Clostridium difficile infection in children

JAMA Pediatrics

Volumn 167, Issue 6, 2013, Pages 567-573

  Sammons, Julia Shaklee ^a,b   Toltzis, Philip ^a,c   Zaoutis, Theoklis E ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACITRACIN; FIDAXOMICIN; FUSIDIC ACID; METRONIDAZOLE; RIFAXIMIN; TEICOPLANIN; TIGECYCLINE; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; CLOSTRIDIUM DIFFICILE INFECTION; DIAGNOSTIC APPROACH ROUTE; DISEASE SEVERITY; DRUG SAFETY; ENTERITIS; HEALTH CARE COST; HUMAN; INCIDENCE; INFECTION PREVENTION; INFECTION RISK; NEOPLASM; POPULATION RESEARCH; PRIORITY JOURNAL; RECURRENT INFECTION; REVIEW; RISK FACTOR;

CHILD; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; COMMUNITY-ACQUIRED INFECTIONS; CROSS INFECTION; DIARRHEA; HUMANS; INCIDENCE; INFANT; INFANT, NEWBORN; RISK FACTORS; UNITED STATES; WORLD HEALTH;

EID: 84878639062     PISSN: 21686203     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamapediatrics.2013.441     Document Type: Review

References (75)

1. Miller BA, Chen LF, Sexton DJ, Anderson DJ. Comparison of the burdens of hospitalonset, healthcare facility-associated Clostridium difficile infection and of healthcare-associated infection due to methicillin-resistant Staphylococcus aureus in community hospitals. Infect Control Hosp Epidemiol. 2011;32(4):387-390.
2. Centers for Disease Control and Prevention (CDC). Surveillance for community-associated Clostridium difficile - Connecticut, 2006. MMWR Morb Mortal Wkly Rep. 2008;57(13):340-343.
3. McDonald LC, Killgore GE, Thompson A, et al. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med. 2005;353(23):2433- 2441. (Pubitemid 41770164)
4. Kim J, Smathers SA, Prasad P, Leckerman KH, Coffin S, Zaoutis T. Epidemiological features of Clostridium difficile-associated disease among inpatients at children's hospitals in the United States, 2001-2006. Pediatrics. 2008;122(6):1266-1270.
5. Klein EJ, Boster DR, Stapp JR, et al. Diarrhea etiology in a children's hospital emergency department: a prospective cohort study. Clin Infect Dis. 2006;43(7):807-813. (Pubitemid 44435504)
6. Benson L, Song X, Campos J, Singh N. Changing epidemiology of Clostridium difficile-associated disease in children. Infect Control Hosp Epidemiol. 2007;28(11):1233-1235. (Pubitemid 47596560)
7. Zilberberg MD, Shorr AF, Kollef MH. Increase in Clostridium difficile-related hospitalizations among infants in the United States, 2000-2005. Pediatr Infect Dis J. 2008;27(12):1111-1113.
8. Zilberberg MD, Tillotson GS, McDonald C. Clostridium difficile infections among hospitalized children, United States, 1997-2006. Emerg Infect Dis. 2010;16(4):604-609.
9. Pokorn M, Radsel A, Cizman M, et al. Severe Clostridium difficile-associated disease in children. Pediatr Infect Dis J. 2008;27(10):944-946.
10. Kim J, Shaklee JF, Smathers S, et al. Risk factors and outcomes associated with severe Clostridium difficile infection in children. Pediatr Infect Dis J. 2012;31(2):134-138.
11. Toltzis P, Kim J, Dul M, Zoltanski J, Smathers S, Zaoutis T. Presence of the epidemic North American pulsed field type 1 Clostridium difficile strain in hospitalized children. J Pediatr. 2009;154(4):607-608.
12. Kyne L, Warny M, Qamar A, Kelly CP. Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N Engl J Med. 2000;342(6):390-397. (Pubitemid 30084537)
13. Hafiz S, Oakley CL. Clostridium difficile: isolation and characteristics. J Med Microbiol. 1976;9(2):129-136.
14. Miyajima F, Roberts P, Swale A, et al. Characterisation and carriage ratio of Clostridium difficile strains isolated from a community-dwelling elderly population in the United Kingdom. PLoS One. 2011;6(8):e22804.
15. Rea MC, O'Sullivan O, Shanahan F, et al. Clostridium difficile carriage in elderly subjects and associated changes in the intestinal microbiota. J Clin Microbiol. 2012;50(3):867-875.
