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Volumn 1, Issue 1, 2016, Pages

Antibiotic-induced alterations of the gut microbiota alter secondary bile acid production and allow for Clostridium difficile spore germination and outgrowth in the large intestine

Author keywords

Antibiotics; Bile acids; Clostridium difficile; Colonization resistance; Microbiota

Indexed keywords


EID: 84964280002     PISSN: None     EISSN: 23795042     Source Type: Journal    
DOI: 10.1128/mSphere.00045-15     Document Type: Article
Times cited : (347)

References (66)
  • 2
    • 84863661973 scopus 로고    scopus 로고
    • Relapse versus reinfection: recurrent Clostridium difficile infection following treatment with fidaxomicin or vancomycin
    • Figueroa I, Johnson S, Sambol SP, Goldstein EJC, Citron DM, Gerding DN. 2012. Relapse versus reinfection: recurrent Clostridium difficile infection following treatment with fidaxomicin or vancomycin. Clin Infect Dis 55(Suppl 2):S104-S109. http://dx.doi.org/10.1093/cid/cis357
    • (2012) Clin Infect Dis , vol.55 , pp. S104-S109
    • Figueroa, I.1    Johnson, S.2    Sambol, S.P.3    Goldstein, E.J.C.4    Citron, D.M.5    Gerding, D.N.6
  • 4
    • 34547133720 scopus 로고    scopus 로고
    • A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity
    • Zar FA, Bakkanagari SR, Moorthi KM, Davis MB. 2007. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin Infect Dis 45:302-307. http://dx.doi.org/10.1086/519265
    • (2007) Clin Infect Dis , vol.45 , pp. 302-307
    • Zar, F.A.1    Bakkanagari, S.R.2    Moorthi, K.M.3    Davis, M.B.4
  • 5
    • 77951026738 scopus 로고    scopus 로고
    • Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)
    • Cohen SH, Gerding DN, Kelly CP, Loo VG, McDonald LC, Pepin J, Wilcox M, Society for Healthcare Epidemiology of America, Infectious Diseases Society of America. 2010. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 31:431-455. http://dx.doi.org/10.1086/651706
    • (2010) Infect Control Hosp Epidemiol , vol.31 , pp. 431-455
    • Cohen, S.H.1    Gerding, D.N.2    Kelly, C.P.3    Loo, V.G.4    McDonald, L.C.5    Pepin, J.6    Wilcox, M.7
  • 6
    • 67149135207 scopus 로고    scopus 로고
    • Clostridium difficile: emerging public health threat and other nosocomial or hospital acquired infections
    • McFee RB. 2009. Clostridium difficile: emerging public health threat and other nosocomial or hospital acquired infections. Introduction. Dis Mon 55:419-421. http://dx.doi.org/10.1016/j.disamonth.2009.03.013
    • (2009) Introduction. Dis Mon , vol.55 , pp. 419-421
    • McFee, R.B.1
  • 8
    • 80051717743 scopus 로고    scopus 로고
    • The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile infection
    • Reeves AE, Theriot CM, Bergin IL, Huffnagle GB, Schloss PD, Young VB. 2011. The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile infection. Gut Microbes 2:145-158. http://dx.doi.org/10.4161/gmic.2.3.16333
    • (2011) Gut Microbes , vol.2 , pp. 145-158
    • Reeves, A.E.1    Theriot, C.M.2    Bergin, I.L.3    Huffnagle, G.B.4    Schloss, P.D.5    Young, V.B.6
  • 9
    • 84857067037 scopus 로고    scopus 로고
    • Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis
    • Buffie CG, Jarchum I, Equinda M, Lipuma L, Gobourne A, Viale A, Ubeda C, Xavier J, Pamer EG. 2012. Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis. Infect Immun 80: 62-73. http://dx.doi.org/10.1128/IAI.05496-11
    • (2012) Infect Immun , vol.80 , pp. 62-73
