Modest overexpression of neuropeptide Y in the brain leads to obesity after high-sucrose feeding

Diabetes

Volumn 50, Issue 5, 2001, Pages 1206-1210

  Kaga, Toshihiro ^a   Inui, Akio ^a   Okita, Minoru ^a   Asakawa, Akihiro ^a   Ueno, Naohiko ^a   Kasuga, Masato ^a   Fujimiya, Mineko ^b   Nishimura, Noriyasu ^c   Dobashi, Rika ^c   Morimoto, Yasuo ^d   Liu, I Min ^e   Cheng, Juei Tang ^e  

^a KOBE UNIVERSITY   (Japan)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^c Nippon Organon KK   (Japan)

^d Kampo and Healthcare Research Laboratories   (Japan)

^e NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; L 152804; N2 DIPHENYLACETYL N (4 UREIDOMETHYLBENZYL)ARGININAMIDE; NEUROPEPTIDE Y; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HOMOZYGOSITY; HYPERGLYCEMIA; HYPERINSULINEMIA; MOUSE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; RISK FACTOR; SUGAR INTAKE;

EID: 0035029206     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.5.1206     Document Type: Article

References (25)

1. Signals that regulate food intake and energy homeostasis
2. Feeding and body-weight regulation by hypothalamic neuropeptides-mediation of the actions of leptin
3. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
4. From lesions to leptin: Hypothalamic control of food intake and body weight
5. Transgenic approach to the study of body weight regulation
6. Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity
7. Anxiety-like behavior in transgenic mice with brain expression of neuropeptide Y
8. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
9. Ethanol consumption and resistance are inversely related to neuropeptide Y levels
10. Neuropeptide Y feeding receptors: Are multiple subtypes involved?
11. A receptor subtype involved in neuropeptide Y-induced food intake
12. Increased appetite augments hypothalamic NPY Y1 receptor gene expression: Effects of anorexigenic ciliary neurotropic factor
13. Down-regulated NPY receptor subtype-5 mRNA expression in genetically obese mouse brain
14. Regionally-selective down-regulation of NPY receptor subtypes in the obese Zucker rat: Relationship to the Y5 'feeding' receptor
15. Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression
16. Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor
17. Role of the Y5 neuropeptide Y receptor in feeding and obesity
18. Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor
19. Defense of differing body weight set points in diet-induced obese and resistant rats
20. Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats
21. Regulation of Thy-1 gene expression in transgenic mice
22. Decreased food intake and body weight in pancreatic polypeptide-overexpressing mice
23. RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination
24. Effects of PP family peptides on feeding and learning behavior in mice
25. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin