Review article: Short chain fatty acids in health and disease

Alimentary Pharmacology and Therapeutics

Volumn 12, Issue 6, 1998, Pages 499-507

  Cook, S I ^a,b   Sellin, J H ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b MSB 4234 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SHORT CHAIN FATTY ACID;

COLON ABSORPTION; COLON CANCER; COLON DISEASE; DIARRHEA; DIETARY FIBER; FERMENTATION; HUMAN; ILEITIS; LIPID ABSORPTION; PRIORITY JOURNAL; PROCTITIS; REVIEW; SODIUM ABSORPTION; ULCERATIVE COLITIS; WATER ABSORPTION;

ANIMALS; DISEASE; FATTY ACIDS, VOLATILE; HEALTH; HUMANS;

EID: 0031840660     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1998.00337.x     Document Type: Review

References (50)

1. Soergel KH. Colonic fermentation: metabolic and clinical implications. Clin Invest 1994; 72: 742-8.
2. Mortenson PB, Clausen MR. Short chain fatty acids in the human colon: relation to gastrointestinal health and disease. Scand J Gastroenterol 1996; 31(Suppl. 216): 132-48.
3. Sellin JH, DeSoignie R. Short-chain fatty acid absorption in rabbit colon in vitro. Gastroenterology 1990; 99: 676-83.
4. Reilly KJ, Rombeau JL. Metabolism and potential clinical applications of short-chain fatty acids. Clin Nutrition 1993; 12(Suppl. 1): S97-105.
5. Dagher PC, Egnor RW, Taglietta-Kohlbrecteri A, Charney AN. Short-chain fatty acids inhibit cAMP-mediated chloride secretion in rat colon. Am J Physiol 1996; 271: C1853-60.
6. Chu S, Montrose MH. Extracellular pH regulation in microdomains of colonic crypts: Effects of short-chain fatty acids. Proc Natl Acad Sci 1995; 92: 3303-7.
7. Jenkins DJ. Editorial. Am J Gastroenterol 1989; 84: 1362-4.
8. Friedel D, Levine GM. Effect of short-chain fatty acid on colonic function and structure. J Parenteral Enteral Nutr 1992; 16: 1-4.
9. Mortensen FV, Nielsen H, Mulvany MJ, Hessou I. Short chain fatty acids dilate isolated human colonic resistance arteries. Gut 1990; 31: 1391-4.
10. Frankel WO, Zhang W, Singh A, et al. Mediation of the trophic effects of short-chain fatty acids on rat jejunum and colon. Gastroenterology 1994; 106: 375-80.
11. Harig JM, Soergel KH, Barry JA, Ramaswamy K. Transport of propionate by human ileal brush border membrane vesicles. Am J Physiol 1991; 260: G776-G782.
12. Rolandelli RH, Buckmire MA, Bernstein KA. Intravenous butyrate and healing of colonic anastomosis in the rat. Dis Colon Rectum 1997; 40: 67-70.
13. Harig JM, Soergel KH, Komorowski RA, Wood CM. Therapy of diversion colitis with short-chain fatty acid irrigation. N Engl J Med 1989; 320: 23-8.
14. Guillemot F, Colombel JF, Neut C, et al. Therapy of DC by short-chain fatty acids. Dis Colon Rectum 1991; 34: 861-4.
15. Patz J, Jacobsohn WZ, Gottschalk-Sabag S, Zeides S, Braverman DZ. Treatment of refractory distal ulcerative colitis with short chain tatty acid enemas. Am J Gastroenterol 1996; 91: 731-4.
16. Steinhart AH, Hirnki T, Brzezinski A, Baker JP. Treatment of left-sided ulcerative colitis with butyrate enemas: a controlled trial. Aliment Pharrnacol Ther 1996; 10: 729-36.
17. Roediger WEW, Duncan A, Kapahiris O, Millard S. Reducing sulfur compounds of the colon impair colonocyte nutrition: Implications for ulcerative colitis. Gastroenterology 1993; 104: 802-9.
18. Pitcher MCL, Cummings JH. Hydrogen sulphide: a bacterial toxin in ulcerative colitis? Gut 1996; 39: 1-4.
19. Vernia P, Gnaedinger MS, Hauck W, Breuer RI. Organic anions and the diarrhea of inflammatory bowel disease. Dig Dis Sci 1988; 33: 1353-8.
20. Brunkhorst BA, Kraus EM, Coppi M, Budwick M, Niederman R. Proprionate induces polymorphonuclear activation and inhibits formyl methioyl-lencyl-phenylalanine stimulated activation. Infection Immunity 1992; 60: 2957-68.
21. Breuer RI, Buto SK, Christ ML, et al. Rectal irrigation with short-chain fatty acids for distal ulcerative colitis preliminary report. Dig Dis Sci 1991; 36: 185-7.
22. Scheppach W, Sommer H, Kirchner T, et al. Effects of butyrate enemas on the colonic mucosa in distal ulcerative colitis. Gastroenlerology 1992; 103: 51-6.
23. Vernia P, Cittadini M, Caprilli R, Torsolli A. Topical treatment of refractory distal ulcerative colitis with SASA and sodium butyrate. Dig Dis Sci 1995; 40: 305-7.
24. Breuer RI, Soergel KH, Lashner BA, et al. Short chain fatty acid rectal irrigation for left-sided ulcerative colitis: A randomized, placebo-controlled trial. Gut 1997; 40: 485-91.
