The role of gastrointestinal vagal afferents in the control of food intake: Current prospects

Nutrition

Volumn 16, Issue 10, 2000, Pages 866-873

  Schwartz, Gary J ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Gut brain axis; Meal size; Nucleus of the solitary tract; Vagotomy; Visceral afferents

Indexed keywords

CAPSAICIN; CHOLECYSTOKININ RECEPTOR; NEUROPEPTIDE; PROTEIN C FOS;

ANIMAL EXPERIMENT; BRAIN STEM; CONFERENCE PAPER; FEEDBACK SYSTEM; FOOD INTAKE; IMMUNOREACTIVITY; INGESTION; MEAL; NEGATIVE FEEDBACK; NEUROANATOMY; NEUROBIOLOGY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE CONDUCTION; VAGUS NERVE;

AFFERENT PATHWAYS; ANIMAL; APPETITE REGULATION; CAPSAICIN; FEEDBACK; GASTROINTESTINAL SYSTEM; PROTO-ONCOGENE PROTEINS C-FOS; SUPPORT, U.S. GOV'T, P.H.S.; VAGUS NERVE;

MAMMALIA;

EID: 0033780625     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(00)00464-0     Document Type: Conference Paper

References (96)

1. Vagotomy attenuates suppression of sham feeding induced by intestinal nutrients
2. Intraduodenal infusions of fats elicit satiety in sham-feeding rats
3. Gastric volume detection after selective vagotomies in rats
4. Gastric volume rather than nutrient content inhibits food intake
5. The fiber composition of the abdominal vagus of the rat
6. Viscerotopic representation of the upper alimentary tract in the rat; sensory ganglia and nuclei of the solitary and spinal trigeminal tracts
7. Central distribution of subdiaphragmatic vagal branches in the rat
8. Longitudinal columnar organization within the dorsal motor nucleus represents separate branches of the abdominal vagus
9. The dorsal vagal complex forms a sensory-motor lattice; the circuitry of gastrointestinal reflexes
10. Vagal afferent innervation of the rat fundic stomach; morphological characterization of the gastric tension receptor
11. Simultaneous labeling of vagal innervation of the gut and afferent projections from the visceral forebrain with dil injected into the dorsal vagal complex in the rat
12. An anterograde tracing study of the vagal innervation of rat liver, portal vein, and biliary system
13. Vagal innervation of the rat pylorus; an anterograde study using carbocyanine dyes and laser scanning confocal microscopy
14. Topographic inventories of vagal afferents in gastrointestinal muscle
15. Vagal sensors in the rat duodenal mucosa; distribution and structure as revealed by in vivo Di-I tracing
16. Anatomical relationship between vagal afferent fibers and CCK-immunoreactive entero-endocrine cells in the rat small intestinal mucosa
17. cholecystokinin decreases food intake in rats
18. Regulation of cholecystokinin synthesis and secretion in rat intestine
19. Blockade of type A, not type B CCK receptors attenuates satiety actions of exogenous and endogenous CCK
20. Transport of cholcesytokinin (CCK) binding sites in subdiaphragmatic vagal branches
21. Central and peripheral vagal transport of choelcystokinin occurs in afferent fibers
22. Expression of cholecystokinin A receptors in neurons innervating the rat stomach and intestine
23. Topography of efferent vagal innervation of the rat gastrointestinal tract
24. Afferent innervation of the gastrointestinal tract smooth muscle by the hepatic branch of the vagus
25. Mechanical properties and sensitivity to CCK of vagal gastric slowly adapting mechanoreceptors
26. Integration of vagal afferent responses to gastric loads and cholecystokinin in rats
27. Effects of cholecystokinin (CCK-8) on two classes of gastroduodenal vagal afferent fibre
28. Load-sensitive rat gastric vagal afferents encode volume but not gastric nutrients
29. Duodenal nutrient exposure elicits nutrient-specific gut motility and vagal afferent signals in rat
30. Integration of vagal afferent responses to duodenal loads and exogenous CCK
31. Sensitivity of vagal mucosal afferents to cholecystokinin and its role in afferent signal transduction in the rat
32. Response of the gastric vagal afferent activity to cholecystokinin in rats lacking type A cholecystokinin receptors
33. CCK-8 activates hepatic vagal C-fiber afferents
34. The role of endogenous cholecystokinin in the sensory transduction of luminal nutrient signals in the rat jejunum
35. Regulation of cholecystokinin secretion by food, hormones, and neural pathways in the rat
36. Electrical physiological evidence for high and low affinity vagal CCK-A receptors
37. Pharmacological dissociation of responses to CCK and gastric loads in rat mechanosensitive vagal afferents
38. CCK satiety is differentially mediated by high- and low-affinity CCK receptors in mice and rats
39. Responses of celiac and cervical vagal afferents to infusions of lipids in the jejunum or ileum of the rat
40. Postabsorptive factors are important for satiation in rats after a liquid meal
41. Role of small intestine in caloric compensations to oil premeals in rats
42. Cholecystokinin-A receptors modulate gastric sensory and motor responses to gastric distension and duodenal lipid
