Early leptin response to a palatable diet predicts dietary obesity in rats: Key role of melanocortin-4 receptors in the ventromedial hypothalamic nucleus

Journal of Neurochemistry

Volumn 74, Issue 3, 2000, Pages 1224-1228

  Harrold, Joanne A ^a   Williams, Gareth ^a   Widdowson, Peter S ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Dietary induced obesity; Hypothalamus; Leptin; Melanocortin 4 receptors; Ventromedial nucleus

Indexed keywords

ALPHA INTERMEDIN; LEPTIN; MELANOCORTIN RECEPTOR; PROOPIOMELANOCORTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET; DISEASE PREDISPOSITION; FOOD INTAKE; HYPOTHALAMUS; MALE; NONHUMAN; OBESITY; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; WEIGHT GAIN;

ANIMALIA;

EID: 0033975409     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.741224.x     Document Type: Article

References (23)

1. Blake A. D., Bot G., Li S., Freeman J. C., and Reisine T. (1997) Differential agonist regulation of the human κ-opioid receptor. J. Neurochem. 68, 1846-1852.
2. Campfield L. A., Smith F. J., Guisez Y., Devos R., and Burn P. (1995) Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 296, 546-549.
3. Cheung C. C., Clifton D. K., and Steiner R. A. (1997) Proopiomela-nocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 138, 4489-4492.
4. Fan W., Boston B. A., Kesterson R. A., Hruby V. J., and Cone R. D. (1997) Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385, 165-168.
5. Frederich R. C., Hamann A., Andersson S., Lollmann B., Lowell B. B., and Flier J. S. (1995) Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat. Med. 1, 1311-1314.
6. Gantz I., Miwa H., Konda Y., Shimoto Y., Tashiro T., Watson S. J., Del Valle J., and Yamada T. (1993) Molecular cloning, expression, and gene localisation of a fourth melanocortin receptor. J. Biol. Chem. 268, 15174-15179.
7. Halaas J. L., Gajiwala K. S., Maffei M., Cohen S. L., Rabinowitz D., Lallone R. L., Burley S. K., and Friedmann J. M. (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543-546.
8. Harrold J. A., Widdowson P. S., and Williams G. (1999a) Altered energy balance causes selective changes in melanocortin-4 (MC4-R) but not melanocortin-3 (MC3-R) receptors in specific hypothalamic regions: further evidence that MC4-R activation is a physiological inhibitor of feeding. Diabetes 48, 267-271.
9. Harrold J. A., Williams G., and Widdowson P. S. (1999b) Changes in hypothalamic agouti-related protein, but not α-MSH or pro-opiomelanocortin concentrations in dietary-obese and food-restricted rats. Biochem. Biophys. Res. Commun. 258, 574-577.
10. Haskell-Luevano C., Chen P., Li C., Chang K., Smith M. S., Cameron J. L., and Cone R. D. (1999) Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat. Endocrinology 140, 1408-1415.
11. Maffei M., Halaas J., Ravussin E., Pratley R. E., Lee G. H., Zhang Y., Fei H., Kim S., Lallone R., Ranganathan S., Kern P. A., and Friedmann J. M. (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese- and weight reduced subjects. Nat. Med. 1, 1155-1161.
12. Mizuno T. M. and Mobbs C. V. (1999) Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology 140, 814-817.
13. Mountjoy K. G., Mortrud M. T., Low M. J., Simerly R. B., and Cone R. D. (1994) Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol. Endocrinol. 8, 1298-1308.
14. Pelleymounter M. A., Cullen M. J., Baker M. B., Hecht R., Winters D., Boone T., and Collins F. (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269, 540-543.
15. Ravussin E., Pratley R. E., Maffei M., Wang H., Friedman J. M., Bennett P. H., and Bogardus C. (1997) Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat. Med. 3, 238-240.
16. Rossi M., Kim M. S., Morgan D. G., Small C. J., Edwards C. M., Sunter D., Abusnana S., Goldstone A. P., Russell S. H., Stanley S. A., Smith D. M., Yagaloff K., Ghatei M. A., and Bloom S. R. (1998) A C-terminal fragment of agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology 139, 4428-4431.
17. Schwartz M. W., Seeley R. J., Woods S. C., Weigle D. S., Campfield A., Burn P., and Baskin D. G. (1997) Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46, 2119-2122.
18. Shockley M. S., Burford N. T., Sadée W., and Lameh J. (1997) Residues specifically involved in down-regulation but not internalization of the m1 muscarinic acetylcholine receptor. J. Neurochem. 68, 601-609.
19. Surwitt R. S., Petro A. E., Parekh P., and Collins S. (1997) Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice. Diabetes 46, 1516-1520.
20. Tsujii S, and Bray G. A. (1989) Acetylation alters the feeding response to MSH and beta-endorphin. Brain Res. Bull. 23, 165-169.
21. Widdowson P. S., Upton R., Buckingham R., Arch J., and Williams G. (1997) Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity. Diabetes 46, 1782-1785.
22. Wilson B. D., Bagnol D., Kaelin C. B., Ollmann M. M., Gantz I., Watson S. J., and Barsh G. S. (1999) Physiological and anatomical circuitry between agouti-related protein and leptin signaling. Endocrinology 140, 2387-2397.
23. Yeo G. S. H., Farooqi I. S., Aminian S., Halsall D. J., Stanhope R. G., and O'Rahilly S. (1998) A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat. Genet. 20, 111-112.