Cellular interactions of therapeutically delivered nanoparticles

Expert Opinion on Drug Delivery

Volumn 8, Issue 2, 2011, Pages 141-151

  Kumari, Avnesh ^a   Yadav, Sudesh Kumar ^a  

^a CSIR INSTITUTE OF HIMALAYAN BIORESOURCE TECHNOLOGY   (India)

Author keywords

cellular interaction; cellular uptake; endocytosis; nanoparticles; targeting

Indexed keywords

2 METHACRYLOYOXYETHYL PHOSPHORYLCHOLINE; CHITOSAN; DOXORUBICIN; FOLIC ACID; GOLD NANOPARTICLE; MACROGOL; MONOCLONAL ANTIBODY; NANOPARTICLE; PACLITAXEL; PHOSPHORYLCHOLINE; POLYAMIDOAMINE; POLYCAPROLACTONE; POLYETHYLENEIMINE; POLYGLACTIN; POLYLACTIC ACID; POLYLYSINE; POLYVINYL ALCOHOL; TAMOXIFEN; UNCLASSIFIED DRUG; WHEAT GERM AGGLUTININ;

CELL INTERACTION; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; HUMAN; LIPID BILAYER; NONHUMAN; PHAGOCYTOSIS; PINOCYTOSIS; REVIEW;

ANIMALS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; DRUG CARRIERS; ENDOCYTOSIS; HUMANS; NANOPARTICLES; PHYSICOCHEMICAL PHENOMENA; SURFACE PROPERTIES;

EID: 79251503013     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425247.2011.547934     Document Type: Review

References (114)

