Differences in outcome according to Clostridium difficile testing method: A prospective multicentre diagnostic validation study of C difficile infection

The Lancet Infectious Diseases

Volumn 13, Issue 11, 2013, Pages 936-945

  Planche, Timothy D ^a,b   Davies, Kerrie A ^c   Coen, Pietro G ^e   Finney, John M ^d   Monahan, Irene M ^a,b   Morris, Kirsti A ^c   O'Connor, Lily ^d   Oakley, Sarah J ^d   Pope, Cassie F ^a,b   Wren, Mike W ^e   Shetty, Nandini P ^e   Crook, Derrick W ^d   Wilcox, Mark H ^c  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b ST GEORGE'S UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c LEEDS TEACHING HOSPITALS NHS TRUST   (United Kingdom)

^d OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE DEHYDROGENASE;

ADULT; ALGORITHM; ARTICLE; BACTERIUM CULTURE; BLOOD SAMPLING; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; FEMALE; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; VALIDATION STUDY;

ADOLESCENT; ADULT; AGED; AREA UNDER CURVE; CHILD; CHILD, PRESCHOOL; CLOSTRIDIUM DIFFICILE; DIARRHEA; DNA, BACTERIAL; ENTEROCOLITIS, PSEUDOMEMBRANOUS; ENTEROTOXINS; FECES; FEMALE; GLUTAMATE DEHYDROGENASE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; ROC CURVE; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84885955622     PISSN: 14733099     EISSN: 14744457     Source Type: Journal    
DOI: 10.1016/S1473-3099(13)70200-7     Document Type: Article

References (39)

