N -Trimethyl Chitosan Chloride-Coated PLGA Nanoparticles Overcoming Multiple Barriers to Oral Insulin Absorption

ACS Applied Materials and Interfaces

Volumn 7, Issue 28, 2015, Pages 15430-15441

  Sheng, Jianyong ^a   Han, Limei ^a   Qin, Jing ^a   Ru, Ge ^a   Li, Ruixiang ^a   Wu, Lihong ^b   Cui, Dongqi ^b   Yang, Pei ^a   He, Yuwei ^a   Wang, Jianxin ^a  

^a FUDAN UNIVERSITY   (China)

^b HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

absorption barriers; insulin; mucus; N trimethyl chitosan chloride; nanoparticles; oral delivery; tight junctions

Indexed keywords

BIOCHEMISTRY; BODY FLUIDS; CELLS; CHITIN; CHITOSAN; EMULSIFICATION; ENCAPSULATION; LIVING SYSTEMS STUDIES; MOLECULAR BIOLOGY; NANOPARTICLES;

DOUBLE EMULSION-SOLVENT EVAPORATION; ENCAPSULATION EFFICIENCY; MACROMOLECULAR THERAPEUTICS; MUCOADHESIVE PROPERTIES; MUCUS; N-TRIMETHYL CHITOSANS; ORAL DELIVERY; TIGHT JUNCTIONS;

INSULIN;

CHITOSAN; DRUG CARRIER; INSULIN; LACTIC ACID; N-TRIMETHYL CHITOSAN CHLORIDE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL; CHEMISTRY; DEVICES; DIABETES MELLITUS, EXPERIMENTAL; DRUG DELIVERY SYSTEM; HUMAN; MALE; MOUSE; ORAL DRUG ADMINISTRATION; PROCEDURES; RAT; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; CHITOSAN; DIABETES MELLITUS, EXPERIMENTAL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; INSULIN; LACTIC ACID; MALE; MICE; POLYGLYCOLIC ACID; RATS; RATS, WISTAR;

EID: 84937678107     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.5b03555     Document Type: Article

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