1. Kumari A, Yadav SK, Pakade YB, et al. Development of biodegradable nanoparticles for delivery of quercetin. Colloids Surf B Biointerfaces 2010;80:184-92
2. Hans M, Lowman A. Biodegradable nanoparticles for drug delivery and targeting. Curr Opin Solid State Mater Sci 2002;6:319-27
3. Moghimi SM, Hunter AC, Murray JC. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev 2001;53:283-318
4. Hughes G. Nanostructure-mediated drug delivery. Nanomedicine 2005;1:22-30
5. Arvizo RR, Miranda OR, Thompson MA, et al. Effect of nanoparticle surface charge at the plasma membrane and beyond. Nano Lett 2010;10:2543-8
6. Sinha R, Kim GJ, Nie S, Shin DM. Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery. Mol Cancer Ther 2006;5:1909-17
7. Zeng F, Lee H and Allen C. Epidermal growth factor-conjugated poly(ethylene glycol)-block-poly(delta-valerolactone) copolymer micelles for targeted delivery of chemotherapeutics. Bioconjug Chem 2006;17:399-409
8. Sonvico F, Mornet S, Vasseur S, et al. Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: synthesis, physicochemical characterization, and in vitro experiments. Bioconjug Chem 2005;16:1181-8
9. Piletska EV, Piletsky SA. Size matters: influence of the size of nanoparticles on their interactions with ligands immobilized on the solid surface. Langmuir 2010;26:3783-5
10. Nel A, Xia T, Madler L, Li N. Toxic potential of materials at the nanolevel. Science 2006;311:622-7
11. Oberdorster G, Oberdorster E, Oberdorster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 2005;113:823-39
12. Kumari A, Yadav SK, Yadav SC. Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf B Biointerfaces 2010;75:1-18
13. Harivardhan Reddy L, Sharma RK, Chuttani K, et al. Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumor bearing mice. J Control Release 2005;105:185-98
14. Stella B, Arpicco S, Peracchia MT, et al. Design of folic acid-conjugated nanoparticles for drug targeting. J Pharm Sci 2000;89:1452-64
15. Cedervall T, Lynch I, Lindman S, et al. Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles. Proc Natl Acad Sci USA 2007;104:2050-5
16. Lindman S, Lynch I, Thulin E, et al. Systematic investigation of the thermodynamics of HSA adsorption to N-iso-propylacrylamide/N-tert- butylacrylamide copolymer nanoparticles. Effects of particle size and hydrophobicity. Nano Lett 2007;7:914-20
17. Jones AT, Gumbleton M, Duncan R. Understanding endocytic pathways and intracellular trafficking. A prerequisite for effective design of advanced drug delivery systems. Adv Drug Deliv Rev 2003;55:1353-7
18. Conner SD, Schmid SL. Regulated portals of entry into the cell. Nature 2003;422:37-44
19. Watson P, Jones AT, Stephens DJ. Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells. Adv Drug Deliv Rev 2005;57:43-61
20. Chang J, Jallouli Y, Kroubi M, et al. Characterization of endocytosis of transferrin-coated PLGA nanoparticles by the blood-brain barrier. Int J Pharm 2009;379:285-92
21. Jallouli Y, Paillard A, Chang J, et al. Influence of surface charge and inner composition of porous nanoparticles to cross blood-brain barrier in vitro. Int J Pharm 2007;344:103-9
22. Shukla R, Bansal V, Chaudhary M, et al. Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview. Langmuir 2005;21:10644-54
23. Xu P, Gullotti E, Tong L, et al. Intracellular drug delivery by poly(lactic-co-glycolic acid) nanoparticles, revisited. Mol Pharm 2009;6:190-201
24. Swanson JA, Watts C. Macropinocytosis. Trends Cell Biol 1995;5:424-8
25. Patel LN, Zaro JL, Shen WC. Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives. Pharm Res 2007;24:1977-92
26. Walsh M, Tangney M, O'Neill MJ, et al. Evaluation of cellular uptake and gene transfer efficiency of pegylated poly-L-lysine compacted DNA: implications for cancer gene therapy. Mol Pharm 2006;3:644-53
27. Bao G, Bao XR. Shedding light on the dynamics of endocytosis and viral budding. Proc Natl Acad Sci USA 2005;102:9997-8
28. Ehrlich M, Boll W, Van Oijen A, et al. Endocytosis by random initiation and stabilization of clathrin-coated pits. Cell 2004;118:591-605
29. Pelkmans L, Helenius A. Endocytosis via caveolae. Traffic 2002;3:311-20
30. Wang Z, Tiruppathi C, Minshall RD, Malik AB. Size and dynamics of caveolae studied using nanoparticles in living endothelial cells. ACS Nano 2009;3:4110-16
