Multiple site acetylation of rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein

Journal of Biological Chemistry

Volumn 287, Issue 1, 2012, Pages 581-588

  Glidden, Emily J ^a   Gray, Lisa G ^a   Vemuru, Suneil ^a   Li, Duo ^a   Harris, Thurl E ^a   Mayo, Marty W ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AKT ACTIVATION; AKT PHOSPHORYLATION; CRITICAL LINKS; GROWTH FACTOR; INSULIN-LIKE GROWTH FACTOR; KINASE ACTIVITY; MAMMALIAN TARGET; MULTI-SITE; NUTRIENT-SENSITIVE; POST-TRANSLATIONAL MODIFICATIONS; PROTEIN KINASE; STABILITY REGIONS; TARGET OF RAPAMYCIN;

ACTIVATION ANALYSIS; AMINO ACIDS; ANTIBIOTICS; ENZYMES; MAMMALS; PEPTIDES; PHOSPHORYLATION;

ACETYLATION;

MAMMALIAN LETHAL WITH SEC13 PROTEIN 8; MAMMALIAN STRESS ACTIVATED MAP KINASE INTERACTING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2 KINASE; MUTANT PROTEIN; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN P300; RAPAMYCIN INSENSITIVE COMPANION OF MAMMALIAN TARGET OF RAPAMYCIN; SIRTUIN; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SUBUNIT;

ACETYLATION; BINDING SITES; CARRIER PROTEINS; HEK293 CELLS; HELA CELLS; HUMANS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHORYLATION; PROTEIN STABILITY; PROTO-ONCOGENE PROTEINS C-AKT; SERINE; TRANSCRIPTION FACTORS; UP-REGULATION;

MAMMALIA;

EID: 84855282748     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.304337     Document Type: Article

References (30)

1. Clemmons, D. R. (2009) Role of IGF-I in skeletal muscle mass maintenance. Trends Endocrinol. Metab. 20, 349-356
2. Rosenzweig, S. A., and Atreya, H. S. (2010) Defining the pathway to insulin-like growth factor system targeting in cancer. Biochem. Pharmacol. 80, 1115-1124
3. Bondy, C. A., and Cheng, C. M. (2004) Signaling by insulin-like growth factor 1 in brain. Eur. J. Pharmacol. 490, 25-31 (Pubitemid 38482159)
4. Zhang, D., Bar-Eli, M., Meloche, S., and Brodt, P. (2004) Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals. J. Biol. Chem. 279, 19683-19690 (Pubitemid 38623405)
5. Manning, B. D., and Cantley, L. C. (2007) AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274 (Pubitemid 46962095)
6. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., and Cohen, P. (1997) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr. Biol. 7, 261-269 (Pubitemid 27176852)
7. Bellacosa, A., Chan, T. O., Ahmed, N. N., Datta, K., Malstrom, S., Stokoe, D., McCormick, F., Feng, J., and Tsichlis, P. (1998) Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene 17, 313-325 (Pubitemid 28383008)
8. Hresko, R. C., and Mueckler, M. (2005) mTOR.RICTOR is the Ser-473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J. Biol. Chem. 280, 40406-40416 (Pubitemid 41780527)
9. Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101 (Pubitemid 40262113)
10. Shiota, C., Woo, J. T., Lindner, J., Shelton, K. D., and Magnuson, M. A. (2006) Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev. Cell 11, 583-589 (Pubitemid 44430900)
11. Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., and Hemmings, B. A. (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15, 6541-6551 (Pubitemid 26413787)
12. Corradetti, M. N., and Guan, K. L. (2006) Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Oncogene 25, 6347-6360 (Pubitemid 44582281)
13. Frias, M. A., Thoreen, C. C., Jaffe, J. D., Schroder, W., Sculley, T., Carr, S. A., and Sabatini, D. M. (2006) mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr. Biol. 16, 1865-1870 (Pubitemid 44354144)
14. Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S. Y., Huang, Q., Qin, J., and Su, B. (2006) SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127, 125-137 (Pubitemid 44466632)
15. Yang, Q., Inoki, K., Ikenoue, T., and Guan, K. L. (2006) Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev. 20, 2820-2832 (Pubitemid 44771744)
16. Zoncu, R., Efeyan, A., and Sabatini, D. M. (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 12, 21-35
17. Zhang, J. (2007) The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation. J. Biol. Chem. 282, 34356-34364
18. Song, H., Li, C. W., Labaff, A. M., Lim, S. O., Li, L. Y., Kan, S. F., Chen, Y., Zhang, K., Lang, J., Xie, X., Wang, Y., Huo, L. F., Hsu, S. C., Chen, X., Zhao, Y., and Hung, M. C. (2011) Acetylation of EGF receptor contributes to tumor cell resistance to histone deacetylase inhibitors. Biochem. Biophys. Res. Commun. 404, 68-73
19. Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., and Thompson, C. B. (2009) ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324, 1076-1080
20. North, B. J., and Verdin, E. (2004) Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol. 5, 224
21. Bao, J., and Sack, M. N. (2010) Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors. Cell Mol. Life Sci. 67, 3073-3087
22. Choudhary, C., Kumar, C., Gnad, F., Nielsen, M. L., Rehman, M., Walther, T. C., Olsen, J. V., and Mann, M. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834-840
23. Thompson, P. R., Wang, D., Wang, L., Fulco, M., Pediconi, N., Zhang, D., An, W., Ge, Q., Roeder, R. G., Wong, J., Levrero, M., Sartorelli, V., Cotter, R. J., and Cole, P. A. (2004) Regulation of the p300HATdomain via a novel activation loop. Nat. Struct. Mol. Biol. 11, 308-315 (Pubitemid 38436794)
24. Foster, K. G., Acosta-Jaquez, H. A., Romeo, Y., Ekim, B., Soliman, G. A., Carriere, A., Roux, P. P., Ballif, B. A., and Fingar, D. C. (2010) Regulation of mTORcomplex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation. J. Biol. Chem. 285, 80-94
25. Tato, I., Bartrons, R., Ventura, F., and Rosa, J. L. (2011) Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling. J. Biol. Chem. 286, 6128-6142
26. Blander, G., and Guarente, L. (2004) The Sir2 family of protein deacetylases. Annu. Rev. Biochem. 73, 417-435 (Pubitemid 39050375)
27. Haigis, M. C., and Sinclair, D. A. (2010) Mammalian sirtuins: biological insights and disease relevance. Annu. Rev. Pathol. 5, 253-295
28. Verdin, E., Hirschey, M. D., Finley, L. W., and Haigis, M. C. (2010) Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem. Sci. 35, 669-675
29. Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., and Mayo, M. W. (2004) Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23, 2369-2380 (Pubitemid 38954844)
30. Madrid, L. V., Wang, C.-Y., Guttridge, D. C., Schotelius, A. J. G., Baldwin, A. S., and Mayo, M. W. (2000) Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-κB. Mol. Cell Biol. 20, 1626-1638 (Pubitemid 30100182)