostridium difficile. J. Med. Microbiol. 60 (2011), 1070–1079.
    • (2011) J. Med. Microbiol. , vol.60 , pp. 1070-1079
    • Kelly, C.P.1    Kyne, L.2
  • 11
    • 84865966570 scopus 로고    scopus 로고
    • IgG antibody response to toxins A and B in patients with Clostridium difficile infection
    • [11] Wullt, M., Norén, T., Ljungh, A., Åkerlund, T., IgG antibody response to toxins A and B in patients with Clostridium difficile infection. Clin. Vaccine Immunol. 19 (2012), 1552–1554.
    • (2012) Clin. Vaccine Immunol. , vol.19 , pp. 1552-1554
    • Wullt, M.1    Norén, T.2    Ljungh, A.3    Åkerlund, T.4
  • 12
    • 74249096590 scopus 로고    scopus 로고
    • Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI)
    • [12] Leav, B.A., et al. Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI). Vaccine 28 (2010), 965–969.
    • (2010) Vaccine , vol.28 , pp. 965-969
    • Leav, B.A.1
  • 13
    • 63849154839 scopus 로고    scopus 로고
    • Clinical risk factors for severe Clostridium difficile-associated disease
    • [13] Henrich, T.J., Krakower, D., Bitton, A., Yokoe, D.S., Clinical risk factors for severe Clostridium difficile-associated disease. Emerg. Infect. Dis. 15 (2009), 415–422.
    • (2009) Emerg. Infect. Dis. , vol.15 , pp. 415-422
    • Henrich, T.J.1    Krakower, D.2    Bitton, A.3    Yokoe, D.S.4
  • 14
    • 56849106496 scopus 로고    scopus 로고
    • The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing
    • [14] Dethlefsen, L., Huse, S., Sogin, M.L., Relman, D.A., The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol., 6, 2008, e280.
    • (2008) PLoS Biol. , vol.6 , pp. e280
    • Dethlefsen, L.1    Huse, S.2    Sogin, M.L.3    Relman, D.A.4
  • 15
    • 79952756960 scopus 로고    scopus 로고
    • Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
    • [15] Dethlefsen, L., Relman, D.A., Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc. Natl. Acad. Sci. U. S. A. 108:Suppl. 1 (2011), 4554–4561.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 4554-4561
    • Dethlefsen, L.1    Relman, D.A.2
  • 16
    • 79953170241 scopus 로고    scopus 로고
    • Effect of antibiotic treatment on the intestinal metabolome
    • [16] Antunes, L.C., et al. Effect of antibiotic treatment on the intestinal metabolome. Antimicrob. Agents Chemother. 55 (2011), 1494–1503.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 1494-1503
    • Antunes, L.C.1
  • 17
    • 84890317759 scopus 로고    scopus 로고
    • Microbial targets for the development of functional foods accordingly with nutritional and immune parameters altered in the elderly
    • [17] Salazar, N., et al. Microbial targets for the development of functional foods accordingly with nutritional and immune parameters altered in the elderly. J. Am. Coll. Nutr. 32 (2013), 399–406.
    • (2013) J. Am. Coll. Nutr. , vol.32 , pp. 399-406
    • Salazar, N.1
  • 18
    • 84870999292 scopus 로고    scopus 로고
    • Intestinal colonization resistance
    • [18] Lawley, T.D., Walker, A.W., Intestinal colonization resistance. Immunology 138 (2013), 1–11.
    • (2013) Immunology , vol.138 , pp. 1-11
    • Lawley, T.D.1    Walker, A.W.2
  • 19
    • 84862770598 scopus 로고    scopus 로고
    • Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance
    • [19] Britton, R.A., Young, V.B., Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance. Trends Microbiol. 20 (2012), 313–319.
    • (2012) Trends Microbiol. , vol.20 , pp. 313-319
    • Britton, R.A.1    Young, V.B.2
  • 20
    • 84927662069 scopus 로고    scopus 로고
    • Microbiota-mediated inflammation and antimicrobial defense in the intestine
    • [20] Caballero, S., Pamer, E.G., Microbiota-mediated inflammation and antimicrobial defense in the intestine. Annu. Rev. Immunol. 33 (2015), 227–256.
    • (2015) Annu. Rev. Immunol. , vol.33 , pp. 227-256
    • Caballero, S.1    Pamer, E.G.2
  • 21
    • 79251585301 scopus 로고    scopus 로고
    • Paneth cell defensins and the regulation of the microbiome: détente at mucosal surfaces
    • [21] Salzman, N.H., Paneth cell defensins and the regulation of the microbiome: détente at mucosal surfaces. Gut Microbes 1 (2010), 401–406.
    • (2010) Gut Microbes , vol.1 , pp. 401-406
    • Salzman, N.H.1
  • 22
    • 84885573828 scopus 로고    scopus 로고
    • Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens
    • [22] Ng, K.M., et al. Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens. Nature 502 (2013), 96–99.
    • (2013) Nature , vol.502 , pp. 96-99
    • Ng, K.M.1
  • 23
    • 84872517425 scopus 로고    scopus 로고
    • Nutritional basis for colonization resistance by human commensal Escherichia coli strains HS and Nissle 1917 against E. coli O157:H7 in the mouse intestine
    • [23] Maltby, R., Leatham-Jensen, M.P., Gibson, T., Cohen, P.S., Conway, T., Nutritional basis for colonization resistance by human commensal Escherichia coli strains HS and Nissle 1917 against E. coli O157:H7 in the mouse intestine. PLoS One, 8, 2013, e53957.
    • (2013) PLoS One , vol.8 , pp. e53957
    • Maltby, R.1    Leatham-Jensen, M.P.2    Gibson, T.3    Cohen, P.S.4    Conway, T.5
  • 24
    • 0023751801 scopus 로고
    • Role of competition for nutrients in suppression of Clostridium difficile by the colonic microflora
    • [24] Wilson, K.H., Perini, F., Role of competition for nutrients in suppression of Clostridium difficile by the colonic microflora. Infect. Immun. 56 (1988), 2610–2614.
    • (1988) Infect. Immun. , vol.56 , pp. 2610-2614
    • Wilson, K.H.1    Perini, F.2
  • 25
    • 0037115014 scopus 로고    scopus 로고
    • Colonization for the prevention of Clostridium difficile disease in hamsters
    • [25] Sambol, S.P., Merrigan, M.M., Tang, J.K., Johnson, S., Gerding, D.N., Colonization for the prevention of Clostridium difficile disease in hamsters. J. Infect. Dis. 186 (2002), 1781–1789.
    • (2002) J. Infect. Dis. , vol.186 , pp. 1781-1789
    • Sambol, S.P.1    Merrigan, M.M.2    Tang, J.K.3    Johnson, S.4    Gerding, D.N.5
  • 26
    • 77649282955 scopus 로고    scopus 로고
    • Metabolism of bile salts in mice influences spore germination in Clostridium difficile
    • [26] Giel, J.L., Sorg, J.A., Sonenshein, A.L., Zhu, J., Metabolism of bile salts in mice influences spore germination in Clostridium difficile. PLoS One, 5, 2010, e8740.
    • (2010) PLoS One , vol.5 , pp. e8740
    • Giel, J.L.1    Sorg, J.A.2    Sonenshein, A.L.3    Zhu, J.4
  • 27
    • 33244467651 scopus 로고    scopus 로고
    • Bile salt biotransformations by human intestinal bacteria
    • [27] Ridlon, J.M., Kang, D.J., Hylemon, P.B., Bile salt biotransformations by human intestinal bacteria. J. Lipid Res. 47 (2006), 241–259.