31. Van Effenterre D, Roux D. Adhesion of colloids on a cell surface in competition for mobile receptors. Europhys Lett 2003;64:543-9
32. Tzlil S, Deserno M, Gelbart WM, Ben-Shaul A. A statistical-thermodynamic model of viral budding. Biophys J 2004;86:2037-48
33. Zhang S, Li J, Lykotrafitis G, et al. Size-dependent endocytosis of Nanoparticles. Adv Mater Deerfield 2009;21:419-24
34. Aoyama Y, Kanamori T, Nakai T, et al. Artificial viruses and their application to gene delivery. Size-controlled gene coating with glycocluster nanoparticles. J Am Chem Soc 2003;125:3455-7
35. Gao H, Shi W, Freund LB. Mechanics of receptor-mediated endocytosis. Proc Natl Acad Sci USA 2005;102:9469-74
36. Decuzzi P, Ferrari M. The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticles. Biomaterials 2007;28:2915-22
37. Harush-Frenkel O, Debotton N, Benita S, Altschuler Y. Targeting of nanoparticles to the clathrin-mediated endocytic pathway. Biochem Biophys Res Commun 2007;353:26-32
38. Nativo P, Prior IA, Brust M. Uptake and intracellular fate of surface-modified gold nanoparticles. ACS Nano 2008;2:1639-44
39. Gou M, Zheng X, Men K, et al. Poly (epsilon-caprolactone)/poly(ethylene glycol)/poly(epsilon-caprolactone) nanoparticles: preparation, characterization, and application in doxorubicin delivery. J Phys Chem B 2009;113:12928-33
40. Hong S, Bielinska AU, Mecke A, et al. Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport. Bioconjug Chem 2004;15:774-82
41. Kirchner C, Liedl T, Kudera S, et al. Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. Nano Lett 2005;5:331-8
42. Roiter Y, Ornatska M, Rammohan AR, et al. Interaction of nanoparticles with lipid membrane. Nano Lett 2008;8:941-4
43. Nam HY, Kwon SM, Chung H, et al. Cellular uptake mechanism and intracellular fate of hydrophobically modified glycol chitosan nanoparticles. J Control Release 2009;135:259-67
44. Luhmann T, Rimann M, Bittermann AG, Hall H. Cellular uptake and intracellular pathways of PLL-g-PEG-DNA nanoparticles. Bioconjug Chem 2008;19:1907-16
45. Harush-Frenkel O, Rozentur E, Benita S, Altschuler Y. Surface charge of nanoparticles determines their endocytic and transcytotic pathway in polarized MDCK cells. Biomacromolecules 2008;9:435-43
46. Chellat F, Grandjean-Laquerriere A, Le Naour R, et al. Metalloproteinase and cytokine production by THP-1 macrophages following exposure to chitosan-DNA nanoparticles. Biomaterials 2005;26:961-70
47. Niidome T, Yamagata M, Okamoto Y, et al. PEG-modified gold nanorods with a stealth character for in vivo applications. J Control Release 2006;114:343-7
48. Desai MP, Labhasetwar V, Walter E, et al. The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. Pharm Res 1997;14:1568-73
49. Zauner W, Farrow NA, Haines AM. In vitro uptake of polystyrene microspheres: effect of particle size, cell line and cell density. J Control Release 2001;71:39-51
50. Chithrani BD, Chan WC Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. Nano Lett 2007;7:1542-50
51. Chithrani BD, Ghazani AA, Chan WC Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett 2006;6:662-8
52. Yoo JW, Doshi N, Mitragotri S. Endocytosis and intracellular distribution of PLGA particles in endothelial cells: effect of particle geometry. Macro Rapid Commun 2010;31:142-8
53. Muro S, Garnacho C, Champion JA, et al. Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers. Mol Ther 2008;16:1450-8
54. Gratton SE, Ropp PA, Pohlhaus PD, et al. The effect of particle design on cellular internalization pathways. Proc Natl Acad Sci USA 2008;105:11613-18
55. De Jong WH, Borm PJ. Drug delivery and nanoparticles:applications and hazards. Int J Nanomedicine 2008;3:133-49
56. Tobio M, Sanchez A, Vila A, et al. The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration. Colloids Surf B Biointerfaces 2000;18:315-23
57. Needham D, McIntosh TJ, Lasic DD. Repulsive interactions and mechanical stability of polymer-grafted lipid membranes. Biochim Biophys Acta 1992;1108:40-8
58. Kim SY, Lee YM. Taxol-loaded block copolymer nanospheres composed of methoxy poly(ethylene glycol) and poly (epsilon-caprolactone) as novel anticancer drug carriers. Biomaterials 2001;22:1697-704
59. Calvo P, Gouritin B, Brigger I, et al. PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases. J Neurosci Methods 2001;111:151-5
