Interleukin 6 signaling regulates promyelocytic leukemia protein gene expression in human normal and cancer cells

Journal of Biological Chemistry

Volumn 287, Issue 32, 2012, Pages 26702-26714

  Hubackova, Sona ^a   Krejcikova, Katerina ^a   Bartek, Jiri ^a,b   Hodny, Zdenek ^b  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^b DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CELLS; CELL LINES; CULTURE MEDIA; CYTOKINES; EXPRESSION PATTERNS; GENOTOXIC STRESS; GROWTH CONDITIONS; HUMAN CELLS; INTERLEUKIN-6; LOCAL STRESS; PARACRINE; PATHOPHYSIOLOGICAL; PROMYELOCYTIC LEUKEMIA PROTEINS; PROTEIN LEVEL; SIGNALING PATHWAYS; TISSUE ADAPTATION; TUMOR SUPPRESSORS;

CELLS; GENE EXPRESSION; SIGNALING;

CELL CULTURE;

I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 6; JANUS KINASE; LATENT MEMBRANE PROTEIN 2; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN KINASE B; STAT3 PROTEIN;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; FIBROBLAST; GENE EXPRESSION; GENE INDUCTION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; OSTEOSARCOMA CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROMOTER REGION; PROMYELOCYTIC LEUKEMIA GENE; PROTEIN EXPRESSION; PROTEIN INDUCTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; CHROMATIN IMMUNOPRECIPITATION; DNA PRIMERS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HELA CELLS; HUMANS; INTERLEUKIN-6; JANUS KINASES; LEUKEMIA, PROMYELOCYTIC, ACUTE; NUCLEAR PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 84864556099     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.316869     Document Type: Article

References (83)

1. Dellaire, G., and Bazett-Jones, D. P. (2007) Beyond repair foci. Subnuclear domains and the cellular response to DNA damage. Cell Cycle 6, 1864-1872 (Pubitemid 47327904)
2. Ruggero, D., Wang, Z. G., and Pandolfi, P. P. (2000) The puzzling multiple lives of PML and its role in the genesis of cancer. Bioessays 22, 827-835
3. Bernardi, R., and Pandolfi, P. P. (2007) Structure, dynamics, and functions of promyelocytic leukaemia nuclear bodies. Nat. Rev. Mol. Cell Biol. 8, 1006-1016 (Pubitemid 350174636)
4. de Thé, H., Chomienne, C., Lanotte, M., Degos, L., and Dejean, A. (1990) The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus. Nature 347, 558-561
5. Wang, Z. G., Delva, L., Gaboli, M., Rivi, R., Giorgio, M., Cordon-Cardo, C., Grosveld, F., and Pandolfi, P. P. (1998) Role of PML in cell growth and the retinoic acid pathway. Science 279, 1547-1551 (Pubitemid 28217080)
6. Gurrieri, C., Capodieci, P., Bernardi, R., Scaglioni, P. P., Nafa, K., Rush, L. J., Verbel, D. A., Cordon-Cardo, C., and Pandolfi, P. P. (2004) Loss of the tumor suppressor PML in human cancers of multiple histologic origins J. Natl. Cancer Inst. 96, 269-279 (Pubitemid 38256272)
7. Gambacorta, M., Flenghi, L., Fagioli, M., Pileri, S., Leoncini, L., Bigerna, B., Pacini, R., Tanci, L. N., Pasqualucci, L., Ascani, S., Mencarelli, A., Liso, A., Pelicci, P. G., and Falini, B. (1996) Heterogeneous nuclear expression of the promyelocytic leukemia (PML) protein in normal and neoplastic human tissues. Am. J. Pathol. 149, 2023-2035 (Pubitemid 26415220)
8. Koken, M. H., Linares-Cruz, G., Quignon, F., Viron, A., Chelbi-Alix, M. K., Sobczak-Thépot, J., Juhlin, L., Degos, L., Calvo, F., and de Thé, H. (1995) The PML growth-suppressor has an altered expression in human oncogenesis. Oncogene 10, 1315-1324
9. Lavau, C., Marchio, A., Fagioli, M., Jansen, J., Falini, B., Lebon, P., Grosveld, F., Pandolfi, P. P., Pelicci, P. G., and Dejean, A. (1995) The acute promyelocytic leukaemia-associated PML gene is induced by interferon. Oncogene 11, 871-876
10. Korioth, F., Gieffers, C., Maul, G. G., and Frey, J. (1995) Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment. J. Cell Biol. 130, 1-13
