Efficacy of mucoadhesive hydrogel microparticles of whey protein and alginate for oral insulin delivery

Pharmaceutical Research

Volumn 30, Issue 3, 2013, Pages 721-734

  Déat Lainé, Emmanuelle ^a   Hoffart, Valérie ^a   Garrait, Ghislain ^a   Jarrige, Jean François ^a   Cardot, Jean Michel ^a   Subirade, Muriel ^b   Beyssac, Eric ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

alginate; insulin; microspheres; oral administration; whey protein

Indexed keywords

ALGINIC ACID; BUFFER; DRUG CARRIER; GLUCOSE; HYDROGEL MICROPARTICLE; NEUTRAL INSULIN; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG; WHEY PROTEIN;

ADSORPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TRANSPORT; GELATION; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROENCAPSULATION; MUCOADHESION; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; RABBIT; RAT;

ADMINISTRATION, ORAL; ALGINATES; ANIMALS; DRUG CARRIERS; DUODENUM; GLUCURONIC ACID; HEXURONIC ACIDS; HYDROGEL; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MICROSPHERES; MILK PROTEINS; RABBITS; RATS; RATS, WISTAR; TISSUE ADHESIVES;

EID: 84878843752     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0913-3     Document Type: Article

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