60. Hobbs SK, Monsky WL, Yuan F, et al. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc Natl Acad Sci USA 1998;95:4607-12
61. Maeda H. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv Enzyme Regul 2001;41:189-207
62. Shenoy D, Little S, Langer R, Amiji M. Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 2. In vivo distribution and tumor localization studies. Pharm Res 2005;22:2107-14
63. Dinauer N, Balthasar S, Weber C, et al. Selective targeting of antibody-conjugated nanoparticles to leukemic cells and primary T-lymphocytes. Biomaterials 2005;26:5898-906
64. Sapra P, Allen TM. Ligand-targeted liposomal anticancer drugs. Prog Lipid Res 2003;42:439-62
65. Kocbek P, Obermajer N, Cegnar M, et al. Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody. J Control Release 2007;120:18-26
66. Souza GR, Christianson DR, Staquicini FI, et al. Networks of gold nanoparticles and bacteriophage as biological sensors and cell-targeting agents. Proc Natl Acad Sci USA 2006;103:1215-20
67. Pissuwan D, Valenzuela SM, Miller CM, Cortie MB. A golden bullet? Selective targeting of Toxoplasma gondii tachyzoites using antibody- functionalized gold nanorods. Nano Lett 2007;7:3808-12
68. Hosta-Rigau L, Olmedo I, Arbiol J, et al. Multifunctionalized gold nanoparticles with peptides targeted to gastrin-releasing peptide receptor of a tumor cell line. Bioconjug Chem 2010;21(6):1070-8
69. Wunderbaldinger P, Josephson L, Weissleder R Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles. Bioconjug Chem 2002;13:264-8
70. De la Fuente JM, Berry CC Tat peptide as an efficient molecule to translocate gold nanoparticles into the cell nucleus. Bioconjug Chem 2005;16:1176-80
71. Moody TW, Carney DN, Cuttitta F, et al. High affinity receptors for bombesin/GRP-like peptides on human small cell lung cancer. Life Sci 1985;37:105-13
72. Moody TW, Mahmoud S, Staley J, et al. Human glioblastoma cell lines have neuropeptide receptors for bombesin/gastrin-releasing peptide. J Mol Neurosci 1989;1:235-42
73. Qin Y, Ertl T, Cai RZ, et al. Inhibitory effect of bombesin receptor antagonist RC-3095 on the growth of human pancreatic cancer cells in vivo and in vitro. Cancer Res 1994;54: 1035-41
74. Yano T, Pinski J, Groot K, Schally AV. Stimulation by bombesin and inhibition by bombesin/gastrin-releasing peptide antagonist RC-3095 of growth of human breast cancer cell lines. Cancer Res 1992;52:4545-7
75. Jabbari E. Targeted delivery with peptidomimetic conjugated self-assembled nanoparticles. Pharm Res 2009;26:612-30
76. Chawla JS, Amiji MM. Cellular uptake and concentrations of tamoxifen upon administration in poly(caprolactone) nanoparticles. AAPS PharmSci 2003;5:1-7
77. Dreaden EC, Mwakwari SC, Sodji QH, et al. Tamoxifen-poly(ethylene glycol)-thiol gold nanoparticle conjugates: enhanced potency and selective delivery for breast cancer treatment. Bioconjug Chem 2009;20:2247-53
78. Yang PH, Sun X, Chiu JF, et al. Transferrin-mediated gold nanoparticle cellular uptake. Bioconjug Chem 2005;16:494-6
79. Weitman SD, Lark RH, Coney LR, et al. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Cancer Res 1992;52:3396-401
80. Dixit V, Van den Bossche J, Sherman DM, et al. Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells. Bioconjug Chem 2006;17:603-9
81. Parker N, Turk MJ, Westrick E, et al. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal Biochem 2005;338:284-93
82. Leamon CP, Low PS. Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis. Proc Natl Acad Sci USA 1991;88:5572-6
83. Rosenholm JM, Meinander A, Peuhu E, et al. Targeting of porous hybrid silica nanoparticles to cancer cells. ACS Nano 2009;3:197-206
84. Park EK, Kim SY, Lee SB, Lee YM. Folate-conjugated methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) amphiphilic block copolymeric micelles for tumor-targeted drug delivery. J Control Release 2005;109:158-68
85. Park EK, Lee SB, Lee YM. Preparation and characterization of methoxy poly (ethylene glycol)/poly(epsilon-caprolactone) amphiphilic block copolymeric nanospheres for tumor-specific folate-mediated targeting of anticancer drugs. Biomaterials 2005;26:1053-61
86. Oyewumi MO, Yokel RA, Jay M, et al. Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice. J Control Release 2004;95:613-26
87. Gans P, Hamelin O, Sounier R, et al. Stereospecific isotopic labeling of methyl groups for NMR spectroscopic studies of high-molecular-weight proteins. Angew Chem Int Ed Engl 2010;49:1958-62