11. Der, S. D., Zhou, A., Williams, B. R., and Silverman, R. H. (1998) Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays. Proc. Natl. Acad. Sci. U.S.A. 95, 15623-15628 (Pubitemid 29018750)
12. Chelbi-Alix, M. K., Pelicano, L., Quignon, F., Koken, M. H., Venturini, L., Stadler, M., Pavlovic, J., Degos, L., and de Thé, H. (1995) Induction of the PML protein by interferons in normal and APL cells. Leukemia 9, 2027-2033 (Pubitemid 26023786)
13. Bourdeau, V., Baudry, D., and Ferbeyre, G. (2009) PML links aberrant cytokine signaling and oncogenic stress to cellular senescence Front. Biosci. 14, 475-485
14. Krieghoff-Henning, E., and Hofmann, T. G. (2008) Role of nuclear bodies in apoptosis signaling. Biochim. Biophys. Acta 1783, 2185-2194
15. Pearson, M., Carbone, R., Sebastiani, C., Cioce, M., Fagioli, M., Saito, S., Higashimoto, Y., Appella, E., Minucci, S., Pandolfi, P. P., and Pelicci, P. G. (2000) PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 406, 207-210 (Pubitemid 30469006)
16. Louria-Hayon, I., Grossman, T., Sionov, R. V., Alsheich, O., Pandolfi, P. P., and Haupt, Y. (2003) The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation. J. Biol. Chem. 278, 33134-33141 (Pubitemid 37055760)
17. de Stanchina, E., Querido, E., Narita, M., Davuluri, R. V., Pandolfi, P. P., Ferbeyre, G., and Lowe, S. W. (2004) PML is a direct p53 target that modulates p53 effector functions. Mol. Cell 13, 523-535 (Pubitemid 38299380)
18. Narita, M., Nũnez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., and Lowe, S. W. (2003) Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113, 703-716 (Pubitemid 36724935)
19. Zhang, R., Poustovoitov, M. V., Ye, X., Santos, H. A., Chen, W., Daganzo, S. M., Erzberger, J. P., Serebriiskii, I. G., Canutescu, A. A., Dunbrack, R. L., Pehrson, J. R., Berger, J. M., Kaufman, P. D., and Adams, P. D. (2005) Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev. Cell 8, 19-30 (Pubitemid 40058002)
20. Zhang, R., Chen, W., and Adams, P. D. (2007) Molecular dissection of formation of senescence-associated heterochromatin foci. Mol. Cell. Biol. 27, 2343-2358 (Pubitemid 46418486)
21. Ye, X., Zerlanko, B., Zhang, R., Somaiah, N., Lipinski, M., Salomoni, P., and Adams, P. D. (2007) Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci. Mol. Cell. Biol. 27, 2452-2465 (Pubitemid 46581338)
22. Kosar, M., Bartkova, J., Hubackova, S., Hodny, Z., Lukas, J., and Bartek, J. (2011) Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Cell Cycle 10, 457-468
23. Janderová-Rossmeislová, L., Nováková, Z., Vlasáková, J., Philimonenko, V., Hozák, P., and Hodný, Z. (2007) PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells. J. Struct. Biol. 159, 56-70
24. Jiang, W. Q., and Ringertz, N. (1997) Altered distribution of the promyelocytic leukemia-associated protein is associated with cellular senescence. Cell Growth Differ. 8, 513-522
25. Ferbeyre, G., de Stanchina, E., Querido, E., Baptiste, N., Prives, C., and Lowe, S. W. (2000) PML is induced by oncogenic ras and promotes premature senescence. Genes Dev. 14, 2015-2027 (Pubitemid 30637352)
26. Blazkova, H., Krejcikova, K., Moudry, P., Frisan, T., Hodny, Z., and Bartek, J. (2010) Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signaling. J. Cell. Mol. Med. 14, 357-367
27. Stadler, M., Chelbi-Alix, M. K., Koken, M. H., Venturini, L., Lee, C., Saïb, A., Quignon, F., Pelicano, L., Guillemin, M. C., and Schindler, C., (1995) Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element. Oncogene 11, 2565-2573 (Pubitemid 26023824)
28. Scaglioni, P. P., Yung, T. M., Cai, L. F., Erdjument-Bromage, H., Kaufman, A. J., Singh, B., Teruya-Feldstein, J., Tempst, P., and Pandolfi, P. P. (2006) A CK2-dependent mechanism for degradation of the PML tumor suppressor. Cell 126, 269-283 (Pubitemid 44092959)