    • Buffie, C.G.1    Jarchum, I.2    Equinda, M.3    Lipuma, L.4    Gobourne, A.5    Viale, A.6    Ubeda, C.7    Xavier, J.8    Pamer, E.G.9
  • 10
    • 84898662818 scopus 로고    scopus 로고
    • Alteration of the murine gastrointestinal microbiota by tigecycline leads to increased susceptibility to Clostridium difficile infection
    • Bassis CM, Theriot CM, Young VB. 2014. Alteration of the murine gastrointestinal microbiota by tigecycline leads to increased susceptibility to Clostridium difficile infection. Antimicrob Agents Chemother 58: 2767-2774. http://dx.doi.org/10.1128/AAC.02262-13
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 2767-2774
    • Bassis, C.M.1    Theriot, C.M.2    Young, V.B.3
  • 12
  • 14
    • 84873342775 scopus 로고    scopus 로고
    • Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-betamuricholic acid, a naturally occurring FXR antagonist
    • Sayin S, Wahlström A, Felin J, Jäntti S, Marschall H, Bamberg K, Angelin B, Hyötyläinen T, Orešič M, Bäckhed F. 2013. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-betamuricholic acid, a naturally occurring FXR antagonist. Cell Metab 17: 225-235. http://dx.doi.org/10.1016/j.cmet.2013.01.003
    • (2013) Cell Metab , vol.17 , pp. 225-235
    • Sayin, S.1    Wahlström, A.2    Felin, J.3    Jäntti, S.4    Marschall, H.5    Bamberg, K.6    Angelin, B.7    Hyötyläinen, T.8    Orešič, M.9    Bäckhed, F.10
  • 16
    • 33244467651 scopus 로고    scopus 로고
    • Bile salt biotransformations by human intestinal bacteria
    • Ridlon JM, Kang D-J, Hylemon PB. 2006. Bile salt biotransformations by human intestinal bacteria. J Lipid Res 47:241-259. http://dx.doi.org/ 10.1194/jlr.R500013-JLR200
    • (2006) J Lipid Res , vol.47 , pp. 241-259
    • Ridlon, J.M.1    Kang, D.-J.2    Hylemon, P.B.3
  • 17
    • 70349430938 scopus 로고    scopus 로고
    • Bile acids: regulation of synthesis
    • Chiang JYL. 2009. Bile acids: regulation of synthesis. J Lipid Res 50: 1955-1966. http://dx.doi.org/10.1194/jlr.R900010-JLR200
    • (2009) J Lipid Res , vol.50 , pp. 1955-1966
    • Chiang, J.Y.L.1
  • 18
    • 0037790917 scopus 로고    scopus 로고
    • The enzymes, regulation, and genetics of bile acid synthesis
    • Russell DW. 2003. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem 72:137-174. http://dx.doi.org/10.1146/ annurev.biochem.72.121801.161712
    • (2003) Annu Rev Biochem , vol.72 , pp. 137-174
    • Russell, D.W.1
  • 20
    • 0016357193 scopus 로고
    • Microbial bile acid transformation
    • Midtvedt T. 1974. Microbial bile acid transformation. Am J Clin Nutr 27:1341-1347
    • (1974) Am J Clin Nutr , vol.27 , pp. 1341-1347
    • Midtvedt, T.1
  • 21
    • 84904742368 scopus 로고    scopus 로고
    • Beyond intestinal soap-bile acids in metabolic control
    • Kuipers F, Bloks VW, Groen AK. 2014. Beyond intestinal soap-bile acids in metabolic control. Nat Rev Endocrinol 10:488-498. http:// dx.doi.org/10.1038/nrendo.2014.60
    • (2014) Nat Rev Endocrinol , vol.10 , pp. 488-498
    • Kuipers, F.1    Bloks, V.W.2    Groen, A.K.3
  • 22
    • 41549142775 scopus 로고    scopus 로고
    • Bile salts and glycine as cogerminants for Clostridium difficile spores
    • Sorg JA, Sonenshein AL. 2008. Bile salts and glycine as cogerminants for Clostridium difficile spores. J Bacteriol 190:2505-2512. http:// dx.doi.org/10.1128/JB.01765-07
    • (2008) J Bacteriol , vol.190 , pp. 2505-2512
    • Sorg, J.A.1    Sonenshein, A.L.2
  • 23
    • 0020084325 scopus 로고