    • (2006) J. Lipid Res. , vol.47 , pp. 241-259
    • Ridlon, J.M.1    Kang, D.J.2    Hylemon, P.B.3
  • 28
    • 84964280002 scopus 로고    scopus 로고
    • Antibiotic-induced alterations of the gut microbiota alter secondary bile acid production and allow for Clostridium difficile spore germination and outgrowth in the large intestine
    • e00045-15
    • [28] Theriot, C.M., Bowman, A.A., Young, V.B., Antibiotic-induced alterations of the gut microbiota alter secondary bile acid production and allow for Clostridium difficile spore germination and outgrowth in the large intestine. mSphere, 1, 2016 e00045-15.
    • (2016) mSphere , vol.1
    • Theriot, C.M.1    Bowman, A.A.2    Young, V.B.3
  • 29
    • 84892894991 scopus 로고    scopus 로고
    • Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection
    • [29] Theriot, C.M., et al. Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection. Nat. Commun., 5, 2014, 3114.
    • (2014) Nat. Commun. , vol.5 , pp. 3114
    • Theriot, C.M.1
  • 30
    • 84903785994 scopus 로고    scopus 로고
    • Metabolomics analysis identifies intestinal microbiota-derived biomarkers of colonization resistance in clindamycin-treated mice
    • [30] Jump, R.L., et al. Metabolomics analysis identifies intestinal microbiota-derived biomarkers of colonization resistance in clindamycin-treated mice. PLoS One, 9, 2014, e101267.
    • (2014) PLoS One , vol.9 , pp. e101267
    • Jump, R.L.1
  • 31
    • 84866158239 scopus 로고    scopus 로고
    • Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop
    • [31] Hasegawa, M., et al. Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop. J. Immunol. 189 (2012), 3085–3091.
    • (2012) J. Immunol. , vol.189 , pp. 3085-3091
    • Hasegawa, M.1
  • 32
    • 53649098280 scopus 로고    scopus 로고
    • Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits
    • [32] Brandl, K., et al. Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits. Nature 455 (2008), 804–807.
    • (2008) Nature , vol.455 , pp. 804-807
    • Brandl, K.1
  • 33
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • [33] Atarashi, K., et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331 (2011), 337–341.
    • (2011) Science , vol.331 , pp. 337-341
    • Atarashi, K.1
  • 34
    • 0033006564 scopus 로고    scopus 로고
    • Differential roles of segmented filamentous bacteria and clostridia in development of the intestinal immune system
    • [34] Umesaki, Y., Setoyama, H., Matsumoto, S., Imaoka, A., Itoh, K., Differential roles of segmented filamentous bacteria and clostridia in development of the intestinal immune system. Infect. Immun. 67 (1999), 3504–3511.
    • (1999) Infect. Immun. , vol.67 , pp. 3504-3511
    • Umesaki, Y.1    Setoyama, H.2    Matsumoto, S.3    Imaoka, A.4    Itoh, K.5
  • 35
    • 84903648103 scopus 로고    scopus 로고
    • Role of microbiota and innate immunity in recurrent Clostridium difficile infection
    • [35] Bibbò, S., et al. Role of microbiota and innate immunity in recurrent Clostridium difficile infection. J. Immunol. Res., 2014, 2014, 462740.
    • (2014) J. Immunol. Res. , vol.2014 , pp. 462740
    • Bibbò, S.1
  • 36
    • 84899812464 scopus 로고    scopus 로고
    • Real-time polymerase chain reaction detection of asymptomatic Clostridium difficile colonization and rising C. difficile-associated disease rates
    • [36] Koo, H.L., et al. Real-time polymerase chain reaction detection of asymptomatic Clostridium difficile colonization and rising C. difficile-associated disease rates. Infect. Control Hosp. Epidemiol. 35 (2014), 667–673.
    • (2014) Infect. Control Hosp. Epidemiol. , vol.35 , pp. 667-673
    • Koo, H.L.1
  • 37
    • 84885955622 scopus 로고    scopus 로고
    • Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection
    • [37] Planche, T.D., et al. Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection. Lancet Infect. Dis. 13 (2013), 936–945.
    • (2013) Lancet Infect. Dis. , vol.13 , pp. 936-945
    • Planche, T.D.1
  • 38
    • 84933278122 scopus 로고    scopus 로고
    • Impact of polymerase chain reaction testing on Clostridium difficile infection rates in an acute health care facility
    • [38] Murad, Y.M., et al. Impact of polymerase chain reaction testing on Clostridium difficile infection rates in an acute health care facility. Am. J. Infect. Control 43 (2015), 383–386.
    • (2015) Am. J. Infect. Control , vol.43 , pp. 383-386
    • Murad, Y.M.1
  • 39
    • 84946124203 scopus 로고    scopus 로고
    • Diagnosis of Clostridium difficile infection: treat the patient, not the test
    • [39] Dubberke, E.R., Burnham, C.A., Diagnosis of Clostridium difficile infection: treat the patient, not the test. JAMA Intern Med. 175 (2015), 1801–1802.
    • (2015) JAMA Intern Med. , vol.175 , pp. 1801-1802
    • Dubberke, E.R.1    Burnham, C.A.2
  • 40
    • 84946147732 scopus 로고    scopus 로고
    • Overdiagnosis of Clostridium difficile infection in the molecular test era
    • [40] Polage, C.R., et al. Overdiagnosis of Clostridium difficile infection in the molecular test era. JAMA Intern Med. 175 (2015), 1792–1801.
    • (2015) JAMA Intern Med. , vol.175 , pp. 1792-1801
    • Polage, C.R.1
  • 41
    • 84946866565 scopus 로고    scopus 로고
    • A high rate of alternative diagnoses in patients referred for presumed Clostridium difficile infection
    • 41 Jackson, M., Olefson, S., Machan, J.T., Kelly, C.R., A high rate of alternative diagnoses in patients referred for presumed Clostridium difficile infection. J. Clin. Gastroenterol., 2015, 10.1097/MCG.0000000000000447.
    • (2015) J. Clin. Gastroenterol.
    • Jackson, M.1    Olefson, S.2    Machan, J.T.3    Kelly, C.R.4
  • 42
    • 0027441911 scopus 로고
    • Evaluation of four commercially available enzyme immunoassays for laboratory diagnosis of Clostridium difficile-associated diseases
    • [42] Whittier, S., et al. Evaluation of four commercially available enzyme immunoassays for laboratory diagnosis of Clostridium difficile-associated diseases. J. Clin. Microbiol. 31 (1993), 2861–2865.
    • (1993) J. Clin. Microbiol. , vol.31 , pp. 2861-2865
    • Whittier, S.1
  • 43
    • 84929949214 scopus 로고    scopus 로고
    • Optimizing the laboratory diagnosis of Clostridium difficile infection
    • [43] Gilligan, P.H., Optimizing the laboratory diagnosis of Clostridium difficile infection. Clin. Lab. Med. 35 (2015), 299–312.
    • (2015) Clin. Lab. Med. , vol.35 , pp. 299-312
    • Gilligan, P.H.1
  • 44
    • 38149108080 scopus 로고    scopus 로고
    • Rapid and reliable diagnostic algorithm for detection of Clostridium difficile
    • [44] Fenner, L., Widmer, A.F., Goy, G., Rudin, S., Frei, R., Rapid and reliable diagnostic algorithm for detection of Clostridium difficile. J. Clin. Microbiol. 46 (2008), 328–330.