16. Cohen SH, Gerding DN, Johnson S, et al Society for Healthcare Epidemiology of America; Infectious Diseases Society of America. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol. 2010;31(5):431-455.
17. Riggs MM, Sethi AK, Zabarsky TF, Eckstein EC, Jump RL, Donskey CJ. Asymptomatic carriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residents. Clin Infect Dis. 2007;45(8):992-998. (Pubitemid 47580347)
18. Sandora TJ, Fung M, Flaherty K, et al. Epidemiology and risk factors for Clostridium difficile infection in children. Pediatr Infect Dis J. 2011;30(7):580-584.
19. Rexach CE, Tang-Feldman YJ, Cantrell MC, Cohen SH. Epidemiologic surveillance of Clostridium difficile diarrhea in a freestanding pediatric hospital and a pediatric hospital at a university medical center. Diagn Microbiol Infect Dis. 2006;56(2):109-114. (Pubitemid 44486623)
20. McFarland LV. Update on the changing epidemiology of Clostridium difficile-associated disease. Nat Clin Pract Gastroenterol Hepatol. 2008;5(1):40-48.
21. Spivack JG, Eppes SC, Klein JD. Clostridium difficile-associated diarrhea in a pediatric hospital. Clin Pediatr (Phila). 2003;42(4):347-352. (Pubitemid 36909148)
22. Wolf LE, Gorbach SL, Granowitz EV. Extraintestinal Clostridium difficile: 10 years' experience at a tertiary-care hospital. Mayo Clin Proc. 1998;73(10):943-947. (Pubitemid 28467693)
23. Durand CL, Miller PF. Severe Clostridium difficile colitis and reactive arthritis in a ten-year-old child. Pediatr Infect Dis J. 2009;28(8):750-751.
24. Wright TW, Linscheid RL, O'Duffy JD. Acute flexor tenosynovitis in association with Clostridium difficile infection: a case report. J Hand Surg Am. 1996;21(2):304-306. (Pubitemid 26099474)
25. Gaglani MJ, Murray JC, Morad AB, Edwards MS. Chronic osteomyelitis caused by Clostridium difficile in an adolescent with sickle cell disease. Pediatr Infect Dis J. 1996;15(11):1054-1056. (Pubitemid 26403809)
26. Huang SC, Yang YJ, Lee CT. Rectal prolapse in a child: an unusual presentation of Clostridium difficile-associated pseudomembranous colitis. Pediatr Neonatol. 2011;52(2):110-112.
27. Kusztrich A, Garten L, Hüseman D, Bührer C. Hemolytic uremic syndrome in a preterm infant. Pediatr Nephrol. 2010;25(5):987-988.
28. Centers for Disease Control and Prevention (CDC). Severe Clostridium difficile-associated disease in populations previously at low risk - four states, 2005. MMWR Morb Mortal Wkly Rep. 2005;54(47):1201-1205.
29. Goorhuis A, Bakker D, Corver J, et al. Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078. Clin Infect Dis. 2008;47(9):1162-1170.
30. Loo VG, Poirier L, Miller MA, et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med. 2005;353(23):2442-2449. (Pubitemid 41770165)
31. Lukkarinen H, Eerola E, Ruohola A, et al. Clostridium difficile ribotype 027-associated disease in children with norovirus infection. Pediatr Infect Dis J. 2009;28(9):847-848.
32. Langley JM, LeBlanc JC, Hanakowski M, Goloubeva O. The role of Clostridium difficile and viruses as causes of nosocomial diarrhea in children. Infect Control Hosp Epidemiol. 2002;23(11):660-664. (Pubitemid 35315988)
33. Nylund CM, Goudie A, Garza JM, Fairbrother G, Cohen MB. Clostridium difficile infection in hospitalized children in the United States. Arch Pediatr Adolesc Med. 2011;165(5):451-457.
34. Shaklee J, Zerr DM, Elward A, et al. Improving surveillance for pediatric Clostridium difficile infection: derivation and validation of an accurate case-finding tool. Pediatr Infect Dis J. 2011;30(3):e38-e40.
35. Baker SS, Faden H, Sayej W, Patel R, Baker RD. Increasing incidence of community-associated atypical Clostridium difficile disease in children. Clin Pediatr (Phila). 2010;49(7):644-647.
36. Owens RC Jr, Donskey CJ, Gaynes RP, Loo VG, Muto CA. Antimicrobial- associated risk factors for Clostridium difficile infection. Clin Infect Dis. 2008;46(suppl 1):S19-S31. (Pubitemid 351323662)