29. Coppé, J. P., Desprez, P. Y., Krtolica, A., and Campisi, J. (2010) The senescence- associated secretory phenotype. The dark side of tumor suppression. Annu. Rev. Pathol. 5, 99-118
30. Kuilman, T., and Peeper, D. S. (2009) Senescence-messaging secretome, SMS-ing cellular stress. Nat. Rev. Cancer 9, 81-94
31. Young, A. R., and Narita, M. (2009) SASP reflects senescence. EMBO Rep. 10, 228-230
32. Novakova, Z., Hubackova, S., Kosar, M., Janderova-Rossmeislova, L., Dobrovolna, J., Vasicova, P., Vancurova, M., Horejsi, Z., Hozak, P., Bartek, J., and Hodny, Z. (2010) Cytokine expression and signaling in drug-induced cellular senescence. Oncogene 29, 273-284
33. Hubackova, S., Novakova, Z., Krejcikova, K., Kosar, M., Dobrovolna, J., Duskova, P., Hanzlikova, H., Vancurova, M., Barath, P., Bartek, J., and Hodny, Z. (2010) Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling. Cell Cycle 9, 3085-3099
34. Carbone, R., Pearson, M., Minucci, S., and Pelicci, P. G. (2002) PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage. Oncogene 21, 1633-1640 (Pubitemid 34259026)
35. Dellaire, G., Kepkay, R., and Bazett-Jones, D. P. (2009) High resolution imaging of changes in the structure and spatial organization of chromatin, γ-H2A.X, and the MRN complex within etoposide-induced DNA repair foci. Cell Cycle 8, 3750-3769
36. Dellaire, G., and Bazett-Jones, D. P. (2004) PML nuclear bodies: dynamic sensors of DNA damage and cellular stress. Bioessays 26, 963-977 (Pubitemid 39273070)
37. Bartkova, J., Horejsí, Z., Koed, K., Krämer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J. M., Lukas, C., Ørntoft, T., Lukas, J., and Bartek, J. (2005) DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434, 864-870 (Pubitemid 40558993)
38. Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L. V., Kolettas, E., Niforou, K., Zoumpourlis, V. C., Takaoka, M., Nakagawa, H., Tort, F., Fugger, K., Johansson, F., Sehested, M., Andersen, C. L., Dyrskjot, L., Ørntoft, T., Lukas, J., Kittas, C., Helleday, T., Halazonetis, T. D., Bartek, J., and Gorgoulis, V. G. (2006) Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444, 633-637 (Pubitemid 44864442)
39. Di Micco, R., Fumagalli, M., Cicalese, A., Piccinin, S., Gasparini, P., Luise, C., Schurra, C., Garre', M., Nuciforo, P. G., Bensimon, A., Maestro, R., Pelicci, P. G., and d'Adda di Fagagna, F. (2006) Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444, 638-642 (Pubitemid 44864443)
40. Gorgoulis, V. G., Vassiliou, L. V., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., Ditullio, R. A., Jr., Kastrinakis, N. G., Levy, B., Kletsas, D., Yoneta, A., Herlyn, M., Kittas, C., and Halazonetis, T. D. (2005) Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434, 907-913 (Pubitemid 40559004)
41. Bartek, J., Lukas, J., and Bartkova, J. (2007) DNA damage response as an anti-cancer barrier. Damage threshold and the concept of "conditional haploinsufficiency." Cell Cycle 6, 2344-2347 (Pubitemid 350058685)
42. Stuurman, N., de Graaf, A., Floore, A., Josso, A., Humbel, B., de Jong, L., and van Driel, R. (1992) A monoclonal antibody recognizing nuclear matrix-associated nuclear bodies. J. Cell Sci. 101, 773-784
43. Koken, M. H., Puvion-Dutilleul, F., Guillemin, M. C., Viron, A., Linares-Cruz, G., Stuurman, N., de Jong, L., Szostecki, C., Calvo, F., and Chomienne, C. (1994) The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion. EMBO J. 13, 1073-1083 (Pubitemid 24074714)
44. Scheller, J., Chalaris, A., Schmidt-Arras, D., and Rose-John, S. (2011) The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim. Biophys. Acta 1813, 878-888
45. Heinrich, P. C., Behrmann, I., Haan, S., Hermanns, H. M., Müller-Newen, G., and Schaper, F. (2003) Principles of interleukin (IL)-6-type cytokine signaling and its regulation. Biochem. J. 374, 1-20 (Pubitemid 37046923)