    • (2008) J. Clin. Microbiol. , vol.46 , pp. 328-330
    • Fenner, L.1    Widmer, A.F.2    Goy, G.3    Rudin, S.4    Frei, R.5
  • 45
    • 0032614375 scopus 로고    scopus 로고
    • Recurrent Clostridium difficile disease: epidemiology and clinical characteristics
    • [45] McFarland, L.V., et al. Recurrent Clostridium difficile disease: epidemiology and clinical characteristics. Infect. Control Hosp. Epidemiol. 20 (1999), 43–50.
    • (1999) Infect. Control Hosp. Epidemiol. , vol.20 , pp. 43-50
    • McFarland, L.V.1
  • 46
    • 84868546746 scopus 로고    scopus 로고
    • Can we identify patients at high risk of recurrent Clostridium difficile infection?
    • [46] Kelly, C.P., Can we identify patients at high risk of recurrent Clostridium difficile infection?. Clin. Microbiol. Infect. 18:Suppl. 6 (2012), 21–27.
    • (2012) Clin. Microbiol. Infect. , vol.18 , pp. 21-27
    • Kelly, C.P.1
  • 47
    • 56249107224 scopus 로고    scopus 로고
    • Meta-analysis to assess risk factors for recurrent Clostridium difficile infection
    • [47] Garey, K.W., Sethi, S., Yadav, Y., DuPont, H.L., Meta-analysis to assess risk factors for recurrent Clostridium difficile infection. J. Hosp. Infect. 70 (2008), 298–304.
    • (2008) J. Hosp. Infect. , vol.70 , pp. 298-304
    • Garey, K.W.1    Sethi, S.2    Yadav, Y.3    DuPont, H.L.4
  • 48
    • 81855199757 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled pilot study to assess the ability of rifaximin to prevent recurrent diarrhoea in patients with Clostridium difficile infection
    • [48] Garey, K.W., et al. A randomized, double-blind, placebo-controlled pilot study to assess the ability of rifaximin to prevent recurrent diarrhoea in patients with Clostridium difficile infection. J. Antimicrob. Chemother. 66 (2011), 2850–2855.
    • (2011) J. Antimicrob. Chemother. , vol.66 , pp. 2850-2855
    • Garey, K.W.1
  • 49
    • 77952564778 scopus 로고    scopus 로고
    • Economic healthcare costs of Clostridium difficile infection: a systematic review
    • [49] Ghantoji, S.S., Sail, K., Lairson, D.R., DuPont, H.L., Garey, K.W., Economic healthcare costs of Clostridium difficile infection: a systematic review. J. Hosp. Infect. 74 (2010), 309–318.
    • (2010) J. Hosp. Infect. , vol.74 , pp. 309-318
    • Ghantoji, S.S.1    Sail, K.2    Lairson, D.R.3    DuPont, H.L.4    Garey, K.W.5
  • 50
    • 84863661973 scopus 로고    scopus 로고
    • Relapse versus reinfection: recurrent Clostridium difficile infection following treatment with fidaxomicin or vancomycin
    • [50] Figueroa, I., et al. Relapse versus reinfection: recurrent Clostridium difficile infection following treatment with fidaxomicin or vancomycin. Clin. Infect. Dis. 55:Suppl. 2 (2012), S104–S109.
    • (2012) Clin. Infect. Dis. , vol.55 , pp. S104-S109
    • Figueroa, I.1
  • 51
    • 84922146498 scopus 로고    scopus 로고
    • Clinical efficacy of fidaxomicin compared with vancomycin and metronidazole in Clostridium difficile infections: a meta-analysis and indirect treatment comparison
    • [51] Cornely, O.A., et al. Clinical efficacy of fidaxomicin compared with vancomycin and metronidazole in Clostridium difficile infections: a meta-analysis and indirect treatment comparison. J. Antimicrob. Chemother. 69 (2014), 2892–2900.
    • (2014) J. Antimicrob. Chemother. , vol.69 , pp. 2892-2900
    • Cornely, O.A.1
  • 52
    • 84859007390 scopus 로고    scopus 로고
    • Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial
    • [52] Cornely, O.A., et al. Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial. Lancet Infect. Dis. 12 (2012), 281–289.
    • (2012) Lancet Infect. Dis. , vol.12 , pp. 281-289
    • Cornely, O.A.1
  • 53
    • 84863676557 scopus 로고    scopus 로고
    • Treatment of first recurrence of Clostridium difficile infection: fidaxomicin versus vancomycin
    • [53] Cornely, O.A., Miller, M.A., Louie, T.J., Crook, D.W., Gorbach, S.L., Treatment of first recurrence of Clostridium difficile infection: fidaxomicin versus vancomycin. Clin. Infect. Dis. 55:Suppl. 2 (2012), S154–S161.
    • (2012) Clin. Infect. Dis. , vol.55 , pp. S154-S161
    • Cornely, O.A.1    Miller, M.A.2    Louie, T.J.3    Crook, D.W.4    Gorbach, S.L.5
  • 54
    • 84900418033 scopus 로고    scopus 로고
    • Fecal microbiota transplant for relapsing Clostridium difficile infection using a frozen inoculum from unrelated donors: a randomized, open-label, controlled pilot study
    • [54] Youngster, I., et al. Fecal microbiota transplant for relapsing Clostridium difficile infection using a frozen inoculum from unrelated donors: a randomized, open-label, controlled pilot study. Clin. Infect. Dis. 58 (2014), 1515–1522.
    • (2014) Clin. Infect. Dis. , vol.58 , pp. 1515-1522
    • Youngster, I.1
  • 55
    • 84908681868 scopus 로고    scopus 로고
    • Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection
    • [55] Youngster, I., et al. Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. JAMA 312 (2014), 1772–1778.
    • (2014) JAMA , vol.312 , pp. 1772-1778
    • Youngster, I.1
  • 56
    • 84896708902 scopus 로고    scopus 로고
    • Microbiota dynamics in patients treated with fecal microbiota transplantation for recurrent Clostridium difficile infection
    • [56] Song, Y., et al. Microbiota dynamics in patients treated with fecal microbiota transplantation for recurrent Clostridium difficile infection. PLoS One, 8, 2013, e81330.
    • (2013) PLoS One , vol.8 , pp. e81330
    • Song, Y.1
  • 57
    • 84906790071 scopus 로고    scopus 로고
    • Efficacy of combined jejunal and colonic fecal microbiota transplantation for recurrent Clostridium difficile Infection
    • [57] Dutta, S.K., et al. Efficacy of combined jejunal and colonic fecal microbiota transplantation for recurrent Clostridium difficile Infection. Clin. Gastroenterol. Hepatol. 12 (2014), 1572–1576.
    • (2014) Clin. Gastroenterol. Hepatol. , vol.12 , pp. 1572-1576
    • Dutta, S.K.1
  • 58
    • 1542513850 scopus 로고    scopus 로고
    • Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota
    • [58] Young, V.B., Schmidt, T.M., Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota. J. Clin. Microbiol. 42 (2004), 1203–1206.