1. Klevens RM, Edwards JR, Richards CL, et al. Estimating health care-associated infections and deaths in U.S. hospitals, 2002. Public Health Rep 2007, 122:160-166.
2. Dallal RM, Harbrecht BG, Boujoukas AJ, et al. Fulminant Clostridium difficile: an underappreciated and increasing cause of death and complications. Ann Surg 2002, 235:363-372.
3. Pepin J, Valiquette L, Cossette B Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec. CMAJ 2005, 173:1037-1042.
4. Wilson V, Cheek L, Satta G, et al. Predictors of death after Clostridium difficile infection: a report on 128 strain-typed cases from a teaching hospital in the United Kingdom. Clin Infect Dis 2010, 50:e77-e81.
5. Pepin J, Valiquette L, Alary ME, et al. Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. CMAJ 2004, 171:466-472.
6. Loo VG, Poirier L, Miller MA, et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005, 353:2442-2449.
7. Goldenberg SD, French GL Diagnostic testing for Clostridium difficile: a comprehensive survey of laboratories in England. J Hosp Infect 2011, 79:4-7.
8. Wilcox MH Laboratory diagnosis of Clostridium difficile infection: in a state of transition or confusion or both?. J Hosp Infect 2011, 79:1-3.
9. Wilcox MH, Planche T, Fang FC, Gilligan P Point-counterpoint. What is the current role of algorithmic approaches for diagnosis of Clostridium difficile infection?. J Clin Microbiol 2010, 48:4347-4353.
10. Cohen SH, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 2010, 31:431-455.
11. Novak-Weekley SM, Marlowe EM, Miller JM, et al. Clostridium difficile testing in the clinical laboratory by use of multiple testing algorithms. J Clin Microbiol 2010, 48:889-893.
12. Planche T, Wilcox M Reference assays for Clostridium difficile infection: one or two gold standards?. J Clin Pathol 2011, 64:1-5.
13. Karen CC, John GB Biology of Clostridium difficile: implications for epidemiology and diagnosis. Annu Rev Microbiol 2011, 65:501-521.
14. Eastwood K, Else P, Charlett A, Wilcox M Comparison of nine commercially available Clostridium difficile toxin detection assays, a real-time PCR assay for C. difficile tcdB, and a glutamate dehydrogenase detection assay to cytotoxin testing and cytotoxigenic culture methods. J Clin Microbiol 2009, 47:3211-3217.
15. Planche T, Aghaizu A, Holliman R, et al. Diagnosis of Clostridium difficile infection by toxin detection kits: a systematic review. Lancet Infect Dis 2008, 8:777-784.
16. Wilcox MH, Eastwood KA CEP08054: evaluation report Clostridium difficile toxin detection assays. Centre for Evidence-Based Purchasing (accessed Aug 12, 2013). https://www.gov.uk/government/publications/clostridium-difficile-toxin-detection-assays-evaluation-report.
17. Ticehurst JR, Aird DZ, Dam LM, et al. Effective detection of toxigenic Clostridium difficile by a two-step algorithm including tests for antigen and cytotoxin. J Clin Microbiol 2006, 44:1145-1149.
18. Fenner L, Widmer AF, Goy G, Rudin S, Frei R Rapid and reliable diagnostic algorithm for detection of Clostridium difficile. J Clin Microbiol 2008, 46:328-330.
19. Reller ME, Lema CA, Perl TM, et al. Yield of stool culture with isolate toxin testing versus a two-step algorithm including stool toxin testing for detection of toxigenic Clostridium difficile. J Clin Microbiol 2007, 45:3601-3605.
20. Wren MW, Sivapalan M, Kinson R, Shetty NR Laboratory diagnosis of Clostridium difficile infection. An evaluation of tests for faecal toxin, glutamate dehydrogenase, lactoferrin and toxigenic culture in the diagnostic laboratory. Br J Biomed Sci 2009, 66:1-5.
21. Sharp SE, Ruden LO, Pohl JC, Hatcher PA, Jayne LM, Ivie WM Evaluation of the C. Diff Quik Chek Complete Assay, a new glutamate dehydrogenase and A/B toxin combination lateral flow assay for use in rapid, simple diagnosis of Clostridium difficile disease. J Clin Microbiol 2010, 48:2082-2086.
22. Freeman J, Baines SD, Jabes D, Wilcox MH Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection. J Antimicrob Chemother 2005, 56:717-725.
23. Hosmer DW, Lemeshow S Applied survival analysis. Regression modeling of time to event data 1999, Wiley, New York.
24. Hosmer DW, Lemeshow S Applied logistic regression 1989, John Wiley & Sons, New York.
25. Efron B, Tibshirani RJ An introduction to the bootstrap 1998, Chapman & Hall/CRC, Boca Raton, FL.
26. Fawcett T An introduction to ROC analysis. Pattern Recogn Lett 2006, 27:861-874.
27. Longtin Y, Trottier S, Brochu G, et al. Impact of the type of diagnostic assay on Clostridium difficile infection and complication rates in a mandatory reporting program. Clin Infect Dis 2013, 56:67-73.
28. Aronsson B, Mollby R, Nord CE Antimicrobial agents and Clostridium difficile in acute enteric disease: epidemiological data from Sweden, 1980-1982. J Infect Dis 1985, 151:476-481.
29. Phillips KD, Rogers PA Rapid detection and presumptive identification of Clostridium difficile by p-cresol production on a selective medium. J Clin Pathol 1981, 34:642-644.
30. Clabots CR, Johnson S, Olson MM, Peterson LR, Gerding DN Acquisition of Clostridium difficile by hospitalized patients: evidence for colonized new admissions as a source of infection. J Infect Dis 1992, 166:561-567.
31. Samore MH, DeGirolami PC, Tlucko A, Lichtenberg DA, Melvin ZA, Karchmer AW Clostridium difficile colonization and diarrhea at a tertiary care hospital. Clin Infect Dis 1994, 18:181-187.
32. Gerding DN, Olson MM, Peterson LR, et al. Clostridium difficile-associated diarrhea and colitis in adults. A prospective case-controlled epidemiologic study. Arch Intern Med 1986, 146:95-100.
33. Lashner BA, Todorczuk J, Sahm DF, Hanauer SB Clostridium difficile culture-positive toxin-negative diarrhea. Am J Gastroenterol 1986, 81:940-943.
34. Humphries RM, Uslan DZ, Rubin Z Performance of Clostridium difficile toxin enzyme immunoassay and nucleic acid amplification tests stratified by patient disease severity. J Clin Microbiol 2013, 51:869-873.
35. Dubberke ER, Han Z, Bobo L, et al. Impact of clinical symptoms on interpretation of diagnostic assays for Clostridium difficile infections. J Clin Microbiol 2011, 49:2887-2893.
36. Walker AS, Eyre DW, Wyllie DH, et al. Characterisation of Clostridium difficile hospital ward-based transmission using extensive epidemiological data and molecular typing. PLoS Med 2012, 9:e1001172.
37. Bauer MP, Notermans DW, van Benthem BH, et al. Clostridium difficile infection in Europe: a hospital-based survey. Lancet 2011, 377:63-73.
38. Surawicz CM, Brandt LJ, Binion DG, et al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am J Gastroenterol 2013, 108:478-498.
39. Alcala L, Marin M, Martin A, et al. Laboratory diagnosis of Clostridium difficile infection in Spain: a population-based survey. J Hosp Infect 2011, 79:13-17.