메뉴 건너뛰기




Volumn 26, Issue 1, 2014, Pages 38-47

The two faces of IL-6 in the tumor microenvironment

Author keywords

Adaptive tumor immunity; IL 6 trans signaling; T cell trafficking; Tumorigenesis

Indexed keywords

INTERLEUKIN 6;

EID: 84896490235     PISSN: 10445323     EISSN: 10963618     Source Type: Journal    
DOI: 10.1016/j.smim.2014.01.008     Document Type: Review
Times cited : (522)

References (86)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144(5):646-674.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0022891340 scopus 로고
    • Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak H.F. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 1986, 315(26):1650-1659.
    • (1986) N Engl J Med , vol.315 , Issue.26 , pp. 1650-1659
    • Dvorak, H.F.1
  • 3
    • 84872445265 scopus 로고    scopus 로고
    • Neutralizing tumor-promoting chronic inflammation: a magic bullet?
    • Coussens L.M., Zitvogel L., Palucka A.K. Neutralizing tumor-promoting chronic inflammation: a magic bullet?. Science 2013, 339(6117):286-291.
    • (2013) Science , vol.339 , Issue.6117 , pp. 286-291
    • Coussens, L.M.1    Zitvogel, L.2    Palucka, A.K.3
  • 5
    • 40649109728 scopus 로고    scopus 로고
    • The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer
    • Naugler W.E., Karin M. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med 2008, 14(3):109-119.
    • (2008) Trends Mol Med , vol.14 , Issue.3 , pp. 109-119
    • Naugler, W.E.1    Karin, M.2
  • 6
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov S.I., Greten F.R., Karin M. Immunity, inflammation, and cancer. Cell 2010, 140(6):883-899.
    • (2010) Cell , vol.140 , Issue.6 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 7
    • 4544327145 scopus 로고    scopus 로고
    • Paul Ehrlich: magister mundi
    • Drews J. Paul Ehrlich: magister mundi. Nat Rev Drug Discov 2004, 3(9):797-801.
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.9 , pp. 797-801
    • Drews, J.1
  • 8
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
    • Schreiber R.D., Old L.J., Smyth M.J. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 2011, 331(6024):1565-1570.
    • (2011) Science , vol.331 , Issue.6024 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 9
    • 84861116448 scopus 로고    scopus 로고
    • Tumor microenvironment complexity: emerging roles in cancer therapy
    • Swartz M.A., Iida N., Roberts E.W., Sangaletti S., Wong M.H., Yull F.E., et al. Tumor microenvironment complexity: emerging roles in cancer therapy. Cancer Res 2012, 72(10):2473-2480.
    • (2012) Cancer Res , vol.72 , Issue.10 , pp. 2473-2480
    • Swartz, M.A.1    Iida, N.2    Roberts, E.W.3    Sangaletti, S.4    Wong, M.H.5    Yull, F.E.6
  • 11
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: functions of cells recruited to the tumor microenvironment
    • Hanahan D., Coussens L.M. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 2012, 21(3):309-322.
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 12
    • 84869797922 scopus 로고    scopus 로고
    • IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6
    • Rose-John S. IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci 2012, 8(9):1237-1247.
    • (2012) Int J Biol Sci , vol.8 , Issue.9 , pp. 1237-1247
    • Rose-John, S.1
  • 13
    • 36849012237 scopus 로고    scopus 로고
    • Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    • Gao S.P., Mark K.G., Leslie K., Pao W., Motoi N., Gerald W.L., et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest 2007, 117(12):3846-3856.
    • (2007) J Clin Invest , vol.117 , Issue.12 , pp. 3846-3856
    • Gao, S.P.1    Mark, K.G.2    Leslie, K.3    Pao, W.4    Motoi, N.5    Gerald, W.L.6
  • 14
    • 36849039660 scopus 로고    scopus 로고
    • IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
    • Sansone P., Storci G., Tavolari S., Guarnieri T., Giovannini C., Taffurelli M., et al. IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J Clin Invest 2007, 117(12):3988-4002.
    • (2007) J Clin Invest , vol.117 , Issue.12 , pp. 3988-4002
    • Sansone, P.1    Storci, G.2    Tavolari, S.3    Guarnieri, T.4    Giovannini, C.5    Taffurelli, M.6
  • 15
    • 0036469114 scopus 로고    scopus 로고
    • Autocrine interleukin-6 production in renal cell carcinoma: evidence for the involvement of p53
    • Angelo L.S., Talpaz M., Kurzrock R. Autocrine interleukin-6 production in renal cell carcinoma: evidence for the involvement of p53. Cancer Res 2002, 62(3):932-940.
