Nanoparticulate delivery system for insulin: Design, characterization and in vitro/in vivo bioactivity

European Journal of Pharmaceutical Sciences

Volumn 30, Issue 5, 2007, Pages 392-397

  Reis, Catarina Pinto ^a   Ribeiro, António J ^b   Houng, Simone ^c   Veiga, Francisco ^a   Neufeld, Ronald J ^c  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY INSTITUTE OF HEALTH SCIENCES IUCS   (Portugal)

^c QUEEN S UNIVERSITY   (Canada)

Author keywords

Alginate dextran nanospheres; Insulin bioactivity; Nanospheres

Indexed keywords

ALGINIC ACID; DEXTRAN; INSULIN; NANOSPHERE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; GELATION; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT; SPECTROSCOPY; STREPTOZOCIN DIABETES; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; WISTAR RAT;

ALGINATES; ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; DEXTRAN SULFATE; DIABETES MELLITUS, EXPERIMENTAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; GLUCURONIC ACID; HEXURONIC ACIDS; HYDROGEN-ION CONCENTRATION; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN; LASERS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MYOBLASTS; NANOPARTICLES; PARTICLE SIZE; RATS; RATS, WISTAR; SCATTERING, RADIATION; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 33947431672     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2006.12.007     Document Type: Article

References (21)

1. Alessi D.R., and Downes C.P. The role of PI 3-kinase in insulin action. Biochim. Biophys. Acta (BBA), Mol. Cell Biol. Lipids 1436 (1998) 151-164
2. Almeida P.F., and Almeida A.J. Cross-linked alginate-gelatine beads: a new matrix for controlled release of pindolol. J. Control. Rel. 97 (2004) 431-439
3. Bam N.B., Cleland J.L., Yang J., Manning M.C., Carpenter J.F., Kelley R.F., and Randolph T.W. Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions. J. Pharm. Sci. 87 (1998) 1554-1559
4. Chien Y.W. Human insulin: basic sciences to therapeutic uses. Drug Dev. Ind. Pharm. 22 (1996) 753-789
5. Damgé C., Maincent P., and Ubrich N. Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J. Control. Rel. 117 (2007) 163-170
6. De Rosa G., Iommelli R., La Rotonda M.I., Miro A., and Quaglia F. Influence of the co-encapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres. J. Control. Rel. 69 (2000) 283-295
7. Draget K.I., Skjåk-Braek G., and SmidsrØd O. Alginic acid gels: the effect of alginate chemical composition and molecular weight. Carbohyd. Polym. 25 (1994) 31-38
8. Eldridge J.H., Hammond C.J., Meulbroek J.A., Staas J.K., Gilley R.M., and Tice T.R. Controlled vaccine release in gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the peyer's patches. J. Control. Rel. 11 (1990) 205-214
9. Elghazi L., Balcazar N., and Bernal-Mizrachi E. Emerging role of protein kinase B/Akt signaling in pancreatic [beta]-cell mass and function. Int. J. Biochem. Cell Biol. 38 (2006) 157-163
10. Gombotz W.R., and Wee S.F. Protein release from alginate matrices. Adv. Drug Deliv. Rev. 31 (1998) 267-285
11. Hovgaard L., Jacobs H., Wilson D.E., and Kim S.W. Stabilization of insulin by alkylmaltosides. B. Oral absorption in vivo in rats. Int. J. Pharm. 132 (1996) 115-121
12. Ma Z., Yeoh H.H., and Lim L.-Y. Formulation pH modulates the interaction of insulin with chitosan nanoparticles. J. Pharm. Sci. 91 (2002) 1396-1404
13. Norris D.A., Puri N., and Sinko P.J. Effect of physical barriers and properties on the oral absorption of particulates. Adv. Drug Deliv. Rev. 34 (1998) 135-154
14. Patel N., Craddock B.L., Staniforth J.N., Tobyn M., and JWelham M. Spray-dried insulin particles retain biological activity in rapid in-vitro assay. J. Pharm. Pharmacol. 53 (2001) 1415-1418
15. Poncelet D., Lencki R., Beaulieu C., Halle J.P., Neufeld R.J., and Fournier A. Production of alginate beads by emulsification/internal gelation. I. Methodology. Appl. Microbiol. Biotechnol. 38 (1992) 39-45
16. Putney S.D. Encapsulation of proteins for improved delivery. Curr. Opin. Chem. Biol. 2 (1998) 548-552
17. Ramdas M., Dileep K.J., Anitha Y., Paul W., and Sharma C.P. Alginate encapsulated bioadhesive chitosan microspheres for intestinal drug delivery. J. Biomater. Appl. 13 (1999) 290-296
18. Reis C.P., Neufeld R.J., Ribeiro A.J., and Veiga F. Design of insulin-loaded alginate nanoparticles: influence of calcium ion on polymer gel matrix properties. Chem. Ind. Chem. Eng. Quart. 12 (2006) 47-52
19. Reis C.P., Ribeiro A.J., Neufeld R.J., and Veiga F. Alginate microparticles as novel carrier for oral insulin delivery. Biotechnol. Bioeng. 96 (2006) 1-13
20. Saez A., Guzman M., Molpeceres J., and Aberturas M.R. Freeze-drying of polycaprolactone and poly(d,l-lactic-glycolic) nanoparticles induce minor particle size changes affecting the oral pharmacokinetics of loaded drugs. Eur. J. Pharm. Biopharm. 50 (2000) 379-387
21. Vandenberg G.W., and Nouè J.D.L. Evaluation of protein release from chitosan-alginate microcapsules produced using external or internal gelation. J. Microencapsulation 18 (2001) 433-441