메뉴 건너뛰기




Volumn 36, Issue 2, 2015, Pages 92-101

Versatile functions for IL-6 in metabolism and cancer

Author keywords

Cancer; Inflammation; Interleukin 6; Metabolism

Indexed keywords

INTERLEUKIN 6;

EID: 84963952313     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2014.12.008     Document Type: Review
Times cited : (331)

References (125)
  • 1
  • 2
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • Mantovani A., et al. Cancer-related inflammation. Nature 2008, 454:436-444.
    • (2008) Nature , vol.454 , pp. 436-444
    • Mantovani, A.1
  • 3
    • 38449084902 scopus 로고    scopus 로고
    • Humanized antihuman IL-6 receptor antibody, tocilizumab
    • Nishimoto N., Kishimoto T. Humanized antihuman IL-6 receptor antibody, tocilizumab. Handb. Exp. Pharmacol. 2008, 181:151-160.
    • (2008) Handb. Exp. Pharmacol. , vol.181 , pp. 151-160
    • Nishimoto, N.1    Kishimoto, T.2
  • 4
    • 81255157471 scopus 로고    scopus 로고
    • Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
    • Ellingsgaard H., et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat. Med. 2011, 17:1481-1489.
    • (2011) Nat. Med. , vol.17 , pp. 1481-1489
    • Ellingsgaard, H.1
  • 5
    • 84902135489 scopus 로고    scopus 로고
    • Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis
    • White P.J., et al. Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis. Nat. Med. 2014, 20:664-669.
    • (2014) Nat. Med. , vol.20 , pp. 664-669
    • White, P.J.1
  • 6
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov S., et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 2009, 15:103-113.
    • (2009) Cancer Cell , vol.15 , pp. 103-113
    • Grivennikov, S.1
  • 7
    • 77958501473 scopus 로고    scopus 로고
    • DNA damage-mediated induction of a chemoresistant niche
    • Gilbert L.A., Hemann M.T. DNA damage-mediated induction of a chemoresistant niche. Cell 2010, 143:355-366.
    • (2010) Cell , vol.143 , pp. 355-366
    • Gilbert, L.A.1    Hemann, M.T.2
  • 8
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park E.J., et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010, 140:197-208.
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1
  • 9
    • 84899124414 scopus 로고    scopus 로고
    • Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin
    • Mauer J., et al. Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat. Immunol. 2014, 15:423-430.
    • (2014) Nat. Immunol. , vol.15 , pp. 423-430
    • Mauer, J.1
  • 10
    • 84883280808 scopus 로고    scopus 로고
    • Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6Ra signaling
    • Gruber S., et al. Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6Ra signaling. Cell Rep. 2013, 4:669-680.
    • (2013) Cell Rep. , vol.4 , pp. 669-680
    • Gruber, S.1
  • 11
    • 79151484704 scopus 로고    scopus 로고
    • Adipokines in inflammation and metabolic disease
    • Ouchi N., et al. Adipokines in inflammation and metabolic disease. Nat. Rev. Immunol. 2011, 11:85-97.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 85-97
    • Ouchi, N.1
  • 12
    • 20044387026 scopus 로고    scopus 로고
    • IKK-beta links inflammation to obesity-induced insulin resistance
    • Arkan M.C., et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat. Med. 2005, 11:191-198.
    • (2005) Nat. Med. , vol.11 , pp. 191-198
    • Arkan, M.C.1
  • 13
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • Cai D., et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat. Med. 2005, 11:183-190.
    • (2005) Nat. Med. , vol.11 , pp. 183-190
    • Cai, D.1
  • 14
    • 70349484212 scopus 로고    scopus 로고
    • MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
    • Kleinridders A., et al. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab. 2009, 10:249-259.
    • (2009) Cell Metab. , vol.10 , pp. 249-259
    • Kleinridders, A.1
  • 15
    • 79151478555 scopus 로고    scopus 로고
    • Type 2 diabetes as an inflammatory disease
    • Donath M.Y., Shoelson S.E. Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol. 2011, 11:98-107.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 98-107
    • Donath, M.Y.1    Shoelson, S.E.2
  • 16
    • 84904044334 scopus 로고    scopus 로고
    • Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling
    • Wernstedt Asterholm I., et al. Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. Cell Metab. 2014, 20:103-118.
    • (2014) Cell Metab. , vol.20 , pp. 103-118
    • Wernstedt Asterholm, I.1
  • 17
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil G.S., et al. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1
  • 18
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    • Yuan M., et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001, 293:1673-1677.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1
  • 19
    • 0030000589 scopus 로고    scopus 로고
    • STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6
    • Zhang D., et al. STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6. J. Biol. Chem. 1996, 271:9503-9509.
