메뉴 건너뛰기




Volumn 162, Issue , 2016, Pages 161-173

The effect of obesogenic diets on brain Neuropeptide Y

Author keywords

Dopamine; Feeding; Neuropeptide; Obesity; Reward

Indexed keywords

BRAIN PROTEIN; NEUROPEPTIDE Y; CARBOHYDRATE DIET;

EID: 84966731094     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2016.04.049     Document Type: Review
Times cited : (20)

References (194)
  • 1
    • 23744470219 scopus 로고    scopus 로고
    • Mechanisms of neuropeptide Y, peptide YY, and pancreatic polypeptide inhibition of identified green fluorescent protein-expressing GABA neurons in the hypothalamic neuroendocrine arcuate nucleus
    • [1] Acuna-Goycolea, C., Tamamaki, N., Yanagawa, Y., Obata, K., van den Pol, A.N., Mechanisms of neuropeptide Y, peptide YY, and pancreatic polypeptide inhibition of identified green fluorescent protein-expressing GABA neurons in the hypothalamic neuroendocrine arcuate nucleus. J. Neurosci. 25:32 (2005), 7406–7419, 10.1523/jneurosci.1008-05.2005.
    • (2005) J. Neurosci. , vol.25 , Issue.32 , pp. 7406-7419
    • Acuna-Goycolea, C.1    Tamamaki, N.2    Yanagawa, Y.3    Obata, K.4    van den Pol, A.N.5
  • 2
    • 34247092060 scopus 로고    scopus 로고
    • Neuropeptide Y-induced enhancement of the evoked release of newly synthesized dopamine in rat striatum: mediation by Y2 receptors
    • [2] Adewale, A.S., Macarthur, H., Westfall, T.C., Neuropeptide Y-induced enhancement of the evoked release of newly synthesized dopamine in rat striatum: mediation by Y2 receptors. Neuropharmacology 52:6 (2007), 1396–1402, 10.1016/j.neuropharm.2007.01.018.
    • (2007) Neuropharmacology , vol.52 , Issue.6 , pp. 1396-1402
    • Adewale, A.S.1    Macarthur, H.2    Westfall, T.C.3
  • 3
    • 0034714045 scopus 로고    scopus 로고
    • Postnatal regulation of hypothalamic neuropeptide expression by leptin: implications for energy balance and body weight regulation
    • Retrieved from
    • [3] Ahima, R.S., Hileman, S.M., Postnatal regulation of hypothalamic neuropeptide expression by leptin: implications for energy balance and body weight regulation. Regul. Pept. 92:1–3 (2000), 1–7 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11024558.
    • (2000) Regul. Pept. , vol.92 , Issue.1-3 , pp. 1-7
    • Ahima, R.S.1    Hileman, S.M.2
  • 5
    • 65549154830 scopus 로고    scopus 로고
    • Fructose-rich diet-induced abdominal adipose tissue endocrine dysfunction in normal male rats
    • [5] Alzamendi, A., Giovambattista, A., Raschia, A., Madrid, V., Gaillard, R.C., Rebolledo, O., Spinedi, E., Fructose-rich diet-induced abdominal adipose tissue endocrine dysfunction in normal male rats. Endocrine 35:2 (2009), 227–232, 10.1007/s12020-008-9143-1.
    • (2009) Endocrine , vol.35 , Issue.2 , pp. 227-232
    • Alzamendi, A.1    Giovambattista, A.2    Raschia, A.3    Madrid, V.4    Gaillard, R.C.5    Rebolledo, O.6    Spinedi, E.7
  • 6
    • 80052826108 scopus 로고    scopus 로고
    • Differential effects of chow and purified diet on the consumption of sucrose solution and lard and the development of obesity
    • [6] Apolzan, J.W., Harris, R.B., Differential effects of chow and purified diet on the consumption of sucrose solution and lard and the development of obesity. Physiol. Behav. 105:2 (2012), 325–331, 10.1016/j.physbeh.2011.08.023.
    • (2012) Physiol. Behav. , vol.105 , Issue.2 , pp. 325-331
    • Apolzan, J.W.1    Harris, R.B.2
  • 7
    • 34249798731 scopus 로고    scopus 로고
    • Solid and liquid obesogenic diets induce obesity and counter-regulatory changes in hypothalamic gene expression in juvenile Sprague-Dawley rats
    • [7] Archer, Z.A., Corneloup, J., Rayner, D.V., Barrett, P., Moar, K.M., Mercer, J.G., Solid and liquid obesogenic diets induce obesity and counter-regulatory changes in hypothalamic gene expression in juvenile Sprague-Dawley rats. J. Nutr. 137:6 (2007), 1483–1490.
    • (2007) J. Nutr. , vol.137 , Issue.6 , pp. 1483-1490
    • Archer, Z.A.1    Corneloup, J.2    Rayner, D.V.3    Barrett, P.4    Moar, K.M.5    Mercer, J.G.6
  • 8
    • 27644591697 scopus 로고    scopus 로고
    • Hypothalamic energy balance gene responses in the Sprague-Dawley rat to supplementation of high-energy diet with liquid ensure and subsequent transfer to chow
    • [8] Archer, Z.A., Rayner, D.V., Barrett, P., Balik, A., Duncan, J.S., Moar, K.M., Mercer, J.G., Hypothalamic energy balance gene responses in the Sprague-Dawley rat to supplementation of high-energy diet with liquid ensure and subsequent transfer to chow. J. Neuroendocrinol. 17:11 (2005), 711–719, 10.1111/j.1365-2826.2005.01363.x.
    • (2005) J. Neuroendocrinol. , vol.17 , Issue.11 , pp. 711-719
    • Archer, Z.A.1    Rayner, D.V.2    Barrett, P.3    Balik, A.4    Duncan, J.S.5    Moar, K.M.6    Mercer, J.G.7
  • 9
    • 2642579261 scopus 로고    scopus 로고
    • Hypothalamic gene expression is altered in underweight but obese juvenile male Sprague-Dawley rats fed a high-energy diet
    • [9] Archer, Z.A., Rayner, D.V., Mercer, J.G., Hypothalamic gene expression is altered in underweight but obese juvenile male Sprague-Dawley rats fed a high-energy diet. J. Nutr. 134:6 (2004), 1369–1374.
    • (2004) J. Nutr. , vol.134 , Issue.6 , pp. 1369-1374
    • Archer, Z.A.1    Rayner, D.V.2    Mercer, J.G.3
  • 10
    • 1542440921 scopus 로고    scopus 로고
    • Normal distribution of body weight gain in male Sprague-Dawley rats fed a high-energy diet
    • [10] Archer, Z.A., Rayner, D.V., Rozman, J., Klingenspor, M., Mercer, J.G., Normal distribution of body weight gain in male Sprague-Dawley rats fed a high-energy diet. Obes. Res. 11:11 (2003), 1376–1383, 10.1038/oby.2003.186.
    • (2003) Obes. Res. , vol.11 , Issue.11 , pp. 1376-1383
    • Archer, Z.A.1    Rayner, D.V.2    Rozman, J.3    Klingenspor, M.4    Mercer, J.G.5
  • 11
    • 0021918223 scopus 로고
    • An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat
    • [11] Bai, F.L., Yamano, M., Shiotani, Y., Emson, P.C., Smith, A.D., Powell, J.F., Tohyama, M., An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat. Brain Res. 331:1 (1985), 172–175.
    • (1985) Brain Res. , vol.331 , Issue.1 , pp. 172-175
    • Bai, F.L.1    Yamano, M.2    Shiotani, Y.3    Emson, P.C.4    Smith, A.D.5    Powell, J.F.6    Tohyama, M.7
  • 12
    • 33747362848 scopus 로고    scopus 로고
    • Effects of neuropeptide Y on feeding microstructure: dissociation of appetitive and consummatory actions
    • [12] Baird, J.P., Gray, N.E., Fischer, S.G., Effects of neuropeptide Y on feeding microstructure: dissociation of appetitive and consummatory actions. Behav. Neurosci. 120:4 (2006), 937–951, 10.1037/0735-7044.120.4.937.
    • (2006) Behav. Neurosci. , vol.120 , Issue.4 , pp. 937-951
    • Baird, J.P.1    Gray, N.E.2    Fischer, S.G.3
  • 13
    • 0034674684 scopus 로고    scopus 로고
    • Behavioral characterization of neuropeptide Y knockout mice
    • Retrieved from
    • [13] Bannon, A.W., Seda, J., Carmouche, M., Francis, J.M., Norman, M.H., Karbon, B., McCaleb, M.L., Behavioral characterization of neuropeptide Y knockout mice. Brain Res. 868:1 (2000), 79–87 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10841890.
    • (2000) Brain Res. , vol.868 , Issue.1 , pp. 79-87
    • Bannon, A.W.1    Seda, J.2    Carmouche, M.3    Francis, J.M.4    Norman, M.H.5    Karbon, B.6    McCaleb, M.L.7
  • 14
    • 84899486552 scopus 로고    scopus 로고
    • Leptin modulates the intrinsic excitability of AgRP/NPY neurons in the arcuate nucleus of the hypothalamus
    • [14] Baver, S.B., Hope, K., Guyot, S., Bjorbaek, C., Kaczorowski, C., O'Connell, K.M., Leptin modulates the intrinsic excitability of AgRP/NPY neurons in the arcuate nucleus of the hypothalamus. J. Neurosci. 34:16 (2014), 5486–5496, 10.1523/jneurosci.4861-12.2014.
    • (2014) J. Neurosci. , vol.34 , Issue.16 , pp. 5486-5496
    • Baver, S.B.1    Hope, K.2    Guyot, S.3    Bjorbaek, C.4    Kaczorowski, C.5    O'Connell, K.M.6
  • 15
    • 0022979652 scopus 로고
    • The effect of neuropeptide Y on striatal catecholamines
    • [15] Beal, M.F., Frank, R.C., Ellison, D.W., Martin, J.B., The effect of neuropeptide Y on striatal catecholamines. Neurosci. Lett. 71:1 (1986), 118–123.
    • (1986) Neurosci. Lett. , vol.71 , Issue.1 , pp. 118-123
    • Beal, M.F.1    Frank, R.C.2    Ellison, D.W.3    Martin, J.B.4
  • 16
    • 33845328075 scopus 로고    scopus 로고
    • Neuropeptide Y in normal eating and in genetic and dietary-induced obesity
    • [16] Beck, B., Neuropeptide Y in normal eating and in genetic and dietary-induced obesity. Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci. 361:1471 (2006), 1159–1185, 10.1098/rstb.2006.1855.
    • (2006) Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci. , vol.361 , Issue.1471 , pp. 1159-1185
    • Beck, B.1
  • 17
    • 0025046607 scopus 로고
    • Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status
    • [17] Beck, B., Jhanwar-Uniyal, M., Burlet, A., Chapleur-Chateau, M., Leibowitz, S.F., Burlet, C., Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status. Brain Res. 528:2 (1990), 245–249.
    • (1990) Brain Res. , vol.528 , Issue.2 , pp. 245-249
    • Beck, B.1    Jhanwar-Uniyal, M.2    Burlet, A.3    Chapleur-Chateau, M.4    Leibowitz, S.F.5    Burlet, C.6
  • 18
    • 0028219004 scopus 로고
    • Macronutrient type independently of energy intake modulates hypothalamic neuropeptide Y in Long-Evans rats
    • Retrieved from
    • [18] Beck, B., Stricker-Krongrad, A., Burlet, A., Max, J.P., Musse, N., Nicolas, J.P., Burlet, C., Macronutrient type independently of energy intake modulates hypothalamic neuropeptide Y in Long-Evans rats. Brain Res. Bull. 34:2 (1994), 85–91 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/8044691.
    • (1994) Brain Res. Bull. , vol.34 , Issue.2 , pp. 85-91
    • Beck, B.1    Stricker-Krongrad, A.2    Burlet, A.3    Max, J.P.4    Musse, N.5    Nicolas, J.P.6    Burlet, C.7
  • 19
    • 0025642628 scopus 로고
    • Influence of diet composition on food intake and hypothalamic neuropeptide Y (NPY) in the rat
    • [19] Beck, B., Stricker-Krongrad, A., Burlet, A., Nicolas, J.P., Burlet, C., Influence of diet composition on food intake and hypothalamic neuropeptide Y (NPY) in the rat. Neuropeptides 17:4 (1990), 197–203.
    • (1990) Neuropeptides , vol.17 , Issue.4 , pp. 197-203
    • Beck, B.1    Stricker-Krongrad, A.2    Burlet, A.3    Nicolas, J.P.4    Burlet, C.5
  • 20
    • 0026642216 scopus 로고
    • Specific hypothalamic neuropeptide Y variation with diet parameters in rats with food choice
    • [20] Beck, B., Stricker-Krongrad, A., Burlet, A., Nicolas, J.P., Burlet, C., Specific hypothalamic neuropeptide Y variation with diet parameters in rats with food choice. Neuroreport 3:7 (1992), 571–574.
    • (1992) Neuroreport , vol.3 , Issue.7 , pp. 571-574
    • Beck, B.1    Stricker-Krongrad, A.2    Burlet, A.3    Nicolas, J.P.4    Burlet, C.5
  • 21
    • 0026562952 scopus 로고
    • Chronic and continuous intracerebroventricular infusion of neuropeptide Y in Long-Evans rats mimics the feeding behaviour of obese Zucker rats
    • [21] Beck, B., Stricker-Krongrad, A., Nicolas, J.P., Burlet, C., Chronic and continuous intracerebroventricular infusion of neuropeptide Y in Long-Evans rats mimics the feeding behaviour of obese Zucker rats. Int. J. Obes. Relat. Metab. Disord. 16:4 (1992), 295–302.
