Evidence of altered hypothalamic pro-opiomelanocortin/neuropeptide Y mRNA expression in tubby mice

Molecular Brain Research

Volumn 59, Issue 2, 1998, Pages 273-279

  Guan, Xiao Ming ^a   Yu, Hong ^a   Van Der Ploeg, Lex H T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Gene expression; In situ hybridization; Neuropeptide; NPY; Obesity; POMC

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; LEPTIN RECEPTOR; MESSENGER RNA; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; HYPOTHALAMUS; MOUSE; MOUSE MUTANT; NONHUMAN; OBESITY; PERCEPTION DEAFNESS; PRIORITY JOURNAL; RETINA DEGENERATION;

ANIMALS; FEMALE; GENE EXPRESSION; HYPOTHALAMUS; IN SITU HYBRIDIZATION; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEUROPEPTIDE Y; OBESITY; PRO-OPIOMELANOCORTIN; PROTEINS; RNA, MESSENGER;

ANIMALIA;

EID: 0032584978     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(98)00150-8     Document Type: Article

References (34)

1. Bernardis L.L. Hypophagia, hypodipsia, and hypoactivity following electrolytic lesions in the dorsomedial hypothalmic nuclei of mature rats of both sexes. J. Neural Transm. 33:1972;1-10.
2. Brady L.S., Smith M.A., Gold P.W., Herkenham M. Altered expression of hypothalmic neuropeptide mRNAs in food-restricted and food-deprived rats. Endocrinology. 52:1990;441-447.
3. Bultman S.J., Michaud E.J., Woychik R.P. Molecular characterization of the mouse agouti locus. Cell. 71:1992;1195-1204.
4. Canteras N.S., Simerly R.B., Swanson L.W. Organization of projections from the ventromedial nucleus of the hypothalmus: a Phaseolus vulgaris-leucoagglutinin study in the rat. J. Compar. Neurol. 348:1994;41-79.
5. Chen H., Charlat O., Tartaglia L.A., Woolf E.A., Weng X., Ellis S.J., Lakey N.D., Culpepper J., Moore K.J., Breitbart R.E., Duyk G.M., Tepper R.I., Morgenstern J.P. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 84:1996;491-495.
6. Coleman D.L., Eicher E.M. Fat (fat) and Tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse. J. Hered. 81:1990;424-427.
7. Comuzzie A.G., Hixson J.E., Almasy L., Mitchell B.D., Mahaney M.C., Dyer T.D., Stern M.P., Maccluer J.W., Blangero J. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nature Genet. 15:1997;273-276.
8. Fan W., Boston B.A., Kesterson R.A., Hruby V.J., Cone R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature. 385:1997;165-168.
9. K.B.J. Franklin, G. Paxinos, The Mouse Brain In Stereotaxic Coordinates, Academic Press, New York, 1997.
10. Graham M., Shutter J.R., Sarmiento U., Sarosi I., Stark K.L. Overexpression of Agrt leads to obesity in transgenic mice. Nature Genet. 17:1997;273-274.
11. Guan X.-M., Hess F.J., Yu H., Hey P.J., Van der Ploeg L.H.T. Differential expression of mRNA for leptin receptor isoforms in the rat brain. Mol. Cell Endocrinol. 133:1997;1-7.
12. Guan X.-M., Yu H., Palyha O.C., McKee K.K., Feighner S.D., Sirinathsinghji D.J.S., Smith R.G., Van der Ploeg L.H.T., Howard A.D. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Mol. Brain Res. 48:1997;23-29.
13. Huszar D., Lynch C.A., Fairchild-Huntress V., Dunmore J.H., Fang Q., Berkemeier L.R., Gu W., Kesterson R.A., Boston B.A., Cone R.D., Smith F.J., Campfield L.A., Burn P., Lee F. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 88:1997;131-141.
14. Kesterson R.A., Huszar D., Lynch C.A., Simerly R.B., Cone R.D. Induction of neuropeptide-Y gene-expression in the dorsal medial hypothalamic nucleus in 2 models of the agouti obesity syndrome. Mol. Endocrinol. 11:1997;630-637.