88. Kamaly N, Kalber T, Thanou M, et al. Folate receptor targeted bimodal liposomes for tumor magnetic resonance imaging. Bioconjug Chem 2009;20:648-55
89. Yang SJ, Lin FH, Tsai KC, et al. Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells. Bioconjug Chem 2010;21:679-89
90. Mo Y, Lim LY. Preparation and in vitro anticancer activity of wheat germ agglutinin (WGA)-conjugated PLGA nanoparticles loaded with paclitaxel and isopropyl myristate. J Control Release 2005;107:30-42
91. Iwasaki Y, Maie H, Akiyoshi K. Cell-specific delivery of polymeric nanoparticles to carbohydrate-tagging cells. Biomacromolecules 2007;8:3162-8
92. Nordstrom JL. Plasmid-based gene transfer and antiprogestin-controllable transgene expression. Ernst Schering Res Found Workshop 2003;43:225-44
93. Verma A, Stellacci F. Effect of surface properties on nanoparticle-cell interactions. Small 2010;6:12-21
94. Cho EC, Xie J, Wurm PA, Xia Y. Understanding the role of surface charges in cellular adsorption versus internalization by selectively removing gold nanoparticles on the cell surface with a I2/KI etchant. Nano Lett 2009;9:1080-4
95. Villanueva A, Canete M, Roca AG, et al. The influence of surface functionalization on the enhanced internalization of magnetic nanoparticles in cancer cells. Nanotechnology 2009;20:1-10
96. Javier AM, Kreft O, Alberola AP, et al. Combined atomic force microscopy and optical microscopy measurements as a method to investigate particle uptake by cells. Small 2006;2:394-400
97. Lockman PR, Koziara J, Roder KE, et al. In vivo and in vitro assessment of baseline blood-brain barrier parameters in the presence of novel nanoparticles. Pharm Res 2003;20:705-13
98. Zhu ZJ, Ghosh PS, Miranda OR, et al. Multiplexed screening of cellular uptake of gold nanoparticles using laser desorption/ionization mass spectrometry. J Am Chem Soc 2008;130:14139-43
99. Xia T, Kovochich M, Liong M, et al. Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. ACS Nano 2009;3:3273-86
100. Lin J, Zhang H, Chen Z, Zheng Y. Penetration of lipid membranes by gold nanoparticles: Insights into cellular uptake, cytotoxicity, and their relationship. ACS Nano 2010;4(9):5421-9
101. Dobrovolskaia MA, Aggarwal P, Hall JB, McNeil SE. Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution. Mol Pharm 2008;5:487-95
102. Bosi S, Feruglio L, Da Ros T, et al. Hemolytic effects of water-soluble fullerene derivatives. J Med Chem 2004;47:6711-15
103. Kim D, El-Shall H, Dennis D, Morey T. Interaction of PLGA nanoparticles with human blood constituents. Colloids Surf B Biointerfaces 2005;40:83-91
104. Koziara JM, Oh JJ, Akers WS, et al. Blood compatibility of cetyl alcohol/polysorbate-based nanoparticles. Pharm Res 2005;22:1821-8
105. Bartlett DW, Davis ME. Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles. Bioconjug Chem 2007;18:456-68
106. Nagayama S, Ogawara K, Fukuoka Y, et al. Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristics. Int J Pharm 2007;342:215-21
107. Paillard A, Passirani C, Saulnier P, et al. Positively-charged, porous, polysaccharide nanoparticles loaded with anionic molecules behave as 'stealth' cationic nanocarriers. Pharm Res 2010;27:126-33
108. Han JH, Oh YK, Kim DS, Kim CK. Enhanced hepatocyte uptake and liver targeting of methotrexate using galactosylated albumin as a carrier. Int J Pharm 1999;188:39-47
109. Murphy EA, Majeti BK, Barnes LA, et al. Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis. Proc Natl Acad Sci USA 2008;105:9343-8
110. Berry CC, Charles S, Wells S, et al. The influence of transferrin stabilised magnetic nanoparticles on human dermal fibroblasts in culture. Int J Pharm 2004;269:211-25
111. Brunner TJ, Wick P, Manser P, et al. In vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effect of particle solubility. Environ Sci Technol 2006;40:4374-81
112. Fortner JD, Lyon DY, Sayes CM, et al. C60 in water: nanocrystal formation and microbial response. Environ Sci Technol 2005;39:4307-16
113. Lin W, Huang YW, Zhou XD, Ma Y. Toxicity of cerium oxide nanoparticles in human lung cancer cells. Int J Toxicol 2006;25:451-7
114. Tabata Y, Murakami Y, Ikada Y. Antitumor effect of poly(ethylene glycol)-modified fullerene. Fullerenes, Nanotubes and Carbon Nanostructures 1997;5(5):989-1007