    • (1992) Int. J. Obes. Relat. Metab. Disord. , vol.16 , Issue.4 , pp. 295-302
    • Beck, B.1    Stricker-Krongrad, A.2    Nicolas, J.P.3    Burlet, C.4
  • 22
    • 16244373061 scopus 로고    scopus 로고
    • The role of previous exposure in the appetitive and consummatory effects of orexigenic neuropeptides
    • [22] Benoit, S.C., Clegg, D.J., Woods, S.C., Seeley, R.J., The role of previous exposure in the appetitive and consummatory effects of orexigenic neuropeptides. Peptides 26:5 (2005), 751–757, 10.1016/j.peptides.2004.12.012.
    • (2005) Peptides , vol.26 , Issue.5 , pp. 751-757
    • Benoit, S.C.1    Clegg, D.J.2    Woods, S.C.3    Seeley, R.J.4
  • 23
    • 33847634405 scopus 로고    scopus 로고
    • The debate over dopamine's role in reward: the case for incentive salience
    • [23] Berridge, K.C., The debate over dopamine's role in reward: the case for incentive salience. Psychopharmacology 191:3 (2007), 391–431, 10.1007/s00213-006-0578-x.
    • (2007) Psychopharmacology , vol.191 , Issue.3 , pp. 391-431
    • Berridge, K.C.1
  • 24
    • 0034814247 scopus 로고    scopus 로고
    • A role for NPY overexpression in the dorsomedial hypothalamus in hyperphagia and obesity of OLETF rats
    • [24] Bi, S., Ladenheim, E.E., Schwartz, G.J., Moran, T.H., A role for NPY overexpression in the dorsomedial hypothalamus in hyperphagia and obesity of OLETF rats. Am. J. Phys. Regul. Integr. Comp. Phys. 281:1 (2001), R254–R260.
    • (2001) Am. J. Phys. Regul. Integr. Comp. Phys. , vol.281 , Issue.1 , pp. R254-R260
    • Bi, S.1    Ladenheim, E.E.2    Schwartz, G.J.3    Moran, T.H.4
  • 25
    • 0042734586 scopus 로고    scopus 로고
    • Response to acute food deprivation in OLETF rats lacking CCK-A receptors
    • [25] Bi, S., Moran, T.H., Response to acute food deprivation in OLETF rats lacking CCK-A receptors. Physiol. Behav. 79:4–5 (2003), 655–661.
    • (2003) Physiol. Behav. , vol.79 , Issue.4-5 , pp. 655-661
    • Bi, S.1    Moran, T.H.2
  • 26
    • 0142116115 scopus 로고    scopus 로고
    • Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression
    • [26] Bi, S., Robinson, B.M., Moran, T.H., Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Am. J. Phys. Regul. Integr. Comp. Phys. 285:5 (2003), R1030–R1036, 10.1152/ajpregu.00734.2002.
    • (2003) Am. J. Phys. Regul. Integr. Comp. Phys. , vol.285 , Issue.5 , pp. R1030-R1036
    • Bi, S.1    Robinson, B.M.2    Moran, T.H.3
  • 27
    • 0030840674 scopus 로고    scopus 로고
    • Y-receptor subtypes—how many more?
    • [27] Blomqvist, A.G., Herzog, H., Y-receptor subtypes—how many more?. Trends Neurosci. 20:7 (1997), 294–298.
    • (1997) Trends Neurosci. , vol.20 , Issue.7 , pp. 294-298
    • Blomqvist, A.G.1    Herzog, H.2
  • 28
    • 77957274035 scopus 로고    scopus 로고
    • Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons
    • [28] Briggs, D.I., Enriori, P.J., Lemus, M.B., Cowley, M.A., Andrews, Z.B., Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons. Endocrinology 151:10 (2010), 4745–4755, 10.1210/en.2010-0556.
    • (2010) Endocrinology , vol.151 , Issue.10 , pp. 4745-4755
    • Briggs, D.I.1    Enriori, P.J.2    Lemus, M.B.3    Cowley, M.A.4    Andrews, Z.B.5
  • 29
    • 0017276160 scopus 로고
    • Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood
    • [29] Broadwell, R.D., Brightman, M.W., Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood. J. Comp. Neurol. 166:3 (1976), 257–283, 10.1002/cne.901660302.
    • (1976) J. Comp. Neurol. , vol.166 , Issue.3 , pp. 257-283
    • Broadwell, R.D.1    Brightman, M.W.2
  • 30
    • 0032443807 scopus 로고    scopus 로고
    • The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
    • [30] Broberger, C., Johansen, J., Johansson, C., Schalling, M., Hokfelt, T., The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc. Natl. Acad. Sci. U. S. A. 95:25 (1998), 15043–15048.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , Issue.25 , pp. 15043-15048
    • Broberger, C.1    Johansen, J.2    Johansson, C.3    Schalling, M.4    Hokfelt, T.5
  • 31
    • 0033782303 scopus 로고    scopus 로고
    • The rewarding properties of neuropeptide Y in perifornical hypothalamus vs. nucleus accumbens
    • [31] Brown, C.M., Coscina, D.V., Fletcher, P.J., The rewarding properties of neuropeptide Y in perifornical hypothalamus vs. nucleus accumbens. Peptides 21:8 (2000), 1279–1287.
    • (2000) Peptides , vol.21 , Issue.8 , pp. 1279-1287
    • Brown, C.M.1    Coscina, D.V.2    Fletcher, P.J.3
  • 32
    • 84884367260 scopus 로고    scopus 로고
    • Food availability of glucose and fat, but not fructose, increased in the U.S. between 1970 and 2009: analysis of the USDA food availability data system
    • [32] Carden, T.J., Carr, T.P., Food availability of glucose and fat, but not fructose, increased in the U.S. between 1970 and 2009: analysis of the USDA food availability data system. Nutr. J., 12, 2013, 130, 10.1186/1475-2891-12-130.
    • (2013) Nutr. J. , vol.12 , pp. 130
    • Carden, T.J.1    Carr, T.P.2
  • 33
    • 18044389338 scopus 로고    scopus 로고
    • Glucose injection reduces neuropeptide Y and agouti-related protein expression in the arcuate nucleus: a possible physiological role in eating behavior
    • [33] Chang, G.Q., Karatayev, O., Davydova, Z., Wortley, K., Leibowitz, S.F., Glucose injection reduces neuropeptide Y and agouti-related protein expression in the arcuate nucleus: a possible physiological role in eating behavior. Brain Res. Mol. Brain Res. 135:1–2 (2005), 69–80, 10.1016/j.molbrainres.2004.12.017.
    • (2005) Brain Res. Mol. Brain Res. , vol.135 , Issue.1-2 , pp. 69-80
    • Chang, G.Q.1    Karatayev, O.2    Davydova, Z.3    Wortley, K.4    Leibowitz, S.F.5
  • 34
    • 77749310482 scopus 로고    scopus 로고
    • Neuropeptide Y suppresses anorexigenic output from the ventromedial nucleus of the hypothalamus
    • [34] Chee, M.J., Myers, M.G. Jr., Price, C.J., Colmers, W.F., Neuropeptide Y suppresses anorexigenic output from the ventromedial nucleus of the hypothalamus. J. Neurosci. 30:9 (2010), 3380–3390, 10.1523/jneurosci.4031-09.2010.
    • (2010) J. Neurosci. , vol.30 , Issue.9 , pp. 3380-3390
    • Chee, M.J.1    Myers, M.G.2    Price, C.J.3    Colmers, W.F.4
  • 35
    • 0041655975 scopus 로고    scopus 로고
    • Suckling-induced activation of neuronal input to the dorsomedial nucleus of the hypothalamus: possible candidates for mediating the activation of DMH neuropeptide Y neurons during lactation
    • [35] Chen, P., Smith, M.S., Suckling-induced activation of neuronal input to the dorsomedial nucleus of the hypothalamus: possible candidates for mediating the activation of DMH neuropeptide Y neurons during lactation. Brain Res. 984:1–2 (2003), 11–20.
    • (2003) Brain Res. , vol.984 , Issue.1-2 , pp. 11-20
    • Chen, P.1    Smith, M.S.2
  • 37
    • 78650199265 scopus 로고    scopus 로고
    • The arcuate nucleus as a circumventricular organ in the mouse
    • [37] Ciofi, P., The arcuate nucleus as a circumventricular organ in the mouse. Neurosci. Lett. 487:2 (2011), 187–190, 10.1016/j.neulet.2010.10.019.
    • (2011) Neurosci. Lett. , vol.487 , Issue.2 , pp. 187-190
    • Ciofi, P.1
  • 38
    • 0031131847 scopus 로고    scopus 로고
    • Neuropeptide Y stimulates feeding but inhibits sexual behavior in rats. 1985.
    • [38] Clark, J.T., Kalra, P.S., Kalra, S.P., Neuropeptide Y stimulates feeding but inhibits sexual behavior in rats. 1985. Obes. Res. 5:3 (1997), 275–283.
    • (1997) Obes. Res. , vol.5 , Issue.3 , pp. 275-283
    • Clark, J.T.1    Kalra, P.S.2    Kalra, S.P.3
  • 39
    • 17844401704 scopus 로고    scopus 로고
    • Anatomy and regulation of the central melanocortin system
    • [39] Cone, R.D., Anatomy and regulation of the central melanocortin system. Nat. Neurosci. 8:5 (2005), 571–578, 10.1038/nn1455.
    • (2005) Nat. Neurosci. , vol.8 , Issue.5 , pp. 571-578
    • Cone, R.D.1
  • 40
    • 0033200153 scopus 로고    scopus 로고
    • Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat
    • [40] Cowley, M.A., Pronchuk, N., Fan, W., Dinulescu, D.M., Colmers, W.F., Cone, R.D., Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24:1 (1999), 155–163.
    • (1999) Neuron , vol.24 , Issue.1 , pp. 155-163
    • Cowley, M.A.1    Pronchuk, N.2    Fan, W.3    Dinulescu, D.M.4    Colmers, W.F.5    Cone, R.D.6
  • 41
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    • [41] Cowley, M.A., Smart, J.L., Rubinstein, M., Cerdan, M.G., Diano, S., Horvath, T.L., Low, M.J., Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411:6836 (2001), 480–484, 10.1038/35078085.
    • (2001) Nature , vol.411 , Issue.6836 , pp. 480-484
    • Cowley, M.A.1    Smart, J.L.2    Rubinstein, M.3    Cerdan, M.G.4    Diano, S.5    Horvath, T.L.6    Low, M.J.7
  • 42
    • 0022447498 scopus 로고
    • Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system—I. Radioimmunoassay and chromatographic characterisation
    • [42] de Quidt, M.E., Emson, P.C., Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system—I. Radioimmunoassay and chromatographic characterisation. Neuroscience 18:3 (1986), 527–543.
    • (1986) Neuroscience , vol.18 , Issue.3 , pp. 527-543
    • de Quidt, M.E.1    Emson, P.C.2
  • 43
    • 84864474183 scopus 로고    scopus 로고
    • AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors
    • [43] Dietrich, M.O., Bober, J., Ferreira, J.G., Tellez, L.A., Mineur, Y.S., Souza, D.O., Horvath, T.L., AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. Nat. Neurosci. 15:8 (2012), 1108–1110, 10.1038/nn.3147.
    • (2012) Nat. Neurosci. , vol.15 , Issue.8 , pp. 1108-1110
    • Dietrich, M.O.1    Bober, J.2    Ferreira, J.G.3    Tellez, L.A.4    Mineur, Y.S.5    Souza, D.O.6    Horvath, T.L.7
  • 44
    • 0026647014 scopus 로고
    • Neuropeptide Y release is elevated from the microdissected paraventricular nucleus of food-deprived rats: an in vitro study
    • [44] Dube, M.G., Sahu, A., Kalra, P.S., Kalra, S.P., Neuropeptide Y release is elevated from the microdissected paraventricular nucleus of food-deprived rats: an in vitro study. Endocrinology 131:2 (1992), 684–688, 10.1210/endo.131.2.1639015.
    • (1992) Endocrinology , vol.131 , Issue.2 , pp. 684-688
    • Dube, M.G.1    Sahu, A.2    Kalra, P.S.3    Kalra, S.P.4
  • 45
    • 0029946644 scopus 로고    scopus 로고
    • Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
    • [45] Erickson, J.C., Clegg, K.E., Palmiter, R.D., Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381:6581 (1996), 415–421, 10.1038/381415a0.
    • (1996) Nature , vol.381 , Issue.6581 , pp. 415-421
    • Erickson, J.C.1    Clegg, K.E.2    Palmiter, R.D.3
  • 46
    • 0029804743 scopus 로고    scopus 로고
    • Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
    • Retrieved from
    • [46] Erickson, J.C., Hollopeter, G., Palmiter, R.D., Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274:5293 (1996), 1704–1707 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/8939859.
    • (1996) Science , vol.274 , Issue.5293 , pp. 1704-1707
    • Erickson, J.C.1    Hollopeter, G.2    Palmiter, R.D.3
  • 47
    • 0026326476 scopus 로고
    • Increased food intake by neuropeptide Y is due to an increased motivation to eat
    • [47] Flood, J.F., Morley, J.E., Increased food intake by neuropeptide Y is due to an increased motivation to eat. Peptides 12:6 (1991), 1329–1332.
    • (1991) Peptides , vol.12 , Issue.6 , pp. 1329-1332
    • Flood, J.F.1    Morley, J.E.2
  • 48
    • 5444263310 scopus 로고    scopus 로고
    • Neuropeptide Y inhibits hypocretin/orexin neurons by multiple presynaptic and postsynaptic mechanisms: tonic depression of the hypothalamic arousal system
    • [48] Fu, L.Y., Acuna-Goycolea, C., van den Pol, A.N., Neuropeptide Y inhibits hypocretin/orexin neurons by multiple presynaptic and postsynaptic mechanisms: tonic depression of the hypothalamic arousal system. J. Neurosci. 24:40 (2004), 8741–8751, 10.1523/jneurosci.2268-04.2004.