    • Use of sodium taurocholate to enhance spore recovery on a medium selective for Clostridium difficile
    • Wilson KH, Kennedy MJ, Fekety FR. 1982. Use of sodium taurocholate to enhance spore recovery on a medium selective for Clostridium difficile. J Clin Microbiol 15:443-446
    • (1982) J Clin Microbiol , vol.15 , pp. 443-446
    • Wilson, K.H.1    Kennedy, M.J.2    Fekety, F.R.3
  • 24
    • 0033806838 scopus 로고    scopus 로고
    • Toxins, butyric acid, and other short-chain fatty acids are coordinately expressed and down-regulated by cysteine in Clostridium difficile
    • Karlsson S, Lindberg A, Norin E, Burman LG, Akerlund T. 2000. Toxins, butyric acid, and other short-chain fatty acids are coordinately expressed and down-regulated by cysteine in Clostridium difficile. Infect Immun 68:5881-5888. http://dx.doi.org/10.1128/IAI.68.10.5881-5888.2000
    • (2000) Infect Immun , vol.68 , pp. 5881-5888
    • Karlsson, S.1    Lindberg, A.2    Norin, E.3    Burman, L.G.4    Akerlund, T.5
  • 25
    • 77957337708 scopus 로고    scopus 로고
    • Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid
    • Sorg JA, Sonenshein AL. 2010. Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid. J Bacteriol 192:4983-4990. http://dx.doi.org/10.1128/JB.00610-10
    • (2010) J Bacteriol , vol.192 , pp. 4983-4990
    • Sorg, J.A.1    Sonenshein, A.L.2
  • 26
    • 84883621976 scopus 로고    scopus 로고
    • Muricholic acids inhibit Clostridium difficile spore germination and growth
    • Francis MB, Allen CA, Sorg JA. 2013. Muricholic acids inhibit Clostridium difficile spore germination and growth. PLoS One 8:e73653. http:// dx.doi.org/10.1371/journal.pone.0073653
    • (2013) PLoS One , vol.8
    • Francis, M.B.1    Allen, C.A.2    Sorg, J.A.3
  • 27
    • 84910677411 scopus 로고    scopus 로고
    • Microbial bile acid metabolic clusters: the bouncers at the bar
    • Sorg J. 2014. Microbial bile acid metabolic clusters: the bouncers at the bar. Cell Host Microbe 16:551-552. http://dx.doi.org/10.1016/ j.chom.2014.10.015
    • (2014) Cell Host Microbe , vol.16 , pp. 551-552
    • Sorg, J.1
  • 30
    • 0020554353 scopus 로고
    • Efficiency of various bile salt preparations for stimulation of Clostridium difficile spore germination
    • Wilson KH. 1983. Efficiency of various bile salt preparations for stimulation of Clostridium difficile spore germination. J Clin Microbiol 18: 1017-1019
    • (1983) J Clin Microbiol , vol.18 , pp. 1017-1019
    • Wilson, K.H.1
  • 31
    • 84922971911 scopus 로고    scopus 로고
    • Dynamics and establishment of Clostridium difficile infection in the murine gastrointestinal tract
    • Koenigsknecht MJ, Theriot CM, Bergin IL, Schumacher CA, Schloss PD, Young VB. 2015. Dynamics and establishment of Clostridium difficile infection in the murine gastrointestinal tract. Infect Immun 83:934-941. http://dx.doi.org/10.1128/IAI.02768-14
    • (2015) Infect Immun , vol.83 , pp. 934-941
    • Koenigsknecht, M.J.1    Theriot, C.M.2    Bergin, I.L.3    Schumacher, C.A.4    Schloss, P.D.5    Young, V.B.6
  • 32
    • 63449096364 scopus 로고    scopus 로고
    • Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination
    • Sorg JA, Sonenshein AL. 2009. Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination. J Bacteriol 191:1115-1117. http:// dx.doi.org/10.1128/JB.01260-08
    • (2009) J Bacteriol , vol.191 , pp. 1115-1117
    • Sorg, J.A.1    Sonenshein, A.L.2
  • 33
    • 78650157537 scopus 로고    scopus 로고