    • (2004) J. Clin. Microbiol. , vol.42 , pp. 1203-1206
    • Young, V.B.1    Schmidt, T.M.2
  • 59
    • 84928287872 scopus 로고    scopus 로고
    • Efficacy of fecal microbiota transplantation in 2 children with recurrent Clostridium difficile infection and its impact on their growth and gut microbiome
    • [59] Walia, R., et al. Efficacy of fecal microbiota transplantation in 2 children with recurrent Clostridium difficile infection and its impact on their growth and gut microbiome. J. Pediatr. Gastroenterol. Nutr. 59 (2014), 565–570.
    • (2014) J. Pediatr. Gastroenterol. Nutr. , vol.59 , pp. 565-570
    • Walia, R.1
  • 60
    • 84928205403 scopus 로고    scopus 로고
    • Fecal microbiota transplantation in the treatment of refractory Clostridium difficile infection in children: an update
    • [60] Walia, R., Kunde, S., Mahajan, L., Fecal microbiota transplantation in the treatment of refractory Clostridium difficile infection in children: an update. Curr. Opin. Pediatr. 26 (2014), 573–578.
    • (2014) Curr. Opin. Pediatr. , vol.26 , pp. 573-578
    • Walia, R.1    Kunde, S.2    Mahajan, L.3
  • 61
    • 84924533173 scopus 로고    scopus 로고
    • Species and genus level resolution analysis of gut microbiota in Clostridium difficile patients following fecal microbiota transplantation
    • [61] Shankar, V., et al. Species and genus level resolution analysis of gut microbiota in Clostridium difficile patients following fecal microbiota transplantation. Microbiome, 2, 2014, 13.
    • (2014) Microbiome , vol.2 , pp. 13
    • Shankar, V.1
  • 62
    • 84953837329 scopus 로고    scopus 로고
    • Identification of key taxa that favor intestinal colonization of Clostridium difficile in an adult Chinese population
    • [62] Gu, S., et al. Identification of key taxa that favor intestinal colonization of Clostridium difficile in an adult Chinese population. Microbes Infect. 18 (2016), 30–38.
    • (2016) Microbes Infect. , vol.18 , pp. 30-38
    • Gu, S.1
  • 63
    • 84882779621 scopus 로고    scopus 로고
    • Intestinal dysbiosis and depletion of butyrogenic bacteria in Clostridium difficile infection and nosocomial diarrhea
    • [63] Antharam, V.C., et al. Intestinal dysbiosis and depletion of butyrogenic bacteria in Clostridium difficile infection and nosocomial diarrhea. J. Clin. Microbiol. 51 (2013), 2884–2892.
    • (2013) J. Clin. Microbiol. , vol.51 , pp. 2884-2892
    • Antharam, V.C.1
  • 64
    • 84904012195 scopus 로고    scopus 로고
    • Microbiome data distinguish patients with Clostridium difficile infection and non-C. difficile-associated diarrhea from healthy controls
    • e01021–14
    • [64] Schubert, A.M., et al. Microbiome data distinguish patients with Clostridium difficile infection and non-C. difficile-associated diarrhea from healthy controls. MBio, 5, 2014 e01021–14.
    • (2014) MBio , vol.5
    • Schubert, A.M.1
  • 65
    • 84898829359 scopus 로고    scopus 로고
    • Reductions in intestinal Clostridiales precede the development of nosocomial Clostridium difficile infection
    • [65] Vincent, C., et al. Reductions in intestinal Clostridiales precede the development of nosocomial Clostridium difficile infection. Microbiome, 1, 2013, 18.
    • (2013) Microbiome , vol.1 , pp. 18
    • Vincent, C.1
  • 66
    • 84961291897 scopus 로고    scopus 로고
    • Insight into alteration of gut microbiota in Clostridium difficile infection and asymptomatic C. difficile colonization
    • [66] Zhang, L., et al. Insight into alteration of gut microbiota in Clostridium difficile infection and asymptomatic C. difficile colonization. Anaerobe 34 (2015), 1–7.
    • (2015) Anaerobe , vol.34 , pp. 1-7
    • Zhang, L.1
  • 67
    • 84925500413 scopus 로고    scopus 로고
    • Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
    • [67] Buffie, C.G., et al. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature 517 (2015), 205–208.
    • (2015) Nature , vol.517 , pp. 205-208
    • Buffie, C.G.1
  • 68
    • 84867520688 scopus 로고    scopus 로고
    • Clostridium difficile carriage in healthy infants in the community: a potential reservoir for pathogenic strains
    • [68] Rousseau, C., et al. Clostridium difficile carriage in healthy infants in the community: a potential reservoir for pathogenic strains. Clin. Infect. Dis. 55 (2012), 1209–1215.
    • (2012) Clin. Infect. Dis. , vol.55 , pp. 1209-1215
    • Rousseau, C.1
  • 69
    • 33749245678 scopus 로고    scopus 로고
    • Epidemiologic surveillance of Clostridium difficile diarrhea in a freestanding pediatric hospital and a pediatric hospital at a university medical center
    • [69] Rexach, C.E., Tang-Feldman, Y.J., Cantrell, M.C., Cohen, S.H., Epidemiologic surveillance of Clostridium difficile diarrhea in a freestanding pediatric hospital and a pediatric hospital at a university medical center. Diagn. Microbiol. Infect. Dis. 56 (2006), 109–114.
    • (2006) Diagn. Microbiol. Infect. Dis. , vol.56 , pp. 109-114
    • Rexach, C.E.1    Tang-Feldman, Y.J.2    Cantrell, M.C.3    Cohen, S.H.4
  • 71
    • 0027464842 scopus 로고
    • Heterogeneity of Clostridium difficile isolates from infants
    • [71] Collignon, A., et al. Heterogeneity of Clostridium difficile isolates from infants. Eur. J. Pediatr. 152 (1993), 319–322.
    • (1993) Eur. J. Pediatr. , vol.152 , pp. 319-322
    • Collignon, A.1
  • 72
    • 84862141704 scopus 로고    scopus 로고
    • Human gut microbiome viewed across age and geography
    • [72] Yatsunenko, T., et al. Human gut microbiome viewed across age and geography. Nature 486 (2012), 222–227.
    • (2012) Nature , vol.486 , pp. 222-227
    • Yatsunenko, T.1
  • 74
    • 79952763661 scopus 로고    scopus 로고
    • Succession of microbial consortia in the developing infant gut microbiome
    • [74] Koenig, J.E., et al. Succession of microbial consortia in the developing infant gut microbiome. Proc. Natl. Acad. Sci. U. S. A. 108:Suppl. 1 (2011), 4578–4585.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 4578-4585
    • Koenig, J.E.1
  • 75
    • 72449145776 scopus 로고    scopus 로고
    • Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses
    • [75] Sjögren, Y.M., et al. Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses. Clin. Exp. Allergy 39 (2009), 1842–1851.
    • (2009) Clin. Exp. Allergy , vol.39 , pp. 1842-1851
    • Sjögren, Y.M.1
  • 76
    • 8644224866 scopus 로고    scopus 로고
    • Effects of intrapartum penicillin prophylaxis on intestinal bacterial colonization in infants
    • [76] Jauréguy, F., et al. Effects of intrapartum penicillin prophylaxis on intestinal bacterial colonization in infants. J. Clin. Microbiol. 42 (2004), 5184–5188.