    • (2002) Cancer Res , vol.62 , Issue.3 , pp. 932-940
    • Angelo, L.S.1    Talpaz, M.2    Kurzrock, R.3
  • 16
    • 78649741783 scopus 로고    scopus 로고
    • Gp130 at the nexus of inflammation, autoimmunity, and cancer
    • Silver J.S., Hunter C.A. gp130 at the nexus of inflammation, autoimmunity, and cancer. J Leukoc Biol 2010, 88(6):1145-1156.
    • (2010) J Leukoc Biol , vol.88 , Issue.6 , pp. 1145-1156
    • Silver, J.S.1    Hunter, C.A.2
  • 17
    • 80053429941 scopus 로고    scopus 로고
    • IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells
    • Fisher D.T., Chen Q., Skitzki J.J., Muhitch J.B., Zhou L., Appenheimer M.M., et al. IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells. J Clin Invest 2011, 121(10):3846-3859.
    • (2011) J Clin Invest , vol.121 , Issue.10 , pp. 3846-3859
    • Fisher, D.T.1    Chen, Q.2    Skitzki, J.J.3    Muhitch, J.B.4    Zhou, L.5    Appenheimer, M.M.6
  • 18
    • 34648832277 scopus 로고    scopus 로고
    • Regulation of a lymphocyte-endothelial-IL-6 trans-signaling axis by fever-range thermal stress: hot spot of immune surveillance
    • Vardam T.D., Zhou L., Appenheimer M.M., Chen Q., Wang W.C., Baumann H., et al. Regulation of a lymphocyte-endothelial-IL-6 trans-signaling axis by fever-range thermal stress: hot spot of immune surveillance. Cytokine 2007, 39(1):84-96.
    • (2007) Cytokine , vol.39 , Issue.1 , pp. 84-96
    • Vardam, T.D.1    Zhou, L.2    Appenheimer, M.M.3    Chen, Q.4    Wang, W.C.5    Baumann, H.6
  • 19
    • 0037064542 scopus 로고    scopus 로고
    • The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex
    • Jones S.A., Rose-John S. The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex. Biochim Biophys Acta 2002, 1592(3):251-263.
    • (2002) Biochim Biophys Acta , vol.1592 , Issue.3 , pp. 251-263
    • Jones, S.A.1    Rose-John, S.2
  • 20
    • 0034658541 scopus 로고    scopus 로고
    • Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
    • Hirano T., Ishihara K., Hibi M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 2000, 19(21):2548-2556.
    • (2000) Oncogene , vol.19 , Issue.21 , pp. 2548-2556
    • Hirano, T.1    Ishihara, K.2    Hibi, M.3
  • 22
    • 0035160256 scopus 로고    scopus 로고
    • Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
    • Jostock T., Mullberg J., Ozbek S., Atreya R., Blinn G., Voltz N., et al. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur J Biochem 2001, 268(1):160-167.
    • (2001) Eur J Biochem , vol.268 , Issue.1 , pp. 160-167
    • Jostock, T.1    Mullberg, J.2    Ozbek, S.3    Atreya, R.4    Blinn, G.5    Voltz, N.6
  • 23
    • 42649129014 scopus 로고    scopus 로고
    • Systematic review of the association between circulating interleukin-6 (IL-6) and cancer
    • Heikkila K., Ebrahim S., Lawlor D.A. Systematic review of the association between circulating interleukin-6 (IL-6) and cancer. Eur J Cancer 2008, 44(7):937-945.
    • (2008) Eur J Cancer , vol.44 , Issue.7 , pp. 937-945
    • Heikkila, K.1    Ebrahim, S.2    Lawlor, D.A.3
  • 24
    • 84877004454 scopus 로고    scopus 로고
    • Cytokine patterns in patients with cancer: a systematic review
    • Lippitz B.E. Cytokine patterns in patients with cancer: a systematic review. Lancet Oncol 2013, 14(6):pe218-pe228.
    • (2013) Lancet Oncol , vol.14 , Issue.6
    • Lippitz, B.E.1
  • 25
    • 5644252874 scopus 로고    scopus 로고
    • TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
    • Becker C., Fantini M.C., Schramm C., Lehr H.A., Wirtz S., Nikolaev A., et al. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity 2004, 21(4):491-501.
    • (2004) Immunity , vol.21 , Issue.4 , pp. 491-501
    • Becker, C.1    Fantini, M.C.2    Schramm, C.3    Lehr, H.A.4    Wirtz, S.5    Nikolaev, A.6
  • 26
    • 79953756112 scopus 로고    scopus 로고
    • Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
    • Lesina M., Kurkowski M.U., Ludes K., Rose-John S., Treiber M., Kloppel G., et al. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell 2011, 19(4):456-469.
