The target of metformin in type 2 diabetes

New England Journal of Medicine

Volumn 371, Issue 16, 2014, Pages 1547-1548

  Ferrannini, Ele ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROXYACETONE PHOSPHATE; GLUCOSE; GLYCEROL; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; GLYCEROPHOSPHATE; LACTIC ACID; METFORMIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; ANTIDIABETIC AGENT;

ANTIDIABETIC ACTIVITY; CYTOPLASM; DRUG ABSORPTION; DRUG ELIMINATION; DRUG MECHANISM; DRUG TARGETING; ENZYME INHIBITION; GLUCONEOGENESIS; HUMAN; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; SHORT SURVEY; ANIMAL; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; LIVER; METABOLISM; RAT;

ANIMALS; DIABETES MELLITUS, TYPE 2; DIHYDROXYACETONE PHOSPHATE; GLUCONEOGENESIS; GLYCEROLPHOSPHATE DEHYDROGENASE; HUMANS; HYPOGLYCEMIC AGENTS; LACTIC ACID; LIVER; METFORMIN; MITOCHONDRIA; RATS;

EID: 84908080513     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcibr1409796     Document Type: Article

References (5)

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3. Madiraju AK, Erion DM, Rahimi Y, et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature 2014;510:542-6.
4. Bailey CJ, Wilcock C, Scarpello JHB. Metformin and the intestine. Diabetologia 2008;51:1552-3.
5. Brown JB, Conner C, Nichols GA. Secondary failure of metformin monotherapy in clinical practice. Diabetes Care 2010;33: 501-6.