37. Morinville V, McDonald J. Clostridium difficile-associated diarrhea in 200 Canadian children. Can J Gastroenterol. 2005;19(8):497-501. (Pubitemid 41283136)
38. Turco R, Martinelli M, Miele E, et al. Proton pump inhibitors as a risk factor for paediatric Clostridium difficile infection. Aliment Pharmacol Ther. 2010;31(7):754-759.
39. Kutty PK, Woods CW, Sena AC, et al. Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA. Emerg Infect Dis. 2010;16(2):197-204.
40. Wilcox MH, Mooney L, Bendall R, Settle CD, Fawley WN. A case-control study of community-associated Clostridium difficile infection. J Antimicrob Chemother. 2008;62(2):388-396. (Pubitemid 351984787)
41. Deshpande A, Pant C, Pasupuleti V, et al. Association between proton pump inhibitor therapy and Clostridium difficile infection in a meta-analysis. Clin Gastroenterol Hepatol. 2012;10(3):225-233.
42. Kwok CS, Arthur AK, Anibueze CI, Singh S, Cavallazzi R, Loke YK. Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis. Am J Gastroenterol. 2012;107(7):1011-1019.
43. Janarthanan S, Ditah I, Adler DG, Ehrinpreis MN. Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: a meta-analysis. Am J Gastroenterol. 2012;107(7):1001-1010.
44. Jump RL, Pultz MJ, Donskey CJ. Vegetative Clostridium difficile survives in room air on moist surfaces and in gastric contents with reduced acidity: a potential mechanism to explain the association between proton pump inhibitors and C. difficile-associated diarrhea? Antimicrob Agents Chemother. 2007;51(8):2883-2887. (Pubitemid 47206226)
45. Mezoff E, Mann EA, Hart KW, Lindsell CJ, Cohen MB. Clostridium difficile infection and treatment in the pediatric inflammatory bowel disease population. J Pediatr Gastroenterol Nutr. 2011;52(4):437-441.
46. Kelsen JR, Kim J, Latta D, et al. Recurrence rate of Clostridium difficile infection in hospitalized pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis. 2011;17(1):50-55.
47. Castagnola E, Battaglia T, Bandettini R, et al. Clostridium difficile-associated disease in children with solid tumors. Support Care Cancer. 2009;17(3):321-324.
48. van de Wetering MD, Kuijpers TW, Taminiau JA, ten Kate FJ, Caron HN. Pseudomembranous and neutropenic enterocolitis in pediatric oncology patients. Support Care Cancer. 2003;11(9):581-586. (Pubitemid 37152629)
49. Tai E, Richardson LC, Townsend J, Howard E, Mcdonald LC. Clostridium difficile infection among children with cancer. Pediatr Infect Dis J. 2011;30(7):610-612.
50. Larson HE, Barclay FE, Honour P, Hill ID. Epidemiology of Clostridium difficile in infants. J Infect Dis. 1982;146(6):727-733. (Pubitemid 13211868)
51. Stark PL, Lee A, Parsonage BD. Colonization of the large bowel by Clostridium difficile in healthy infants: quantitative study. Infect Immun. 1982;35(3):895-899.
52. Matsuki S, Ozaki E, Shozu M, et al. Colonization by Clostridium difficile of neonates in a hospital, and infants and children in three day-care facilities of Kanazawa, Japan. Int Microbiol. 2005;8(1):43-48. (Pubitemid 43126754)
53. Bacon AE, Fekety R, Schaberg DR, Faix RG. Epidemiology of Clostridium difficile colonization in newborns: results using a bacteriophage and bacteriocin typing system. J Infect Dis. 1988;158(2):349-354.
54. Tullus K, Aronsson B, Marcus S, Möllby R. Intestinal colonization with Clostridium difficile in infants up to 18 months of age. Eur J Clin Microbiol Infect Dis. 1989;8(5):390-393. (Pubitemid 19142004)
55. Rousseau C, Lemée L, Le Monnier A, Poilane I, Pons JL, Collignon A. Prevalence and diversity of Clostridium difficile strains in infants. J Med Microbiol. 2011;60(pt 8):1112-1118.
56. Eglow R, Pothoulakis C, Itzkowitz S, et al. Diminished Clostridium difficile toxin A sensitivity in newborn rabbit ileum is associated with decreased toxin A receptor. J Clin Invest. 1992;90(3):822-829.