    • (2011) Cancer Cell , vol.19 , Issue.4 , pp. 456-469
    • Lesina, M.1    Kurkowski, M.U.2    Ludes, K.3    Rose-John, S.4    Treiber, M.5    Kloppel, G.6
  • 27
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov S., Karin E., Terzic J., Mucida D., Yu G.Y., Vallabhapurapu S., et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 2009, 15(2):103-113.
    • (2009) Cancer Cell , vol.15 , Issue.2 , pp. 103-113
    • Grivennikov, S.1    Karin, E.2    Terzic, J.3    Mucida, D.4    Yu, G.Y.5    Vallabhapurapu, S.6
  • 28
    • 65049084189 scopus 로고    scopus 로고
    • Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation
    • Mantovani A., Sica A., Allavena P., Garlanda C., Locati M. Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation. Hum Immunol 2009, 70(5):325-330.
    • (2009) Hum Immunol , vol.70 , Issue.5 , pp. 325-330
    • Mantovani, A.1    Sica, A.2    Allavena, P.3    Garlanda, C.4    Locati, M.5
  • 29
    • 76349096670 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner
    • Erez N., Truitt M., Olson P., Arron S.T., Hanahan D. Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner. Cancer Cell 2010, 17(2):135-147.
    • (2010) Cancer Cell , vol.17 , Issue.2 , pp. 135-147
    • Erez, N.1    Truitt, M.2    Olson, P.3    Arron, S.T.4    Hanahan, D.5
  • 30
    • 84883609975 scopus 로고    scopus 로고
    • A mutual activation loop between breast cancer cells and myeloid-derived suppressor cells facilitates spontaneous metastasis through IL-6 trans-signaling in a murine model
    • Oh K., Lee O.Y., Shon S.Y., Nam O., Ryu P.M., Seo M.W., et al. A mutual activation loop between breast cancer cells and myeloid-derived suppressor cells facilitates spontaneous metastasis through IL-6 trans-signaling in a murine model. Breast Cancer Res 2013, 15(5):pR79.
    • (2013) Breast Cancer Res , vol.15 , Issue.5
    • Oh, K.1    Lee, O.Y.2    Shon, S.Y.3    Nam, O.4    Ryu, P.M.5    Seo, M.W.6
  • 31
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
    • Iliopoulos D., Hirsch H.A., Struhl K. An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 2009, 139(4):693-706.
    • (2009) Cell , vol.139 , Issue.4 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 32
    • 84873468174 scopus 로고    scopus 로고
    • Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses
    • Mitchem J.B., Brennan D.J., Knolhoff B.L., Belt B.A., Zhu Y., Sanford D.E., et al. Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses. Cancer Res 2013, 73(3):1128-1141.
    • (2013) Cancer Res , vol.73 , Issue.3 , pp. 1128-1141
    • Mitchem, J.B.1    Brennan, D.J.2    Knolhoff, B.L.3    Belt, B.A.4    Zhu, Y.5    Sanford, D.E.6
  • 34
    • 0033521595 scopus 로고    scopus 로고
    • STAT3 is required for the gp130-mediated full activation of the c-myc gene
    • Kiuchi N., Nakajima K., Ichiba M., Fukada T., Narimatsu M., Mizuno K., et al. STAT3 is required for the gp130-mediated full activation of the c-myc gene. J Exp Med 1999, 189(1):63-73.
    • (1999) J Exp Med , vol.189 , Issue.1 , pp. 63-73
    • Kiuchi, N.1    Nakajima, K.2    Ichiba, M.3    Fukada, T.4    Narimatsu, M.5    Mizuno, K.6
  • 35
    • 58149326854 scopus 로고    scopus 로고
    • Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
    • Rebouissou S., Amessou M., Couchy G., Poussin K., Imbeaud S., Pilati C., et al. Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. Nature 2009, 457(7226):200-204.
    • (2009) Nature , vol.457 , Issue.7226 , pp. 200-204
    • Rebouissou, S.1    Amessou, M.2    Couchy, G.3    Poussin, K.4    Imbeaud, S.5    Pilati, C.6
  • 36
    • 79960346759 scopus 로고    scopus 로고
    • Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas
    • Pilati C., Amessou M., Bihl M.P., Balabaud C., Nhieu J.T., Paradis V., et al. Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas. J Exp Med 2011, 208(7):1359-1366.
