Responsivity to NPY and melanocortins in obese OLETF rats lacking CCK-A receptors

Physiology and Behavior

Volumn 75, Issue 3, 2002, Pages 397-402

  Moran, Timothy H ^a   Lee, Pikki ^a   Ladenheim, Ellen E ^a   Schwartz, Gary J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Proopiomelanocortin; Satiety; MSH

Indexed keywords

ANOREXIGENIC AGENT; APPETITE STIMULANT; CHOLECYSTOKININ A RECEPTOR; HORMONE RECEPTOR STIMULATING AGENT; MELANOCORTIN 3 AGONIST; MELANOCORTIN 4 AGONIST; MELANOCORTIN RECEPTOR ANTAGONIST; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; NEUROPEPTIDE Y; PEPTIDE HORMONE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APPETITE; ARTICLE; CONTROLLED STUDY; FEEDING BEHAVIOR; FOOD INTAKE; GENE EXPRESSION; HYPERPHAGIA; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0036124418     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(01)00667-9     Document Type: Article

References (16)

1. Disrupted cholecystokinin-type A receptor (CCKAR) gene in OLETF rats
2. An animal model of congenital defect of gene expression of cholecystokinin (CCK)-A receptor
3. Receptor subtype and affinity state mediating the satiety actions of cholecystokinin (CCK)
4. Disordered food intake and obesity in rats lacking cholecystokinin A (CCKA) receptors
5. Decreased responsiveness to dietary fat in Otsuka Long-Evans Tokushima Fatty (OLETF) rats lacking CCKA receptors
6. Attenuated satiation response to intestinal nutrients in rats that do not express CCK-A receptors
7. A role for NPY overexpression in the dorsomedial hypothalamus in the hyperphagia and obesity of OLETF rats
8. Effects of central and peripheral injection of leptin on food intake and on brain fos expression in the Otsuka Long-Evans Tokushima Fatty rat with hyperleptinemia
9. Downregulation of melanocortin receptors in brain areas involved in food intake and reward mechanisms in obese (OLETF) rats
10. Identification of targets of leptin action in rat hypothalamus
11. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
12. Increased threshold concentrations of neuropeptide Y for a stimulatory effect on food intake in obese Zucker rats - Changes in the microstructure of the feeding behavior
13. A potent neuropeptide Y antagonist, 1229U91, suppressed spontaneous food intake in Zucker fatty rats
14. Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats
15. Role of the CNS melanocortin system in the response to overfeeding
16. The cholecystokinin A-receptor mediates inhibition of food intake yet is not essential for maintenance of body weight