    • (1996) J. Biol. Chem. , vol.271 , pp. 9503-9509
    • Zhang, D.1
  • 20
    • 0033537013 scopus 로고    scopus 로고
    • Elevated C-reactive protein levels in overweight and obese adults
    • Visser M., et al. Elevated C-reactive protein levels in overweight and obese adults. JAMA 1999, 282:2131-2135.
    • (1999) JAMA , vol.282 , pp. 2131-2135
    • Visser, M.1
  • 21
    • 0033678516 scopus 로고    scopus 로고
    • Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss
    • Bastard J.P., et al. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J. Clin. Endocrinol. Metab. 2000, 85:3338-3342.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 3338-3342
    • Bastard, J.P.1
  • 22
    • 0035908632 scopus 로고    scopus 로고
    • C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
    • Pradhan A.D., et al. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001, 286:327-334.
    • (2001) JAMA , vol.286 , pp. 327-334
    • Pradhan, A.D.1
  • 23
    • 0036098188 scopus 로고    scopus 로고
    • Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro
    • Bastard J-P., et al. Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. J. Clin. Endocrinol. Metab. 2002, 87:2084-2089.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 2084-2089
    • Bastard, J.-P.1
  • 24
    • 12144290761 scopus 로고    scopus 로고
    • Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo
    • Kim H-J., et al. Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes 2004, 53:1060-1067.
    • (2004) Diabetes , vol.53 , pp. 1060-1067
    • Kim, H.-J.1
  • 25
    • 23044468612 scopus 로고    scopus 로고
    • Interleukin-6 depletion selectively improves hepatic insulin action in obesity
    • Klover P.J., et al. Interleukin-6 depletion selectively improves hepatic insulin action in obesity. Endocrinology 2005, 146:3417-3427.
    • (2005) Endocrinology , vol.146 , pp. 3417-3427
    • Klover, P.J.1
  • 26
    • 3142710172 scopus 로고    scopus 로고
    • Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness
    • Carey A.L., et al. Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness. Diabetologia 2004, 47:1029-1037.
    • (2004) Diabetologia , vol.47 , pp. 1029-1037
    • Carey, A.L.1
  • 27
    • 33750859187 scopus 로고    scopus 로고
    • Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
    • Carey A.L., et al. Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes 2006, 55:2688-2697.
    • (2006) Diabetes , vol.55 , pp. 2688-2697
    • Carey, A.L.1
  • 28
    • 0036152683 scopus 로고    scopus 로고
    • Interleukin-6-deficient mice develop mature-onset obesity
    • Wallenius V., et al. Interleukin-6-deficient mice develop mature-onset obesity. Nat. Med. 2002, 8:75-79.
    • (2002) Nat. Med. , vol.8 , pp. 75-79
    • Wallenius, V.1
  • 29
    • 0036295573 scopus 로고    scopus 로고
    • Intracerebroventricular interleukin-6 treatment decreases body fat in rats
    • Wallenius K., et al. Intracerebroventricular interleukin-6 treatment decreases body fat in rats. Biochem. Biophys. Res. Commun. 2002, 293:560-565.
    • (2002) Biochem. Biophys. Res. Commun. , vol.293 , pp. 560-565
    • Wallenius, K.1
  • 30
    • 0037049259 scopus 로고    scopus 로고
    • Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats
    • Li G., et al. Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats. Neuroscience 2002, 115:879-889.
    • (2002) Neuroscience , vol.115 , pp. 879-889
    • Li, G.1
  • 31
    • 3042739678 scopus 로고    scopus 로고
    • Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity
    • Di Gregorio G.B., et al. Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity. Am. J. Physiol. Endocrinol. Metab. 2004, 287:E182-E187.
    • (2004) Am. J. Physiol. Endocrinol. Metab. , vol.287 , pp. E182-E187
    • Di Gregorio, G.B.1
  • 32
    • 77957661299 scopus 로고    scopus 로고
    • Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
    • Matthews V.B., et al. Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance. Diabetologia 2010, 53:2431-2441.
    • (2010) Diabetologia , vol.53 , pp. 2431-2441
    • Matthews, V.B.1
  • 33
    • 0032539893 scopus 로고    scopus 로고
    • Sympathetic neurons can produce and respond to interleukin 6
    • März P., et al. Sympathetic neurons can produce and respond to interleukin 6. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:3251-3256.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 3251-3256
    • März, P.1
  • 34
    • 0141743347 scopus 로고    scopus 로고
    • On the site and mechanism of action of the anti-obesity effects of interleukin-6
    • Jansson J-O., et al. On the site and mechanism of action of the anti-obesity effects of interleukin-6. Growth Horm. IGF Res. 2003, 13:S28-S32.
    • (2003) Growth Horm. IGF Res. , vol.13 , pp. S28-S32
    • Jansson, J.-O.1
  • 35
    • 84909595107 scopus 로고    scopus 로고
    • Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress
    • Hodes G.E., et al. Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:16136-16141.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 16136-16141
    • Hodes, G.E.1
  • 36
    • 0023432812 scopus 로고
    • Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells
    • Gauldie J., et al. Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc. Natl. Acad. Sci. U.S.A. 1987, 84:7251-7255.
    • (1987) Proc. Natl. Acad. Sci. U.S.A. , vol.84 , pp. 7251-7255
    • Gauldie, J.1
  • 37
    • 66449091275 scopus 로고    scopus 로고
    • STAT3 targets the regulatory regions of gluconeogenic genes in vivo
    • Ramadoss P., et al. STAT3 targets the regulatory regions of gluconeogenic genes in vivo. Mol. Endocrinol. 2009, 23:827-837.
    • (2009) Mol. Endocrinol. , vol.23 , pp. 827-837
    • Ramadoss, P.1
  • 38
    • 11144357516 scopus 로고    scopus 로고
    • Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
    • Inoue H., et al. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nat. Med. 2004, 10:168-174.
    • (2004) Nat. Med. , vol.10 , pp. 168-174
    • Inoue, H.1
  • 39
    • 84875076718 scopus 로고    scopus 로고
    • Quantifying the contribution of the liver to glucose homeostasis: a detailed kinetic model of human hepatic glucose metabolism
    • König M., et al. Quantifying the contribution of the liver to glucose homeostasis: a detailed kinetic model of human hepatic glucose metabolism. PLoS Comput. Biol. 2012, 8:e1002577.
    • (2012) PLoS Comput. Biol. , vol.8 , pp. e1002577
    • König, M.1
  • 40
    • 84908080513 scopus 로고    scopus 로고
    • The target of metformin in type 2 diabetes
    • Ferrannini E. The target of metformin in type 2 diabetes. N. Engl. J. Med. 2014, 371:1547-1548.
    • (2014) N. Engl. J. Med. , vol.371 , pp. 1547-1548
    • Ferrannini, E.1
  • 41
    • 33645579324 scopus 로고    scopus 로고
    • Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
    • Inoue H., et al. Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab. 2006, 3:267-275.
    • (2006) Cell Metab. , vol.3 , pp. 267-275
    • Inoue, H.1
  • 42
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • Brüning J.C., et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000, 289:2122-2125.
    • (2000) Science , vol.289 , pp. 2122-2125
    • Brüning, J.C.1
  • 43
    • 70349624987 scopus 로고    scopus 로고
    • NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse
    • McGuinness O.P., et al. NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse. Am. J. Physiol. Endocrinol. Metab. 2009, 297:E849-E855.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297 , pp. E849-E855
    • McGuinness, O.P.1
  • 44
    • 34249651956 scopus 로고    scopus 로고
    • Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
    • Könner A.C., et al. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab. 2007, 5:438-449.
    • (2007) Cell Metab. , vol.5 , pp. 438-449
    • Könner, A.C.1
  • 45
    • 77956335194 scopus 로고    scopus 로고
    • Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action
    • Wunderlich F.T., et al. Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. Cell Metab. 2010, 12:237-249.
    • (2010) Cell Metab. , vol.12 , pp. 237-249
    • Wunderlich, F.T.1
  • 46
    • 79953765855 scopus 로고    scopus 로고
    • Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway
    • Awazawa M., et al. Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway. Cell Metab. 2011, 13:401-412.
    • (2011) Cell Metab. , vol.13 , pp. 401-412
    • Awazawa, M.1
  • 47
    • 57349101675 scopus 로고    scopus 로고
    • A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
    • Sabio G., et al. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 2008, 322:1539-1543.
    • (2008) Science , vol.322 , pp. 1539-1543
    • Sabio, G.1
  • 48
    • 84856019342 scopus 로고    scopus 로고
    • The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines
    • Gibbs J.E., et al. The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:582-587.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 582-587
    • Gibbs, J.E.1
  • 49
    • 0023751203 scopus 로고
    • Strenuous exercise causes systemic endotoxemia
    • Bosenberg A.T., et al. Strenuous exercise causes systemic endotoxemia. J. Appl. Physiol. 1988, 65:106-108.
    • (1988) J. Appl. Physiol. , vol.65 , pp. 106-108
    • Bosenberg, A.T.1
  • 50
    • 0028856075 scopus 로고
    • Endurance run increases circulating IL-6 and IL-1ra but downregulates ex vivo TNF-alpha and IL-1 beta production
    • Drenth J.P., et al. Endurance run increases circulating IL-6 and IL-1ra but downregulates ex vivo TNF-alpha and IL-1 beta production. J. Appl. Physiol. 1995, 79:1497-1503.
    • (1995) J. Appl. Physiol. , vol.79 , pp. 1497-1503
    • Drenth, J.P.1
  • 51
    • 0034668926 scopus 로고    scopus 로고
    • Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6
    • Steensberg A., et al. Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J. Physiol. 2000, 529:237-242.
    • (2000) J. Physiol. , vol.529 , pp. 237-242
    • Steensberg, A.1
  • 52
    • 33947720482 scopus 로고    scopus 로고
    • Beneficial health effects of exercise - the role of IL-6 as a myokine
    • Pedersen B.K., Fischer C.P. Beneficial health effects of exercise - the role of IL-6 as a myokine. Trends Pharmacol. Sci. 2007, 28:152-156.
    • (2007) Trends Pharmacol. Sci. , vol.28 , pp. 152-156
    • Pedersen, B.K.1    Fischer, C.P.2
  • 53
    • 70349131219 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization
    • Kelly M., et al. Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization. Diabetes 2009, 58:1953-1960.
    • (2009) Diabetes , vol.58 , pp. 1953-1960
    • Kelly, M.1
  • 54
    • 37449022587 scopus 로고    scopus 로고
    • Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy
    • Serrano A.L., et al. Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy. Cell Metab. 2008, 7:33-44.
    • (2008) Cell Metab. , vol.7 , pp. 33-44
    • Serrano, A.L.1
  • 55
    • 51349133256 scopus 로고    scopus 로고
    • Interleukin-6 regulates pancreatic alpha-cell mass expansion
    • Ellingsgaard H., et al. Interleukin-6 regulates pancreatic alpha-cell mass expansion. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:13163-13168.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 13163-13168
    • Ellingsgaard, H.1
  • 56
    • 0347985272 scopus 로고    scopus 로고
    • Obesity-induced inflammatory changes in adipose tissue
    • Wellen K.E., Hotamisligil G.S. Obesity-induced inflammatory changes in adipose tissue. J. Clin. Invest. 2003, 112:1785-1788.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1785-1788
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 57
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 2003, 112:1821-1830.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1821-1830
    • Xu, H.1
  • 58
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng C.N., et al. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 2007, 117:175-184.
    • (2007) J. Clin. Invest. , vol.117 , pp. 175-184
    • Lumeng, C.N.1
  • 59
    • 77954735369 scopus 로고    scopus 로고
    • Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation
    • Krawczyk C.M., et al. Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood 2010, 115:4742-4749.
    • (2010) Blood , vol.115 , pp. 4742-4749
    • Krawczyk, C.M.1
  • 60
    • 84859464555 scopus 로고    scopus 로고
    • Orchestration of metabolism by macrophages
    • Biswas S.K., Mantovani A. Orchestration of metabolism by macrophages. Cell Metab. 2012, 15:432-437.
    • (2012) Cell Metab. , vol.15 , pp. 432-437
    • Biswas, S.K.1    Mantovani, A.2
  • 61
    • 52749092267 scopus 로고    scopus 로고
    • Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals
    • Patsouris D., et al. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab. 2008, 8:301-309.
    • (2008) Cell Metab. , vol.8 , pp. 301-309
    • Patsouris, D.1
  • 62
    • 34347354309 scopus 로고    scopus 로고
    • Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    • Odegaard J.I., et al. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 2007, 447:1116-1120.
    • (2007) Nature , vol.447 , pp. 1116-1120
    • Odegaard, J.I.1
  • 63
    • 80355131976 scopus 로고    scopus 로고
    • Protective and pathogenic functions of macrophage subsets
    • Murray P.J., Wynn T.A. Protective and pathogenic functions of macrophage subsets. Nat. Rev. Immunol. 2011, 11:723-737.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 723-737
    • Murray, P.J.1    Wynn, T.A.2
  • 64
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: mechanism and functions
    • Gordon S., Martinez F.O. Alternative activation of macrophages: mechanism and functions. Immunity 2010, 32:593-604.
    • (2010) Immunity , vol.32 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 65
    • 39649120597 scopus 로고    scopus 로고
    • Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells
    • Duluc D., et al. Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Blood 2007, 110:4319-4330.
    • (2007) Blood , vol.110 , pp. 4319-4330
    • Duluc, D.1
  • 66
    • 84904394690 scopus 로고    scopus 로고
    • Perspective
    • Murray P.J., et al. Perspective. Immunity 2014, 41:14-20.
    • (2014) Immunity , vol.41 , pp. 14-20
    • Murray, P.J.1
  • 67
    • 58149347227 scopus 로고    scopus 로고
    • Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes
    • Lumeng C.N., et al. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 2008, 57:3239-3246.
    • (2008) Diabetes , vol.57 , pp. 3239-3246
    • Lumeng, C.N.1
  • 68
    • 0036721716 scopus 로고    scopus 로고
    • Shaping gene expression in activated and resting primary macrophages by IL-10
    • Lang R., et al. Shaping gene expression in activated and resting primary macrophages by IL-10. J. Immunol. 2002, 169:2253-2263.
    • (2002) J. Immunol. , vol.169 , pp. 2253-2263
    • Lang, R.1
  • 69
    • 2442717844 scopus 로고    scopus 로고
    • Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology
    • Herbert D.R., et al. Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity 2004, 20:623-635.
    • (2004) Immunity , vol.20 , pp. 623-635
    • Herbert, D.R.1
  • 70
    • 33745428666 scopus 로고    scopus 로고
    • Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation
    • Vats D., et al. Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab. 2006, 4:13-24.
    • (2006) Cell Metab. , vol.4 , pp. 13-24
    • Vats, D.1
  • 71
    • 79953815551 scopus 로고    scopus 로고
    • Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
    • Wu D., et al. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 2011, 332:243-247.
    • (2011) Science , vol.332 , pp. 243-247
    • Wu, D.1
  • 72
    • 84882441487 scopus 로고    scopus 로고
    • Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling
    • Wermeling F., et al. Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:13487-13491.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 13487-13491
    • Wermeling, F.1
  • 73
    • 84861697180 scopus 로고    scopus 로고
    • Plasticity and cross-talk of interleukin 6-type cytokines
    • Garbers C., et al. Plasticity and cross-talk of interleukin 6-type cytokines. Cytokine Growth Factor Rev. 2012, 23:85-97.
    • (2012) Cytokine Growth Factor Rev. , vol.23 , pp. 85-97
    • Garbers, C.1
  • 74
    • 84881250115 scopus 로고    scopus 로고
    • Lack of oncostatin M receptor leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype
    • Komori T., et al. Lack of oncostatin M receptor leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype. J. Biol. Chem. 2013, 288:21861-21875.
    • (2013) J. Biol. Chem. , vol.288 , pp. 21861-21875
    • Komori, T.1
  • 75
    • 84900992804 scopus 로고    scopus 로고
    • Deficiency of oncostatin receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice
    • Komori T., et al. Deficiency of oncostatin receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice. J. Biol. Chem. 2014, 289:13821-13837.
    • (2014) J. Biol. Chem. , vol.289 , pp. 13821-13837
    • Komori, T.1
  • 76
    • 70449532042 scopus 로고    scopus 로고
    • Oncostatin M (OSM) primes IL-13- and IL-4-induced eotaxin responses in fibroblasts: regulation of the type-II IL-4 receptor chains IL-4Ralpha and IL-13Ralpha1
    • Fritz D.K., et al. Oncostatin M (OSM) primes IL-13- and IL-4-induced eotaxin responses in fibroblasts: regulation of the type-II IL-4 receptor chains IL-4Ralpha and IL-13Ralpha1. Exp. Cell Res. 2009, 315:3486-3499.
    • (2009) Exp. Cell Res. , vol.315 , pp. 3486-3499
    • Fritz, D.K.1
  • 77
    • 84859324848 scopus 로고    scopus 로고
    • Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages
    • Hutchins A.P., et al. Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages. Blood 2012, 119:e110-e119.
    • (2012) Blood , vol.119 , pp. e110-e119
    • Hutchins, A.P.1
  • 78
    • 84887419072 scopus 로고    scopus 로고
    • Adipose natural regulatory B cells negatively control adipose tissue inflammation
    • Published online October 22, 2014
    • Nishimura S., et al. Adipose natural regulatory B cells negatively control adipose tissue inflammation. Cell Metab. 2013, Published online October 22, 2014. http://dx.doi.org/10.1016/j.cmet.2013.09.017.
    • (2013) Cell Metab.
    • Nishimura, S.1
  • 79
    • 23944502314 scopus 로고    scopus 로고
    • Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
    • Kemna E. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 2005, 106:1864-1866.
    • (2005) Blood , vol.106 , pp. 1864-1866
    • Kemna, E.1
  • 80
    • 82555186955 scopus 로고    scopus 로고
    • Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
    • Nguyen K.D., et al. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 2011, 480:104-108.
    • (2011) Nature , vol.480 , pp. 104-108
    • Nguyen, K.D.1
  • 81
    • 84873854027 scopus 로고    scopus 로고
    • Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
    • Stanford K.I., et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J. Clin. Invest. 2013, 123:215-223.
    • (2013) J. Clin. Invest. , vol.123 , pp. 215-223
    • Stanford, K.I.1
  • 82
    • 84873518501 scopus 로고    scopus 로고
    • Adaptive thermogenesis in adipocytes: is beige the new brown?
    • Wu J., et al. Adaptive thermogenesis in adipocytes: is beige the new brown?. Genes Dev. 2013, 27:234-250.
    • (2013) Genes Dev. , vol.27 , pp. 234-250
    • Wu, J.1
  • 83
    • 84913602920 scopus 로고    scopus 로고
    • A switch from white to brown fat increases energy expenditure in cancer-associated cachexia
    • Petruzzelli M., et al. A switch from white to brown fat increases energy expenditure in cancer-associated cachexia. Cell Metab. 2014, 20:433-437.
    • (2014) Cell Metab. , vol.20 , pp. 433-437
    • Petruzzelli, M.1
  • 84
    • 0029846756 scopus 로고    scopus 로고
    • Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
    • Cressman D.E., et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 1996, 274:1379-1383.
    • (1996) Science , vol.274 , pp. 1379-1383
    • Cressman, D.E.1
  • 85
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler W.E., et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007, 317:121-124.
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1
  • 86
    • 36849012237 scopus 로고    scopus 로고
    • Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    • Gao S.P., et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J. Clin. Invest. 2007, 117:3846-3856.
    • (2007) J. Clin. Invest. , vol.117 , pp. 3846-3856
    • Gao, S.P.1
  • 87
    • 36849039660 scopus 로고    scopus 로고
    • IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
    • Sansone P., et al. IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J. Clin. Invest. 2007, 117:3988-4002.
    • (2007) J. Clin. Invest. , vol.117 , pp. 3988-4002
    • Sansone, P.1
  • 88
    • 58149326854 scopus 로고    scopus 로고
    • Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
    • Rebouissou S., et al. Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. Nature 2009, 457:200-204.
    • (2009) Nature , vol.457 , pp. 200-204
    • Rebouissou, S.1
  • 89
    • 81255189474 scopus 로고    scopus 로고
    • IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development
    • Reynaud D., et al. IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development. Cancer Cell 2011, 20:661-673.
    • (2011) Cancer Cell , vol.20 , pp. 661-673
    • Reynaud, D.1
  • 90
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
    • Calle E.E., Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat. Rev. Cancer 2004, 4:579-591.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 91
    • 39549101229 scopus 로고    scopus 로고
    • Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis
    • Wunderlich F.T., et al. Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis. Proceedings of the National Academy of Sciences 2008, 105:1297-1302.
    • (2008) Proceedings of the National Academy of Sciences , vol.105 , pp. 1297-1302
    • Wunderlich, F.T.1
  • 92
    • 84896490235 scopus 로고    scopus 로고
    • The two faces of IL-6 in the tumor microenvironment
    • Fisher D.T., et al. The two faces of IL-6 in the tumor microenvironment. Semin. Immunol. 2014, 26:38-47.
    • (2014) Semin. Immunol. , vol.26 , pp. 38-47
    • Fisher, D.T.1
  • 93
    • 84864744709 scopus 로고    scopus 로고
    • Context-specific roles for paracrine IL-6 in lymphomagenesis
    • Gilbert L.A., Hemann M.T. Context-specific roles for paracrine IL-6 in lymphomagenesis. Genes Dev. 2012, 26:1758-1768.
    • (2012) Genes Dev. , vol.26 , pp. 1758-1768
    • Gilbert, L.A.1    Hemann, M.T.2
  • 94
    • 0020665587 scopus 로고
    • B cell growth factors and B cell differentiation factor from human T hybridomas. Two distinct kinds of B cell growth factor and their synergism in B cell proliferation
    • Okada M., et al. B cell growth factors and B cell differentiation factor from human T hybridomas. Two distinct kinds of B cell growth factor and their synergism in B cell proliferation. J. Exp. Med. 1983, 157:583-590.
    • (1983) J. Exp. Med. , vol.157 , pp. 583-590
    • Okada, M.1
  • 95
    • 0024360388 scopus 로고
    • The biology of interleukin-6
    • Kishimoto T. The biology of interleukin-6. Blood 1989, 74:1-10.
    • (1989) Blood , vol.74 , pp. 1-10
    • Kishimoto, T.1
  • 96
    • 0023627308 scopus 로고
    • High-affinity binding sites for human 26-kDa protein (interleukin 6, B cell stimulatory factor-2, human hybridoma plasmacytoma growth factor, interferon-beta 2), different from those of type I interferon (alpha, beta), on lymphoblastoid cells
    • Coulie P.G., et al. High-affinity binding sites for human 26-kDa protein (interleukin 6, B cell stimulatory factor-2, human hybridoma plasmacytoma growth factor, interferon-beta 2), different from those of type I interferon (alpha, beta), on lymphoblastoid cells. Eur. J. Immunol. 1987, 17:1435-1440.
    • (1987) Eur. J. Immunol. , vol.17 , pp. 1435-1440
    • Coulie, P.G.1
  • 97
    • 0022499547 scopus 로고
    • Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
    • Hirano T., et al. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 1986, 324:73-76.
    • (1986) Nature , vol.324 , pp. 73-76
    • Hirano, T.1
  • 98
    • 0022801346 scopus 로고
    • Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines
    • Zilberstein A., et al. Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines. EMBO J. 1986, 5:2529-2537.
    • (1986) EMBO J. , vol.5 , pp. 2529-2537
    • Zilberstein, A.1
  • 99
    • 0003430005 scopus 로고
    • Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved
    • May L.T., et al. Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved. Proc. Natl. Acad. Sci. U.S.A. 1986, 83:8957-8961.
    • (1986) Proc. Natl. Acad. Sci. U.S.A. , vol.83 , pp. 8957-8961
    • May, L.T.1
  • 100
    • 0022447204 scopus 로고
    • Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts
    • Haegeman G., et al. Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts. Eur. J. Biochem. 1986, 159:625-632.
    • (1986) Eur. J. Biochem. , vol.159 , pp. 625-632
    • Haegeman, G.1
  • 101
    • 0023685762 scopus 로고
    • Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor
    • Yamasaki K., et al. Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. Science 1988, 241:825-828.
    • (1988) Science , vol.241 , pp. 825-828
    • Yamasaki, K.1
  • 102
    • 0024393839 scopus 로고
    • Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
    • Taga T., et al. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 1989, 58:573-581.
    • (1989) Cell , vol.58 , pp. 573-581
    • Taga, T.1
  • 103
    • 0028303977 scopus 로고
    • Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    • Akira S., et al. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 1994, 77:63-71.
    • (1994) Cell , vol.77 , pp. 63-71
    • Akira, S.1
  • 104
    • 0030792590 scopus 로고    scopus 로고
    • A family of cytokine-inducible inhibitors of signalling
    • Starr R., et al. A family of cytokine-inducible inhibitors of signalling. Nature 1997, 387:917-921.
    • (1997) Nature , vol.387 , pp. 917-921
    • Starr, R.1
  • 105
    • 0034327736 scopus 로고    scopus 로고
    • Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways
    • Ahmed S.T., Ivashkiv L.B. Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways. J. Immunol. 2000, 165:5227-5237.
    • (2000) J. Immunol. , vol.165 , pp. 5227-5237
    • Ahmed, S.T.1    Ivashkiv, L.B.2
  • 106
    • 33847375865 scopus 로고    scopus 로고
    • Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade
    • Ehlting C., et al. Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade. J. Immunol. 2007, 178:2813-2826.
    • (2007) J. Immunol. , vol.178 , pp. 2813-2826
    • Ehlting, C.1
  • 107
    • 84922130866 scopus 로고    scopus 로고
    • STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13
    • Zhang H., et al. STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13. Nat. Commun. 2014, 5:1-10.
    • (2014) Nat. Commun. , vol.5 , pp. 1-10
    • Zhang, H.1
  • 108
    • 84155178400 scopus 로고    scopus 로고
    • Glucocorticoids increase interleukin-6-dependent gene induction by interfering with the expression of the suppressor of cytokine signaling 3 feedback inhibitor
    • Dittrich A., et al. Glucocorticoids increase interleukin-6-dependent gene induction by interfering with the expression of the suppressor of cytokine signaling 3 feedback inhibitor. Hepatology 2012, 55:256-266.
    • (2012) Hepatology , vol.55 , pp. 256-266
    • Dittrich, A.1
  • 109
    • 15744385061 scopus 로고    scopus 로고
    • Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation
    • Wang R., et al. Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation. J. Biol. Chem. 2005, 280:11528-11534.