46. Aarden, L. A. (1989) Hybridoma growth factor. Ann. N.Y. Acad. Sci. 557, 192-198, discussion 198-199
47. Vlasáková, J., Nováková, Z., Rossmeislová, L., Kahle, M., Hozák, P., and Hodny, Z. (2007) Histone deacetylase inhibitors suppress IFNα-induced up-regulation of promyelocytic leukemia protein. Blood 109, 1373-1380 (Pubitemid 46239567)
48. Carey, M., Peterson, C. L., and Smale, S. T. (2008) Transcriptional Regulation in Eukaryotes: Concepts, Strategies, and Techniques, 2 Ed., pp. 132-139, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
49. Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., and Bonner, W. M. (1998) DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273, 5858-5868 (Pubitemid 28124064)
50. Eda, H., Burnette, B. L., Shimada, H., Hope, H. R., and Monahan, J. B. (2011) Interleukin-1β-induced interleukin-6 production in A549 cells is mediated by both phosphatidylinositol 3-kinase and interleukin-1receptor- associated kinase-4. Cell Biol. Int. 35, 355-358
51. Walter, M., Liang, S., Ghosh, S., Hornsby, P. J., and Li, R. (2009) Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene 28, 2745-2755
52. Ehret, G. B., Reichenbach, P., Schindler, U., Horvath, C. M., Fritz, S., Nabholz, M., and Bucher, P. (2001)DNAbinding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites. J. Biol. Chem. 276, 6675-6688
53. Takahashi-Tezuka, M., Hibi, M., Fujitani, Y., Fukada, T., Yamaguchi, T., and Hirano, T. (1997) Tec tyrosine kinase links the cytokine receptors to PI 3-kinase probably through JAK. Oncogene 14, 2273-2282 (Pubitemid 27260719)
54. Matsusaka, T., Fujikawa, K., Nishio, Y., Mukaida, N., Matsushima, K., Kishimoto, T., and Akira, S. (1993) Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6, and interleukin 8. Proc. Natl. Acad. Sci. U.S.A. 90, 10193-10197 (Pubitemid 23328278)
55. Tegethoff, S., Behlke, J., and Scheidereit, C. (2003) Tetrameric oligomerization of IκB kinase γ (IKKγ) is obligatory for IKK complex activity and NF-κB activation. Mol. Cell. Biol. 23, 2029-2041 (Pubitemid 36278814)
56. Biron, C. A. (1998) Role of early cytokines, including α, and β interferons (IFN-α/β) in innate and adaptive immune responses to viral infections. Semin. Immunol. 10, 383-390
57. Mallette, F. A., Gaumont-Leclerc, M. F., Huot, G., and Ferbeyre, G. (2007) Myc down-regulation as a mechanism to activate the Rb pathway in STAT5A-induced senescence. J. Biol. Chem. 282, 34938-34944 (Pubitemid 350232462)
58. Shtutman, M., Zhurinsky, J., Oren, M., Levina, E., and Ben-Ze'ev, A. (2002) PML is a target gene of β-catenin and plakoglobin and coactivates β-catenin-mediated transcription. Cancer Res. 62, 5947-5954 (Pubitemid 35204758)
59. Everett, R. D. (2006) Interactions between DNA viruses, ND10 and the DNA damage response. Cell. Microbiol. 8, 365-374
60. Chelbi-Alix, M. K., Quignon, F., Pelicano, L., Koken, M. H., and de Thé, H. (1998) Resistance to virus infection conferred by the interferon-induced promyelocytic leukemia protein. J. Virol. 72, 1043-1051 (Pubitemid 28116883)
61. Regad, T., and Chelbi-Alix, M. K. (2001) Role and fate of PML nuclear bodies in response to interferon and viral infections. Oncogene 20, 7274-7286 (Pubitemid 33105016)
62. Maul, G. G., Guldner, H. H., and Spivack, J. G. (1993) Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICP0) J. Gen. Virol. 74, 2679-2690 (Pubitemid 24020661)
63. Everett, R. D., and Maul, G. G. (1994) HSV-1 IE protein Vmw110 causes redistribution of PML. EMBO J. 13, 5062-5069 (Pubitemid 24341087)
64. Wilkinson, G. W., Kelly, C., Sinclair, J. H., and Rickards, C. (1998) Disruption of PML-associated nuclear bodies mediated by the human cytomegalovirus major immediate early gene product. J. Gen. Virol. 79, 1233-1245 (Pubitemid 28203865)
