Targeted Restoration of the Intestinal Microbiota with a Simple, Defined Bacteriotherapy Resolves Relapsing Clostridium difficile Disease in Mice

PLoS Pathogens

Volumn 8, Issue 10, 2012, Pages

  Lawley, Trevor D ^a   Clare, Simon ^a   Walker, Alan W ^a   Stares, Mark D ^a   Connor, Thomas R ^a   Raisen, Claire ^a   Goulding, David ^a   Rad, Roland ^a   Schreiber, Fernanda ^a   Brandt, Cordelia ^a   Deakin, Laura J ^a   Pickard, Derek J ^a   Duncan, Sylvia H ^b   Flint, Harry J ^b   Clark, Taane G ^c   Parkhill, Julian ^a   Dougan, Gordon ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; CLINDAMYCIN; ERYTHROMYCIN; TETRACYCLINE; THIAMPHENICOL; VANCOMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL TRANSMISSION; BACTERIOTHERAPY; BACTERIUM CULTURE; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDEMIC; FECES; FEMALE; INTESTINE FLORA; MICROBIAL COMMUNITY; MICROFLORA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; RECURRENT DISEASE;

ANIMALS; CLOSTRIDIUM DIFFICILE; DRUG RESISTANCE, BACTERIAL; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FECES; FEMALE; INTESTINES; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICROBIAL CONSORTIA; MICROBIAL INTERACTIONS; MOLECULAR SEQUENCE DATA; PROBIOTICS; RECURRENCE; VANCOMYCIN;

CLOSTRIDIUM DIFFICILE; HARNESS; MUS;

EID: 84868158515     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002995     Document Type: Article

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