    • (2004) J. Neurosci. , vol.24 , Issue.40 , pp. 8741-8751
    • Fu, L.Y.1    Acuna-Goycolea, C.2    van den Pol, A.N.3
  • 49
    • 12344310130 scopus 로고    scopus 로고
    • AAV mediated expression of anti-sense neuropeptide Y cRNA in the arcuate nucleus of rats results in decreased weight gain and food intake
    • [49] Gardiner, J.V., Kong, W.M., Ward, H., Murphy, K.G., Dhillo, W.S., Bloom, S.R., AAV mediated expression of anti-sense neuropeptide Y cRNA in the arcuate nucleus of rats results in decreased weight gain and food intake. Biochem. Biophys. Res. Commun. 327:4 (2005), 1088–1093, 10.1016/j.bbrc.2004.12.113.
    • (2005) Biochem. Biophys. Res. Commun. , vol.327 , Issue.4 , pp. 1088-1093
    • Gardiner, J.V.1    Kong, W.M.2    Ward, H.3    Murphy, K.G.4    Dhillo, W.S.5    Bloom, S.R.6
  • 51
    • 78449256186 scopus 로고    scopus 로고
    • Hyperphagia induced by sucrose: relation to circulating and CSF glucose and corticosterone and orexigenic peptides in the arcuate nucleus
    • [51] Gaysinskaya, V.A., Karatayev, O., Shuluk, J., Leibowitz, S.F., Hyperphagia induced by sucrose: relation to circulating and CSF glucose and corticosterone and orexigenic peptides in the arcuate nucleus. Pharmacol. Biochem. Behav. 97:3 (2011), 521–530, 10.1016/j.pbb.2010.10.008.
    • (2011) Pharmacol. Biochem. Behav. , vol.97 , Issue.3 , pp. 521-530
    • Gaysinskaya, V.A.1    Karatayev, O.2    Shuluk, J.3    Leibowitz, S.F.4
  • 52
    • 27744469753 scopus 로고    scopus 로고
    • PYY3-36 inhibits the action potential firing activity of POMC neurons of arcuate nucleus through postsynaptic Y2 receptors
    • [52] Ghamari-Langroudi, M., Colmers, W.F., Cone, R.D., PYY3-36 inhibits the action potential firing activity of POMC neurons of arcuate nucleus through postsynaptic Y2 receptors. Cell Metab. 2:3 (2005), 191–199, 10.1016/j.cmet.2005.08.003.
    • (2005) Cell Metab. , vol.2 , Issue.3 , pp. 191-199
    • Ghamari-Langroudi, M.1    Colmers, W.F.2    Cone, R.D.3
  • 53
    • 0036729931 scopus 로고    scopus 로고
    • Fat intake affects adiposity, comorbidity factors, and energy metabolism of sprague-dawley rats
    • [53] Ghibaudi, L., Cook, J., Farley, C., van Heek, M., Hwa, J.J., Fat intake affects adiposity, comorbidity factors, and energy metabolism of sprague-dawley rats. Obes. Res. 10:9 (2002), 956–963, 10.1038/oby.2002.130.
    • (2002) Obes. Res. , vol.10 , Issue.9 , pp. 956-963
    • Ghibaudi, L.1    Cook, J.2    Farley, C.3    van Heek, M.4    Hwa, J.J.5
  • 54
    • 0028292297 scopus 로고
    • Rat hypothalamic NPY mRNA and brown fat uncoupling protein mRNA after high-carbohydrate or high-fat diets
    • [54] Giraudo, S.Q., Kotz, C.M., Grace, M.K., Levine, A.S., Billington, C.J., Rat hypothalamic NPY mRNA and brown fat uncoupling protein mRNA after high-carbohydrate or high-fat diets. Am. J. Phys. 266:5 Pt 2 (1994), R1578–R1583.
    • (1994) Am. J. Phys. , vol.266 , Issue.5 , pp. R1578-R1583
    • Giraudo, S.Q.1    Kotz, C.M.2    Grace, M.K.3    Levine, A.S.4    Billington, C.J.5
  • 55
    • 0022617388 scopus 로고
    • Neuropeptide Y: anatomical distribution and possible function in mammalian nervous system
    • [55] Gray, T.S., Morley, J.E., Neuropeptide Y: anatomical distribution and possible function in mammalian nervous system. Life Sci. 38:5 (1986), 389–401.
    • (1986) Life Sci. , vol.38 , Issue.5 , pp. 389-401
    • Gray, T.S.1    Morley, J.E.2
  • 56
    • 0032569615 scopus 로고    scopus 로고
    • Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet-induced obese mice
    • [56] Guan, X.M., Yu, H., Trumbauer, M., Frazier, E., Van der Ploeg, L.H., Chen, H., Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet-induced obese mice. Neuroreport 9:15 (1998), 3415–3419.
    • (1998) Neuroreport , vol.9 , Issue.15 , pp. 3415-3419
    • Guan, X.M.1    Yu, H.2    Trumbauer, M.3    Frazier, E.4    Van der Ploeg, L.H.5    Chen, H.6
  • 57
    • 0032584978 scopus 로고    scopus 로고
    • Evidence of altered hypothalamic pro-opiomelanocortin/neuropeptide Y mRNA expression in tubby mice
    • [57] Guan, X.M., Yu, H., Van der Ploeg, L.H., Evidence of altered hypothalamic pro-opiomelanocortin/neuropeptide Y mRNA expression in tubby mice. Brain Res. Mol. Brain Res. 59:2 (1998), 273–279.
    • (1998) Brain Res. Mol. Brain Res. , vol.59 , Issue.2 , pp. 273-279
    • Guan, X.M.1    Yu, H.2    Van der Ploeg, L.H.3
  • 58
    • 0032130554 scopus 로고    scopus 로고
    • Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
    • [58] Hahn, T.M., Breininger, J.F., Baskin, D.G., Schwartz, M.W., Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat. Neurosci. 1:4 (1998), 271–272, 10.1038/1082.
    • (1998) Nat. Neurosci. , vol.1 , Issue.4 , pp. 271-272
    • Hahn, T.M.1    Breininger, J.F.2    Baskin, D.G.3    Schwartz, M.W.4
  • 59
    • 1042266534 scopus 로고    scopus 로고
    • Adaptive responses in hypothalamic neuropeptide Y in the face of prolonged high-fat feeding in the rat
    • [59] Hansen, M.J., Jovanovska, V., Morris, M.J., Adaptive responses in hypothalamic neuropeptide Y in the face of prolonged high-fat feeding in the rat. J. Neurochem. 88:4 (2004), 909–916.
    • (2004) J. Neurochem. , vol.88 , Issue.4 , pp. 909-916
    • Hansen, M.J.1    Jovanovska, V.2    Morris, M.J.3
  • 60
    • 78650535334 scopus 로고    scopus 로고
    • High-fat diet-induced obesity in animal models
    • [60] Hariri, N., Thibault, L., High-fat diet-induced obesity in animal models. Nutr. Res. Rev. 23:2 (2010), 270–299, 10.1017/s0954422410000168.
    • (2010) Nutr. Res. Rev. , vol.23 , Issue.2 , pp. 270-299
    • Hariri, N.1    Thibault, L.2
  • 61
    • 0033975409 scopus 로고    scopus 로고
    • Early leptin response to a palatable diet predicts dietary obesity in rats: key role of melanocortin-4 receptors in the ventromedial hypothalamic nucleus
    • [61] Harrold, J.A., Williams, G., Widdowson, P.S., Early leptin response to a palatable diet predicts dietary obesity in rats: key role of melanocortin-4 receptors in the ventromedial hypothalamic nucleus. J. Neurochem. 74:3 (2000), 1224–1228.
    • (2000) J. Neurochem. , vol.74 , Issue.3 , pp. 1224-1228
    • Harrold, J.A.1    Williams, G.2    Widdowson, P.S.3
  • 62
    • 27944481748 scopus 로고    scopus 로고
    • High fat diet induced hepatic insulin resistance is not related to changes in hypothalamic mRNA expression of NPY, AgRP, POMC and CART in mice
    • [62] Heijboer, A.C., Voshol, P.J., Donga, E., van Eden, C.G., Havekes, L.M., Romijn, J.A., Corssmit, E.P., High fat diet induced hepatic insulin resistance is not related to changes in hypothalamic mRNA expression of NPY, AgRP, POMC and CART in mice. Peptides 26:12 (2005), 2554–2558, 10.1016/j.peptides.2005.05.013.
    • (2005) Peptides , vol.26 , Issue.12 , pp. 2554-2558
    • Heijboer, A.C.1    Voshol, P.J.2    Donga, E.3    van Eden, C.G.4    Havekes, L.M.5    Romijn, J.A.6    Corssmit, E.P.7
  • 63
    • 84893537741 scopus 로고    scopus 로고
    • Resistant starch and energy balance: impact on weight loss and maintenance
    • [63] Higgins, J.A., Resistant starch and energy balance: impact on weight loss and maintenance. Crit. Rev. Food Sci. Nutr. 54:9 (2014), 1158–1166, 10.1080/10408398.2011.629352.
    • (2014) Crit. Rev. Food Sci. Nutr. , vol.54 , Issue.9 , pp. 1158-1166
    • Higgins, J.A.1
  • 64
    • 0038411365 scopus 로고    scopus 로고
    • The level of NPY receptor mRNA expression in diet-induced obese and resistant mice
    • Retrieved from
    • [64] Huang, X.F., Han, M., Storlien, L.H., The level of NPY receptor mRNA expression in diet-induced obese and resistant mice. Brain Res. Mol. Brain Res. 115:1 (2003), 21–28 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12824051.
    • (2003) Brain Res. Mol. Brain Res. , vol.115 , Issue.1 , pp. 21-28
    • Huang, X.F.1    Han, M.2    Storlien, L.H.3
  • 65
    • 20444428364 scopus 로고    scopus 로고
    • NPY-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats
    • [65] Israel, Y., Kandov, Y., Khaimova, E., Kest, A., Lewis, S.R., Pasternak, G.W., Bodnar, R.J., NPY-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. Peptides 26:7 (2005), 1167–1175, 10.1016/j.peptides.2005.01.017.
    • (2005) Peptides , vol.26 , Issue.7 , pp. 1167-1175
    • Israel, Y.1    Kandov, Y.2    Khaimova, E.3    Kest, A.4    Lewis, S.R.5    Pasternak, G.W.6    Bodnar, R.J.7
  • 66
    • 0032901784 scopus 로고    scopus 로고
    • Characterization of neuropeptide Y-induced feeding in mice: do Y1-Y6 receptor subtypes mediate feeding?
    • [66] Iyengar, S., Li, D.L., Simmons, R.M., Characterization of neuropeptide Y-induced feeding in mice: do Y1-Y6 receptor subtypes mediate feeding?. J. Pharmacol. Exp. Ther. 289:2 (1999), 1031–1040.
    • (1999) J. Pharmacol. Exp. Ther. , vol.289 , Issue.2 , pp. 1031-1040
    • Iyengar, S.1    Li, D.L.2    Simmons, R.M.3
  • 67
    • 0029056265 scopus 로고
    • Effects of neuropeptide Y, insulin, 2-deoxyglucose, and food deprivation on food-motivated behavior
    • [67] Jewett, D.C., Cleary, J., Levine, A.S., Schaal, D.W., Thompson, T., Effects of neuropeptide Y, insulin, 2-deoxyglucose, and food deprivation on food-motivated behavior. Psychopharmacology 120:3 (1995), 267–271.
    • (1995) Psychopharmacology , vol.120 , Issue.3 , pp. 267-271
    • Jewett, D.C.1    Cleary, J.2    Levine, A.S.3    Schaal, D.W.4    Thompson, T.5
  • 68
    • 0027422340 scopus 로고
    • Neuropeptide Y projection from arcuate nucleus to parvocellular division of paraventricular nucleus: specific relation to the ingestion of carbohydrate
    • [68] Jhanwar-Uniyal, M., Beck, B., Jhanwar, Y.S., Burlet, C., Leibowitz, S.F., Neuropeptide Y projection from arcuate nucleus to parvocellular division of paraventricular nucleus: specific relation to the ingestion of carbohydrate. Brain Res. 631:1 (1993), 97–106.
    • (1993) Brain Res. , vol.631 , Issue.1 , pp. 97-106
    • Jhanwar-Uniyal, M.1    Beck, B.2    Jhanwar, Y.S.3    Burlet, C.4    Leibowitz, S.F.5
  • 71
    • 0035029206 scopus 로고    scopus 로고
    • Modest overexpression of neuropeptide Y in the brain leads to obesity after high-sucrose feeding
    • Retrieved from
    • [71] Kaga, T., Inui, A., Okita, M., Asakawa, A., Ueno, N., Kasuga, M., Cheng, J.T., Modest overexpression of neuropeptide Y in the brain leads to obesity after high-sucrose feeding. Diabetes 50:5 (2001), 1206–1210 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11334428.
    • (2001) Diabetes , vol.50 , Issue.5 , pp. 1206-1210
    • Kaga, T.1    Inui, A.2    Okita, M.3    Asakawa, A.4    Ueno, N.5    Kasuga, M.6    Cheng, J.T.7
  • 72
    • 0031972988 scopus 로고    scopus 로고
    • Neuropeptide Y (NPY) Y1 receptor mRNA is upregulated in association with transient hyperphagia and body weight gain: evidence for a hypothalamic site for concurrent development of leptin resistance
    • Retrieved from
    • [72] Kalra, P.S., Dube, M.G., Xu, B., Farmerie, W.G., Kalra, S.P., Neuropeptide Y (NPY) Y1 receptor mRNA is upregulated in association with transient hyperphagia and body weight gain: evidence for a hypothalamic site for concurrent development of leptin resistance. J. Neuroendocrinol. 10:1 (1998), 43–49 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9510057.
    • (1998) J. Neuroendocrinol. , vol.10 , Issue.1 , pp. 43-49
    • Kalra, P.S.1    Dube, M.G.2    Xu, B.3    Farmerie, W.G.4    Kalra, S.P.5
  • 73
    • 0031592881 scopus 로고    scopus 로고
    • Increased receptor sensitivity to neuropeptide Y in the hypothalamus may underlie transient hyperphagia and body weight gain
    • Retrieved from
    • [73] Kalra, P.S., Dube, M.G., Xu, B., Kalra, S.P., Increased receptor sensitivity to neuropeptide Y in the hypothalamus may underlie transient hyperphagia and body weight gain. Regul. Pept. 72:2–3 (1997), 121–130 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9652971.
