A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor

Journal of Biological Chemistry

Volumn 271, Issue 10, 1996, Pages 5487-5494

  Dittrich, Elke ^a   Haft, Carol Renfrew ^b   Muys, Leon ^a   Heinrich, Peter C ^a   Graeve, Lutz ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CHIMERIC PROTEIN; GLYCOPROTEIN GP 130; INSULIN RECEPTOR; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; LEUCINE; LIGAND; SERINE;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; ENDOCYTOSIS; GENE DELETION; HUMAN; HUMAN CELL; INTERNALIZATION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN TARGETING; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD; BASE SEQUENCE; BINDING SITES; CELL LINE; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; CYTOKINE RECEPTOR GP130; DNA MUTATIONAL ANALYSIS; DOWN-REGULATION; ENDOCYTOSIS; HUMANS; INTERLEUKIN-6; KINETICS; LEUCINE; LIGANDS; LYSOSOMES; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; OLIGODEOXYRIBONUCLEOTIDES; PHOSPHORYLATION; POINT MUTATION; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-6; RECOMBINANT PROTEINS; SEQUENCE DELETION; SERINE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

ANIMALIA;

EID: 0029961666     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.10.5487     Document Type: Article

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