Oral delivery of proteins by biodegradable nanoparticles

Advanced Drug Delivery Reviews

Volumn 65, Issue 6, 2013, Pages 811-821

  Bakhru, Sasha H ^a   Furtado, Stacia ^a   Morello, A Peter ^a   Mathiowitz, Edith ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Biodegradable polymer; Nanoparticles; Oral protein delivery; Uptake

Indexed keywords

ACIDIC ENVIRONMENT; BIODEGRADABLE NANOPARTICLE; GASTROINTESTINAL TRACT; INTESTINAL MUCOSA; MATERIAL SYSTEMS; ORAL PROTEIN DELIVERY; THERAPEUTIC PROTEIN; UPTAKE;

BIOCHEMISTRY; BIODEGRADABLE POLYMERS; DRUG DELIVERY; DRUG PRODUCTS; NANOPARTICLES;

PROTEINS;

CHITOSAN; DEOXYCHOLATE SODIUM; EDETIC ACID; ETOPOSIDE; EUDRAGIT RS; FUMARIC ACID; GLYCOCHOLATE SODIUM; IMMUNOGLOBULIN A; INSULIN; LECTIN; MACROGOL; MICROSPHERE; NANOPARTICLE; OCTANOIC ACID; PHOSPHATIDYLCHOLINE; POLY(FUMARIC CO SEBACIC)ANHYDRIDE; POLY(GAMMA GLUTAMIC ACID); POLYANHYDRIDE; POLYCAPROLACTONE; POLYGLACTIN; POLYGLUTAMIC ACID; POLYMER; POLYMETHACRYLIC ACID; POLYSTYRENE; PROTEIN; SEBACIC ACID; UNCLASSIFIED DRUG;

ADHESION; ANATOMICAL VARIATION; AREA UNDER THE CURVE; DIABETES MELLITUS; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; ENCAPSULATION; GLUCOSE BLOOD LEVEL; INTESTINE ABSORPTION; NONHUMAN; ORAL DRUG ADMINISTRATION; PARACELLULAR TRANSPORT; PARTICLE SIZE; PHAGOCYTOSIS; PRIORITY JOURNAL; REVIEW; SMALL INTESTINE; TRANSCYTOSIS; TRANSPORT AT THE CELLULAR LEVEL; TRANSPORT KINETICS;

ADMINISTRATION, ORAL; BIOLOGICAL AVAILABILITY; DRUG CARRIERS; GASTROINTESTINAL TRACT; HUMANS; INSULIN; INTESTINAL ABSORPTION; NANOPARTICLES; PHARMACEUTICAL PREPARATIONS; POLYMERS; PROTEINS; TRANSCYTOSIS;

EID: 84878839445     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2013.04.006     Document Type: Review

References (126)