    • (1997) Regul. Pept. , vol.72 , Issue.2-3 , pp. 121-130
    • Kalra, P.S.1    Dube, M.G.2    Xu, B.3    Kalra, S.P.4
  • 74
    • 0025721025 scopus 로고
    • Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food
    • [74] Kalra, S.P., Dube, M.G., Sahu, A., Phelps, C.P., Kalra, P.S., Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Natl. Acad. Sci. U. S. A. 88:23 (1991), 10931–10935.
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , Issue.23 , pp. 10931-10935
    • Kalra, S.P.1    Dube, M.G.2    Sahu, A.3    Phelps, C.P.4    Kalra, P.S.5
  • 75
    • 84919414314 scopus 로고    scopus 로고
    • 40-year trends in meal and snack eating behaviors of American adults
    • [75] Kant, A.K., Graubard, B.I., 40-year trends in meal and snack eating behaviors of American adults. J Acad Nutr Diet 115:1 (2015), 50–63, 10.1016/j.jand.2014.06.354.
    • (2015) J Acad Nutr Diet , vol.115 , Issue.1 , pp. 50-63
    • Kant, A.K.1    Graubard, B.I.2
  • 76
    • 0031830008 scopus 로고    scopus 로고
    • Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226
    • [76] Kask, A., Rago, L., Harro, J., Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. Br. J. Pharmacol. 124:7 (1998), 1507–1515, 10.1038/sj.bjp.0701969.
    • (1998) Br. J. Pharmacol. , vol.124 , Issue.7 , pp. 1507-1515
    • Kask, A.1    Rago, L.2    Harro, J.3
  • 77
    • 28444442694 scopus 로고    scopus 로고
    • Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward
    • [77] Kelley, A.E., Baldo, B.A., Pratt, W.E., Will, M.J., Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward. Physiol. Behav. 86:5 (2005), 773–795, 10.1016/j.physbeh.2005.08.066.
    • (2005) Physiol. Behav. , vol.86 , Issue.5 , pp. 773-795
    • Kelley, A.E.1    Baldo, B.A.2    Pratt, W.E.3    Will, M.J.4
  • 78
    • 80054800194 scopus 로고    scopus 로고
    • Common cellular and molecular mechanisms in obesity and drug addiction
    • [78] Kenny, P.J., Common cellular and molecular mechanisms in obesity and drug addiction. Nat. Rev. Neurosci. 12:11 (2011), 638–651, 10.1038/nrn3105.
    • (2011) Nat. Rev. Neurosci. , vol.12 , Issue.11 , pp. 638-651
    • Kenny, P.J.1
  • 79
    • 79951699573 scopus 로고    scopus 로고
    • Reward mechanisms in obesity: new insights and future directions
    • [79] Kenny, P.J., Reward mechanisms in obesity: new insights and future directions. Neuron 69:4 (2011), 664–679, 10.1016/j.neuron.2011.02.016.
    • (2011) Neuron , vol.69 , Issue.4 , pp. 664-679
    • Kenny, P.J.1
  • 80
    • 0026599087 scopus 로고
    • Intracerebroventricular administration of neuropeptide Y affects parameters of dopamine, glutamate and GABA activities in the rat striatum
    • [80] Kerkerian-Le Goff, L., Forni, C., Samuel, D., Bloc, A., Dusticier, N., Nieoullon, A., Intracerebroventricular administration of neuropeptide Y affects parameters of dopamine, glutamate and GABA activities in the rat striatum. Brain Res. Bull. 28:2 (1992), 187–193.
    • (1992) Brain Res. Bull. , vol.28 , Issue.2 , pp. 187-193
    • Kerkerian-Le Goff, L.1    Forni, C.2    Samuel, D.3    Bloc, A.4    Dusticier, N.5    Nieoullon, A.6
  • 81
    • 0032556058 scopus 로고    scopus 로고
    • Effects of palatability-induced hyperphagia and food restriction on mRNA levels of neuropeptide-Y in the arcuate nucleus
    • [81] Kim, E.M., Welch, C.C., Grace, M.K., Billington, C.J., Levine, A.S., Effects of palatability-induced hyperphagia and food restriction on mRNA levels of neuropeptide-Y in the arcuate nucleus. Brain Res. 806:1 (1998), 117–121.
    • (1998) Brain Res. , vol.806 , Issue.1 , pp. 117-121
    • Kim, E.M.1    Welch, C.C.2    Grace, M.K.3    Billington, C.J.4    Levine, A.S.5
  • 82
    • 33644803270 scopus 로고    scopus 로고
    • Altered hypothalamic signaling and responses to food deprivation in rats fed a low-carbohydrate diet
    • [82] Kinzig, K.P., Scott, K.A., Hyun, J., Bi, S., Moran, T.H., Altered hypothalamic signaling and responses to food deprivation in rats fed a low-carbohydrate diet. Obes. Res. 13:10 (2005), 1672–1682, 10.1038/oby.2005.205.
    • (2005) Obes. Res. , vol.13 , Issue.10 , pp. 1672-1682
    • Kinzig, K.P.1    Scott, K.A.2    Hyun, J.3    Bi, S.4    Moran, T.H.5
  • 83
    • 11244289511 scopus 로고    scopus 로고
    • Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor
    • [83] Kishi, T., Aschkenasi, C.J., Choi, B.J., Lopez, M.E., Lee, C.E., Liu, H., Elmquist, J.K., Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor. J. Comp. Neurol. 482:3 (2005), 217–243, 10.1002/cne.20432.
    • (2005) J. Comp. Neurol. , vol.482 , Issue.3 , pp. 217-243
    • Kishi, T.1    Aschkenasi, C.J.2    Choi, B.J.3    Lopez, M.E.4    Lee, C.E.5    Liu, H.6    Elmquist, J.K.7
  • 84
    • 84869882415 scopus 로고    scopus 로고
    • Arcuate NPY neurons sense and integrate peripheral metabolic signals to control feeding
    • [84] Kohno, D., Yada, T., Arcuate NPY neurons sense and integrate peripheral metabolic signals to control feeding. Neuropeptides 46:6 (2012), 315–319, 10.1016/j.npep.2012.09.004.
    • (2012) Neuropeptides , vol.46 , Issue.6 , pp. 315-319
    • Kohno, D.1    Yada, T.2
  • 85
    • 0034748735 scopus 로고    scopus 로고
    • Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus
    • Retrieved from
    • [85] Korner, J., Savontaus, E., Chua, S.C. Jr., Leibel, R.L., Wardlaw, S.L., Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus. J. Neuroendocrinol. 13:11 (2001), 959–966 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11737554.
    • (2001) J. Neuroendocrinol. , vol.13 , Issue.11 , pp. 959-966
    • Korner, J.1    Savontaus, E.2    Chua, S.C.3    Leibel, R.L.4    Wardlaw, S.L.5
  • 86
    • 33744500233 scopus 로고    scopus 로고
    • Effects of arousal- and feeding-related neuropeptides on dopaminergic and GABAergic neurons in the ventral tegmental area of the rat
    • [86] Korotkova, T.M., Brown, R.E., Sergeeva, O.A., Ponomarenko, A.A., Haas, H.L., Effects of arousal- and feeding-related neuropeptides on dopaminergic and GABAergic neurons in the ventral tegmental area of the rat. Eur. J. Neurosci. 23:10 (2006), 2677–2685, 10.1111/j.1460-9568.2006.04792.x.
    • (2006) Eur. J. Neurosci. , vol.23 , Issue.10 , pp. 2677-2685
    • Korotkova, T.M.1    Brown, R.E.2    Sergeeva, O.A.3    Ponomarenko, A.A.4    Haas, H.L.5
  • 87
    • 77950683380 scopus 로고    scopus 로고
    • A pause in nucleus accumbens neuron firing is required to initiate and maintain feeding
    • [87] Krause, M., German, P.W., Taha, S.A., Fields, H.L., A pause in nucleus accumbens neuron firing is required to initiate and maintain feeding. J. Neurosci. 30:13 (2010), 4746–4756, 10.1523/jneurosci.0197-10.2010.
    • (2010) J. Neurosci. , vol.30 , Issue.13 , pp. 4746-4756
    • Krause, M.1    German, P.W.2    Taha, S.A.3    Fields, H.L.4
  • 88
    • 84899964371 scopus 로고    scopus 로고
    • The snacking rat as model of human obesity: effects of a free-choice high-fat high-sugar diet on meal patterns
    • [88] la Fleur, S.E., Luijendijk, M.C., van der Zwaal, E.M., Brans, M.A., Adan, R.A., The snacking rat as model of human obesity: effects of a free-choice high-fat high-sugar diet on meal patterns. Int. J. Obes. 38:5 (2014), 643–649, 10.1038/ijo.2013.159.
    • (2014) Int. J. Obes. , vol.38 , Issue.5 , pp. 643-649
    • la Fleur, S.E.1    Luijendijk, M.C.2    van der Zwaal, E.M.3    Brans, M.A.4    Adan, R.A.5
  • 89
    • 79954429502 scopus 로고    scopus 로고
    • A free-choice high-fat high-sugar diet induces glucose intolerance and insulin unresponsiveness to a glucose load not explained by obesity
    • [89] la Fleur, S.E., Luijendijk, M.C., van Rozen, A.J., Kalsbeek, A., Adan, R.A., A free-choice high-fat high-sugar diet induces glucose intolerance and insulin unresponsiveness to a glucose load not explained by obesity. Int. J. Obes. 35:4 (2011), 595–604, 10.1038/ijo.2010.164.
    • (2011) Int. J. Obes. , vol.35 , Issue.4 , pp. 595-604
    • la Fleur, S.E.1    Luijendijk, M.C.2    van Rozen, A.J.3    Kalsbeek, A.4    Adan, R.A.5
  • 90
    • 77949540269 scopus 로고    scopus 로고
    • A free-choice high-fat high-sugar diet induces changes in arcuate neuropeptide expression that support hyperphagia
    • [90] la Fleur, S.E., van Rozen, A.J., Luijendijk, M.C., Groeneweg, F., Adan, R.A., A free-choice high-fat high-sugar diet induces changes in arcuate neuropeptide expression that support hyperphagia. Int. J. Obes. 34:3 (2010), 537–546, 10.1038/ijo.2009.257.
    • (2010) Int. J. Obes. , vol.34 , Issue.3 , pp. 537-546
    • la Fleur, S.E.1    van Rozen, A.J.2    Luijendijk, M.C.3    Groeneweg, F.4    Adan, R.A.5
  • 91
    • 34547466155 scopus 로고    scopus 로고
    • A reciprocal interaction between food-motivated behavior and diet-induced obesity
    • [91] la Fleur, S.E., Vanderschuren, L.J., Luijendijk, M.C., Kloeze, B.M., Tiesjema, B., Adan, R.A., A reciprocal interaction between food-motivated behavior and diet-induced obesity. Int. J. Obes. 31:8 (2007), 1286–1294, 10.1038/sj.ijo.0803570.
    • (2007) Int. J. Obes. , vol.31 , Issue.8 , pp. 1286-1294
    • la Fleur, S.E.1    Vanderschuren, L.J.2    Luijendijk, M.C.3    Kloeze, B.M.4    Tiesjema, B.5    Adan, R.A.6
  • 92
    • 84887114618 scopus 로고    scopus 로고
    • Reward and aversion in a heterogeneous midbrain dopamine system
    • [92] Lammel, S., Lim, B.K., Malenka, R.C., Reward and aversion in a heterogeneous midbrain dopamine system. Neuropharmacology 76:Pt B (2014), 351–359, 10.1016/j.neuropharm.2013.03.019.
    • (2014) Neuropharmacology , vol.76 , pp. 351-359
    • Lammel, S.1    Lim, B.K.2    Malenka, R.C.3
  • 93
    • 56849099017 scopus 로고    scopus 로고
    • Central and peripheral regulation of food intake and physical activity: pathways and genes
    • [93] Lenard, N.R., Berthoud, H.R., Central and peripheral regulation of food intake and physical activity: pathways and genes. Obesity (Silver Spring) 16:Suppl. 3 (2008), S11–S22, 10.1038/oby.2008.511.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. S11-S22
    • Lenard, N.R.1    Berthoud, H.R.2
  • 94
    • 0028961718 scopus 로고
    • Reduced norepinephrine turnover in organs and brains of obesity-prone rats
    • Retrieved from
    • [94] Levin, B.E., Reduced norepinephrine turnover in organs and brains of obesity-prone rats. Am. J. Phys. 268:2 Pt 2 (1995), R389–R394 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/7864233.
    • (1995) Am. J. Phys. , vol.268 , Issue.2 , pp. R389-R394
    • Levin, B.E.1
  • 95
    • 0032980181 scopus 로고    scopus 로고
    • Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats
    • Retrieved from
    • [95] Levin, B.E., Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats. Am. J. Phys. 276:2 Pt 2 (1999), R382–R387 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9950915.
    • (1999) Am. J. Phys. , vol.276 , Issue.2 , pp. R382-R387
    • Levin, B.E.1
  • 96
    • 0030938684 scopus 로고    scopus 로고
    • Dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet-induced obese rats
    • Retrieved from
    • [96] Levin, B.E., Dunn-Meynell, A.A., Dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet-induced obese rats. Am. J. Phys. 272:5 Pt 2 (1997), R1365–R1370 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9176325.
    • (1997) Am. J. Phys. , vol.272 , Issue.5 , pp. R1365-R1370
    • Levin, B.E.1    Dunn-Meynell, A.A.2
  • 97
    • 0021732102 scopus 로고
    • Neuropeptide Y: a potent inducer of consummatory behavior in rats
    • [97] Levine, A.S., Morley, J.E., Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides 5:6 (1984), 1025–1029.