    • (2004) J. Clin. Microbiol. , vol.42 , pp. 5184-5188
    • Jauréguy, F.1
  • 77
    • 46349111355 scopus 로고    scopus 로고
    • Toxigenic and non-toxigenic Clostridium difficile: determinants of intestinal colonisation and role in childhood atopic manifestations
    • [77] Penders, J., Stobberingh, E.E., van den Brandt, P.A., van Ree, R., Thijs, C., Toxigenic and non-toxigenic Clostridium difficile: determinants of intestinal colonisation and role in childhood atopic manifestations. Gut 57 (2008), 1025–1026.
    • (2008) Gut , vol.57 , pp. 1025-1026
    • Penders, J.1    Stobberingh, E.E.2    van den Brandt, P.A.3    van Ree, R.4    Thijs, C.5
  • 78
    • 0026669330 scopus 로고
    • Diminished Clostridium difficile toxin A sensitivity in newborn rabbit ileum is associated with decreased toxin A receptor
    • [78] Eglow, R., et al. Diminished Clostridium difficile toxin A sensitivity in newborn rabbit ileum is associated with decreased toxin A receptor. J. Clin. Investig. 90 (1992), 822–829.
    • (1992) J. Clin. Investig. , vol.90 , pp. 822-829
    • Eglow, R.1
  • 79
    • 84936946364 scopus 로고    scopus 로고
    • Impacts of infection with different toxigenic Clostridium difficile strains on faecal microbiota in children
    • [79] Ling, Z., et al. Impacts of infection with different toxigenic Clostridium difficile strains on faecal microbiota in children. Sci. Rep., 4, 2014, 7485.
    • (2014) Sci. Rep. , vol.4 , pp. 7485
    • Ling, Z.1
  • 80
    • 39349107697 scopus 로고    scopus 로고
    • Decreased diversity of the fecal Microbiome in recurrent Clostridium difficile-associated diarrhea
    • [80] Chang, J.Y., et al. Decreased diversity of the fecal Microbiome in recurrent Clostridium difficile-associated diarrhea. J. Infect. Dis. 197 (2008), 435–438.
    • (2008) J. Infect. Dis. , vol.197 , pp. 435-438
    • Chang, J.Y.1
  • 81
    • 84963891450 scopus 로고    scopus 로고
    • Recurrent Clostridium difficile infection associates with distinct bile acid and microbiome profiles
    • 81 Allegretti, J.R., et al. Recurrent Clostridium difficile infection associates with distinct bile acid and microbiome profiles. Aliment. Pharmacol Ther. 43 (2016), 1142–1153.
    • (2016) Aliment. Pharmacol Ther. , vol.43 , pp. 1142-1153
    • Allegretti, J.R.1
  • 82
    • 84868361276 scopus 로고    scopus 로고
    • Toward an understanding of changes in diversity associated with fecal microbiome transplantation based on 16S rRNA gene deep sequencing
    • [82] Shahinas, D., et al. Toward an understanding of changes in diversity associated with fecal microbiome transplantation based on 16S rRNA gene deep sequencing. MBio, 3, 2012.
    • (2012) MBio , vol.3
    • Shahinas, D.1
  • 83
    • 84894105226 scopus 로고    scopus 로고
    • Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection
    • [83] Weingarden, A.R., et al. Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection. Am. J. Physiol. Gastrointest. Liver Physiol. 306 (2014), G310–G319.
    • (2014) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.306 , pp. G310-G319
    • Weingarden, A.R.1
  • 84
    • 58749112734 scopus 로고    scopus 로고
    • A core gut microbiome in obese and lean twins
    • [84] Turnbaugh, P.J., et al. A core gut microbiome in obese and lean twins. Nature 457 (2009), 480–484.
    • (2009) Nature , vol.457 , pp. 480-484
    • Turnbaugh, P.J.1
  • 85
    • 84942195767 scopus 로고    scopus 로고
    • Clostridium difficile heterogeneously impacts intestinal community architecture but drives stable metabolome responses
    • [85] Rojo, D., et al. Clostridium difficile heterogeneously impacts intestinal community architecture but drives stable metabolome responses. ISME J. 9 (2015), 2206–2220.
    • (2015) ISME J. , vol.9 , pp. 2206-2220
    • Rojo, D.1
  • 86
    • 77957337708 scopus 로고    scopus 로고
    • Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid
    • [86] Sorg, J.A., Sonenshein, A.L., Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid. J. Bacteriol. 192 (2010), 4983–4990.
    • (2010) J. Bacteriol. , vol.192 , pp. 4983-4990
    • Sorg, J.A.1    Sonenshein, A.L.2
  • 87
    • 63449096364 scopus 로고    scopus 로고
    • Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination
    • [87] Sorg, J.A., Sonenshein, A.L., Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination. J. Bacteriol. 191 (2009), 1115–1117.
    • (2009) J. Bacteriol. , vol.191 , pp. 1115-1117
    • Sorg, J.A.1    Sonenshein, A.L.2
  • 88
    • 41549142775 scopus 로고    scopus 로고
    • Bile salts and glycine as cogerminants for Clostridium difficile spores
    • [88] Sorg, J.A., Sonenshein, A.L., Bile salts and glycine as cogerminants for Clostridium difficile spores. J. Bacteriol. 190 (2008), 2505–2512.
    • (2008) J. Bacteriol. , vol.190 , pp. 2505-2512
    • Sorg, J.A.1    Sonenshein, A.L.2
  • 89
    • 0020084325 scopus 로고
    • Use of sodium taurocholate to enhance spore recovery on a medium selective for Clostridium difficile
    • [89] Wilson, K.H., Kennedy, M.J., Fekety, F.R., Use of sodium taurocholate to enhance spore recovery on a medium selective for Clostridium difficile. J. Clin. Microbiol. 15 (1982), 443–446.
    • (1982) J. Clin. Microbiol. , vol.15 , pp. 443-446
    • Wilson, K.H.1    Kennedy, M.J.2    Fekety, F.R.3
  • 90
    • 0020554353 scopus 로고
    • Efficiency of various bile salt preparations for stimulation of Clostridium difficile spore germination
    • [90] Wilson, K.H., Efficiency of various bile salt preparations for stimulation of Clostridium difficile spore germination. J. Clin. Microbiol. 18 (1983), 1017–1019.
    • (1983) J. Clin. Microbiol. , vol.18 , pp. 1017-1019
    • Wilson, K.H.1
  • 91
    • 84876544830 scopus 로고    scopus 로고
    • A new strategy for the prevention of Clostridium difficile infection
    • [91] Howerton, A., Patra, M., Abel-Santos, E., A new strategy for the prevention of Clostridium difficile infection. J. Infect. Dis. 207 (2013), 1498–1504.
    • (2013) J. Infect. Dis. , vol.207 , pp. 1498-1504
    • Howerton, A.1    Patra, M.2    Abel-Santos, E.3
  • 92
    • 56649120585 scopus 로고    scopus 로고
    • Physical and chemical factors influencing the germination of Clostridium difficile spores
    • [92] Wheeldon, L.J., Worthington, T., Hilton, A.C., Elliott, T.S., Lambert, P.A., Physical and chemical factors influencing the germination of Clostridium difficile spores. J. Appl. Microbiol. 105 (2008), 2223–2230.
    • (2008) J. Appl. Microbiol. , vol.105 , pp. 2223-2230
    • Wheeldon, L.J.1    Worthington, T.2    Hilton, A.C.3    Elliott, T.S.4    Lambert, P.A.5
  • 93
    • 79954578379 scopus 로고    scopus 로고
    • Histidine acts as a co-germinant with glycine and taurocholate for Clostridium difficile spores
    • [93] Wheeldon, L.J., Worthington, T., Lambert, P.A., Histidine acts as a co-germinant with glycine and taurocholate for Clostridium difficile spores. J. Appl. Microbiol. 110 (2011), 987–994.