    • (2011) J Exp Med , vol.208 , Issue.7 , pp. 1359-1366
    • Pilati, C.1    Amessou, M.2    Bihl, M.P.3    Balabaud, C.4    Nhieu, J.T.5    Paradis, V.6
  • 37
    • 84873328655 scopus 로고    scopus 로고
    • MTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice
    • Thiem S., Pierce T.P., Palmieri M., Putoczki T.L., Buchert M., Preaudet A., et al. mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice. J Clin Invest 2013, 123(2):767-781.
    • (2013) J Clin Invest , vol.123 , Issue.2 , pp. 767-781
    • Thiem, S.1    Pierce, T.P.2    Palmieri, M.3    Putoczki, T.L.4    Buchert, M.5    Preaudet, A.6
  • 38
    • 0037474270 scopus 로고    scopus 로고
    • Opposite regulation of myc and p21waf1 transcription by STAT3 proteins
    • Barre B., Avril S., Coqueret O. Opposite regulation of myc and p21waf1 transcription by STAT3 proteins. J Biol Chem 2003, 278(5):2990-2996.
    • (2003) J Biol Chem , vol.278 , Issue.5 , pp. 2990-2996
    • Barre, B.1    Avril, S.2    Coqueret, O.3
  • 39
    • 31544458469 scopus 로고    scopus 로고
    • Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells
    • Gritsko T., Williams A., Turkson J., Kaneko S., Bowman T., Huang M., et al. Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clin Cancer Res 2006, 12(1):11-19.
    • (2006) Clin Cancer Res , vol.12 , Issue.1 , pp. 11-19
    • Gritsko, T.1    Williams, A.2    Turkson, J.3    Kaneko, S.4    Bowman, T.5    Huang, M.6
  • 40
    • 19644389279 scopus 로고    scopus 로고
    • Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation
    • Hodge D.R., Peng B., Cherry J.C., Hurt E.M., Fox S.D., Kelley J.A., et al. Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation. Cancer Res 2005, 65(11):4673-4682.
    • (2005) Cancer Res , vol.65 , Issue.11 , pp. 4673-4682
    • Hodge, D.R.1    Peng, B.2    Cherry, J.C.3    Hurt, E.M.4    Fox, S.D.5    Kelley, J.A.6
  • 41
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens L.M., Werb Z. Inflammation and cancer. Nature 2002, 420(6917):860-867.
    • (2002) Nature , vol.420 , Issue.6917 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 42
    • 2442685645 scopus 로고    scopus 로고
    • Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis
    • Xie T.X., Wei D., Liu M., Gao A.C., Ali-Osman F., Sawaya R., et al. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 2004, 23(20):3550-3560.
    • (2004) Oncogene , vol.23 , Issue.20 , pp. 3550-3560
    • Xie, T.X.1    Wei, D.2    Liu, M.3    Gao, A.C.4    Ali-Osman, F.5    Sawaya, R.6
  • 43
    • 0037435011 scopus 로고    scopus 로고
    • Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway
    • Wei L.H., Kuo M.L., Chen C.A., Chou C.H., Lai K.B., Lee C.N., et al. Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. Oncogene 2003, 22(10):1517-1527.
    • (2003) Oncogene , vol.22 , Issue.10 , pp. 1517-1527
    • Wei, L.H.1    Kuo, M.L.2    Chen, C.A.3    Chou, C.H.4    Lai, K.B.5    Lee, C.N.6
  • 45
    • 55849107422 scopus 로고    scopus 로고
    • Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice
    • Kujawski M., Kortylewski M., Lee H., Herrmann A., Kay H., Yu H. Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice. J Clin Invest 2008, 118(10):3367-3377.
    • (2008) J Clin Invest , vol.118 , Issue.10 , pp. 3367-3377
    • Kujawski, M.1    Kortylewski, M.2    Lee, H.3    Herrmann, A.4    Kay, H.5    Yu, H.6
  • 46
    • 70249140303 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells down-regulate l-selectin expression on CD4+ and CD8+ T cells
    • Hanson E.M., Clements V.K., Sinha P., Ilkovitch D., Ostrand-Rosenberg S. Myeloid-derived suppressor cells down-regulate l-selectin expression on CD4+ and CD8+ T cells. J Immunol 2009, 183(2):937-944.
    • (2009) J Immunol , vol.183 , Issue.2 , pp. 937-944
    • Hanson, E.M.1    Clements, V.K.2    Sinha, P.3    Ilkovitch, D.4    Ostrand-Rosenberg, S.5
  • 47
    • 0034577943 scopus 로고    scopus 로고
    • IL-6 switches the differentiation of monocytes from dendritic cells to macrophages
    • Chomarat P., Banchereau J., Davoust J., Palucka A.K. IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat Immunol 2000, 1(6):510-514.