    • (1984) Peptides , vol.5 , Issue.6 , pp. 1025-1029
    • Levine, A.S.1    Morley, J.E.2
  • 98
    • 0032566823 scopus 로고    scopus 로고
    • Neuropeptide Y (NPY) neurons in the arcuate nucleus (ARH) and dorsomedial nucleus (DMH), areas activated during lactation, project to the paraventricular nucleus of the hypothalamus (PVH)
    • [98] Li, C., Chen, P., Smith, M.S., Neuropeptide Y (NPY) neurons in the arcuate nucleus (ARH) and dorsomedial nucleus (DMH), areas activated during lactation, project to the paraventricular nucleus of the hypothalamus (PVH). Regul. Pept. 75–76 (1998), 93–100.
    • (1998) Regul. Pept. , vol.75-76 , pp. 93-100
    • Li, C.1    Chen, P.2    Smith, M.S.3
  • 99
    • 33751243625 scopus 로고    scopus 로고
    • Combined deletion of Y1, Y2, and Y4 receptors prevents hypothalamic neuropeptide Y overexpression-induced hyperinsulinemia despite persistence of hyperphagia and obesity
    • [99] Lin, E.J., Sainsbury, A., Lee, N.J., Boey, D., Couzens, M., Enriquez, R., Herzog, H., Combined deletion of Y1, Y2, and Y4 receptors prevents hypothalamic neuropeptide Y overexpression-induced hyperinsulinemia despite persistence of hyperphagia and obesity. Endocrinology 147:11 (2006), 5094–5101, 10.1210/en.2006-0097.
    • (2006) Endocrinology , vol.147 , Issue.11 , pp. 5094-5101
    • Lin, E.J.1    Sainsbury, A.2    Lee, N.J.3    Boey, D.4    Couzens, M.5    Enriquez, R.6    Herzog, H.7
  • 100
    • 0034284520 scopus 로고    scopus 로고
    • Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain
    • [100] Lin, S., Storlien, L.H., Huang, X.F., Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain. Brain Res. 875:1–2 (2000), 89–95.
    • (2000) Brain Res. , vol.875 , Issue.1-2 , pp. 89-95
    • Lin, S.1    Storlien, L.H.2    Huang, X.F.3
  • 101
    • 51249118983 scopus 로고    scopus 로고
    • Effects of sucrose, glucose and fructose on peripheral and central appetite signals
    • [101] Lindqvist, A., Baelemans, A., Erlanson-Albertsson, C., Effects of sucrose, glucose and fructose on peripheral and central appetite signals. Regul. Pept. 150:1–3 (2008), 26–32, 10.1016/j.regpep.2008.06.008.
    • (2008) Regul. Pept. , vol.150 , Issue.1-3 , pp. 26-32
    • Lindqvist, A.1    Baelemans, A.2    Erlanson-Albertsson, C.3
  • 102
    • 84868095524 scopus 로고    scopus 로고
    • Overview of animal models of obesity
    • [102] Lutz, T.A., Woods, S.C., Overview of animal models of obesity. Curr Protoc Pharmacol, Chapter 5(Unit5.61), 2012, 10.1002/0471141755.ph0561s58.
    • (2012) Curr Protoc Pharmacol
    • Lutz, T.A.1    Woods, S.C.2
  • 103
    • 78650920491 scopus 로고    scopus 로고
    • Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis
    • [103] Malik, V.S., Popkin, B.M., Bray, G.A., Despres, J.P., Willett, W.C., Hu, F.B., Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes Care 33:11 (2010), 2477–2483, 10.2337/dc10-1079.
    • (2010) Diabetes Care , vol.33 , Issue.11 , pp. 2477-2483
    • Malik, V.S.1    Popkin, B.M.2    Bray, G.A.3    Despres, J.P.4    Willett, W.C.5    Hu, F.B.6
  • 104
    • 0026632281 scopus 로고
    • Effect of fasting on regional levels of neuropeptide Y mRNA and insulin receptors in the rat hypothalamus: an autoradiographic study
    • [104] Marks, J.L., Li, M., Schwartz, M., Porte, D. Jr., Baskin, D.G., Effect of fasting on regional levels of neuropeptide Y mRNA and insulin receptors in the rat hypothalamus: an autoradiographic study. Mol. Cell. Neurosci. 3:3 (1992), 199–205.
    • (1992) Mol. Cell. Neurosci. , vol.3 , Issue.3 , pp. 199-205
    • Marks, J.L.1    Li, M.2    Schwartz, M.3    Porte, D.4    Baskin, D.G.5
  • 105
    • 0031779336 scopus 로고    scopus 로고
    • Role of the Y5 neuropeptide Y receptor in feeding and obesity
    • Retrieved from
    • [105] Marsh, D.J., Hollopeter, G., Kafer, K.E., Palmiter, R.D., Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat. Med. 4:6 (1998), 718–721 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9623983.
    • (1998) Nat. Med. , vol.4 , Issue.6 , pp. 718-721
    • Marsh, D.J.1    Hollopeter, G.2    Kafer, K.E.3    Palmiter, R.D.4
  • 106
    • 84875685109 scopus 로고    scopus 로고
    • Altered feeding patterns in rats exposed to a palatable cafeteria diet: increased snacking and its implications for development of obesity
    • e60407
    • [106] Martire, S.I., Holmes, N., Westbrook, R.F., Morris, M.J., Altered feeding patterns in rats exposed to a palatable cafeteria diet: increased snacking and its implications for development of obesity. PLoS One, 8(4), 2013, e60407, 10.1371/journal.pone.0060407.
    • (2013) PLoS One , vol.8 , Issue.4
    • Martire, S.I.1    Holmes, N.2    Westbrook, R.F.3    Morris, M.J.4
  • 107
    • 42249091040 scopus 로고    scopus 로고
    • Putting the diet back into diet-induced obesity: diet-induced hypothalamic gene expression
    • [108] Mercer, J.G., Archer, Z.A., Putting the diet back into diet-induced obesity: diet-induced hypothalamic gene expression. Eur. J. Pharmacol. 585:1 (2008), 31–37, 10.1016/j.ejphar.2007.11.077.
    • (2008) Eur. J. Pharmacol. , vol.585 , Issue.1 , pp. 31-37
    • Mercer, J.G.1    Archer, Z.A.2
  • 108
    • 80053094974 scopus 로고    scopus 로고
    • The role of NPY in hypothalamic mediated food intake
    • [109] Mercer, R.E., Chee, M.J., Colmers, W.F., The role of NPY in hypothalamic mediated food intake. Front. Neuroendocrinol. 32:4 (2011), 398–415, 10.1016/j.yfrne.2011.06.001.
    • (2011) Front. Neuroendocrinol. , vol.32 , Issue.4 , pp. 398-415
    • Mercer, R.E.1    Chee, M.J.2    Colmers, W.F.3
  • 109
    • 0031919929 scopus 로고    scopus 로고
    • XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors
    • [110] Michel, M.C., Beck-Sickinger, A., Cox, H., Doods, H.N., Herzog, H., Larhammar, D., Westfall, T., XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol. Rev. 50:1 (1998), 143–150.
    • (1998) Pharmacol. Rev. , vol.50 , Issue.1 , pp. 143-150
    • Michel, M.C.1    Beck-Sickinger, A.2    Cox, H.3    Doods, H.N.4    Herzog, H.5    Larhammar, D.6    Westfall, T.7
  • 110
    • 0027944535 scopus 로고
    • Lack of satiety effect of cholecystokinin (CCK) in a new rat model not expressing the CCK-A receptor gene
    • [111] Miyasaka, K., Kanai, S., Ohta, M., Kawanami, T., Kono, A., Funakoshi, A., Lack of satiety effect of cholecystokinin (CCK) in a new rat model not expressing the CCK-A receptor gene. Neurosci. Lett. 180:2 (1994), 143–146.
    • (1994) Neurosci. Lett. , vol.180 , Issue.2 , pp. 143-146
    • Miyasaka, K.1    Kanai, S.2    Ohta, M.3    Kawanami, T.4    Kono, A.5    Funakoshi, A.6
  • 111
    • 33746268381 scopus 로고    scopus 로고
    • Hyperphagia and obesity of OLETF rats lacking CCK1 receptors: developmental aspects
    • [112] Moran, T.H., Bi, S., Hyperphagia and obesity of OLETF rats lacking CCK1 receptors: developmental aspects. Dev. Psychobiol. 48:5 (2006), 360–367, 10.1002/dev.20149.
    • (2006) Dev. Psychobiol. , vol.48 , Issue.5 , pp. 360-367
    • Moran, T.H.1    Bi, S.2
  • 112
    • 0036124418 scopus 로고    scopus 로고
    • Responsivity to NPY and melanocortins in obese OLETF rats lacking CCK-A receptors
    • [113] Moran, T.H., Lee, P., Ladenheim, E.E., Schwartz, G.J., Responsivity to NPY and melanocortins in obese OLETF rats lacking CCK-A receptors. Physiol. Behav. 75:3 (2002), 397–402.
    • (2002) Physiol. Behav. , vol.75 , Issue.3 , pp. 397-402
    • Moran, T.H.1    Lee, P.2    Ladenheim, E.E.3    Schwartz, G.J.4
  • 113
    • 39449087112 scopus 로고    scopus 로고
    • Brain neuropeptide Y and CCK and peripheral adipokine receptors: temporal response in obesity induced by palatable diet
    • [114] Morris, M.J., Chen, H., Watts, R., Shulkes, A., Cameron-Smith, D., Brain neuropeptide Y and CCK and peripheral adipokine receptors: temporal response in obesity induced by palatable diet. Int. J. Obes. 32:2 (2008), 249–258, 10.1038/sj.ijo.0803716.
    • (2008) Int. J. Obes. , vol.32 , Issue.2 , pp. 249-258
    • Morris, M.J.1    Chen, H.2    Watts, R.3    Shulkes, A.4    Cameron-Smith, D.5
  • 114
    • 33748931457 scopus 로고    scopus 로고
    • Central nervous system control of food intake and body weight
    • [115] Morton, G.J., Cummings, D.E., Baskin, D.G., Barsh, G.S., Schwartz, M.W., Central nervous system control of food intake and body weight. Nature 443:7109 (2006), 289–295, 10.1038/nature05026.
    • (2006) Nature , vol.443 , Issue.7109 , pp. 289-295
    • Morton, G.J.1    Cummings, D.E.2    Baskin, D.G.3    Barsh, G.S.4    Schwartz, M.W.5
  • 116
    • 84971674653 scopus 로고
    • Nutrient Requirements of Laboratory Animals: Fourth Revised Edition, 1995
    • Washington (DC) National Academy Press (US)
    • [117] National Research Council (US) Subcommittee on Laboratory Animal Nutrition, Nutrient Requirements of Laboratory Animals: Fourth Revised Edition, 1995. 1995, Washington (DC), National Academy Press (US).
    • (1995)
    • National Research Council (US) Subcommittee on Laboratory Animal Nutrition1
  • 117
    • 0032861562 scopus 로고    scopus 로고
    • Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor
    • [118] Naveilhan, P., Hassani, H., Canals, J.M., Ekstrand, A.J., Larefalk, A., Chhajlani, V., Ernfors, P., Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor. Nat. Med. 5:10 (1999), 1188–1193, 10.1038/13514.
    • (1999) Nat. Med. , vol.5 , Issue.10 , pp. 1188-1193
    • Naveilhan, P.1    Hassani, H.2    Canals, J.M.3    Ekstrand, A.J.4    Larefalk, A.5    Chhajlani, V.6    Ernfors, P.7
  • 118
    • 84876281256 scopus 로고    scopus 로고
    • Sweetened-fat intake sensitizes gamma-aminobutyric acid-mediated feeding responses elicited from the nucleus accumbens shell
    • [119] Newman, S., Pascal, L., Sadeghian, K., Baldo, B.A., Sweetened-fat intake sensitizes gamma-aminobutyric acid-mediated feeding responses elicited from the nucleus accumbens shell. Biol. Psychiatry 73:9 (2013), 843–850, 10.1016/j.biopsych.2012.11.027.
    • (2013) Biol. Psychiatry , vol.73 , Issue.9 , pp. 843-850
    • Newman, S.1    Pascal, L.2    Sadeghian, K.3    Baldo, B.A.4
  • 119
    • 0025764241 scopus 로고
    • Insatiable feeding evoked in rats by recurrent perfusion of neuropeptide Y in the hypothalamus
    • [120] Paez, X., Myers, R.D., Insatiable feeding evoked in rats by recurrent perfusion of neuropeptide Y in the hypothalamus. Peptides 12:3 (1991), 609–616.
    • (1991) Peptides , vol.12 , Issue.3 , pp. 609-616
    • Paez, X.1    Myers, R.D.2
  • 120
    • 79952213256 scopus 로고    scopus 로고
    • Rodent models for metabolic syndrome research
    • [121] Panchal, S.K., Brown, L., Rodent models for metabolic syndrome research. J. Bioenerg. Biomembr., 2011, 2011, 351982, 10.1155/2011/351982.
    • (2011) J. Bioenerg. Biomembr. , vol.2011 , pp. 351982
    • Panchal, S.K.1    Brown, L.2
  • 121
    • 84888286745 scopus 로고    scopus 로고
    • The role of melanocortins and neuropeptide Y in food reward
    • [122] Pandit, R., la Fleur, S.E., Adan, R.A., The role of melanocortins and neuropeptide Y in food reward. Eur. J. Pharmacol. 719:1–3 (2013), 208–214, 10.1016/j.ejphar.2013.04.059.
    • (2013) Eur. J. Pharmacol. , vol.719 , Issue.1-3 , pp. 208-214
    • Pandit, R.1    la Fleur, S.E.2    Adan, R.A.3
  • 122
    • 84899981631 scopus 로고    scopus 로고
    • Limbic substrates of the effects of neuropeptide Y on intake of and motivation for palatable food
    • [123] Pandit, R., Luijendijk, M.C., Vanderschuren, L.J., la Fleur, S.E., Adan, R.A., Limbic substrates of the effects of neuropeptide Y on intake of and motivation for palatable food. Obesity (Silver Spring) 22:5 (2014), 1216–1219, 10.1002/oby.20718.