43. Inhibition of food intake in response to intestinal lipid is mediated by cholecystokinin in humans
44. Cholecystokinin suppresses food intake by inhibiting gastric emptying
45. Gastric loads potentiate inhibition of food intake produced by a cholecystokinin analogue
46. Effect of a soup preload on reduction of food intake by cholecystokinin in humans
47. Interactions between CCK and a preload on reduction of food intake is mediated by CCK-A receptors in humans
48. Relationships between the morphology and function of gastric- and intestine-sensitive neurons in the nucleus of the solitary tract
49. CNS effects of circulating CCK8; involvement of brainstem neurones responding to gastric distension
50. Meal-induced c-fos expression in brainstem is not dependent on cholecystokinin release
51. Medullary c-Fos activation in rats after ingestion of a satieting meal
52. Oral-pharyngeal-esophageal and gastric cues contribute to meal-induced c-fos expression
53. Gastric distension-induced c-fos expression in catecholaminergic neurons of rat dorsal vagal complex
54. Fos protein expression in the nucleus of the solitary tract in response to intestinal nutrients in awake rats
55. Pathways of Fos expression in locus ceruleus, dorsal vagal complex, and PVN in response to intestinal lipid
56. Duodenal nutrient infusions differentially affect sham feeding and Fos expression in rat brain stem
57. Cholecystokinin-induced c-fos expression in the rat brain stem is influenced by vagal nerve integrity
58. Distribution and neurochemical phenotypes of caudal medullary neurons activated to express cFos following peripheral administration of cholecystokinin
59. C-fos protein expression in the nucleus of the solitary tract correlates with cholecystokinin dose injected and food intake in rats
60. Cafeteria diet-induced sleep is blocked by subdiaphragmatic vagotomy in rats
61. Cholecystokinin elicits the complete behavioral sequence of satiety in rats
62. Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat
63. A method for selective section of vagal afferent or efferent axons in the rat
64. Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats
65. Selective vagal rhizotomies; a new dorsal surgical approach used for intestinal deafferentations
66. Suppression of meal size by intestinal nutrients is eliminated by celiac vagal deafferentation
67. Gut vagal afferent lesions increase meal size but do not block gastric preload-induced feeding suppression
68. Capsaicin-induced neuronal degeneration; silver impregnation of cell bodies, axons, and terminals in the central nervous system of the adult rat
69. Reduced vagal sensory innervation of the small intestinal myenteric plexus following capsaicin treatment of adult rats
70. Enhanced fluid intake by rats after capsaicin treatment
71. Chemical lesion of visceral afferents causes transient overconsumption of unfamiliar high-fat diets in rats
72. Capsaicin attenuates suppression of sham feeding induced by intestinal nutrients
73. Capsaicin attenuates feeding suppression but not reinforcement by intestinal nutrients
74. Effect of neonatal capsaicin treatment on cholecystokinin-(CCK8) satiety and axonal transport of CCK binding sites in the rat vagus nerve
75. Capsaicin-sensitive fibers are required for the anorexic action of systemic but not central bombesin
76. Relationships between gastric motility and gastric vagal afferent responses to CCK and GRP in rats differ
77. Capsaicin application to central or peripheral vagal fibers attenuates CCK satiety
78. Intestinal capsaicin transiently attenuates suppression of sham feeding by oleate
79. Capsaicin-resistant vagal afferent fibers in the rat gastrointestinal tract; anatomical identification and functional integrity
80. Acute effects of capsaicin on gastrointestinal vagal afferents
81. The capsaicin receptor; a hat-activated ion channel in the pain pathway
82. the cloned capsaicin receptor integrates multiple pain-producing stimuli
83. Impaired nociception and pain sensation in mice lacking the capsaicin receptor
84. Neural injury, repair, and adaptation in the GI tract II. The elusive action of capsaicin on the vagus nerve
85. The direct and indirect controls of meal size
86. Identification of targets of leptin action in the rat hypothalamus
87. Chronic administration of OB protein decreases food intake by selectively reducing meal size in female rats
88. Decussations of the descending paraventricular pathways to the brainstem and spinal cord autonomic centers
89. Sham feeding in intact and chronic decerebrate rats
90. Leptin modulates behavioral and neural responsivity to CCK
91. Stimulation of the paraventricular nucleus modulates the activity of gut-sensitive neurons in the vagal complex
92. Stimulation of the paraventricular nucleus modulates firing of neurons in the nucleus of the solitary tract
93. Cholecystokinin and leptin act synergistically to reduce body weight
94. Long-term CCK-leptin synergy suggests a role for CCK in the regulation of body weight