1. Atuma C., Strugala V., Allen A., Holm L. The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. Am. J. Physiol. Gastrointest. Liver Physiol. 2001, 280:G922-G929.
2. Ponchel G., Touchard F., Duchêne D., Peppas A. Bioadhesive analysis of controlled-release systems. I. Fracture and interpenetration analysis in poly(acrylic acid)-containing systems. J. Control. Release 1987, 5:129-141.
3. Mathiowitz E., Jacob J.S., Jong Y.S., Carino G.P., Chickering D.E., Chaturverdi P., Santos C.A., Vijayaraghavan K., Montgomery S., Bassett M., Morrell C. Biologically erodible microspheres as potential oral drug delivery systems. Nature 1997, 386:410-414.
4. Langer R. Polymers for the sustained release of macromolecules: their use in a single-step method of immunization. Methods Enzymol. 1981, 73:57-75.
5. Horowitz M.I., Pigman W. The Glycoconjugates 1977, 560. Academic Press, Inc., New York.
6. Horowitz M.I. Mucopolysaccharides and glycoproteins of the alimentary tract. Alimentary Canal 1967, 1063-1085. American Physiological Society, Washington. C.F. Code (Ed.).
7. Labat-Robert J., Decaeus C. Glycoproteins du Mucus Gastrique: Structure, Fonction, et Pathologie. Pathol. Biol. (Paris) 1979, 24:241.
8. Scawen M., Allen A. The action of proteolytic enzymes on the glycoprotein from pig gastric mucus. Biochem. J. 1977, 163:363-368.
9. Allen A., Hutton D.A., Pearson J.P., Sellers L.A. Mucus glycoprotein structure, gel formation and gastrointestinal mucus function. Mucus and Mucosa, Ciba Foundation Symposium 109, Pitman, London 1984, 137. J. Nugent, M. O'Connor (Eds.).
10. Payne J.M., Sansom B.F., Garner R.J., Thomson A.R., Miles B.J. Uptake of small resin particles (1-5microns diameter) by the alimentary canal of the calf. Nature 1960, 188:586-587.
11. Sanders E., Ashworth C.T. A study of particulate intestinal absorption and hepatocellular uptake. Exp. Cell Res. 1961, 22:137-145.
12. Volkheimer G., Schulz F.H. The phenomenon of persorption. Digestion 1968, 1:213-218.
13. Volkheimer G., Schulz F., Hofmann I., Pieser J., Rack O., Reichelt G., Rothenbaecher W., Schmelich G., Schurig B., Teicher G., Weiss B. The effect of drugs on the rate of persorption. Pharmacology 1968, 1:8-14.
14. Volkheimer G. Passage of particles through the wall of the gastrointestinal tract. Environ. Health Perspect. 1974, 9:215-225.
15. Volkheimer G. Hematogenous dissemination of ingested polyvinyl chloride particles. Ann. N. Y. Acad. Sci. 1975, 246:164-171.
16. Florence A., Hillery A.M., Hussain N., Jani P.U. Nanoparticles as carriers for oral peptide absorption: studies on particle uptake and fate. J. Control. Release 1995, 36:39-46.
17. McClean S., Prosser E., Meehan E., O'Malley D., Clarke N., Ramtoola Z., Brayden D. Binding and uptake of biodegradable poly-dl-lactide micro- and nanoparticles in intestinal epithelia. Eur. J. Pharm. Sci. 1998, 6:153-163.
18. Desai M.P., Labhasetwar, Amidon G.L., Levy R.J. Gastrointestinal uptake of biodegradable microspheres: effect of particle size. Pharm. Res. 1996, 13:1838-1845.
19. Carr K., Hazzard R.A., Reid S., Hodges G.M. The effect of size on uptake of orally administered latex microparticles in the small intestine and transport to mesenteric lymph nodes. Pharm. Res. 1996, 13:1205-1209.
20. Damgé C., Aprahamian M., Marchais H., Benoit J.P., Pinget M. Intestinal absorption of PLAGA microspheres in rat. J. Anat. 1996, 189:491-501.
21. Jani P., Halbert W., Langridge J., Florence A.T. The uptake and translocation of latex nanospheres and microspheres after oral administration to rats. J. Pharm. Pharmacol. 1989, 41:809-812.
22. Jenkins P., Howard K.A., Blackball N.W., Thomas N.W., Davis S.S., O'Hagan D.T. Microparticulate absorption from the rat intestine. J. Control. Release 1994, 29:339-350.
23. Jani P., Halbert W., Langridge J., Florence A.T. Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J. Pharm. Pharmacol. 1990, 42:821-826.