    • (2014) Obesity (Silver Spring) , vol.22 , Issue.5 , pp. 1216-1219
    • Pandit, R.1    Luijendijk, M.C.2    Vanderschuren, L.J.3    la Fleur, S.E.4    Adan, R.A.5
  • 123
    • 84861890334 scopus 로고    scopus 로고
    • Dietary factors affect food reward and motivation to eat
    • [124] Pandit, R., Mercer, J.G., Overduin, J., la Fleur, S.E., Adan, R.A., Dietary factors affect food reward and motivation to eat. Obes. Facts 5:2 (2012), 221–242, 10.1159/000338073.
    • (2012) Obes. Facts , vol.5 , Issue.2 , pp. 221-242
    • Pandit, R.1    Mercer, J.G.2    Overduin, J.3    la Fleur, S.E.4    Adan, R.A.5
  • 124
    • 33845525815 scopus 로고    scopus 로고
    • Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice
    • [125] Patel, H.R., Qi, Y., Hawkins, E.J., Hileman, S.M., Elmquist, J.K., Imai, Y., Ahima, R.S., Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice. Diabetes 55:11 (2006), 3091–3098, 10.2337/db05-0624.
    • (2006) Diabetes , vol.55 , Issue.11 , pp. 3091-3098
    • Patel, H.R.1    Qi, Y.2    Hawkins, E.J.3    Hileman, S.M.4    Elmquist, J.K.5    Imai, Y.6    Ahima, R.S.7
  • 125
    • 0142250829 scopus 로고    scopus 로고
    • Hyperdopaminergic mutant mice have higher “wanting” but not “liking” for sweet rewards
    • [126] Pecina, S., Cagniard, B., Berridge, K.C., Aldridge, J.W., Zhuang, X., Hyperdopaminergic mutant mice have higher “wanting” but not “liking” for sweet rewards. J. Neurosci. 23:28 (2003), 9395–9402.
    • (2003) J. Neurosci. , vol.23 , Issue.28 , pp. 9395-9402
    • Pecina, S.1    Cagniard, B.2    Berridge, K.C.3    Aldridge, J.W.4    Zhuang, X.5
  • 126
    • 0031779479 scopus 로고    scopus 로고
    • Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor
    • Retrieved from
    • [127] Pedrazzini, T., Seydoux, J., Kunstner, P., Aubert, J.F., Grouzmann, E., Beermann, F., Brunner, H.R., Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor. Nat. Med. 4:6 (1998), 722–726 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9623984.
    • (1998) Nat. Med. , vol.4 , Issue.6 , pp. 722-726
    • Pedrazzini, T.1    Seydoux, J.2    Kunstner, P.3    Aubert, J.F.4    Grouzmann, E.5    Beermann, F.6    Brunner, H.R.7
  • 127
    • 0025542173 scopus 로고
    • Ultrastructural localization of neuropeptide Y in the hypothalamus
    • [128] Pelletier, G., Ultrastructural localization of neuropeptide Y in the hypothalamus. Ann. N. Y. Acad. Sci. 611 (1990), 232–246.
    • (1990) Ann. N. Y. Acad. Sci. , vol.611 , pp. 232-246
    • Pelletier, G.1
  • 128
    • 0032054968 scopus 로고    scopus 로고
    • Y1 receptors in the nucleus accumbens: ultrastructural localization and association with neuropeptide Y
    • [129] Pickel, V.M., Beck-Sickinger, A.G., Chan, J., Weiland, H.A., Y1 receptors in the nucleus accumbens: ultrastructural localization and association with neuropeptide Y. J. Neurosci. Res. 52:1 (1998), 54–68.
    • (1998) J. Neurosci. Res. , vol.52 , Issue.1 , pp. 54-68
    • Pickel, V.M.1    Beck-Sickinger, A.G.2    Chan, J.3    Weiland, H.A.4
  • 129
    • 80054901454 scopus 로고    scopus 로고
    • Increased portion sizes from energy-dense foods affect total energy intake at eating occasions in US children and adolescents: patterns and trends by age group and sociodemographic characteristics, 1977–2006
    • [130] Piernas, C., Popkin, B.M., Increased portion sizes from energy-dense foods affect total energy intake at eating occasions in US children and adolescents: patterns and trends by age group and sociodemographic characteristics, 1977–2006. Am. J. Clin. Nutr. 94:5 (2011), 1324–1332, 10.3945/ajcn.110.008466.
    • (2011) Am. J. Clin. Nutr. , vol.94 , Issue.5 , pp. 1324-1332
    • Piernas, C.1    Popkin, B.M.2
  • 130
    • 0142241298 scopus 로고    scopus 로고
    • Hypothalamic leptin receptor and signaling molecule expressions in cafeteria diet-fed rats
    • [131] Plut, C., Ribiere, C., Giudicelli, Y., Dausse, J.P., Hypothalamic leptin receptor and signaling molecule expressions in cafeteria diet-fed rats. J. Pharmacol. Exp. Ther. 307:2 (2003), 544–549, 10.1124/jpet.103.054726.
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , Issue.2 , pp. 544-549
    • Plut, C.1    Ribiere, C.2    Giudicelli, Y.3    Dausse, J.P.4
  • 131
    • 1542545600 scopus 로고    scopus 로고
    • The sweetening of the world's diet
    • [132] Popkin, B.M., Nielsen, S.J., The sweetening of the world's diet. Obes. Res. 11:11 (2003), 1325–1332, 10.1038/oby.2003.179.
    • (2003) Obes. Res. , vol.11 , Issue.11 , pp. 1325-1332
    • Popkin, B.M.1    Nielsen, S.J.2
  • 132
    • 0036150947 scopus 로고    scopus 로고
    • Multiple NPY receptors inhibit GABA(A) synaptic responses of rat medial parvocellular effector neurons in the hypothalamic paraventricular nucleus
    • [133] Pronchuk, N., Beck-Sickinger, A.G., Colmers, W.F., Multiple NPY receptors inhibit GABA(A) synaptic responses of rat medial parvocellular effector neurons in the hypothalamic paraventricular nucleus. Endocrinology 143:2 (2002), 535–543, 10.1210/endo.143.2.8655.
    • (2002) Endocrinology , vol.143 , Issue.2 , pp. 535-543
    • Pronchuk, N.1    Beck-Sickinger, A.G.2    Colmers, W.F.3
  • 133
    • 84899925678 scopus 로고    scopus 로고
    • Rewarding, reinforcing and incentive salient events involve orexigenic hypothalamic neuropeptides regulating mesolimbic dopaminergic neurotransmission
    • [134] Quarta, D., Smolders, I., Rewarding, reinforcing and incentive salient events involve orexigenic hypothalamic neuropeptides regulating mesolimbic dopaminergic neurotransmission. Eur. J. Pharm. Sci. 57 (2014), 2–10, 10.1016/j.Ejps.2014.01.008.
    • (2014) Eur. J. Pharm. Sci. , vol.57 , pp. 2-10
    • Quarta, D.1    Smolders, I.2
  • 135
    • 0035924078 scopus 로고    scopus 로고
    • Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6 J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism
    • [136] Raposinho, P.D., Pierroz, D.D., Broqua, P., White, R.B., Pedrazzini, T., Aubert, M.L., Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6 J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism. Mol. Cell. Endocrinol. 185:1–2 (2001), 195–204.
    • (2001) Mol. Cell. Endocrinol. , vol.185 , Issue.1-2 , pp. 195-204
    • Raposinho, P.D.1    Pierroz, D.D.2    Broqua, P.3    White, R.B.4    Pedrazzini, T.5    Aubert, M.L.6
  • 136
    • 0035055943 scopus 로고    scopus 로고
    • SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats
    • Retrieved from
    • [137] Rodgers, R.J., Halford, J.C., Nunes de Souza, R.L., Canto de Souza, A.L., Piper, D.C., Arch, J.R., Blundell, J.E., SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats. Eur. J. Neurosci. 13:7 (2001), 1444–1452 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11298806.
    • (2001) Eur. J. Neurosci. , vol.13 , Issue.7 , pp. 1444-1452
    • Rodgers, R.J.1    Halford, J.C.2    Nunes de Souza, R.L.3    Canto de Souza, A.L.4    Piper, D.C.5    Arch, J.R.6    Blundell, J.E.7
  • 137
    • 77649276018 scopus 로고    scopus 로고
    • The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: the former opens to the portal blood and the latter to the cerebrospinal fluid
    • [138] Rodriguez, E.M., Blazquez, J.L., Guerra, M., The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: the former opens to the portal blood and the latter to the cerebrospinal fluid. Peptides 31:4 (2010), 757–776, 10.1016/j.peptides.2010.01.003.
    • (2010) Peptides , vol.31 , Issue.4 , pp. 757-776
    • Rodriguez, E.M.1    Blazquez, J.L.2    Guerra, M.3
  • 138
    • 0021736711 scopus 로고
    • Meal patterns and food selection during the development of obesity in rats fed a cafeteria diet
    • [139] Rogers, P.J., Blundell, J.E., Meal patterns and food selection during the development of obesity in rats fed a cafeteria diet. Neurosci. Biobehav. Rev. 8:4 (1984), 441–453.
    • (1984) Neurosci. Biobehav. Rev. , vol.8 , Issue.4 , pp. 441-453
    • Rogers, P.J.1    Blundell, J.E.2
  • 139
    • 80051784027 scopus 로고    scopus 로고
    • Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake
    • [140] Roncal-Jimenez, C.A., Lanaspa, M.A., Rivard, C.J., Nakagawa, T., Sanchez-Lozada, L.G., Jalal, D., Johnson, R.J., Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake. Metabolism 60:9 (2011), 1259–1270, 10.1016/j.metabol.2011.01.008.
    • (2011) Metabolism , vol.60 , Issue.9 , pp. 1259-1270
    • Roncal-Jimenez, C.A.1    Lanaspa, M.A.2    Rivard, C.J.3    Nakagawa, T.4    Sanchez-Lozada, L.G.5    Jalal, D.6    Johnson, R.J.7
  • 140
    • 1542358816 scopus 로고    scopus 로고
    • Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice
    • [141] Roseberry, A.G., Liu, H., Jackson, A.C., Cai, X., Friedman, J.M., Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron 41:5 (2004), 711–722.
    • (2004) Neuron , vol.41 , Issue.5 , pp. 711-722
    • Roseberry, A.G.1    Liu, H.2    Jackson, A.C.3    Cai, X.4    Friedman, J.M.5
  • 141
    • 0020436171 scopus 로고
    • Effects of feeding a “cafeteria” diet on energy balance and diet-induced thermogenesis in four strains of rat
    • [142] Rothwell, N.J., Saville, M.E., Stock, M.J., Effects of feeding a “cafeteria” diet on energy balance and diet-induced thermogenesis in four strains of rat. J. Nutr. 112:8 (1982), 1515–1524.
    • (1982) J. Nutr. , vol.112 , Issue.8 , pp. 1515-1524
    • Rothwell, N.J.1    Saville, M.E.2    Stock, M.J.3
  • 142
    • 0020134105 scopus 로고
    • Effects of feeding a palatable "cafeteria’ diet on energy balance in young and adult lean (+/?) Zucker rats
    • [143] Rothwell, N.J., Stock, M.J., Effects of feeding a palatable "cafeteria’ diet on energy balance in young and adult lean (+/?) Zucker rats. Br J Nutr 47:3 (1982), 461–471.
    • (1982) Br J Nutr , vol.47 , Issue.3 , pp. 461-471
    • Rothwell, N.J.1    Stock, M.J.2
  • 143
    • 0023867209 scopus 로고
    • Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus
    • [144] Sahu, A., Kalra, P.S., Kalra, S.P., Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus. Peptides 9:1 (1988), 83–86.
    • (1988) Peptides , vol.9 , Issue.1 , pp. 83-86
    • Sahu, A.1    Kalra, P.S.2    Kalra, S.P.3
  • 144
    • 84907938556 scopus 로고    scopus 로고
    • The antero-posterior heterogeneity of the ventral tegmental area
    • [145] Sanchez-Catalan, M.J., Kaufling, J., Georges, F., Veinante, P., Barrot, M., The antero-posterior heterogeneity of the ventral tegmental area. Neuroscience 282C (2014), 198–216, 10.1016/j.neuroscience.2014.09.025.
    • (2014) Neuroscience , vol.282C , pp. 198-216
    • Sanchez-Catalan, M.J.1    Kaufling, J.2    Georges, F.3    Veinante, P.4    Barrot, M.5
  • 145
    • 0033780625 scopus 로고    scopus 로고
    • The role of gastrointestinal vagal afferents in the control of food intake: current prospects
    • Retrieved from
    • [146] Schwartz, G.J., The role of gastrointestinal vagal afferents in the control of food intake: current prospects. Nutrition 16:10 (2000), 866–873 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11054591.
    • (2000) Nutrition , vol.16 , Issue.10 , pp. 866-873
    • Schwartz, G.J.1
  • 146
    • 0031733326 scopus 로고    scopus 로고
    • Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene
    • [147] Schwartz, M.W., Erickson, J.C., Baskin, D.G., Palmiter, R.D., Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene. Endocrinology 139:5 (1998), 2629–2635, 10.1210/endo.139.5.6000.
    • (1998) Endocrinology , vol.139 , Issue.5 , pp. 2629-2635
    • Schwartz, M.W.1    Erickson, J.C.2    Baskin, D.G.3    Palmiter, R.D.4
  • 147
    • 0028900950 scopus 로고
    • Neuropeptide Y fails to increase intraoral intake in rats
    • [148] Seeley, R.J., Payne, C.J., Woods, S.C., Neuropeptide Y fails to increase intraoral intake in rats. Am. J. Phys. 268:2 Pt 2 (1995), R423–R427.