57. Stark PL, Lee A. Clostridia isolated from the feces of infants during the first year of life. J Pediatr. 1982;100(3):362-365. (Pubitemid 12179995)
58. Pozo F, Soler P, Ladrón de Guevara C. Pseudomembranous colitis associated with Hirschsprung's disease. Clin Infect Dis. 1994;19(6):1160-1161. (Pubitemid 24380040)
59. Enad D, Meislich D, Brodsky NL, Hurt H. Is Clostridium difficile a pathogen in the newborn intensive care unit? a prospective evaluation. J Perinatol. 1997;17(5):355-359. (Pubitemid 127454927)
60. el-Mohandes AE, Keiser JF, Refat M, Jackson BJ. Prevalence and toxigenicity of Clostridium difficile isolates in fecal microflora of preterm infants in the intensive care nursery. Biol Neonate. 1993;63(4):225-229. (Pubitemid 23170620)
61. Toltzis P, Nerandzic MM, Saade E, et al. High proportion of false-positive Clostridium difficile enzyme immunoassays for toxin A and B in pediatric patients. Infect Control Hosp Epidemiol. 2012;33(2):175-179.
62. Luna RA, Boyanton BL Jr, Mehta S, et al. Rapid stool-based diagnosis of Clostridium difficile infection by real-time PCR in a children's hospital. J Clin Microbiol. 2011;49(3):851-857.
63. Wilcox MH, Planche T, Fang FC, Gilligan P. What is the current role of algorithmic approaches for diagnosis of Clostridium difficile infection? J Clin Microbiol. 2010;48(12):4347-4353.
64. Selvaraju SB, Gripka M, Estes K, Nguyen A, Jackson MA, Selvarangan R. Detection of toxigenic Clostridium difficile in pediatric stool samples: an evaluation of Quik Check Complete Antigen assay, BD GeneOhm Cdiff PCR, and ProGastro Cd PCR assays. Diagn Microbiol Infect Dis. 2011;71(3):224-229.
65. Ota KV, McGowan KL. Clostridium difficile testing algorithms using glutamate dehydrogenase antigen and C. difficile toxin enzyme immunoassays with C. difficile nucleic acid amplification testing increase diagnostic yield in a tertiary pediatric population. J Clin Microbiol. 2012;50(4):1185-1188.
66. Angel CA, Green J, Swischuk L, Patel J. Severe ciprofloxacin-associated pseudomembranous colitis in an eight-year-old child. J Pediatr Surg. 2004;39(10):1590-1592. (Pubitemid 39349753)
67. Zar FA, Bakkanagari SR, Moorthi KM, Davis MB. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin Infect Dis. 2007;45(3):302-307. (Pubitemid 47101025)
68. Gerding DN, Johnson S. Management of Clostridium difficile infection: thinking inside and outside the box. Clin Infect Dis. 2010;51(11):1306-1313.
69. Johnson S, Schriever C, Galang M, Kelly CP, Gerding DN. Interruption of recurrent Clostridium difficile-associated diarrhea episodes by serial therapy with vancomycin and rifaximin. Clin Infect Dis. 2007;44(6):846-848. (Pubitemid 46365312)
70. Tannock GW, Munro K, Taylor C, et al. A new macrocyclic antibiotic, fidaxomicin (OPT-80), causes less alteration to the bowel microbiota of Clostridium difficile-infected patients than does vancomycin. Microbiology. 2010;156(pt 11):3354-3359.
71. Louie TJ, Miller MA, Mullane KM, et al; OPT-80-003 Clinical Study Group. Fidaxomicin versus vancomycin for Clostridium difficile infection. N Engl J Med. 2011;364(5):422-431.
72. Mullane KM, Miller MA, Weiss K, et al. Efficacy of fidaxomicin versus vancomycin as therapy for Clostridium difficile infection in individuals taking concomitant antibiotics for other concurrent infections. Clin Infect Dis. 2011;53(5):440-447.
73. Na X, Kelly C. Probiotics in Clostridium difficile Infection. J Clin Gastroenterol. 2011;45(suppl):S154-S158.
74. Russell G, Kaplan J, Ferraro M, Michelow IC. Fecal bacteriotherapy for relapsing Clostridium difficile infection in a child: a proposed treatment protocol. Pediatrics. 2010;126(1):e239-e242.
75. Dubberke ER, Gerding DN, Classen D, et al. Strategies to prevent Clostridium difficile infections in acute care hospitals. Infect Control Hosp Epidemiol. 2008;29(suppl 1):S81-S92.