24. Wells C.L., Maddaus M.A., Erlandsen S.L., Simmons R.L. Evidence for the phagocytic transport of intestinal particles in dogs and rats. Infect. Immun. 1988, 56:278-282.
25. Sass W., Dreyer H.P., Seifert J. Rapid insorption of small particles in the gut. Am. J. Gastroenterol. 1990, 85:255-260.
26. Jepson M., Simmons N.L., O'Hagan D.T., Birst B.H. Comparison of poly(dl-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells. J. Drug Target. 1993, 1:245-249.
27. Behrens I., Pena A.I.V., Alonso M.J., Kissel T. Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport. Pharm. Res. 2002, 19:1185-1193.
28. Frey A., Giannasca K.T., Weltzin R., Giannasca P.J., Reggio H., Lencer W.I., Neutra M.R. Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting. J. Exp. Med. 1996, 184:1045-1059.
29. Pappo J., Ermak T.H., Steger H.J. Monoclonal antibody-directed targeting of fluorescent polystyrene microspheres to Peyer's patch M cells. Immunology 1991, 73:277-280.
30. Eldridge J., Hammond C.J., Meulbroek J.A., Staas J.K., Gilley R.M., Tice T.R. Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the Peyer's patches. J. Control. Release 1990, 11:205-214.
31. Jepson M., Clark M.A., Foster N., Mason C.M., Bennett M.K., Simmons N.L., Hirst B.H. Targeting to intestinal M cells. J. Anat. 1996, 189:507-516.
32. Hodges G., Carr E.A., Hazzard R.A., Carr K.E. Uptake and translocation of microparticles in small intestine. Dig. Dis. Sci. 1995, 40:967-975.
33. Araujo L., Sheppard M., Lobenberg R., Kreuter J. Uptake of PMMA nanoparticles from the gastrointestinal tract after oral administration to rats: modification of the body distribution after suspension in surfactant solutions and in oil vehicles. Int. J. Pharm. 1999, 176:209.
34. Hazzard R.A., Hodges G.M., Scott J.D., McGuinness C.B., Carr K.E. Early intestinal microparticle uptake in rats. J. Anat. 1996, 189:265-271.
35. Beier R., Gebert A. Kinetics of particle uptake in the domes of Peyer's patches. Am. J. Physiol. 1998, 275:G130-G137.
36. Pappo J., Ermak T.H. Uptake and translocation of fluorescent latex particles by rabbit Peyer's patch follicle epithelium: a quantitative model for M cell uptake. Clin. Exp. Immunol. 1989, 76:144.
37. Ebel J. A method for quantifying particle absorption from the small intestine of the mouse. Pharm. Res. 1990, 7:848-851.
38. McMinn L.H., Hodges G.M., Carr K.E. Gastrointestinal uptake and translocation of microparticles in the streptozotocin-diabetic rat. J. Anat. 1996, 189:553-559.
39. Simon L., Warren I., Dayan A.D. Effect of solid and liquid diet on uptake of large particulates across intestinal epithelium in rats. Dig. Dis. Sci. 1997, 42:1519-1523.
40. Simon L., Shine G., Dayan A.D. Effect of animal age on the uptake of large particulates across the epithelium of the rat small intestine. Int. J. Exp. Pathol. 1994, 75:369-373.
41. LeFevre M., Boccio A.M., Joel D.D. Intestinal uptake of fluorescent microspheres in young and aged mice. Proc. Soc. Exp. Biol. Med. 1989, 190:23-27.
42. Kotkoskie L.A., Butt M.T., Selinger E., Freeman C., Weiner M.L. Qualitative investigation of uptake of fine particle size microcrystalline cellulose following oral administration in rats. J. Anat. 1996, 189:531-535.
43. LeFevre M., Joel D.D., Schidlovsky G. Retention of ingested latex particles in Peyer's patches of germfree and conventional mice. Proc. Soc. Exp. Biol. Med. 1985, 179:522-528.
44. Alpar H.O., Field W.N., Hyde R., Lewis D.A. The transport of microspheres from the gastro-intestinal tract to inflammatory air pouches in the rat. J. Pharm. Pharmacol. 1989, 41:194-196.
45. Davda J., Labhasetwar V. Characterization of nanoparticle uptake by endothelial cells. Int. J. Pharm. 2002, 233:51-59.
46. Mooren F., Berthold A., Domschke W., Kreuter J. Influence of chitosan microspheres on the transport of prednisone sodium phosphate across HT-29 cell monolayers. Pharm. Res. 1998, 15:58-65.