25. Nostrant TT, Robertson JM, Lawrence TS. Radiation injury. In: Yamada T, Alpers DH, Owyang C, Powell DW, Silverstein FE, eds. Textbook of Gastroenterology, 2nd edn. Philadelphia: JB Lipincott Company, 1995; 2530.
26. Earnest DL, Trier JS. Radiation enteritis and colitis. In: Sleisenger MH, Fordtran JS, eds. Gastrointestinal Disease, 5th edn. Philadelphia: WB Saunders Company, 1993; 1182.
27. Al-Sabbagh R, Sinicrope FA, Sellin JH, Shen Y, Roubein L. Evaluation of short-chain fatty acid enemas: Treatment of radiation proctitis. Am J Gastroenterol 1996; 91: 1814-18.
28. Salemans JMJI, Nagengast FM, Lubbers EJC, Kuigpers JH. Postoperative and long-term results of ileal pouch-anal anastomosis for ulcerative colitis and familial polyposis coli. Dig Dis Sci 1992; 37: 1882-9.
29. Clausen MR, Tuede M, Mortensen PB. Short-chain fatty acids in pouch contents from patients with and without pouchitis after ileal pouch-anal anastomosis. Gastroenterology 1992; 103: 1144-53.
30. DeSilva HJ, Ireland A, Kettlewell M, et al. Short chain fatty acid irrigation in severe pouchitis. N Engl J Med 1989; 321: 1416-17.
31. Wischmeyer P, Pemberton JH, Phillips SF. Chronic pouchitis after ileal pouch-anal anastomosis: responses to butyrate and glutamine suppositories in a pilot study. Mayo Clin Proc 1993; 68: 978-81.
32. Clausen MR, Bannen H, Tuede M, Mortensen PB. Colonic fermentation to short chain fatty acid is decreased in antibiotic-associated diarrhea. Gastroenterology 1991; 101: 1497-504.
33. Binder JH, Mehta P. Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon. Gastroenterology 1989; 96: 989-96.
34. Hague A, Elder DJE, Hicks DJ, Paraskeva C. Apoptosis in colorectal tumor cells: Induction by the short chain fatty acid butyrate, proprionate and acetate and by the bile salt deoxycholate. Int J Cancer 1995; 60: 400-6.
35. McIntyre A, Gibson PR, Young GP. Butyrate production from dietary fiber and protection against large bowel cancer in a rat model. Gut 1993; 34: 386-91.
36. Weaver GA, Krause JA, Miller TL, Wolin MJ. Short chain fatty acid distribution of enema samples from a sigmoidoscopy population: An association of high acetate and low butyrate ratios with adenomatous polyps and colon cancer. Gut 1988; 29: 1539-43.
37. Arends MJ, Wylie AH. Apoptosis: mechanisms and roles in pathology. Int Rev Exp Pathol 1991; 32: 223-54.
38. Hague A, Manning AM, Hanlon KA, Huschtscha LI, Hart D, Paraskeva C. Sodium butyrate induces apoptosis in human colonic tumour cell lives in a P53-independent pathway: Implications for the possible role of dietary libre in the prevention of large bowel cancer. Int J Cancer 1993; 55: 498-505.
39. Luciano L, Hass R, Busche R, Von Engelhardt W, Reale E. Withdrawal of butyrate from the colonic mucosa triggers 'mass apoptosis' primarily in the G0, G1 phase of the cell cycle. Cell Tiss Res 1996; 286: 81-92.
40. Barnard JA, Warwick G. Butyrate rapidly induces growth inhibition and differentiation in HT-29 cells. Cell Growth Differentiation 1993; 4: 495-501.
41. Scheppach W, Bartran HP, Richter F. Role of short-chain fatly acids in the prevention of colorectal cancer. European J Cancer 1995; 31A: 1077-80.
42. Perrine SP, Greene MF, Faller DV. Delay in the fetal globin switch in infants of diabetic mothers. N Engl J Med 1985; 312: 334-8.
43. Perrine SP, Ginder GD, Faller DV, Dover GH, et al. Gene expression in the B-globin disorders. N Engl J Med 1943; 328: 81-6.
44. Collins AF, Pearson HA, Giardina P, McDonogh KT, Brusilow SW, Dover GH. Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial. Blood 1947; 85(1): 43-9.
45. Kim YS, Tsao D, Siddiqui B, et al. Effects of sodium butyrate and dimethylsulfoxide on biochemical properties of human colon cancer cells. Cancer 1980; 45: 1185-92.
46. Hass R, Buscke R, Luciano L, Reale E, Engelherdt WV. Lack of butyrate is associated with induction of Bax and subsequent apoptosis in the proximal colon of guinea pig. Gastroenterology 1997; 112(3): 875-81.
47. 3 in nuclei from butyrate treated HeLa cells. J Biol Chem 1983; 258: 1299-304.
48. Gibson P, Rosella O, Rosella G, Young G. Secretion of urokinase and plasminogen activator inhibitor-1 by normal colonic epithelium in vitro. Gut 1494; 35: 969-75.
49. Sier CFM, Vloedgraven HJM, Gauesh S, et al. Inactive urokinase and increased levels of its inhibitor type 1 in colorectal cancer liver metastasis. Gastroenterology 1994; 107: 1449-56.
50. Gibson PR, Rosella O, Rosella G, Young GP. Butyrate is a potent inhibitor of urokinase secretion by normal colonic epithelium in vitro. Gastroenterology 1994; 107: 410-19.