    • Mapping interactions between germinants and Clostridium difficile spores
    • Howerton A, Ramirez N, Abel-Santos E. 2011. Mapping interactions between germinants and Clostridium difficile spores. J Bacteriol 193: 274-282. http://dx.doi.org/10.1128/JB.00980-10
    • (2011) J Bacteriol , vol.193 , pp. 274-282
    • Howerton, A.1    Ramirez, N.2    Abel-Santos, E.3
  • 34
    • 63449133317 scopus 로고    scopus 로고
    • Improved analysis of bile acids in tissues and intestinal contents of rats using LC/ESI-MS
    • Hagio M, Matsumoto M, Fukushima M, Hara H, Ishizuka S. 2009. Improved analysis of bile acids in tissues and intestinal contents of rats using LC/ESI-MS. J Lipid Res 50:173-180. http://dx.doi.org/10.1194/ jlr.D800041-JLR200
    • (2009) J Lipid Res , vol.50 , pp. 173-180
    • Hagio, M.1    Matsumoto, M.2    Fukushima, M.3    Hara, H.4    Ishizuka, S.5
  • 35
    • 77649282955 scopus 로고    scopus 로고
    • Metabolism of bile salts in mice influences spore germination in Clostridium difficile
    • Giel JL, Sorg JA, Sonenshein AL, Zhu J. 2010. Metabolism of bile salts in mice influences spore germination in Clostridium difficile. PLoS One 5:e8740. http://dx.doi.org/10.1371/journal.pone.0008740
    • (2010) PLoS One , vol.5
    • Giel, J.L.1    Sorg, J.A.2    Sonenshein, A.L.3    Zhu, J.4
  • 36
    • 0021963779 scopus 로고
    • Population dynamics of ingested Clostridium difficile in the gastrointestinal tract of the Syrian hamster
    • Wilson KH, Sheagren JN, Freter R. 1985. Population dynamics of ingested Clostridium difficile in the gastrointestinal tract of the Syrian hamster. J Infect Dis 151:355-361. http://dx.doi.org/10.1093/infdis/ 151.2.355
    • (1985) J Infect Dis , vol.151 , pp. 355-361
    • Wilson, K.H.1    Sheagren, J.N.2    Freter, R.3
  • 37
    • 84922426336 scopus 로고    scopus 로고
    • Metabolic profiling of bile acids in human and mouse blood by LC-MS/MS in combination with phospholipid-depletion solid-phase extraction
    • Han J, Liu Y, Wang R, Yang J, Ling V, Borchers CH. 2015. Metabolic profiling of bile acids in human and mouse blood by LC-MS/MS in combination with phospholipid-depletion solid-phase extraction. Anal Chem 87:1127-1136. http://dx.doi.org/10.1021/ac503816u
    • (2015) Anal Chem , vol.87 , pp. 1127-1136
    • Han, J.1    Liu, Y.2    Wang, R.3    Yang, J.4    Ling, V.5    Borchers, C.H.6
  • 38
    • 0033551085 scopus 로고    scopus 로고
    • Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging
    • He G, Shankar RA, Chzhan M, Samouilov A, Kuppusamy P, Zweier JL. 1999. Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging. Proc Natl Acad Sci U S A 96:4586-4591. http:// dx.doi.org/10.1073/pnas.96.8.4586
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 4586-4591
    • He, G.1    Shankar, R.A.2    Chzhan, M.3    Samouilov, A.4    Kuppusamy, P.5    Zweier, J.L.6
  • 39
    • 0013829449 scopus 로고
    • Measurements of the oxygen tension in the lumen of the small intestine of the domestic duck
    • Crompton DW, Shrimpton DH, Silver IA. 1965. Measurements of the oxygen tension in the lumen of the small intestine of the domestic duck. J Exp Biol 43:473-478
    • (1965) J Exp Biol , vol.43 , pp. 473-478
    • Crompton, D.W.1    Shrimpton, D.H.2    Silver, I.A.3
  • 40
    • 84970588371 scopus 로고
    • On the relative importance of aerobic metabolism in small nematode parasites of the alimentary tract: oxygen tensions in the normal environment of the parasites
