Epidemiologic surveillance of Clostridium difficile diarrhea in a freestanding pediatric hospital and a pediatric hospital at a university medical center

Diagnostic Microbiology and Infectious Disease

Volumn 56, Issue 2, 2006, Pages 109-114

  Rexach, Carmen E ^a   Tang Feldman, Yajarayma J ^b   Cantrell, Mary C ^b   Cohen, Stuart H ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Clostridium difficile; Diarrhea; Epidemiology; Infectious disease; Pediatrics

Indexed keywords

ANTIINFECTIVE AGENT; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; HISTAMINE H2 RECEPTOR ANTAGONIST;

ADULT; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM CULTURE; BACTERIUM ISOLATE; CLOSTRIDIUM DIFFICILE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DRUG USE; FECES CULTURE; FEMALE; HOSPITAL INFECTION; HUMAN; INFECTION RISK; INFECTIOUS DIARRHEA; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PEDIATRIC HOSPITAL; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; UNIVERSITY HOSPITAL;

CARRIER STATE; CHILD; CHILD, PRESCHOOL; CLOSTRIDIUM DIFFICILE; DIARRHEA; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FECES; HOSPITALS; HUMANS; INFANT; INPATIENTS; LOGISTIC MODELS; MULTIVARIATE ANALYSIS; ODDS RATIO; POPULATION SURVEILLANCE;

EID: 33749245678     PISSN: 07328893     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2006.03.002     Document Type: Article

References (22)

1. Bartlett J.G. Clostridium difficile: history of its role as an enteric pathogen and the current state of knowledge about the organism. Clin. Infect. Dis. 18 Suppl. 4 (1994) S265-S272
2. Cohen S.H., Tang Y.J., and Silva Jr. J. Molecular typing method for epidemiological identification of Clostridium difficile strains. Expert Rev. Mol. Diagn. 1 (2001) 61-70
3. Cunningham R., Dale B., Undy B., and Gaunt N. Proton pump inhibitors as a risk factor for Clostridium difficile diarrheoa. J. Hosp. Infect. 54 (2003) 243-245
4. de Boissieu M., Chaussain M., Badoual J., Raymond J., and Dupont C. Small-bowel bacterial overgrowth in children with chronic diarrhea, abdominal pain, or both. J. Pediatr. 128 (1996) 203-207
5. Dial S., Alrasadi K., Manoukian C., Huang A., and Menzies D. Risk of Clostridium difficile diarrhea among hospitalized inpatients prescribed proton pump inhibitors: cohort and case control studies. CMAJ 171 (2004) 33-38
6. Frost F., Craun G., and Calderon R. Increasing hospitalization and death due to Clostridium difficile diarrheal disease. Emerg. Infect. Dis. 4 (1998) 619-625
7. Gaglani M.J., Murray J.C., Morad A.B., and Edwards M.S. Chronic osteomyelitis caused by Clostridium difficile in an adolescent with sickle cell disease. Pediatr. Infect. Dis. J. 15 (1996) 1054-1056
8. Genta V.M., Gilligan P.H., and McCarthy L.R. Clostridium difficile peritonitis in a neonate: a case report. Arch. Pathol. Lab. Med. 108 (1984) 82-83
9. Gonçalves C., Decre D., Barbut F., Burghoffer B., and Petit J.C. Prevalence and characterization of a binary toxin (actin specific ADP ribosyltransferase) from Clostridium difficile. J. Clin. Microbiol. (2004) 1933-1939
10. Grinblat J., Weiss A., Grossman B., Dicker D., and Beloosesky Y. Diarrhea in elderly patients due to Clostridium difficile associated with Salmonella and Shigella infection. Arch. Gerontol. Geriatr. 39 (2004) 277-282
11. Gumerlock P.H., Tang Y.J., Weiss J.B., and Silva Jr. J. Specific detection of toxigenic strains of Clostridium difficile in stool specimens. J. Clin. Microbiol. 31 (1993) 507-511
12. Harris P.R., and Figueroa-Colon R. Rectal prolapse in children associated with Clostridium difficile infection. Pediatr. Infect. Dis. J. 14 (1995) 78-79
13. Kato S., Ebina K., Ozawa A., Naganuma H., and Nakagawa H. Antibiotic associated hemorrhagic colitis without Clostridium difficile toxin in children. J. Pediatr. 126 (1995) 1008-1010
14. Langley J.M., LeBlanc J.C., Hanakowski M., and Goloubeva O. The role of Clostridium difficile and viruses as causes of nosocomial diarrhea in children. Infect. Control Hosp. Epidemiol. 23 (2002) 660-664
15. Lyerly D.M., Krivan H.C., and Wilkins T.D. Clostridium difficile: its disease and toxins. Clin. Microbiol. Rev. 1 (1988) 1-18
16. McFarland L.V. Diarrhea acquired in the hospital. Gastroenterol. Clin. North Am. 22 (1993) 563-577
17. McFarland L.V., Brandmarker S., and Guandalini S. Pediatric Clostridium difficile: a phantom menace or clinical reality?. J. Pediatr. Gastroenterol. Nutr. 31 (2000) 220-231
18. Silva Jr. J., Tang Y.J., and Gumerlock P.H. Genotyping of Clostridium difficile isolates. J. Infect. Dis. 169 (1993) 661-664
19. Simor A.E., Yake S.L., and Tsimidis K. Infection due to Clostridium difficile among elderly residents of a long-term care facility. Clin. Infect. Dis17 (1993) 672-678
20. Tang Y.J., Gumerlock P.H., Weiss J.B., and Silva Jr. J. Specific detection of Clostridium difficile toxin A gene sequences in clinical isolates. Mol. Cell. Probes 8 (1994) 463-467
21. Tang Y.J., Houston S.T., Gumerlock P.H., Mulligan M.E., Gerding D.N., Johnson S., Fekety F.R., and Silva Jr. J. Comparison of arbitrarily primed PCR with restriction endonuclease and immunoblot analyses for typing Clostridium difficile isolates. J. Clin. Microbiol. 33 (1995) 3169-3173
22. Wanahita A., Goldsmith E., and Musher D. Conditions associated with leukocytosis in a tertiary care hospital, with particular attention to the role of infection caused by Clostridium difficile. Clin. Infect. Dis. 34 (2002) 1585-1592