    • (2000) Nat Immunol , vol.1 , Issue.6 , pp. 510-514
    • Chomarat, P.1    Banchereau, J.2    Davoust, J.3    Palucka, A.K.4
  • 48
    • 4644249098 scopus 로고    scopus 로고
    • IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation
    • Park S.J., Nakagawa T., Kitamura H., Atsumi T., Kamon H., Sawa S., et al. IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation. J Immunol 2004, 173(6):3844-3854.
    • (2004) J Immunol , vol.173 , Issue.6 , pp. 3844-3854
    • Park, S.J.1    Nakagawa, T.2    Kitamura, H.3    Atsumi, T.4    Kamon, H.5    Sawa, S.6
  • 49
    • 84877076923 scopus 로고    scopus 로고
    • From the immune contexture to the immunoscore: the role of prognostic and predictive immune markers in cancer
    • Angell H., Galon J. From the immune contexture to the immunoscore: the role of prognostic and predictive immune markers in cancer. Curr Opin Immunol 2013, 25(2):261-267.
    • (2013) Curr Opin Immunol , vol.25 , Issue.2 , pp. 261-267
    • Angell, H.1    Galon, J.2
  • 50
    • 84858800620 scopus 로고    scopus 로고
    • The immune contexture in human tumours: impact on clinical outcome
    • Fridman W.H., Pages F., Sautes-Fridman C., Galon J. The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer 2012, 12(4):298-306.
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 298-306
    • Fridman, W.H.1    Pages, F.2    Sautes-Fridman, C.3    Galon, J.4
  • 52
    • 65249155463 scopus 로고    scopus 로고
    • Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells
    • Dejean A.S., Beisner D.R., Ch'en I.L., Kerdiles Y.M., Babour A., Arden K.C., et al. Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol 2009, 10(5):504-513.
    • (2009) Nat Immunol , vol.10 , Issue.5 , pp. 504-513
    • Dejean, A.S.1    Beisner, D.R.2    Ch'en, I.L.3    Kerdiles, Y.M.4    Babour, A.5    Arden, K.C.6
  • 54
    • 34848876937 scopus 로고    scopus 로고
    • Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells
    • Dominitzki S., Fantini M.C., Neufert C., Nikolaev A., Galle P.R., Scheller J., et al. Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells. J Immunol 2007, 179(4):2041-2045.
    • (2007) J Immunol , vol.179 , Issue.4 , pp. 2041-2045
    • Dominitzki, S.1    Fantini, M.C.2    Neufert, C.3    Nikolaev, A.4    Galle, P.R.5    Scheller, J.6
  • 55
    • 35348819991 scopus 로고    scopus 로고
    • Conservation of IL-6 trans-signaling mechanisms controlling l-selectin adhesion by fever-range thermal stress
    • Appenheimer M.M., Girard R.A., Chen Q., Wang W.C., Bankert K.C., Hardison J., et al. Conservation of IL-6 trans-signaling mechanisms controlling l-selectin adhesion by fever-range thermal stress. Eur J Immunol 2007, 37(10):2856-2867.
    • (2007) Eur J Immunol , vol.37 , Issue.10 , pp. 2856-2867
    • Appenheimer, M.M.1    Girard, R.A.2    Chen, Q.3    Wang, W.C.4    Bankert, K.C.5    Hardison, J.6
  • 56
    • 33846325078 scopus 로고    scopus 로고
    • Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism
    • Chen Q., Fisher D.T., Clancy K.A., Gauguet J.M., Wang W.C., Unger E., et al. Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism. Nat Immunol 2006, 7(12):1299-1308.
    • (2006) Nat Immunol , vol.7 , Issue.12 , pp. 1299-1308
    • Chen, Q.1    Fisher, D.T.2    Clancy, K.A.3    Gauguet, J.M.4    Wang, W.C.5    Unger, E.6
  • 57
    • 9144220760 scopus 로고    scopus 로고
    • Central role of IL-6 receptor signal-transducing chain gp130 in activation of l-selectin adhesion by fever-range thermal stress
    • Chen Q., Wang W.C., Bruce R., Li H., Schleider D.M., Mulbury M.J., et al. Central role of IL-6 receptor signal-transducing chain gp130 in activation of l-selectin adhesion by fever-range thermal stress. Immunity 2004, 20(1):59-70.