47. Desai M., Labhasetwar V., Walter E., Levy R.J., Amidon G.L. The mechanism of uptake of biodegradable microspheres in Caco-2 cells is size dependent. Pharm. Res. 1997, 14:1568-1573.
48. Eyles J., Alpar H.O., Field W.N., Lewis D.A., Keswick M. The transfer of polystyrene microspheres from the gastrointestinal tract to the circulation after oral administration in the rat. J. Pharm. Pharmacol. 1995, 47:561-565.
49. Simon L., Shine G., Dayan A.D. Translocation of particulates across the gut wall-a quantitative approach. J. Drug Target. 1995, 3:217-219.
50. Mladenovska K., Janevik I.E., Glavas D.M., Kumbaradzi F.E., Goracinova K. Biodistribution studies of BSA loaded gelatin microspheres after peroral administration. Int. J. Pharm. 2002, 242:251-253.
51. Li X., Zhang Y., Yan R., Zhang M., Yuan M., Deng X., Huang Z. Body distribution of poly-d-lactide-poly(ethylene glycol) microspheres with entrapped leptospira interrogans antigens following intravenous and oral administration to guinea-pigs. J. Pharm. Pharmacol. 2000, 52:763-770. (768).
52. Florence A., Hillery A.M., Hussain N., Jani P.U. The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual. Pharm. Res. 1997, 14:259-266.
53. O'Hagan D.T. The intestinal uptake of particles and the implications for drug and antigen delivery. J. Anat. 1996, 189(Pt 3):477-482.
54. Thomas N.W., Jenkins P.G., Howard K.A., Smith M.W., Lavelle E.C., Holland J., Davis S.S. Particle uptake and translocation across epithelial membranes. J. Anat. 1996, 189(Pt 3):487-490.
55. Gebert A., Fassbender S., Werner K., Weissferdt A. The development of M cells in Peyer's patches is restricted to specialized dome-associated crypts. Am. J. Pathol. 1999, 154:1573-1582.
56. Clark M.A., Jepson M.A., Simmons N.L., Booth T.A., Hirst B.H. Differential expression of lectin-binding sites defines mouse intestinal M-cells. J. Histochem. Cytochem. 1993, 41:1679-1687.
57. Eldridge J., Staas J.K., Meulbroek J.A., Tice T.R., Gilley R.M. Biodegradable and biocompatible poly(dl-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies. Infect. Immun. 1991, 59:2978-2986.
58. Ermak T., Dougherty E.P., Bhagat H.R., Kabok Z., Pappo J. Uptake and transport of copolymer biodegradable microspheres by rabbit Peyer's patch M cells. Cell Tissue Res. 1995, 279:433-436.
59. LeFevre M., Olivo R., Vanderhoff J.W., Joel D.D. Accumulation of latex in Peyer's patches and its subsequent appearance in villi and mesenteric lymph nodes. Proc. Soc. Exp. Biol. Med. 1978, 159:298-302.
60. LeFevre M., Vanderhoff J.W., Laissue J.A., Joel D.D. Accumulation of 2-micron latex particles in mouse Peyer's patches during chronic latex feeding. Experientia 1978, 34:120-122.
61. Torche A.-M., Jouan H., Le Corre P., Albina E., Primault R., Jestin A., Le Verge R. Ex vivo and in situ PLGA microspheres uptake by pig ileal Peyer's patch segment. Int. J. Pharm. 2000, 201:15.
62. Eldridge J., Staas J.K., Meulbroek J.A., McGhee J.R., Tice T.R., Gilley R.M. Biodegradable microspheres as a vaccine delivery system. Med. Immunol. 1991, 28:287-294.
63. Alpar H., Field W.N., Hyde R., Lewis D.A. The transport of microspheres from the gastro-intestinal tract to inflammatory air pouches in the rat. J. Pharm. Pharmacol. 1989, 41:194-196.
64. Porta C., James P.S., Phillips A.D., Savidge T.C., Smith M.W., Cremaschi D. Confocal analysis of fluorescent bead uptake by mouse Peyer's patch follicle-associated M cells. Exp. Physiol. 1992, 77:929-932.
65. Seifert J., Haraszti B., Sass W. The influence of age and particle number on absorption of polystyrene particles from the rat gut. J. Anat. 1996, 189:483-486.
66. Hillery A.M., Jani P.U., Florence A.T. Comparative, quantitative study of lymphoid and non-lymphoid uptake of 60nm polystyrene particles. J. Drug Target. 1994, 2:151-156.
67. Madara J. Intestinal absorptive cell tight junctions are linked to cytoskeleton. Am. J. Physiol. 1987, 253:C171-C175.