    • Rogers WP. 1949. On the relative importance of aerobic metabolism in small nematode parasites of the alimentary tract: oxygen tensions in the normal environment of the parasites. Aust J Biol Sci 2:157-165
    • (1949) Aust J Biol Sci , vol.2 , pp. 157-165
    • Rogers, W.P.1
  • 41
    • 39749120072 scopus 로고    scopus 로고
    • Antimicrobialassociated risk factors for Clostridium difficile infection
    • Owens R, Donskey C, Gaynes R, Loo V, Muto C. 2008. Antimicrobialassociated risk factors for Clostridium difficile infection. Clin Infect Dis 46(Suppl 1):S19-S31. http://dx.doi.org/10.1086/521859
    • (2008) Clin Infect Dis , vol.46 , pp. S19-S31
    • Owens, R.1    Donskey, C.2    Gaynes, R.3    Loo, V.4    Muto, C.5
  • 42
    • 0032726458 scopus 로고    scopus 로고
    • Antibiotics and Clostridium difficile
    • Freeman J, Wilcox MH. 1999. Antibiotics and Clostridium difficile. Microbes Infect 1:377-384. http://dx.doi.org/10.1016/S1286-4579(99)80054-9
    • (1999) Microbes Infect , vol.1 , pp. 377-384
    • Freeman, J.1    Wilcox, M.H.2
  • 43
    • 84899145858 scopus 로고    scopus 로고
    • Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice
    • Zhang Y, Limaye PB, Renaud HJ, Klaassen CD. 2014. Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice. Toxicol Appl Pharmacol 277:138-145. http://dx.doi.org/10.1016/ j.taap.2014.03.009
    • (2014) Toxicol Appl Pharmacol , vol.277 , pp. 138-145
    • Zhang, Y.1    Limaye, P.B.2    Renaud, H.J.3    Klaassen, C.D.4
  • 44
    • 84983048071 scopus 로고    scopus 로고
    • Loss of microbiota-mediated colonization resistance to Clostridium difficile infection with oral vancomycin compared with metronidazole
    • Lewis BB, Buffie CG, Carter RA, Leiner I, Toussaint NC, Miller LC, Gobourne A, Ling L, Pamer EG. 2015. Loss of microbiota-mediated colonization resistance to Clostridium difficile infection with oral vancomycin compared with metronidazole. J Infect Dis 212:1656-1665. http://dx.doi.org/10.1093/infdis/jiv256
    • (2015) J Infect Dis , vol.212 , pp. 1656-1665
    • Lewis, B.B.1    Buffie, C.G.2    Carter, R.A.3    Leiner, I.4    Toussaint, N.C.5    Miller, L.C.6    Gobourne, A.7    Ling, L.8    Pamer, E.G.9
  • 45
    • 84940868812 scopus 로고    scopus 로고
    • Antibiotic-induced alterations of the murine gut microbiota and subsequent effects on colonization resistance against Clostridium difficile
    • Schubert AM, Sinani H, Schloss PD. 2015. Antibiotic-induced alterations of the murine gut microbiota and subsequent effects on colonization resistance against Clostridium difficile. mBio 6:e00974. http:// dx.doi.org/10.1128/mBio.00974-15
    • (2015) mBio , vol.6
    • Schubert, A.M.1    Sinani, H.2    Schloss, P.D.3
  • 46
    • 0034010274 scopus 로고    scopus 로고
    • Identification and characterization of a bile acid 7alpha-dehydroxylation operon in Clostridium s. strain TO-931, a highly active 7alpha-dehydroxylating strain isolated from human feces
    • Wells JE, Hylemon PB. 2000. Identification and characterization of a bile acid 7alpha-dehydroxylation operon in Clostridium sp. strain TO-931, a highly active 7alpha-dehydroxylating strain isolated from human feces. Appl Environ Microbiol 66:1107-1113. http://dx.doi.org/10.1128/ AEM.66.3.1107-1113.2000
    • (2000) Appl Environ Microbiol , vol.66 , pp. 1107-1113
    • Wells, J.E.1    Hylemon, P.B.2
  • 47
    • 0025606274 scopus 로고
    • Cloning and sequencing of a bile acid-inducible operon from Eubacterium s. strain vpi 12708