    • (2004) Immunity , vol.20 , Issue.1 , pp. 59-70
    • Chen, Q.1    Wang, W.C.2    Bruce, R.3    Li, H.4    Schleider, D.M.5    Mulbury, M.J.6
  • 58
    • 0031964619 scopus 로고    scopus 로고
    • Fever-range hyperthermia enhances l-selectin-dependent adhesion of lymphocytes to vascular endothelium
    • Wang W.C., Goldman L.M., Schleider D.M., Appenheimer M.M., Subjeck J.R., Repasky E.A., et al. Fever-range hyperthermia enhances l-selectin-dependent adhesion of lymphocytes to vascular endothelium. J Immunol 1998, 160(2):961-969.
    • (1998) J Immunol , vol.160 , Issue.2 , pp. 961-969
    • Wang, W.C.1    Goldman, L.M.2    Schleider, D.M.3    Appenheimer, M.M.4    Subjeck, J.R.5    Repasky, E.A.6
  • 59
    • 0035353162 scopus 로고    scopus 로고
    • Fever-range hyperthermia dynamically regulates lymphocyte delivery to high endothelial venules
    • Evans S.S., Wang W.C., Bain M.D., Burd R., Ostberg J.R., Repasky E.A. Fever-range hyperthermia dynamically regulates lymphocyte delivery to high endothelial venules. Blood 2001, 97(9):2727-2733.
    • (2001) Blood , vol.97 , Issue.9 , pp. 2727-2733
    • Evans, S.S.1    Wang, W.C.2    Bain, M.D.3    Burd, R.4    Ostberg, J.R.5    Repasky, E.A.6
  • 60
    • 0036277212 scopus 로고    scopus 로고
    • A phase I study of fever-range whole body hyperthermia (FR-WBH) in patients with advanced solid tumours: correlation with mouse models
    • Kraybill W.G., Olenki T., Evans S.S., Ostberg J.R., O'Leary K.A., Gibbs J.F., et al. A phase I study of fever-range whole body hyperthermia (FR-WBH) in patients with advanced solid tumours: correlation with mouse models. Int J Hyperthermia 2002, 18(3):253-266.
    • (2002) Int J Hyperthermia , vol.18 , Issue.3 , pp. 253-266
    • Kraybill, W.G.1    Olenki, T.2    Evans, S.S.3    Ostberg, J.R.4    O'Leary, K.A.5    Gibbs, J.F.6
  • 62
    • 58449135493 scopus 로고    scopus 로고
    • Thermal facilitation of lymphocyte trafficking involves temporal induction of intravascular ICAM-1
    • Chen Q., Appenheimer M.M., Muhitch J.B., Fisher D.T., Clancy K.A., Miecznikowski J.C., et al. Thermal facilitation of lymphocyte trafficking involves temporal induction of intravascular ICAM-1. Microcirculation 2009, 16(2):143-158.
    • (2009) Microcirculation , vol.16 , Issue.2 , pp. 143-158
    • Chen, Q.1    Appenheimer, M.M.2    Muhitch, J.B.3    Fisher, D.T.4    Clancy, K.A.5    Miecznikowski, J.C.6
  • 63
    • 0033954317 scopus 로고    scopus 로고
    • Fever-range hyperthermia stimulates alpha4beta7 integrin-dependent lymphocyte-endothelial adhesion
    • Evans S.S., Bain M.D., Wang W.C. Fever-range hyperthermia stimulates alpha4beta7 integrin-dependent lymphocyte-endothelial adhesion. Int J Hyperthermia 2000, 16(1):45-59.
    • (2000) Int J Hyperthermia , vol.16 , Issue.1 , pp. 45-59
    • Evans, S.S.1    Bain, M.D.2    Wang, W.C.3
  • 65
    • 0030891228 scopus 로고    scopus 로고
    • Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
    • Romano M., Sironi M., Toniatti C., Polentarutti N., Fruscella P., Ghezzi P., et al. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 1997, 6(3):315-325.
    • (1997) Immunity , vol.6 , Issue.3 , pp. 315-325
    • Romano, M.1    Sironi, M.2    Toniatti, C.3    Polentarutti, N.4    Fruscella, P.5    Ghezzi, P.6
  • 66
    • 84880747672 scopus 로고    scopus 로고
    • Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance
    • Zitvogel L., Galluzzi L., Smyth M.J., Kroemer G. Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity 2013, 39(1):74-88.
    • (2013) Immunity , vol.39 , Issue.1 , pp. 74-88
    • Zitvogel, L.1    Galluzzi, L.2    Smyth, M.J.3    Kroemer, G.4
  • 68
    • 0037501371 scopus 로고    scopus 로고
    • Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes
    • Bousso P., Robey E. Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes. Nat Immunol 2003, 4(6):579-585.