    • (2005) J. Biol. Chem. , vol.280 , pp. 11528-11534
    • Wang, R.1
  • 110
    • 0031806534 scopus 로고    scopus 로고
    • Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase
    • Takahashi-Tezuka M., et al. Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase. Mol. Cell. Biol. 1998, 18:4109-4117.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 4109-4117
    • Takahashi-Tezuka, M.1
  • 111
    • 0033583240 scopus 로고    scopus 로고
    • The STAT3-independent signaling pathway by glycoprotein 130 in hepatic cells
    • Lai C.F., et al. The STAT3-independent signaling pathway by glycoprotein 130 in hepatic cells. J. Biol. Chem. 1999, 274:7793-7802.
    • (1999) J. Biol. Chem. , vol.274 , pp. 7793-7802
    • Lai, C.F.1
  • 112
    • 0141866756 scopus 로고    scopus 로고
    • Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)
    • Matthews V., et al. Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J. Biol. Chem. 2003, 278:38829-38839.
    • (2003) J. Biol. Chem. , vol.278 , pp. 38829-38839
    • Matthews, V.1
  • 113
    • 34548856204 scopus 로고    scopus 로고
    • Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils
    • Chalaris A., et al. Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. Blood 2007, 110:1748-1755.
    • (2007) Blood , vol.110 , pp. 1748-1755
    • Chalaris, A.1
  • 114
    • 0028087834 scopus 로고
    • Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism
    • Horiuchi S., et al. Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism. Eur. J. Immunol. 1994, 24:1945-1948.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 1945-1948
    • Horiuchi, S.1
  • 115
    • 0025010583 scopus 로고
    • Purification and characterization of soluble human IL-6 receptor expressed in CHO cells
    • Yasukawa K., et al. Purification and characterization of soluble human IL-6 receptor expressed in CHO cells. J. Biochem. 1990, 108:673-676.
    • (1990) J. Biochem. , vol.108 , pp. 673-676
    • Yasukawa, K.1
  • 116
    • 0026828552 scopus 로고
    • Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor
    • Lust J.A., et al. Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor. Cytokine 1992, 4:96-100.
    • (1992) Cytokine , vol.4 , pp. 96-100
    • Lust, J.A.1
  • 117
    • 18344410191 scopus 로고    scopus 로고
    • Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo
    • Atreya R., et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat. Med. 2000, 6:583-588.
    • (2000) Nat. Med. , vol.6 , pp. 583-588
    • Atreya, R.1
  • 118
    • 0034960582 scopus 로고    scopus 로고
    • Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation
    • Hurst S.M., et al. Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 2001, 14:705-714.
    • (2001) Immunity , vol.14 , pp. 705-714
    • Hurst, S.M.1
  • 119
    • 0042834261 scopus 로고    scopus 로고
    • Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130
    • Nowell M.A., et al. Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. J. Immunol. 2003, 171:3202-3209.
    • (2003) J. Immunol. , vol.171 , pp. 3202-3209
    • Nowell, M.A.1
  • 120
    • 5644252874 scopus 로고    scopus 로고
    • TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
    • Becker C., et al. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity 2004, 21:491-501.
    • (2004) Immunity , vol.21 , pp. 491-501
    • Becker, C.1
  • 121
    • 0027293104 scopus 로고
    • Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
    • Narazaki M., et al. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood 1993, 82:1120-1126.
    • (1993) Blood , vol.82 , pp. 1120-1126
    • Narazaki, M.1
  • 122
    • 18644385612 scopus 로고    scopus 로고
    • IL-6 trans-signaling: the in vivo consequences
    • Jones S.A., et al. IL-6 trans-signaling: the in vivo consequences. J. Interferon Cytokine Res. 2005, 25:241-253.
    • (2005) J. Interferon Cytokine Res. , vol.25 , pp. 241-253
    • Jones, S.A.1
  • 123
    • 79955650634 scopus 로고    scopus 로고
    • The pro- and anti-inflammatory properties of the cytokine interleukin-6
    • Scheller J., et al. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim. Biophys. Acta 2011, 1813:878-888.
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 878-888
    • Scheller, J.1
  • 124
    • 0029961666 scopus 로고    scopus 로고
    • A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor
    • Dittrich E., et al. A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor. J. Biol. Chem. 1996, 271:5487-5494.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5487-5494
    • Dittrich, E.1
  • 125
    • 84895544568 scopus 로고    scopus 로고
    • Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity
    • Wunderlich C.M., et al. Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity. JAKSTAT 2013, 2:e23878.
    • (2013) JAKSTAT , vol.2 , pp. e23878
    • Wunderlich, C.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.