    • Mallonee DH, White WB, Hylemon PB. 1990. Cloning and sequencing of a bile acid-inducible operon from Eubacterium sp. strain vpi 12708. J Bacteriol 172:7011-7019
    • (1990) J Bacteriol , vol.172 , pp. 7011-7019
    • Mallonee, D.H.1    White, W.B.2    Hylemon, P.B.3
  • 48
    • 77951768945 scopus 로고    scopus 로고
    • Isolation and characterization of a bile acid inducible 7alpha-dehydroxylating operon in Clostridium hylemonae TN271
    • Ridlon JM, Kang D, Hylemon PB. 2010. Isolation and characterization of a bile acid inducible 7alpha-dehydroxylating operon in Clostridium hylemonae TN271. Anaerobe 16:137-146. http://dx.doi.org/10.1016/ j.anaerobe.2009.05.004
    • (2010) Anaerobe , vol.16 , pp. 137-146
    • Ridlon, J.M.1    Kang, D.2    Hylemon, P.B.3
  • 50
    • 11844262660 scopus 로고    scopus 로고
    • Bile acids as carcinogens in human gastrointestinal cancers
    • Bernstein H, Bernstein C, Payne C, Dvorakova K, Garewal H. 2005. Bile acids as carcinogens in human gastrointestinal cancers. Mutat Res 589:47-65. http://dx.doi.org/10.1016/j.mrrev.2004.08.001
    • (2005) Mutat Res , vol.589 , pp. 47-65
    • Bernstein, H.1    Bernstein, C.2    Payne, C.3    Dvorakova, K.4    Garewal, H.5
  • 51
    • 12344253203 scopus 로고    scopus 로고
    • Diet, anaerobic bacterial metabolism, and colon cancer: a review of the literature
    • McGarr SE, Ridlon JM, Hylemon PB. 2005. Diet, anaerobic bacterial metabolism, and colon cancer: a review of the literature. J Clin Gastroenterol 39:98-109
    • (2005) J Clin Gastroenterol , vol.39 , pp. 98-109
    • McGarr, S.E.1    Ridlon, J.M.2    Hylemon, P.B.3
  • 53
    • 0035217635 scopus 로고    scopus 로고
    • Genes encoding bile salt hydrolases and conjugated bile salt transporters in Lactobacillus johnsonii 100-100 and other Lactobacillus species
    • Elkins CA, Moser SA, Savage DC. 2001. Genes encoding bile salt hydrolases and conjugated bile salt transporters in Lactobacillus johnsonii 100-100 and other Lactobacillus species. Microbiology 147: 3403-3412. http://dx.doi.org/10.1099/00221287-147-12-3403
    • (2001) Microbiology , vol.147 , pp. 3403-3412
    • Elkins, C.A.1    Moser, S.A.2    Savage, D.C.3
  • 54
    • 51649086648 scopus 로고    scopus 로고
    • Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome
    • Jones BV, Begley M, Hill C, Gahan CGM, Marchesi JR. 2008. Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proc Natl Acad Sci U S A 105:13580-13585. http://dx.doi.org/10.1073/pnas.0804437105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13580-13585
    • Jones, B.V.1    Begley, M.2    Hill, C.3    Gahan, C.G.M.4    Marchesi, J.R.5
  • 55
    • 84874737205 scopus 로고    scopus 로고
    • High-throughput DNA sequence analysis reveals stable engraftment of gut microbiota following transplantation of previously frozen fecal bacteria
    • Hamilton MJ, Weingarden AR, Unno T, Khoruts A, Sadowsky MJ. 2013. High-throughput DNA sequence analysis reveals stable engraftment of gut microbiota following transplantation of previously frozen fecal bacteria. Gut Microbes 4:125-135. http://dx.doi.org/10.4161/ gmic.23571
    • (2013) Gut Microbes , vol.4 , pp. 125-135
    • Hamilton, M.J.1    Weingarden, A.R.2    Unno, T.3    Khoruts, A.4    Sadowsky, M.J.5
  • 56
    • 84889080458 scopus 로고    scopus 로고
    • The relationship between phenotype, ribotype, and clinical disease in human Clostridium difficile isolates
    • Carlson PE, Jr, Walk ST, Bourgis AE, Liu MW, Kopliku F, Lo E, Young VB, Aronoff DM, Hanna PC. 2013. The relationship between phenotype, ribotype, and clinical disease in human Clostridium difficile isolates. Anaerobe 24: 109-116. http://dx.doi.org/10.1016/ j.anaerobe.2013.04.003
    • (2013) Anaerobe , vol.24 , pp. 109-116
    • Carlson, P.E.1    Walk, S.T.2    Bourgis, A.E.3    Liu, M.W.4    Kopliku, F.5    Lo, E.6    Young, V.B.7    Aronoff, D.M.8    Hanna, P.C.9
  • 57
    • 84857472906 scopus 로고    scopus 로고
    • Spores of Clostridium difficile clinical isolates display a diverse germination response to bile salts
    • Heeg D, Burns DA, Cartman ST, Minton NP. 2012. Spores of Clostridium difficile clinical isolates display a diverse germination response to bile salts. PLoS One 7:e32381. http://dx.doi.org/10.1371/ journal.pone.0032381
    • (2012) PLoS One , vol.7
    • Heeg, D.1    Burns, D.A.2    Cartman, S.T.3    Minton, N.P.4
  • 59
  • 60
    • 84867598881 scopus 로고    scopus 로고
    • Cefoperazone-treated mice as an experimental platform to assess differential virulence of Clostridium difficile strains
    • Theriot CM, Koumpouras CC, Carlson PE, Bergin II, Aronoff DM, Young VB. 2011. Cefoperazone-treated mice as an experimental platform to assess differential virulence of Clostridium difficile strains. Gut Microbes 2:326-334. http://dx.doi.org/10.4161/gmic.19142
    • (2011) Gut Microbes , vol.2 , pp. 326-334
    • Theriot, C.M.1    Koumpouras, C.C.2    Carlson, P.E.3    Bergin, I.I.4    Aronoff, D.M.5    Young, V.B.6
  • 61
    • 84884251320 scopus 로고    scopus 로고
    • Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform
    • Kozich JJ, Westcott SL, Baxter NT, Highlander SK, Schloss PD. 2013. Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform. Appl Environ Microbiol 79:5112-5120. http://dx.doi.org/ 10.1128/AEM.01043-13
    • (2013) Appl Environ Microbiol , vol.79 , pp. 5112-5120
    • Kozich, J.J.1    Westcott, S.L.2    Baxter, N.T.3    Highlander, S.K.4    Schloss, P.D.5
  • 63
    • 37549027613 scopus 로고    scopus 로고
    • Silva: a comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB
    • Pruesse E, Quast C, Knittel K, Fuchs BM, Ludwig W, Peplies J, Glockner FO. 2007. Silva: a comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB. Nucleic Acids Res 35:7188-7196. http://dx.doi.org/10.1093/nar/ gkm864
    • (2007) Nucleic Acids Res , vol.35 , pp. 7188-7196
    • Pruesse, E.1    Quast, C.2    Knittel, K.3    Fuchs, B.M.4    Ludwig, W.5    Peplies, J.6    Glockner, F.O.7
  • 65
    • 34548293679 scopus 로고    scopus 로고
    • Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy
    • Wang Q, Garrity GM, Tiedje JM, Cole JR. 2007. Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl Environ Microbiol 73:5261-5267. http://dx.doi.org/10.1128/ AEM.00062-07
    • (2007) Appl Environ Microbiol , vol.73 , pp. 5261-5267
    • Wang, Q.1    Garrity, G.M.2    Tiedje, J.M.3    Cole, J.R.4
  • 66
    • 79961181125 scopus 로고    scopus 로고
    • UCHIME improves sensitivity and speed of chimera detection
    • Edgar RC, Haas BJ, Clemente JC, Quince C, Knight R. 2011. UCHIME improves sensitivity and speed of chimera detection. Bioinformatics 27:2194-2200. http://dx.doi.org/10.1093/bioinformatics/btr381
    • (2011) Bioinformatics , vol.27 , pp. 2194-2200
    • Edgar, R.C.1    Haas, B.J.2    Clemente, J.C.3    Quince, C.4    Knight, R.5


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