Dual chitosan/albumin-coated alginate/dextran sulfate nanoparticles for enhanced oral delivery of insulin

Journal of Controlled Release

Volumn 232, Issue , 2016, Pages 29-41

  Lopes, Marlene ^a,b,c   Shrestha, Neha ^a   Correia, Alexandra ^a   Shahbazi, Mohammad Ali ^a   Sarmento, Bruno ^d,e,f   Hirvonen, Jouni ^a   Veiga, Francisco ^b,c   Seiça, Raquel ^g   Ribeiro, António ^b,f,h   Santos, Hélder A ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d INSTITUTO DE INVESTIGAÇÃO E FORMAÇÃO AVANÇADA EM CIÊNCIAS E TECNOLOGIAS DA SAÚDE   (Portugal)

^e INEB INSTITUTO DE ENGENHARIA BIOMÉDICA   (Portugal)

^f UNIVERSITY OF PORTO   (Portugal)

^g UNIVERSITY OF COIMBRA   (Portugal)

^h UNIVERSITY OF PORTO   (Portugal)

Author keywords

Diabetes; Insulin; Nanoparticles; Oral delivery; Triple co culture; Uptake mechanisms

Indexed keywords

BIOCHEMISTRY; CHITIN; CHITOSAN; MEDICAL PROBLEMS; MOLECULAR BIOLOGY; NANOPARTICLES; NANOSYSTEMS;

CO-CULTURES; DRUG DELIVERY TECHNOLOGIES; INTESTINAL EPITHELIUM; NANOPARTICLE (NPS); ORAL DELIVERY; SIMULATED GASTRIC CONDITIONS; TYPE 1 DIABETES MELLITUS; UPTAKE MECHANISM;

INSULIN;

ALBUMIN; ALGINIC ACID; CHITOSAN; CHLORPROMAZINE; DEXTRAN SULFATE; INSULIN; NANOPARTICLE; ALBUMINOID;

ANIMAL CELL; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; IN VITRO STUDY; INCUBATION TIME; INSULIN RELEASE; INTESTINE CELL; INTESTINE EPITHELIUM; INTESTINE MUCOSA PERMEABILITY; MORPHOLOGY; MUCOADHESION; NONHUMAN; PRIORITY JOURNAL; STOMACH PH; TEMPERATURE; CACO-2 CELL LINE; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG RELEASE; HT-29 CELL LINE; HUMAN; INTESTINE MUCOSA; METABOLISM; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ALBUMINS; CACO-2 CELLS; CELL LINE; CELL SURVIVAL; CHITOSAN; DEXTRAN SULFATE; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; HT29 CELLS; HUMANS; INSULIN; INTESTINAL MUCOSA; NANOPARTICLES;

EID: 84963815763     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2016.04.012     Document Type: Article

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