Overcoming the diffusion barrier of mucus and absorption barrier of epithelium by self-Assembled nanoparticles for oral delivery of insulin

ACS Nano

Volumn 9, Issue 3, 2015, Pages 2345-2356

  Shan, Wei ^a   Zhu, Xi ^a   Liu, Min ^a   Li, Lian ^a   Zhong, Jiaju ^a   Sun, Wei ^a   Zhang, Zhirong ^a   Huang, Yuan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

cell penetrating peptide; epithelium; insulin; mucus; nanoparticles; oral delivery

Indexed keywords

BIOCHEMISTRY; CELLS; COATINGS; CONTROLLED DRUG DELIVERY; CYTOLOGY; DIFFUSION BARRIERS; HYDROPHILICITY; INSULIN; NANOPARTICLES; PEPTIDES;

CELL-PENETRATING PEPTIDE; ENDOPLASMIC RETICULUM; EPITHELIUM; MUCUS; ORAL BIOAVAILABILITIES; ORAL DELIVERY; SELF ASSEMBLED NANOPARTICLES; TRANSEPITHELIAL TRANSPORT;

TARGETED DRUG DELIVERY;

ANTIDIABETIC AGENT; CELL PENETRATING PEPTIDE; DRUG CARRIER; INSULIN; NANOPARTICLE; POLYMETHACRYLIC ACID DERIVATIVE; POLY[N (2 HYDROXYPROPYL)METHACRYLAMIDE];

ABSORPTION; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL PHENOMENA; CHEMISTRY; DIFFUSION; EPITHELIUM; HT 29 CELL LINE; HUMAN; INTRACELLULAR SPACE; MALE; METABOLISM; MOLECULAR GENETICS; MOUTH MUCOSA; ORAL DRUG ADMINISTRATION; PERMEABILITY; RAT; SPRAGUE DAWLEY RAT; SYNTHESIS; TRANSPORT AT THE CELLULAR LEVEL;

ABSORPTION, PHYSICOCHEMICAL; ADMINISTRATION, ORAL; AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL TRANSPORT; CELL-PENETRATING PEPTIDES; DIFFUSION; DRUG CARRIERS; EPITHELIUM; HT29 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYPOGLYCEMIC AGENTS; INSULIN; INTRACELLULAR SPACE; MALE; MOLECULAR SEQUENCE DATA; MOUTH MUCOSA; NANOPARTICLES; PERMEABILITY; POLYMETHACRYLIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84925679329     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/acsnano.5b00028     Document Type: Article

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