IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2

Oncogene

Volumn 35, Issue 10, 2016, Pages 1236-1249

  Hubackova, S ^a   Kucerova, A ^a   Michlits, G ^a   Kyjacova, L ^a   Reinis, M ^a   Korolov, O ^a   Bartek, J ^a,b   Hodny, Z ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^b DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; ANT2 PROTEIN; GAMMA INTERFERON; JANUS KINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMAD PROTEIN; SMALL INTERFERING RNA; STAT PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; NOX1 PROTEIN, HUMAN; NOX4 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOCRINE EFFECT; CANCER CELL LINE; CELL AGING; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA DAMAGE; ENZYME ACTIVITY; ENZYME MECHANISM; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR CELL; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; ENZYME INDUCTION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; TUMOR CELL LINE;

ADENINE NUCLEOTIDE TRANSLOCATOR 2; ANIMALS; CELL AGING; CELL LINE, TUMOR; DNA DAMAGE; ENZYME INDUCTION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERFERON-GAMMA; MICE; NADPH OXIDASE; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SMAD PROTEINS; STAT TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84960800958     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2015.162     Document Type: Article

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