    • (1995) Am. J. Phys. , vol.268 , Issue.2 , pp. R423-R427
    • Seeley, R.J.1    Payne, C.J.2    Woods, S.C.3
  • 148
    • 84906979430 scopus 로고    scopus 로고
    • MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus
    • [149] Shah, B.P., Vong, L., Olson, D.P., Koda, S., Krashes, M.J., Ye, C., Lowell, B.B., MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus. Proc. Natl. Acad. Sci. U. S. A. 111:36 (2014), 13193–13198, 10.1073/pnas.1407843111.
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , Issue.36 , pp. 13193-13198
    • Shah, B.P.1    Vong, L.2    Olson, D.P.3    Koda, S.4    Krashes, M.J.5    Ye, C.6    Lowell, B.B.7
  • 149
    • 0036158240 scopus 로고    scopus 로고
    • Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]
    • Retrieved from
    • [150] Sheriff, S., A, F.Q., W, T.C., Kasckow, J.W., Balasubramaniam, A., Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]. Peptides 23:1 (2002), 87–96 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11814622.
    • (2002) Peptides , vol.23 , Issue.1 , pp. 87-96
    • Sheriff, S.1    A, F.Q.2    W, T.C.3    Kasckow, J.W.4    Balasubramaniam, A.5
  • 150
    • 0031002007 scopus 로고    scopus 로고
    • Neuropeptide Y treatment and food deprivation increase cyclic AMP response element-binding in rat hypothalamus
    • Retrieved from
    • [151] Sheriff, S., Chance, W.T., Fischer, J.E., Balasubramaniam, A., Neuropeptide Y treatment and food deprivation increase cyclic AMP response element-binding in rat hypothalamus. Mol. Pharmacol. 51:4 (1997), 597–604 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9106624.
    • (1997) Mol. Pharmacol. , vol.51 , Issue.4 , pp. 597-604
    • Sheriff, S.1    Chance, W.T.2    Fischer, J.E.3    Balasubramaniam, A.4
  • 151
    • 68649091204 scopus 로고    scopus 로고
    • An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat
    • [152] Shin, A.C., Zheng, H., Berthoud, H.R., An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat. Physiol. Behav. 97:5 (2009), 572–580, 10.1016/j.physbeh.2009.02.010.
    • (2009) Physiol. Behav. , vol.97 , Issue.5 , pp. 572-580
    • Shin, A.C.1    Zheng, H.2    Berthoud, H.R.3
  • 152
    • 0019444888 scopus 로고
    • The descending afferent connections of the paraventricular nucleus of the hypothalamus (PVN)
    • [153] Silverman, A.J., Hoffman, D.L., Zimmerman, E.A., The descending afferent connections of the paraventricular nucleus of the hypothalamus (PVN). Brain Res. Bull. 6:1 (1981), 47–61.
    • (1981) Brain Res. Bull. , vol.6 , Issue.1 , pp. 47-61
    • Silverman, A.J.1    Hoffman, D.L.2    Zimmerman, E.A.3
  • 153
    • 27944503531 scopus 로고    scopus 로고
    • Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y
    • [154] Sindelar, D.K., Palmiter, R.D., Woods, S.C., Schwartz, M.W., Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y. Peptides 26:12 (2005), 2597–2602, 10.1016/j.peptides.2005.04.018.
    • (2005) Peptides , vol.26 , Issue.12 , pp. 2597-2602
    • Sindelar, D.K.1    Palmiter, R.D.2    Woods, S.C.3    Schwartz, M.W.4
  • 154
    • 0024422757 scopus 로고
    • Repeated hypothalamic stimulation with neuropeptide Y increases daily carbohydrate and fat intake and body weight gain in female rats
    • Retrieved from
    • [155] Stanley, B.G., Anderson, K.C., Grayson, M.H., Leibowitz, S.F., Repeated hypothalamic stimulation with neuropeptide Y increases daily carbohydrate and fat intake and body weight gain in female rats. Physiol. Behav. 46:2 (1989), 173–177 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/2602454.
    • (1989) Physiol. Behav. , vol.46 , Issue.2 , pp. 173-177
    • Stanley, B.G.1    Anderson, K.C.2    Grayson, M.H.3    Leibowitz, S.F.4
  • 155
    • 0022343686 scopus 로고
    • Feeding and drinking elicited by central injection of neuropeptide Y: evidence for a hypothalamic site(s) of action
    • [156] Stanley, B.G., Chin, A.S., Leibowitz, S.F., Feeding and drinking elicited by central injection of neuropeptide Y: evidence for a hypothalamic site(s) of action. Brain Res. Bull. 14:6 (1985), 521–524.
    • (1985) Brain Res. Bull. , vol.14 , Issue.6 , pp. 521-524
    • Stanley, B.G.1    Chin, A.S.2    Leibowitz, S.F.3
  • 156
    • 0022396692 scopus 로고
    • Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion
    • Retrieved from
    • [157] Stanley, B.G., Daniel, D.R., Chin, A.S., Leibowitz, S.F., Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion. Peptides 6:6 (1985), 1205–1211 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/3841735.
    • (1985) Peptides , vol.6 , Issue.6 , pp. 1205-1211
    • Stanley, B.G.1    Daniel, D.R.2    Chin, A.S.3    Leibowitz, S.F.4
  • 157
    • 0022873040 scopus 로고
    • Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity
    • [158] Stanley, B.G., Kyrkouli, S.E., Lampert, S., Leibowitz, S.F., Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7:6 (1986), 1189–1192.
    • (1986) Peptides , vol.7 , Issue.6 , pp. 1189-1192
    • Stanley, B.G.1    Kyrkouli, S.E.2    Lampert, S.3    Leibowitz, S.F.4
  • 158
    • 0027450918 scopus 로고
    • The perifornical area: the major focus of (a) patchily distributed hypothalamic neuropeptide Y-sensitive feeding system(s)
    • [159] Stanley, B.G., Magdalin, W., Seirafi, A., Thomas, W.J., Leibowitz, S.F., The perifornical area: the major focus of (a) patchily distributed hypothalamic neuropeptide Y-sensitive feeding system(s). Brain Res. 604:1–2 (1993), 304–317.
    • (1993) Brain Res. , vol.604 , Issue.1-2 , pp. 304-317
    • Stanley, B.G.1    Magdalin, W.2    Seirafi, A.3    Thomas, W.J.4    Leibowitz, S.F.5
  • 159
    • 34547687830 scopus 로고    scopus 로고
    • Chronic consumption of a low-fat diet leads to increased hypothalamic agouti-related protein and reduced leptin
    • [160] Staszkiewicz, J., Horswell, R., Argyropoulos, G., Chronic consumption of a low-fat diet leads to increased hypothalamic agouti-related protein and reduced leptin. Nutrition 23:9 (2007), 665–671, 10.1016/j.nut.2007.06.001.
    • (2007) Nutrition , vol.23 , Issue.9 , pp. 665-671
    • Staszkiewicz, J.1    Horswell, R.2    Argyropoulos, G.3
  • 160
    • 27744457512 scopus 로고    scopus 로고
    • Topographic mapping of VMH –– > arcuate nucleus microcircuits and their reorganization by fasting
    • [161] Sternson, S.M., Shepherd, G.M., Friedman, J.M., Topographic mapping of VMH –– > arcuate nucleus microcircuits and their reorganization by fasting. Nat. Neurosci. 8:10 (2005), 1356–1363, 10.1038/nn1550.
    • (2005) Nat. Neurosci. , vol.8 , Issue.10 , pp. 1356-1363
    • Sternson, S.M.1    Shepherd, G.M.2    Friedman, J.M.3
  • 161
    • 84869180863 scopus 로고    scopus 로고
    • National, regional, and global trends in adult overweight and obesity prevalences
    • [162] Stevens, G.A., Singh, G.M., Lu, Y., Danaei, G., Lin, J.K., Finucane, M.M., Ezzati, M., National, regional, and global trends in adult overweight and obesity prevalences. Popul. Health Metrics, 10(1), 2012, 22, 10.1186/1478-7954-10-22.
    • (2012) Popul. Health Metrics , vol.10 , Issue.1 , pp. 22
    • Stevens, G.A.1    Singh, G.M.2    Lu, Y.3    Danaei, G.4    Lin, J.K.5    Finucane, M.M.6    Ezzati, M.7
  • 162
    • 0032476154 scopus 로고    scopus 로고
    • Hypothalamic neuropeptide Y and plasma leptin after long-term high-fat feeding in the rat
    • [163] Stricker-Krongrad, A., Cumin, F., Burlet, C., Beck, B., Hypothalamic neuropeptide Y and plasma leptin after long-term high-fat feeding in the rat. Neurosci. Lett. 254:3 (1998), 157–160.
    • (1998) Neurosci. Lett. , vol.254 , Issue.3 , pp. 157-160
    • Stricker-Krongrad, A.1    Cumin, F.2    Burlet, C.3    Beck, B.4
  • 163
    • 0030845706 scopus 로고    scopus 로고
    • Disrupted cholecystokinin type-A receptor (CCKAR) gene in OLETF rats
    • [164] Takiguchi, S., Takata, Y., Funakoshi, A., Miyasaka, K., Kataoka, K., Fujimura, Y., Kono, A., Disrupted cholecystokinin type-A receptor (CCKAR) gene in OLETF rats. Gene 197:1–2 (1997), 169–175.
    • (1997) Gene , vol.197 , Issue.1-2 , pp. 169-175
    • Takiguchi, S.1    Takata, Y.2    Funakoshi, A.3    Miyasaka, K.4    Kataoka, K.5    Fujimura, Y.6    Kono, A.7
  • 164
    • 0031937482 scopus 로고    scopus 로고
    • A disrupted cholecystokinin A receptor gene induces diabetes in obese rats synergistically with ODB1 gene
    • [165] Takiguchi, S., Takata, Y., Takahashi, N., Kataoka, K., Hirashima, T., Kawano, K., Kono, A., A disrupted cholecystokinin A receptor gene induces diabetes in obese rats synergistically with ODB1 gene. Am. J. Phys. 274:2 Pt 1 (1998), E265–E270.
    • (1998) Am. J. Phys. , vol.274 , Issue.2 , pp. E265-E270
    • Takiguchi, S.1    Takata, Y.2    Takahashi, N.3    Kataoka, K.4    Hirashima, T.5    Kawano, K.6    Kono, A.7
  • 165
    • 0000613769 scopus 로고
    • Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion
    • [166] Tatemoto, K., Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc. Natl. Acad. Sci. U. S. A. 79:8 (1982), 2514–2518.
    • (1982) Proc. Natl. Acad. Sci. U. S. A. , vol.79 , Issue.8 , pp. 2514-2518
    • Tatemoto, K.1
  • 166
    • 38449086275 scopus 로고    scopus 로고
    • Differential effects of recombinant adeno-associated virus-mediated neuropeptide Y overexpression in the hypothalamic paraventricular nucleus and lateral hypothalamus on feeding behavior
    • [167] Tiesjema, B., Adan, R.A., Luijendijk, M.C., Kalsbeek, A., la Fleur, S.E., Differential effects of recombinant adeno-associated virus-mediated neuropeptide Y overexpression in the hypothalamic paraventricular nucleus and lateral hypothalamus on feeding behavior. J. Neurosci. 27:51 (2007), 14139–14146, 10.1523/jneurosci.3280-07.2007.
    • (2007) J. Neurosci. , vol.27 , Issue.51 , pp. 14139-14146
    • Tiesjema, B.1    Adan, R.A.2    Luijendijk, M.C.3    Kalsbeek, A.4    la Fleur, S.E.5
  • 167
    • 0031697756 scopus 로고    scopus 로고
    • Functional interactions between melanin-concentrating hormone, neuropeptide Y, and anorectic neuropeptides in the rat hypothalamus
    • Retrieved from
    • [168] Tritos, N.A., Vicent, D., Gillette, J., Ludwig, D.S., Flier, E.S., Maratos-Flier, E., Functional interactions between melanin-concentrating hormone, neuropeptide Y, and anorectic neuropeptides in the rat hypothalamus. Diabetes 47:11 (1998), 1687–1692 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9792536.
    • (1998) Diabetes , vol.47 , Issue.11 , pp. 1687-1692
    • Tritos, N.A.1    Vicent, D.2    Gillette, J.3    Ludwig, D.S.4    Flier, E.S.5    Maratos-Flier, E.6
  • 168
    • 84900456389 scopus 로고    scopus 로고
    • Differential modulation of arcuate nucleus and mesolimbic gene expression levels by central leptin in rats on short-term high-fat high-sugar diet
    • e87729
    • [169] van den Heuvel, J.K., Eggels, L., Fliers, E., Kalsbeek, A., Adan, R.A., la Fleur, S.E., Differential modulation of arcuate nucleus and mesolimbic gene expression levels by central leptin in rats on short-term high-fat high-sugar diet. PLoS One, 9(1), 2014, e87729, 10.1371/journal.pone.0087729.
    • (2014) PLoS One , vol.9 , Issue.1
    • van den Heuvel, J.K.1    Eggels, L.2    Fliers, E.3    Kalsbeek, A.4    Adan, R.A.5    la Fleur, S.E.6
  • 170
    • 84924605442 scopus 로고    scopus 로고
    • Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity
    • [171] van den Heuvel, J.K., Furman, K., Gumbs, M.C., Eggels, L., Opland, D.M., Land, B.B., la Fleur, S.E., Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity. Biol. Psychiatry 77:7 (2015), 633–641, 10.1016/j.biopsych.2014.06.008.
    • (2015) Biol. Psychiatry , vol.77 , Issue.7 , pp. 633-641
    • van den Heuvel, J.K.1    Furman, K.2    Gumbs, M.C.3    Eggels, L.4    Opland, D.M.5    Land, B.B.6    la Fleur, S.E.7
  • 171
    • 2442538044 scopus 로고    scopus 로고
    • Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection
    • [172] van den Pol, A.N., Acuna-Goycolea, C., Clark, K.R., Ghosh, P.K., Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection. Neuron 42:4 (2004), 635–652.