68. Li Q., Dunn E.T., Grandmaison E.W., Goosen M.F.A. Applications and properties of chitosan. J. Bioact. Compat. Polym. 1992, 7:370-397.
69. Lacasse F.X., Filion M.C., Phillips N.C., Escher E., McMullen J.N., Hildgen P. Influence of surface properties at biodegradable microsphere surfaces: effects on plasma protein adsorption and phagocytosis. Pharm. Res. 1998, 15:312-317.
70. Peppas N.A., Buri P.A. Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissue. J. Control. Release 1985, 2:257-275.
71. Lenaerts V., Couvreur P., Grislain L., Maincent P. Nanoparticles as a gastroadhesive drug delivery system. Bioadhesive Drug Delivery Systems 1990, 93-104. CRC Press, Boca Raton, FL. V. Lenaerts, R. Gurny (Eds.).
72. Mikos A.G., Peppas N.A. Comparison of experimental technique for the measurement of the bioadhesive forces of polymeric materials with soft tissues (abstract). Proceedings of the 13th International Symposium on Controlled Release of Bioactive Materials 1986, 97. The Controlled Release Society, Inc.
73. Manly R.S. Adhesion in Biological Systems 1970, 302. Academic Press, New York.
74. Achar L., Peppas N.A. Preparation, characterization and mucoadhesive interactions of poly(methacrylic acid) copolymers with rat mucosa. J. Control. Release 1994, 31:271-276.
75. Peppas N.A. Hydrogels in Medicine and Pharmacy 1987, 195. CRC Press, Inc., Boca Raton, FL.
76. Peppas N.A., Ponchel G., Duchêne D. Bioadhesive analysis of controlled-release systems. II. Time-dependent bioadhesive stress in poly(acrylic acid)-containing systems. J. Control. Release 1987, 5:143-149.
77. Chickering D.E., Jacob J.S., Panol G., Mathiowitz E. Evaluation of bioadhesive forces between individual microspheres and intestinal mucosa (abstract). The Fourth World Biomaterials Congress, Berlin, FRG 1992.
78. Mathiowitz E., Chickering D.E., Jacob J.S. Mechanism study on the interaction of bioadhesive microspheres with intestinal mucosa (abstract). Surface in Biomaterials Symposium, Minneapolis, MN 1992.
79. Chickering D.E., Mathiowitz E. Bioadhesive microspheres: I. A novel electrobalance-based method to study adhesive interactions between individual microspheres and intestinal mucosa. J. Control. Release 1995, 34:251-261.
80. Chickering D.E., Jacob J.S., Mathiowitz E. Bioadhesive microspheres: II. Characterization and evaluation of bioadhesion involving hard, bioerodible polymers and soft tissue. React. Polym. 1995, 25:189-206.
81. Chickering D., Jacob J., Harris B., Morrell C., Mathiowitz E. Bioavailability of bioadhesive polyanhydride delivery systems (abstract). 22nd International Symposium on Controlled Release of Bioactive Materials 1995, The Controlled Release Society, Inc., Seattle, WA.
82. Santos C., Freedman B., Leach K., Press D., Scarpulla M., Mathiowitz E.x.J.o.C.R. Polytumaric-co-sebacic anhydride: a degradation study as evaluated by FTIR, DSC, GPC, and X-ray diffraction. J. Control. Release 1999, 60(1):11-22.
83. Carino G., Santos C., Chen C.J., Mathiowitz E. Radiographic study of intestinal transit times of various spray-dried polymer microspheres. Proceedings of the 22nd International Symposium on the Controlled Release of Bioactive Materials 1995, 314-315.
84. Carino G., Mathiowitz E. Oral insulin delivery. Adv. Drug Deliv. Rev. 1999, 35:2-3.
85. Carino G.P., Jacob J.S., Chen J., Santos C.A., Hertzog B.A., Mathiowitz E. Bioadhesive, bioerodible polymers for increased intestinal uptake. Bioadhesive Drug Delivery Systems: Fundamentals, Novel Approaches, and Development 1999, 459-474. Marcel Dekker, Inc., New York. E. Mathiowitz, I. Chickering, E. Donald, C.-M. Lehr (Eds.).
86. Chickering D., Santos C., Mathiowitz E. Adaption of a microbalance to measure bioadhesive properties of microspheres. Encyclopedia of Controlled Drug Delivery 1999, Jhon Willy. E. Mathiowitz (Ed.).