    • (2011) J. Appl. Microbiol. , vol.110 , pp. 987-994
    • Wheeldon, L.J.1    Worthington, T.2    Lambert, P.A.3
  • 94
    • 62649151803 scopus 로고    scopus 로고
    • Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
    • [94] Wikoff, W.R., et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 3698–3703.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 3698-3703
    • Wikoff, W.R.1
  • 95
    • 0016799056 scopus 로고
    • Formation of indoleacetic acid by intestinal anaerobes
    • [95] Chung, K.T., Anderson, G.M., Fulk, G.E., Formation of indoleacetic acid by intestinal anaerobes. J. Bacteriol. 124 (1975), 573–575.
    • (1975) J. Bacteriol. , vol.124 , pp. 573-575
    • Chung, K.T.1    Anderson, G.M.2    Fulk, G.E.3
  • 96
    • 79961227411 scopus 로고    scopus 로고
    • Variation in antibiotic-induced microbial recolonization impacts on the host metabolic phenotypes of rats
    • [96] Swann, J.R., et al. Variation in antibiotic-induced microbial recolonization impacts on the host metabolic phenotypes of rats. J. Proteom. Res. 10 (2011), 3590–3603.
    • (2011) J. Proteom. Res. , vol.10 , pp. 3590-3603
    • Swann, J.R.1
  • 97
    • 0029785098 scopus 로고    scopus 로고
    • Antibiotic-associated diarrhoea, Clostridium difficile, and short-chain fatty acids
    • [97] Hove, H., Tvede, M., Mortensen, P.B., Antibiotic-associated diarrhoea, Clostridium difficile, and short-chain fatty acids. Scand. J. Gastroenterol. 31 (1996), 688–693.
    • (1996) Scand. J. Gastroenterol. , vol.31 , pp. 688-693
    • Hove, H.1    Tvede, M.2    Mortensen, P.B.3
  • 98
    • 0022531628 scopus 로고
    • Influence of oral intake of seven different antibiotics on faecal short-chain fatty acid excretion in healthy subjects
    • [98] Høverstad, T., et al. Influence of oral intake of seven different antibiotics on faecal short-chain fatty acid excretion in healthy subjects. Scand. J. Gastroenterol. 21 (1986), 997–1003.
    • (1986) Scand. J. Gastroenterol. , vol.21 , pp. 997-1003
    • Høverstad, T.1
  • 99
    • 0022977676 scopus 로고
    • Short-chain fatty acids in germfree mice and rats
    • [99] Høverstad, T., Midtvedt, T., Short-chain fatty acids in germfree mice and rats. J. Nutr. 116 (1986), 1772–1776.
    • (1986) J. Nutr. , vol.116 , pp. 1772-1776
    • Høverstad, T.1    Midtvedt, T.2
  • 100
    • 72249105772 scopus 로고    scopus 로고
    • NMR-based metabonomics analysis of mouse urine and fecal extracts following oral treatment with the broad-spectrum antibiotic enrofloxacin (Baytril)
    • [100] Romick-Rosendale, L.E., et al. NMR-based metabonomics analysis of mouse urine and fecal extracts following oral treatment with the broad-spectrum antibiotic enrofloxacin (Baytril). Magn. Reson Chem. 47:Suppl. 1 (2009), S36–S46.
    • (2009) Magn. Reson Chem. , vol.47 , pp. S36-S46
    • Romick-Rosendale, L.E.1
  • 101
    • 0028080726 scopus 로고
    • Effect of fiber source on short-chain fatty acid production and on the growth and toxin production by Clostridium difficile
    • [101] May, T., Mackie, R.I., Fahey, G.C., Cremin, J.C., Garleb, K.A., Effect of fiber source on short-chain fatty acid production and on the growth and toxin production by Clostridium difficile. Scand. J. Gastroenterol. 29 (1994), 916–922.
    • (1994) Scand. J. Gastroenterol. , vol.29 , pp. 916-922
    • May, T.1    Mackie, R.I.2    Fahey, G.C.3    Cremin, J.C.4    Garleb, K.A.5
  • 102
    • 0021141415 scopus 로고
    • Role of volatile fatty acids in colonization resistance to Clostridium difficile
    • [102] Rolfe, R.D., Role of volatile fatty acids in colonization resistance to Clostridium difficile. Infect. Immun. 45 (1984), 185–191.
    • (1984) Infect. Immun. , vol.45 , pp. 185-191
    • Rolfe, R.D.1
  • 103
    • 0026078596 scopus 로고
    • Short-chain organic acids at ph 5.0 kill Escherichia coli and Salmonella spp. without causing membrane perturbation
    • [103] Cherrington, C.A., Hinton, M., Pearson, G.R., Chopra, I., Short-chain organic acids at ph 5.0 kill Escherichia coli and Salmonella spp. without causing membrane perturbation. J. Appl. Bacteriol. 70 (1991), 161–165.
    • (1991) J. Appl. Bacteriol. , vol.70 , pp. 161-165
    • Cherrington, C.A.1    Hinton, M.2    Pearson, G.R.3    Chopra, I.4
  • 104
    • 68249110221 scopus 로고    scopus 로고
    • The role of pH in determining the species composition of the human colonic microbiota
    • [104] Duncan, S.H., Louis, P., Thomson, J.M., Flint, H.J., The role of pH in determining the species composition of the human colonic microbiota. Environ. Microbiol. 11 (2009), 2112–2122.
    • (2009) Environ. Microbiol. , vol.11 , pp. 2112-2122
    • Duncan, S.H.1    Louis, P.2    Thomson, J.M.3    Flint, H.J.4
  • 105
    • 84957717801 scopus 로고    scopus 로고
    • Does alkaline colonic pH predispose to Clostridium difficile infection?
    • [105] Gupta, P., et al. Does alkaline colonic pH predispose to Clostridium difficile infection?. South Med. J. 109 (2016), 91–96.
    • (2016) South Med. J. , vol.109 , pp. 91-96
    • Gupta, P.1
  • 106
    • 0031840660 scopus 로고    scopus 로고
    • Review article: short chain fatty acids in health and disease
    • [106] Cook, S.I., Sellin, J.H., Review article: short chain fatty acids in health and disease. Aliment. Pharmacol. Ther. 12 (1998), 499–507.
    • (1998) Aliment. Pharmacol. Ther. , vol.12 , pp. 499-507
    • Cook, S.I.1    Sellin, J.H.2
  • 108
    • 0022493972 scopus 로고
    • An in-vitro model of colonisation resistance to Clostridium difficile infection
    • [108] Borriello, S.P., Barclay, F.E., An in-vitro model of colonisation resistance to Clostridium difficile infection. J. Med. Microbiol. 21 (1986), 299–309.
    • (1986) J. Med. Microbiol. , vol.21 , pp. 299-309
    • Borriello, S.P.1    Barclay, F.E.2
  • 109
    • 84868158515 scopus 로고    scopus 로고
    • Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice
    • [109] Lawley, T.D., et al. Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice. PLoS Pathog., 8, 2012, e1002995.