15. Kleyn P.W., Fan W., Kovats S.G., Lee J.J., Pulido J.C., Wu Y., Berkemeier L.R., Misumi D.J., Holmgren L., Charlat O., Woolf E.A., Tayber O., Brody T., Shu P., Hawkins F., Kennedy B., Baldini L., Ebeling C., Alperin G.D., Deeds J., Lakey N.D., Culpepper J., Chen H., Glucksmann Kuis M.A., Carlson G.A., Duyk G.M., Moore K.J. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell. 85:1996;281-290.
16. Krude H., Biebermann H., Luck W., Horn R., Brabant G., Gruters A. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genet. 19:1998;155-157.
17. Lee G.-H., Proenca R., Montez J.M., Carroll K.M., Darvishzadeh J.G., Lee J.I., Friedman J.M. Abnormal splicing of the leptin receptor in diabetic mice. Nature. 379:1996;632-635.
18. Lu D., Willar D., Patel I.R., Kadwell S., Overton L., Kost T., Luther M., Chen W., Woychik R.P., Wilkison W.O., Cone R.D. Agouti protein is an antagonist of the melanocyte-stimulating hormone receptor. Nature. 371:1994;799-802.
19. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (OB-Rb) in mouse hypothalamus and adjacent brain-regions by in situ hybridization. FEBS Lett. 387:1996;113-116.
20. Morley J.E., Lavine A.S., Gosnell B.A., Krahb D.D. Peptides as central regulators of feeding. Brain. Res. Bull. 14:1985;511-519.
21. Naggert J.K., Fricker L.D., Varlamov O., Nishina P.M., Rouille Y., Steiner D.F., Carroll R.J., Paigen B.J., Leiter E.H. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nature Genet. 10:1995;135-142.
22. Noben-Trauth K., Naggert J.K., North M.A., Nishina P.M. A candidate gene for the mouse mutation tubby. Nature. 380:1996;534-538.
23. North M.A., Naggert J.K., Yan Y., Noben-Trauth K., Nishina P.M. Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. Proc. Natl. Acad. Sci. USA. 94:1997;3128-3133.
24. Ohlemiller K.K., Hughes R.M., Mosinger-Ogilvie J., Speck J.D., Grosof D.H., Silverman M.S. Cochlear and retinal degeneration in the tubby mouse. Neuroreport. 6:1995;845-849.
25. Ollmann M.M., Wilson D.B., Yang Y.K., Kerns J.A., Chen Y., Gantz I., Barzh G.S. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science. 278:1997;135-138.
26. Poggioli R., Vergoni A.V., Bertolini A. ACTH-(1-24) and alpha-MSH antagonize feeding behavior stimulated by kappa opiate agonists. Peptides. 7:1986;843-848.
27. Schwartz M.W., Seeley R.J., Woods S.C., Weigle D.S., Campfield L.A., Burn P., Baskin D.G. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes. 46:1997;2119-2123.
28. Smith M.S. Lactation alters neuropeptide-Y and proopiomelanocortin gene expression in the arcuate nucleus of the rat. Endocrinology. 133:1993;1258-1265.
29. Stanley B.G., Magdalin W., Seirafi A., Nguyen M.M., Leibowitz S.F. Evidence for Neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect. Peptides. 13:1992;381-387.
30. Tartaglia L.A., Dembski M., Weng X., Deng N., Culpepper J., Devos R., Richards G.J., Campfield L.A., Clark F.T., Deeds J., Muir C., Sanker S., Moriarty A., Moore K.J., Smutko J.S., Mays G.G., Woolf E.A., Monroe C.A., Tepper R.I. Identification and expression cloning of a leptin receptor, OB-R. Cell. 83:1995;1263-1271.
31. Thompson R.H., Canteras N.S., Swanson L.W. Organization of projections from the dorsomedial nucleus of the hypothalamus: a PHA-L study in the rat. J. Compar. Neurol. 376:1996;143-173.
32. Thornton J.E., Cheung C.C., Clifton D.K., Steiner R.A. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology. 138:1997;5063-5066.
33. Tsujii S., Bray G.A. Acetylation alters the feeding response to MSH and beta-endorphin. Brain Res. Bull. 23:1989;165-169.
34. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:1994;425-432.