    • (2004) Neuron , vol.42 , Issue.4 , pp. 635-652
    • van den Pol, A.N.1    Acuna-Goycolea, C.2    Clark, K.R.3    Ghosh, P.K.4
  • 172
    • 2142758640 scopus 로고    scopus 로고
    • Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
    • [173] van den Top, M., Lee, K., Whyment, A.D., Blanks, A.M., Spanswick, D., Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat. Neurosci. 7:5 (2004), 493–494, 10.1038/nn1226.
    • (2004) Nat. Neurosci. , vol.7 , Issue.5 , pp. 493-494
    • van den Top, M.1    Lee, K.2    Whyment, A.D.3    Blanks, A.M.4    Spanswick, D.5
  • 173
    • 78650752631 scopus 로고    scopus 로고
    • Reward, dopamine and the control of food intake: implications for obesity
    • [174] Volkow, N.D., Wang, G.J., Baler, R.D., Reward, dopamine and the control of food intake: implications for obesity. Trends Cogn. Sci. 15:1 (2011), 37–46, 10.1016/j.tics.2010.11.001.
    • (2011) Trends Cogn. Sci. , vol.15 , Issue.1 , pp. 37-46
    • Volkow, N.D.1    Wang, G.J.2    Baler, R.D.3
  • 174
    • 84927774781 scopus 로고    scopus 로고
    • Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons
    • [175] Wang, D., He, X., Zhao, Z., Feng, Q., Lin, R., Sun, Y., Zhan, C., Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons. Front. Neuroanat., 9, 2015, 40, 10.3389/fnana.2015.00040.
    • (2015) Front. Neuroanat. , vol.9 , pp. 40
    • Wang, D.1    He, X.2    Zhao, Z.3    Feng, Q.4    Lin, R.5    Sun, Y.6    Zhan, C.7
  • 175
    • 0036088134 scopus 로고    scopus 로고
    • Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression
    • [176] Wang, H., Storlien, L.H., Huang, X.F., Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression. Am. J. Physiol. Endocrinol. Metab. 282:6 (2002), E1352–E1359, 10.1152/ajpendo.00230.2001.
    • (2002) Am. J. Physiol. Endocrinol. Metab. , vol.282 , Issue.6 , pp. E1352-E1359
    • Wang, H.1    Storlien, L.H.2    Huang, X.F.3
  • 177
    • 0033406683 scopus 로고    scopus 로고
    • Rapid changes in hypothalamic neuropeptide Y produced by carbohydrate-rich meals that enhance corticosterone and glucose levels
    • [178] Wang, J., Dourmashkin, J.T., Yun, R., Leibowitz, S.F., Rapid changes in hypothalamic neuropeptide Y produced by carbohydrate-rich meals that enhance corticosterone and glucose levels. Brain Res. 848:1–2 (1999), 124–136.
    • (1999) Brain Res. , vol.848 , Issue.1-2 , pp. 124-136
    • Wang, J.1    Dourmashkin, J.T.2    Yun, R.3    Leibowitz, S.F.4
  • 178
    • 84871798072 scopus 로고    scopus 로고
    • Neuropeptide Y loses its orexigenic effect in rats with lesions of the hypothalamic paraventricular nucleus
    • [179] Wang, J., Yuan, Z., Dong, J., Zhang, D., Usami, T., Murata, T., Higuchi, T., Neuropeptide Y loses its orexigenic effect in rats with lesions of the hypothalamic paraventricular nucleus. Endocr. Res. 38:1 (2013), 8–14, 10.3109/07435800.2012.683226.
    • (2013) Endocr. Res. , vol.38 , Issue.1 , pp. 8-14
    • Wang, J.1    Yuan, Z.2    Dong, J.3    Zhang, D.4    Usami, T.5    Murata, T.6    Higuchi, T.7
  • 179
    • 84947967549 scopus 로고    scopus 로고
    • Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY neurons in mice
    • [180] Wei, W., Pham, K., Gammons, J.W., Sutherland, D., Liu, Y., Smith, A., O'Connell, K.M., Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY neurons in mice. Sci. Report., 5, 2015, 16810, 10.1038/srep16810.
    • (2015) Sci. Report. , vol.5 , pp. 16810
    • Wei, W.1    Pham, K.2    Gammons, J.W.3    Sutherland, D.4    Liu, Y.5    Smith, A.6    O'Connell, K.M.7
  • 180
    • 13844300187 scopus 로고
    • Increased hypothalamic neuropeptide Y expression following food deprivation
    • [181] White, J.D., Kershaw, M., Increased hypothalamic neuropeptide Y expression following food deprivation. Mol. Cell. Neurosci. 1:1 (1990), 41–48.
    • (1990) Mol. Cell. Neurosci. , vol.1 , Issue.1 , pp. 41-48
    • White, J.D.1    Kershaw, M.2
  • 181
    • 0032853212 scopus 로고    scopus 로고
    • Hypothalamic NPY status during positive energy balance and the effects of the NPY antagonist, BW 1229U91, on the consumption of highly palatable energy-rich diet
    • [182] Widdowson, P.S., Henderson, L., Pickavance, L., Buckingham, R., Tadayyon, M., Arch, J.R., Williams, G., Hypothalamic NPY status during positive energy balance and the effects of the NPY antagonist, BW 1229U91, on the consumption of highly palatable energy-rich diet. Peptides 20:3 (1999), 367–372.
    • (1999) Peptides , vol.20 , Issue.3 , pp. 367-372
    • Widdowson, P.S.1    Henderson, L.2    Pickavance, L.3    Buckingham, R.4    Tadayyon, M.5    Arch, J.R.6    Williams, G.7
  • 182
    • 0031558626 scopus 로고    scopus 로고
    • Reciprocal regional changes in brain NPY receptor density during dietary restriction and dietary-induced obesity in the rat
    • Retrieved from
    • [183] Widdowson, P.S., Upton, R., Henderson, L., Buckingham, R., Wilson, S., Williams, G., Reciprocal regional changes in brain NPY receptor density during dietary restriction and dietary-induced obesity in the rat. Brain Res. 774:1–2 (1997), 1–10 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9452185.
    • (1997) Brain Res. , vol.774 , Issue.1-2 , pp. 1-10
    • Widdowson, P.S.1    Upton, R.2    Henderson, L.3    Buckingham, R.4    Wilson, S.5    Williams, G.6
  • 183
    • 0026663521 scopus 로고
    • Dexfenfluramine treatment and hypothalamic neuropeptides in diet-induced obesity in rats
    • [184] Wilding, J.P., Gilbey, S.G., Jones, P.M., Mannan, M.M., Ghatei, M.A., Bloom, S.R., Dexfenfluramine treatment and hypothalamic neuropeptides in diet-induced obesity in rats. Peptides 13:3 (1992), 557–563.
    • (1992) Peptides , vol.13 , Issue.3 , pp. 557-563
    • Wilding, J.P.1    Gilbey, S.G.2    Jones, P.M.3    Mannan, M.M.4    Ghatei, M.A.5    Bloom, S.R.6
  • 184
    • 0026537083 scopus 로고
    • Increased neuropeptide Y content in individual hypothalamic nuclei, but not neuropeptide Y mRNA, in diet-induced obesity in rats
    • [185] Wilding, J.P., Gilbey, S.G., Mannan, M., Aslam, N., Ghatei, M.A., Bloom, S.R., Increased neuropeptide Y content in individual hypothalamic nuclei, but not neuropeptide Y mRNA, in diet-induced obesity in rats. J. Endocrinol. 132:2 (1992), 299–304.
    • (1992) J. Endocrinol. , vol.132 , Issue.2 , pp. 299-304
    • Wilding, J.P.1    Gilbey, S.G.2    Mannan, M.3    Aslam, N.4    Ghatei, M.A.5    Bloom, S.R.6
  • 185
    • 0033316562 scopus 로고    scopus 로고
    • Physiological and anatomical circuitry between Agouti-related protein and leptin signaling
    • [186] Wilson, B.D., Bagnol, D., Kaelin, C.B., Ollmann, M.M., Gantz, I., Watson, S.J., Barsh, G.S., Physiological and anatomical circuitry between Agouti-related protein and leptin signaling. Endocrinology 140:5 (1999), 2387–2397, 10.1210/endo.140.5.6728.
    • (1999) Endocrinology , vol.140 , Issue.5 , pp. 2387-2397
    • Wilson, B.D.1    Bagnol, D.2    Kaelin, C.B.3    Ollmann, M.M.4    Gantz, I.5    Watson, S.J.6    Barsh, G.S.7
  • 186
    • 0042567303 scopus 로고    scopus 로고
    • Comparative distribution of neuropeptide Y Y1 and Y5 receptors in the rat brain by using immunohistochemistry
    • [187] Wolak, M.L., DeJoseph, M.R., Cator, A.D., Mokashi, A.S., Brownfield, M.S., Urban, J.H., Comparative distribution of neuropeptide Y Y1 and Y5 receptors in the rat brain by using immunohistochemistry. J. Comp. Neurol. 464:3 (2003), 285–311, 10.1002/cne.10823.
    • (2003) J. Comp. Neurol. , vol.464 , Issue.3 , pp. 285-311
    • Wolak, M.L.1    DeJoseph, M.R.2    Cator, A.D.3    Mokashi, A.S.4    Brownfield, M.S.5    Urban, J.H.6
  • 187
    • 0037383261 scopus 로고    scopus 로고
    • A controlled high-fat diet induces an obese syndrome in rats
    • [188] Woods, S.C., Seeley, R.J., Rushing, P.A., D'Alessio, D., Tso, P., A controlled high-fat diet induces an obese syndrome in rats. J. Nutr. 133:4 (2003), 1081–1087.
    • (2003) J. Nutr. , vol.133 , Issue.4 , pp. 1081-1087
    • Woods, S.C.1    Seeley, R.J.2    Rushing, P.A.3    D'Alessio, D.4    Tso, P.5
  • 188
    • 84868019776 scopus 로고    scopus 로고
    • Causes of obesity
    • [189] Wright, S.M., Aronne, L.J., Causes of obesity. Abdom. Imaging 37:5 (2012), 730–732, 10.1007/s00261-012-9862-x.
    • (2012) Abdom. Imaging , vol.37 , Issue.5 , pp. 730-732
    • Wright, S.M.1    Aronne, L.J.2
  • 189
    • 74949132999 scopus 로고    scopus 로고
    • PI3K integrates the effects of insulin and leptin on large-conductance Ca2 + -activated K + channels in neuropeptide Y neurons of the hypothalamic arcuate nucleus
    • [190] Yang, M.J., Wang, F., Wang, J.H., Wu, W.N., Hu, Z.L., Cheng, J., Chen, J.G., PI3K integrates the effects of insulin and leptin on large-conductance Ca2 + -activated K + channels in neuropeptide Y neurons of the hypothalamic arcuate nucleus. Am. J. Physiol. Endocrinol. Metab. 298:2 (2010), E193–E201, 10.1152/ajpendo.00155.2009.
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.298 , Issue.2 , pp. E193-E201
    • Yang, M.J.1    Wang, F.2    Wang, J.H.3    Wu, W.N.4    Hu, Z.L.5    Cheng, J.6    Chen, J.G.7
  • 190
    • 0027362079 scopus 로고
    • Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity
    • [191] Zarjevski, N., Cusin, I., Vettor, R., Rohner-Jeanrenaud, F., Jeanrenaud, B., Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 133:4 (1993), 1753–1758, 10.1210/endo.133.4.8404618.
    • (1993) Endocrinology , vol.133 , Issue.4 , pp. 1753-1758
    • Zarjevski, N.1    Cusin, I.2    Vettor, R.3    Rohner-Jeanrenaud, F.4    Jeanrenaud, B.5
  • 191
    • 84881359391 scopus 로고    scopus 로고
    • Overexpression of neuropeptide Y in the dorsomedial hypothalamus causes hyperphagia and obesity in rats
    • [192] Zheng, F., Kim, Y.J., Chao, P.T., Bi, S., Overexpression of neuropeptide Y in the dorsomedial hypothalamus causes hyperphagia and obesity in rats. Obesity (Silver Spring) 21:6 (2013), 1086–1092, 10.1002/oby.20467.
    • (2013) Obesity (Silver Spring) , vol.21 , Issue.6 , pp. 1086-1092
    • Zheng, F.1    Kim, Y.J.2    Chao, P.T.3    Bi, S.4
  • 192
    • 36549027795 scopus 로고    scopus 로고
    • Eating for pleasure or calories
    • [193] Zheng, H., Berthoud, H.R., Eating for pleasure or calories. Curr. Opin. Pharmacol. 7:6 (2007), 607–612, 10.1016/j.coph.2007.10.011.
    • (2007) Curr. Opin. Pharmacol. , vol.7 , Issue.6 , pp. 607-612
    • Zheng, H.1    Berthoud, H.R.2
  • 193
    • 67649523146 scopus 로고    scopus 로고
    • Appetite control and energy balance regulation in the modern world: reward-driven brain overrides repletion signals
    • [194] Zheng, H., Lenard, N.R., Shin, A.C., Berthoud, H.R., Appetite control and energy balance regulation in the modern world: reward-driven brain overrides repletion signals. Int. J. Obes. 33:Suppl. 2 (2009), S8–13, 10.1038/ijo.2009.65.
    • (2009) Int. J. Obes. , vol.33 , pp. S8-13
    • Zheng, H.1    Lenard, N.R.2    Shin, A.C.3    Berthoud, H.R.4
  • 194
    • 0033695523 scopus 로고    scopus 로고
    • Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice
    • [195] Ziotopoulou, M., Mantzoros, C.S., Hileman, S.M., Flier, J.S., Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice. Am. J. Physiol. Endocrinol. Metab. 279:4 (2000), E838–E845.
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.279 , Issue.4 , pp. E838-E845
    • Ziotopoulou, M.1    Mantzoros, C.S.2    Hileman, S.M.3    Flier, J.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.