87. Mathiowitz E., Chickering D., Lehr C.-M.e. Bioadhesive Drug Delivery Systems Fundamentals, Novel Approaches & Development 1999, Marcel Dekker, Inc.
88. Mathiowitz E., Chickering D., Jacob J., Santos C. Bioadhesive drug delivery systems. Encyclopedia of Controlled Drug Delivery 1999, Jhon Willy. E. Mathiowitz (Ed.).
89. Uchiyama T., Sugiyama T., Quan Y.S., Kotani A., Okada N., Fujita T., Muranishi S., Yamamoto A. Enhanced permeability of insulin across the rat intestinal membrane by various absorption enhancers: their intestinal mucosal toxicity and absorption-enhancing mechanism of n-lauryl-beta-d-maltopyranoside. J. Pharm. Pharmacol. 1999, 51:1241-1250.
90. Agarwal V., Reddy I.K., Khan M.A. Polymethyacrylate based microparticulates of insulin for oral delivery: preparation and in vitro dissolution stability in the presence of enzyme inhibitors. Int. J. Pharm. 2001, 225:31-39.
91. Ma Z., Lim T.M., Lim L.Y. Pharmacological activity of peroral chitosan-insulin nanoparticles in diabetic rats. Int. J. Pharm. 2005, 293:271-280.
92. Toorisaka E., Hashida M., Kamiya N., Ono H., Kokazu Y., Goto M. An enteric-coated dry emulsion formulation for oral insulin delivery. J. Control. Release 2005, 107:91-96.
93. Katsuma M., Watanabe S., Kawai H., Takemura S., Sako K. Effects of absorption promoters on insulin absorption through colon-targeted delivery. Int. J. Pharm. 2006, 307:156-162. (Epub 2005 Nov 2009).
94. Morishita M., Goto T., Nakamura K., Lowman A.M., Takayama K., Peppas N.A. Novel oral insulin delivery systems based on complexation polymer hydrogels: single and multiple administration studies in type 1 and 2 diabetic rats. J. Control. Release 2006, 110:587-594. (Epub 2005 Dec 2002).
95. Zhang N., Ping Q., Huang G., Xu W., Cheng Y., Han X. Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin. Int. J. Pharm. 2006, 327:153-159. (Epub 2006 Jul 2021).
96. Damge C., Maincent P., Ubrich N. Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J. Control. Release 2007, 117:163-170. (Epub 2006 Oct 2025).
97. Sung H.W., Sonaje K., Liao Z.X., Hsu L.W., Chuang E.Y. pH-responsive nanoparticles shelled with chitosan for oral delivery of insulin: from mechanism to therapeutic applications. Acc. Chem. Res. 2012, 45:619-629. (Epub 202012 Jan 200211). 10.1021/ar200234q.
98. Lin Y.H., Mi F.L., Chen C.T., Chang W.C., Peng S.F., Liang H.F., Sung H.W. Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery. Biomacromolecules 2007, 8:146-152.
99. Chuang E.Y., Lin K.J., Su F.Y., Chen H.L., Maiti B., Ho Y.C., Yen T.C., Panda N., Sung H.W. Calcium depletion-mediated protease inhibition and apical-junctional-complex disassembly via an EGTA-conjugated carrier for oral insulin delivery. J. Control. Release 2012, 27:803-807.
100. Carino G.P., Jacob J.S., Mathiowitz E. Nanosphere based oral insulin delivery. J. Control. Release 2000, 65:261-269.
101. Mathiowitz E., Jacob J.S., Jong Y.S., Carino G.P., Chickering D.E., Chaturvedi P., Santos C.A., Vijayaraghavan K., Montgomery S., Bassett M., Morrell C. Biologically erodable microspheres as potential oral drug delivery systems. Nature 1997, 386:410-414.
102. Chickering D., Jacob J., Mathiowitz E. Poly(fumaric-co-sebacic) microspheres as oral drug delivery systems. Biotechnol. Bioeng. 1996, 52:96-101.
103. Thanos C., Yip K.P., Mathiowitz E. Intestinal uptake of polymeric microspheres in the rabbit studies with confocal microscopy. J. Bioact. Compat. Polym. 2004, 19:247-266.
104. Florence A.T., Hillery A.M., Hussain N., Jani P.U. Factors affecting the oral uptake and translocation of polystyrene nanoparticles: histological and analytical evidence. J. Drug Target. 1995, 3:65-70.
105. Carr K.E., Hazzard R.A., Reid S., Hodges G.M. The effect of size on uptake of orally administered latex microparticles in the small intestine and transport to mesenteric lymph nodes. Pharm. Res. 1996, 13:1205-1209.