65. Sternsdorf, T., Grötzinger, T., Jensen, K., and Will, H. (1997) Nuclear dots. Actors on many stages. Immunobiology 198, 307-331 (Pubitemid 28021406)
66. Müller, S., and Dejean, A. (1999) Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption. J. Virol. 73, 5137-5143 (Pubitemid 29246776)
67. Puvion-Dutilleul, F., Venturini, L., Guillemin, M. C., de Thé, H., and Puvion, E. (1995) Sequestration of PML and Sp100 proteins in an intranuclear viral structure during herpes simplex virus type 1 infection. Exp. Cell Res. 221, 448-461
68. Burkham, J., Coen, D. M., and Weller, S. K. (1998) ND10 protein PML is recruited to herpes simplex virus type 1 prereplicative sites and replication compartments in the presence of viral DNA polymerase. J. Virol. 72, 10100-10107 (Pubitemid 28520880)
69. Burkham, J., Coen, D. M., Hwang, C. B., and Weller, S. K. (2001) Interactions of herpes simplex virus type 1 with ND10 and recruitment of PML to replication compartments. J. Virol. 75, 2353-2367 (Pubitemid 32147574)
70. Everett, R. D., and Murray, J. (2005) ND10 components relocate to sites associated with herpes simplex virus type 1 nucleoprotein complexes during virus infection. J. Virol. 79, 5078-5089 (Pubitemid 40464258)
71. Everett, R. D., Rechter, S., Papior, P., Tavalai, N., Stamminger, T., and Orr, A. (2006)PMLcontributes to a cellular mechanism of repression of herpes simplex virus type 1 infection that is inactivated by ICP0. J. Virol. 80, 7995-8005 (Pubitemid 44182300)
72. Chelbi-Alix, M. K., and de Thé, H. (1999) Herpes virus induced proteasome-dependent degradation of the nuclear body-associated PML and Sp100 proteins. Oncogene 18, 935-941 (Pubitemid 29086270)
73. Herzer, K., Weyer, S., Krammer, P. H., Galle, P. R., and Hofmann, T. G. (2005) Hepatitis C virus core protein inhibits tumor suppressor protein promyelocytic leukemia function in human hepatoma cells. Cancer Res. 65, 10830-10837 (Pubitemid 41713350)
74. Lombard, D. B., and Guarente, L. (2000) Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres. Cancer Res. 60, 2331-2334 (Pubitemid 30262415)
75. Mirzoeva, O. K., and Petrini, J. H. (2001) DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol. Cell. Biol. 21, 281-288
76. Kuilman, T., Michaloglou, C., Vredeveld, L. C., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., and Peeper, D. S. (2008) Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 133, 1019-1031 (Pubitemid 351787746)
77. Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., Takatsu, Y., Melamed, J., d'Adda di Fagagna, F., Bernard, D., Hernando, E., and Gil, J. (2008) Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 133, 1006-1018 (Pubitemid 351795610)
78. Rodier, F., Coppé, J. P., Patil, C. K., Hoeijmakers, W. A., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., and Campisi, J. (2009) Persistent DNA damage signaling triggers senescence- associated inflammatory cytokine secretion. Nat. Cell Biol. 11, 973-979
79. Horvath, C. M., Wen, Z., and Darnell, J. E., Jr. (1995) A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev. 9, 984-994
80. Libermann, T. A., and Baltimore, D. (1990) Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol. Cell. Biol. 10, 2327-2334
81. Rein, T., Müller, M., and Zorbas, H. (1994) In vivo footprinting of the IRF-1 promoter. Inducible occupation of a GAS element next to a persistent structural alteration of the DNA. Nucleic Acids Res. 22, 3033-3037 (Pubitemid 24260632)
82. Wright, K. L., White, L. C., Kelly, A., Beck, S., Trowsdale, J., and Ting, J. P. (1995) Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter. J. Exp. Med. 181, 1459-1471
83. Minamino, T., Yoshida, T., Tateno, K., Miyauchi, H., Zou, Y., Toko, H., and Komuro, I. (2003) Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis. Circulation 108, 2264-2269 (Pubitemid 37363045)