    • (2012) PLoS Pathog. , vol.8 , pp. e1002995
    • Lawley, T.D.1
  • 110
    • 84901251583 scopus 로고    scopus 로고
    • Phylogenetic distribution of three pathways for propionate production within the human gut microbiota
    • [110] Reichardt, N., et al. Phylogenetic distribution of three pathways for propionate production within the human gut microbiota. ISME J. 8 (2014), 1323–1335.
    • (2014) ISME J. , vol.8 , pp. 1323-1335
    • Reichardt, N.1
  • 111
    • 84920621547 scopus 로고    scopus 로고
    • Gut microbiota-produced succinate promotes C. difficile infection after antibiotic treatment or motility disturbance
    • [111] Ferreyra, J.A., et al. Gut microbiota-produced succinate promotes C. difficile infection after antibiotic treatment or motility disturbance. Cell Host Microbe 16 (2014), 770–777.
    • (2014) Cell Host Microbe , vol.16 , pp. 770-777
    • Ferreyra, J.A.1
  • 112
    • 79959687178 scopus 로고    scopus 로고
    • Epidemiology and risk factors for Clostridium difficile infection in children
    • [112] Sandora, T.J., et al. Epidemiology and risk factors for Clostridium difficile infection in children. Pediatr. Infect. Dis. J. 30 (2011), 580–584.
    • (2011) Pediatr. Infect. Dis. J. , vol.30 , pp. 580-584
    • Sandora, T.J.1
  • 113
    • 84878639062 scopus 로고    scopus 로고
    • Clostridium difficile Infection in children
    • [113] Sammons, J.S., Toltzis, P., Zaoutis, T.E., Clostridium difficile Infection in children. JAMA Pediatr. 167 (2013), 567–573.
    • (2013) JAMA Pediatr. , vol.167 , pp. 567-573
    • Sammons, J.S.1    Toltzis, P.2    Zaoutis, T.E.3
  • 114
    • 84949126929 scopus 로고    scopus 로고
    • Diagnosis and management of Clostridium difficile infection by pediatric infectious diseases physicians
    • [114] Sammons, J.S., et al. Diagnosis and management of Clostridium difficile infection by pediatric infectious diseases physicians. J. Pediatr. Infect. Dis. Soc. 3 (2014), 43–48.
    • (2014) J. Pediatr. Infect. Dis. Soc. , vol.3 , pp. 43-48
    • Sammons, J.S.1
  • 115
    • 84924250556 scopus 로고    scopus 로고
    • Similar proportions of stool specimens from hospitalized children with and without diarrhea test positive for Clostridium difficile
    • [115] Leibowitz, J., Soma, V.L., Rosen, L., Ginocchio, C.C., Rubin, L.G., Similar proportions of stool specimens from hospitalized children with and without diarrhea test positive for Clostridium difficile. Pediatr. Infect. Dis. J. 34 (2015), 261–266.
    • (2015) Pediatr. Infect. Dis. J. , vol.34 , pp. 261-266
    • Leibowitz, J.1    Soma, V.L.2    Rosen, L.3    Ginocchio, C.C.4    Rubin, L.G.5
  • 116
    • 33846288887 scopus 로고    scopus 로고
    • Comparison of DNA extraction methods for analysis of turkey cecal microbiota
    • [116] Scupham, A.J., Jones, J.A., Wesley, I.V., Comparison of DNA extraction methods for analysis of turkey cecal microbiota. J. Appl. Microbiol. 102 (2007), 401–409.
    • (2007) J. Appl. Microbiol. , vol.102 , pp. 401-409
    • Scupham, A.J.1    Jones, J.A.2    Wesley, I.V.3
  • 117
    • 77951977802 scopus 로고    scopus 로고
    • Comparative analysis of fecal DNA extraction methods with phylogenetic microarray: effective recovery of bacterial and archaeal DNA using mechanical cell lysis
    • [117] Salonen, A., et al. Comparative analysis of fecal DNA extraction methods with phylogenetic microarray: effective recovery of bacterial and archaeal DNA using mechanical cell lysis. J. Microbiol. Methods 81 (2010), 127–134.
    • (2010) J. Microbiol. Methods , vol.81 , pp. 127-134
    • Salonen, A.1
  • 118
    • 77957723630 scopus 로고    scopus 로고
    • Effects of polymerase, template dilution and cycle number on PCR based 16 S rRNA diversity analysis using the deep sequencing method
    • [118] Wu, J.Y., et al. Effects of polymerase, template dilution and cycle number on PCR based 16 S rRNA diversity analysis using the deep sequencing method. BMC Microbiol., 10, 2010, 255.
    • (2010) BMC Microbiol. , vol.10 , pp. 255
    • Wu, J.Y.1
  • 119
    • 84865060813 scopus 로고    scopus 로고
    • PCR biases distort bacterial and archaeal community structure in pyrosequencing datasets
    • [119] Pinto, A.J., Raskin, L., PCR biases distort bacterial and archaeal community structure in pyrosequencing datasets. PLoS One, 7, 2012, e43093.
    • (2012) PLoS One , vol.7 , pp. e43093
    • Pinto, A.J.1    Raskin, L.2
  • 120
    • 84940984953 scopus 로고    scopus 로고
    • Primer and platform effects on 16S rRNA tag sequencing
    • [120] Tremblay, J., et al. Primer and platform effects on 16S rRNA tag sequencing. Front. Microbiol., 6, 2015, 771.
    • (2015) Front. Microbiol. , vol.6 , pp. 771
    • Tremblay, J.1
  • 121
    • 78650214082 scopus 로고    scopus 로고
    • Evaluation of different partial 16S rRNA gene sequence regions for phylogenetic analysis of microbiomes
    • [121] Kim, M., Morrison, M., Yu, Z., Evaluation of different partial 16S rRNA gene sequence regions for phylogenetic analysis of microbiomes. J. Microbiol. Methods 84 (2011), 81–87.
    • (2011) J. Microbiol. Methods , vol.84 , pp. 81-87
    • Kim, M.1    Morrison, M.2    Yu, Z.3
  • 122
    • 84874536596 scopus 로고    scopus 로고
    • The variability of the 16S rRNA gene in bacterial genomes and its consequences for bacterial community analyses
    • [122] Větrovský, T., Baldrian, P., The variability of the 16S rRNA gene in bacterial genomes and its consequences for bacterial community analyses. PLoS One, 8, 2013, e57923.
    • (2013) PLoS One , vol.8 , pp. e57923
    • Větrovský, T.1    Baldrian, P.2
  • 123
    • 84899531657 scopus 로고    scopus 로고
    • Analysis, optimization and verification of Illumina-generated 16S rRNA gene amplicon surveys
    • [123] Nelson, M.C., Morrison, H.G., Benjamino, J., Grim, S.L., Graf, J., Analysis, optimization and verification of Illumina-generated 16S rRNA gene amplicon surveys. PLoS One, 9, 2014, e94249.
    • (2014) PLoS One , vol.9 , pp. e94249
    • Nelson, M.C.1    Morrison, H.G.2    Benjamino, J.3    Grim, S.L.4    Graf, J.5
  • 124
    • 84951059585 scopus 로고    scopus 로고
    • De novo clustering methods outperform reference-based methods for assigning 16S rRNA gene sequences to operational taxonomic units
    • [124] Westcott, S., Schloss, P., De novo clustering methods outperform reference-based methods for assigning 16S rRNA gene sequences to operational taxonomic units. PeerJ, 3, 2015.