    • (2003) Nat Immunol , vol.4 , Issue.6 , pp. 579-585
    • Bousso, P.1    Robey, E.2
  • 69
    • 84867900263 scopus 로고    scopus 로고
    • HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes
    • Girard J.P., Moussion C., Forster R. HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes. Nat Rev Immunol 2012, 12(11):762-773.
    • (2012) Nat Rev Immunol , vol.12 , Issue.11 , pp. 762-773
    • Girard, J.P.1    Moussion, C.2    Forster, R.3
  • 70
    • 0028812784 scopus 로고
    • Identification of dendritic cells as a major source of interleukin-6 in draining lymph nodes following skin sensitization of mice
    • Hope J.C., Cumberbatch M., Fielding I., Dearman R.J., Kimber I., Hopkins S.J. Identification of dendritic cells as a major source of interleukin-6 in draining lymph nodes following skin sensitization of mice. Immunology 1995, 86(3):441-447.
    • (1995) Immunology , vol.86 , Issue.3 , pp. 441-447
    • Hope, J.C.1    Cumberbatch, M.2    Fielding, I.3    Dearman, R.J.4    Kimber, I.5    Hopkins, S.J.6
  • 71
    • 0034938735 scopus 로고    scopus 로고
    • Interleukin-6 regulates the phenotype of the immune response to a tuberculosis subunit vaccine
    • Leal I.S., Florido M., Andersen P., Appelberg R. Interleukin-6 regulates the phenotype of the immune response to a tuberculosis subunit vaccine. Immunology 2001, 103(3):375-381.
    • (2001) Immunology , vol.103 , Issue.3 , pp. 375-381
    • Leal, I.S.1    Florido, M.2    Andersen, P.3    Appelberg, R.4
  • 72
    • 63849275584 scopus 로고    scopus 로고
    • Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities
    • Eddahri F., Denanglaire S., Bureau F., Spolski R., Leonard W.J., Leo O., et al. Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood 2009, 113(11):2426-2433.
    • (2009) Blood , vol.113 , Issue.11 , pp. 2426-2433
    • Eddahri, F.1    Denanglaire, S.2    Bureau, F.3    Spolski, R.4    Leonard, W.J.5    Leo, O.6
  • 73
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare C., Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003, 299(5609):1033-1036.
    • (2003) Science , vol.299 , Issue.5609 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 74
    • 78650124721 scopus 로고    scopus 로고
    • Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice
    • Sharma M.D., Hou D.Y., Baban B., Koni P.A., He Y., Chandler P.R., et al. Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice. Immunity 2010, 33(6):942-954.
    • (2010) Immunity , vol.33 , Issue.6 , pp. 942-954
    • Sharma, M.D.1    Hou, D.Y.2    Baban, B.3    Koni, P.A.4    He, Y.5    Chandler, P.R.6
  • 75
    • 0030229587 scopus 로고    scopus 로고
    • Intravital microscopy of the peripheral lymph node microcirculation in mice
    • von Andrian U.H. Intravital microscopy of the peripheral lymph node microcirculation in mice. Microcirculation 1996, 3(3):287-300.
    • (1996) Microcirculation , vol.3 , Issue.3 , pp. 287-300
    • von Andrian, U.H.1
  • 76
    • 84896489618 scopus 로고    scopus 로고
    • Temperature matters! And why it should matter to tumor immunologists
    • Repasky E.A., Evans S.S., Dewhirst M.W. Temperature matters! And why it should matter to tumor immunologists. Cancer Immunol Res 2013, 1(4):210-216.
    • (2013) Cancer Immunol Res , vol.1 , Issue.4 , pp. 210-216
    • Repasky, E.A.1    Evans, S.S.2    Dewhirst, M.W.3
  • 77
    • 0033674461 scopus 로고    scopus 로고
    • Regulatory effects of fever-range whole-body hyperthermia on the LPS-induced acute inflammatory response
    • Ostberg J.R., Taylor S.L., Baumann H., Repasky E.A. Regulatory effects of fever-range whole-body hyperthermia on the LPS-induced acute inflammatory response. J Leukoc Biol 2000, 68(6):815-820.
    • (2000) J Leukoc Biol , vol.68 , Issue.6 , pp. 815-820
    • Ostberg, J.R.1    Taylor, S.L.2    Baumann, H.3    Repasky, E.A.4
  • 78
    • 0033002659 scopus 로고    scopus 로고
    • Febrile-range temperature modifies early systemic tumor necrosis factor alpha expression in mice challenged with bacterial endotoxin
    • Jiang Q., DeTolla L., van Rooijen N., Singh I.S., Fitzgerald B., Lipsky M.M., et al. Febrile-range temperature modifies early systemic tumor necrosis factor alpha expression in mice challenged with bacterial endotoxin. Infect Immun 1999, 67(4):1539-1546.