106. Desai M.P., Labhasetwar V., Amidon G.L., Levy R.J. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm. Res. 1996, 13:1838-1845.
107. Furtado S., Abramson D., Burrill R., Olivier G., Gourd C., Bubbers E., Mathiowitz E. Oral delivery of insulin loaded poly(fumaric-co-sebacic) anhydride microspheres. Int. J. Pharm. 2008, 347:149-155. (Epub 2007 Jun 2030).
108. Furtado S., Abramson D., Simhkay L., Wobbekind D., Mathiowitz E. Subcutaneous delivery of insulin loaded poly(fumaric-co-sebacic anhydride) microspheres to type 1 diabetic rats. Eur. J. Pharm. Biopharm. 2006, 63:229-236. (Epub 2006 May 2006).
109. Danhier F., Ansorena E., Silva J.M., Coco R., Le Breton A., Preat V. PLGA-based nanoparticles: an overview of biomedical applications. J. Control. Release 2012, 161:505-522. (Epub 2012 Feb 2014).
110. Chen M.C., Sonaje K., Chen K.J., Sung H.W. A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery. Biomaterials 2011, 32:9826-9838. (Epub 2011 Sep 9817).
111. des Rieux A., Fievez V., Garinot M., Schneider Y.J., Preat V. Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J. Control. Release 2006, 116:1-27. (Epub 2006 Aug 2023).
112. Yamanaka Y.J., Leong K.W. Engineering strategies to enhance nanoparticle-mediated oral delivery. J. Biomater. Sci. Polym. Ed. 2008, 19:1549-1570.
113. Pan Y., Li Y.J., Zhao H.Y., Zheng J.M., Xu H., Wei G., Hao J.S., Cui F.D. Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int. J. Pharm. 2002, 249:139-147.
114. Cui F., Shi K., Zhang L., Tao A., Kawashima Y. Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: preparation, in vitro characterization and in vivo evaluation. J. Control. Release 2006, 114:242-250. (Epub 2006 May 2024).
115. Zhang T., Chen J., Zhang Y., Shen Q., Pan W. Characterization and evaluation of nanostructured lipid carrier as a vehicle for oral delivery of etoposide. Eur. J. Pharm. Sci. 2011, 43:174-179. (Epub 2011 Apr 2020).
116. Elgart A., Cherniakov I., Aldouby Y., Domb A.J., Hoffman A. Lipospheres and pro-nano lipospheres for delivery of poorly water soluble compounds. Chem. Phys. Lipids 2012, 165:438-453. (Epub 2012 Feb 2019).
117. Jain S., Rathi V.V., Jain A.K., Das M., Godugu C. Folate-decorated PLGA nanoparticles as a rationally designed vehicle for the oral delivery of insulin. Nanomedicine (Lond.) 2012, 7:1311-1337. (Epub 2012 May 1314).
118. Scherer D., Mooren F.C., Kinne R.K., Kreuter J. In vitro permeability of PBCA nanoparticles through porcine small intestine. J. Drug Target. 1993, 1:21-27.
119. Delie F. Evaluation of nano- and microparticle uptake by the gastrointestinal tract. Adv. Drug Deliv. Rev. 1998, 34:221-233.
120. 14C-poly(d, l-lactic acid) nanoparticles coated with human serum albumin or polyvinyl alcohol to guinea pigs. J. Drug Target. 1998, 6:293-307.
121. Jung T., Kamm W., Breitenbach A., Kaiserling E., Xiao J.X., Kissel T. Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake?. Eur. J. Pharm. Biopharm. 2000, 50:147-160.
122. Soppimath K.S., Aminabhavi T.M., Kulkarni A.R., Rudzinski W.E. Biodegradable polymeric nanoparticles as drug delivery devices. J. Control. Release 2001, 70:1-20.
123. Jani P., Florence A., Mccarthy D. Further histological evidence of the gastrointestinal absorption of polystyrene nanospheres in the rat. International Journal of Pharmaceutics 1992, 84:245-252.
124. Kreuter J. Peroral administration of nanoparticles. Advanced Drug Delivery Reviews 1991, 7:71-86.
125. 14C]poly(-lactide-co¬glycolide) nanoparticles after intravenous and oral administration to mice. International Journal of Pharmaceutics 1994, 106:201-211.
126. Araujo L., Sheppard M., Lobenberg R., Kreuter J. Uptake of PMMA nanoparticles from the gastrointestinal tract after oral administration to rats: modifica¬tion of the body distribution after suspension in surfactant solutions and in oil vehicles. International Journal of Pharmaceutics 1999, 176(2):209.