    • (2015) PeerJ , vol.3
    • Westcott, S.1    Schloss, P.2
  • 125
    • 84948992933 scopus 로고    scopus 로고
    • Gut microbiota and aging
    • [125] O'Toole, P.W., Jeffery, I.B., Gut microbiota and aging. Science 350 (2015), 1214–1215.
    • (2015) Science , vol.350 , pp. 1214-1215
    • O'Toole, P.W.1    Jeffery, I.B.2
  • 126
    • 77955602581 scopus 로고    scopus 로고
    • Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians
    • [126] Biagi, E., et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One, 5, 2010, e10667.
    • (2010) PLoS One , vol.5 , pp. e10667
    • Biagi, E.1
  • 128
    • 66049127999 scopus 로고    scopus 로고
    • Combined PCR-DGGE fingerprinting and quantitative-PCR indicates shifts in fecal population sizes and diversity of Bacteroides, bifidobacteria and Clostridium cluster IV in institutionalized elderly
    • [128] Zwielehner, J., et al. Combined PCR-DGGE fingerprinting and quantitative-PCR indicates shifts in fecal population sizes and diversity of Bacteroides, bifidobacteria and Clostridium cluster IV in institutionalized elderly. Exp. Gerontol. 44 (2009), 440–446.
    • (2009) Exp. Gerontol. , vol.44 , pp. 440-446
    • Zwielehner, J.1
  • 129
    • 78650973052 scopus 로고    scopus 로고
    • High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease
    • [129] Walker, A.W., et al. High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease. BMC Microbiol., 11, 2011, 7.
    • (2011) BMC Microbiol. , vol.11 , pp. 7
    • Walker, A.W.1
  • 130
    • 35348857386 scopus 로고    scopus 로고
    • Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
    • [130] Frank, D.N., et al. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc. Natl. Acad. Sci. U. S. A. 104 (2007), 13780–13785.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 13780-13785
    • Frank, D.N.1
  • 131
    • 79959961092 scopus 로고    scopus 로고
    • Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis
    • [131] Lepage, P., et al. Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis. Gastroenterology 141 (2011), 227–236.
    • (2011) Gastroenterology , vol.141 , pp. 227-236
    • Lepage, P.1
  • 132
    • 34548483459 scopus 로고    scopus 로고
    • Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum
    • [132] Baumgart, M., et al. Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum. ISME J. 1 (2007), 403–418.
    • (2007) ISME J. , vol.1 , pp. 403-418
    • Baumgart, M.1
  • 133
    • 4143069158 scopus 로고    scopus 로고
    • High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease
    • [133] Darfeuille-Michaud, A., et al. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 127 (2004), 412–421.
    • (2004) Gastroenterology , vol.127 , pp. 412-421
    • Darfeuille-Michaud, A.1
  • 134
    • 67649509224 scopus 로고    scopus 로고
    • Molecular diversity of Escherichia coli in the human gut: new ecological evidence supporting the role of adherent-invasive E. coli (AIEC) in Crohn's disease
    • [134] Martinez-Medina, M., et al. Molecular diversity of Escherichia coli in the human gut: new ecological evidence supporting the role of adherent-invasive E. coli (AIEC) in Crohn's disease. Inflamm. Bowel Dis. 15 (2009), 872–882.
    • (2009) Inflamm. Bowel Dis. , vol.15 , pp. 872-882
    • Martinez-Medina, M.1
  • 135
    • 3242737791 scopus 로고    scopus 로고
    • Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer
    • [135] Martin, H.M., et al. Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer. Gastroenterology 127 (2004), 80–93.
    • (2004) Gastroenterology , vol.127 , pp. 80-93
    • Martin, H.M.1
  • 136
    • 34247500287 scopus 로고    scopus 로고
    • High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease
    • [136] Kotlowski, R., Bernstein, C.N., Sepehri, S., Krause, D.O., High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease. Gut 56 (2007), 669–675.
    • (2007) Gut , vol.56 , pp. 669-675
    • Kotlowski, R.1    Bernstein, C.N.2    Sepehri, S.3    Krause, D.O.4
  • 137
    • 34548770119 scopus 로고    scopus 로고
    • Invasive Escherichia coli are a feature of Crohn's disease
    • [137] Sasaki, M., et al. Invasive Escherichia coli are a feature of Crohn's disease. Lab. Investig. 87 (2007), 1042–1054.
    • (2007) Lab. Investig. , vol.87 , pp. 1042-1054
    • Sasaki, M.1
  • 138
    • 0036378418 scopus 로고    scopus 로고
    • Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody
    • [138] Ohkusa, T., et al. Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody. J. Gastroenterol. Hepatol. 17 (2002), 849–853.
    • (2002) J. Gastroenterol. Hepatol. , vol.17 , pp. 849-853
    • Ohkusa, T.1
  • 139
    • 34547714253 scopus 로고    scopus 로고
    • Terminal restriction fragment length polymorphism analysis of the diversity of fecal microbiota in patients with ulcerative colitis
    • [139] Andoh, A., et al. Terminal restriction fragment length polymorphism analysis of the diversity of fecal microbiota in patients with ulcerative colitis. Inflamm. Bowel Dis. 13 (2007), 955–962.
    • (2007) Inflamm. Bowel Dis. , vol.13 , pp. 955-962
    • Andoh, A.1
  • 141
    • 84954286470 scopus 로고    scopus 로고
    • Proton pump inhibitors alter the composition of the gut microbiota
    • [141] Jackson, M.A., et al. Proton pump inhibitors alter the composition of the gut microbiota. Gut 65 (2016), 749–756.
    • (2016) Gut , vol.65 , pp. 749-756
    • Jackson, M.A.1
  • 142
    • 84954286591 scopus 로고    scopus 로고
    • Proton pump inhibitors affect the gut microbiome
    • [142] Imhann, F., et al. Proton pump inhibitors affect the gut microbiome. Gut 65 (2016), 740–748.
    • (2016) Gut , vol.65 , pp. 740-748
    • Imhann, F.1
  • 143
    • 84942342601 scopus 로고    scopus 로고
    • Proton pump inhibitors alter specific taxa in the human gastrointestinal microbiome: a crossover trial
    • e889
    • [143] Freedberg, D.E., et al. Proton pump inhibitors alter specific taxa in the human gastrointestinal microbiome: a crossover trial. Gastroenterology 149 (2015), 883–885 e889.
    • (2015) Gastroenterology , vol.149 , pp. 883-885
    • Freedberg, D.E.1
  • 144
    • 84909993511 scopus 로고    scopus 로고
    • 16S rRNA gene pyrosequencing reveals shift in patient faecal microbiota during high-dose chemotherapy as conditioning regimen for bone marrow transplantation
    • [144] Montassier, E., et al. 16S rRNA gene pyrosequencing reveals shift in patient faecal microbiota during high-dose chemotherapy as conditioning regimen for bone marrow transplantation. Microb. Ecol. 67 (2014), 690–699.
    • (2014) Microb. Ecol. , vol.67 , pp. 690-699
    • Montassier, E.1
  • 145
    • 84938555496 scopus 로고    scopus 로고
    • Chemotherapy-driven dysbiosis in the intestinal microbiome
    • [145] Montassier, E., et al. Chemotherapy-driven dysbiosis in the intestinal microbiome. Aliment. Pharmacol. Ther. 42 (2015), 515–528.
    • (2015) Aliment. Pharmacol. Ther. , vol.42 , pp. 515-528
    • Montassier, E.1


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