    • (1999) Infect Immun , vol.67 , Issue.4 , pp. 1539-1546
    • Jiang, Q.1    DeTolla, L.2    van Rooijen, N.3    Singh, I.S.4    Fitzgerald, B.5    Lipsky, M.M.6
  • 79
    • 29244481992 scopus 로고    scopus 로고
    • Cancer cells regulate lymphocyte recruitment and leukocyte-endothelium interactions in the tumor-draining lymph node
    • Carriere V., Colisson R., Jiguet-Jiglaire C., Bellard E., Bouche G., Al Saati T., et al. Cancer cells regulate lymphocyte recruitment and leukocyte-endothelium interactions in the tumor-draining lymph node. Cancer Res 2005, 65(24):11639-11648.
    • (2005) Cancer Res , vol.65 , Issue.24 , pp. 11639-11648
    • Carriere, V.1    Colisson, R.2    Jiguet-Jiglaire, C.3    Bellard, E.4    Bouche, G.5    Al Saati, T.6
  • 80
    • 0026662561 scopus 로고
    • Diminished leukocyte-endothelium interaction in tumor microvessels
    • Wu N.Z., Klitzman B., Dodge R., Dewhirst M.W. Diminished leukocyte-endothelium interaction in tumor microvessels. Cancer Res 1992, 52(15):4265-4268.
    • (1992) Cancer Res , vol.52 , Issue.15 , pp. 4265-4268
    • Wu, N.Z.1    Klitzman, B.2    Dodge, R.3    Dewhirst, M.W.4
  • 81
    • 0029793371 scopus 로고    scopus 로고
    • During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium
    • Melder R.J., Koenig G.C., Witwer B.P., Safabakhsh N., Munn L.L., Jain R.K. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Nat Med 1996, 2(9):992-997.
    • (1996) Nat Med , vol.2 , Issue.9 , pp. 992-997
    • Melder, R.J.1    Koenig, G.C.2    Witwer, B.P.3    Safabakhsh, N.4    Munn, L.L.5    Jain, R.K.6
  • 82
    • 33845310374 scopus 로고    scopus 로고
    • Epigenetic regulation of tumor endothelial cell anergy: silencing of intercellular adhesion molecule-1 by histone modifications
    • Hellebrekers D.M., Castermans K., Vire E., Dings R.P., Hoebers N.T., Mayo K.H., et al. Epigenetic regulation of tumor endothelial cell anergy: silencing of intercellular adhesion molecule-1 by histone modifications. Cancer Res 2006, 66(22):10770-10777.
    • (2006) Cancer Res , vol.66 , Issue.22 , pp. 10770-10777
    • Hellebrekers, D.M.1    Castermans, K.2    Vire, E.3    Dings, R.P.4    Hoebers, N.T.5    Mayo, K.H.6
  • 83
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • Gajewski T.F., Schreiber H., Fu Y.X. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol 2013, 14(10):1014-1022.
    • (2013) Nat Immunol , vol.14 , Issue.10 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.X.3
  • 84
    • 84858758766 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer: harnessing the T cell response
    • Restifo N.P., Dudley M.E., Rosenberg S.A. Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol 2012, 12(4):269-281.
    • (2012) Nat Rev Immunol , vol.12 , Issue.4 , pp. 269-281
    • Restifo, N.P.1    Dudley, M.E.2    Rosenberg, S.A.3
  • 85
    • 0032846613 scopus 로고    scopus 로고
    • Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor
    • Klouche M., Bhakdi S., Hemmes M., Rose-John S. Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. J Immunol 1999, 163(8):4583-4589.
    • (1999) J Immunol , vol.163 , Issue.8 , pp. 4583-4589
    • Klouche, M.1    Bhakdi, S.2    Hemmes, M.3    Rose-John, S.4
  • 86
    • 79960004119 scopus 로고    scopus 로고
    • Interactive Tree Of Life v2: online annotation and display of phylogenetic trees made easy
    • Letunic I., Bork P. Interactive Tree Of Life v2: online annotation and display of phylogenetic trees made easy. Nucleic Acids Res 2011, 39(Web Server issue):W475-W478.
    • (2011) Nucleic Acids Res , vol.39 , Issue.WEB SERVER ISSUE
    • Letunic, I.1    Bork, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.