Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-β-induced cell death through impairing up-regulation of the NADPH oxidase NOX4

Cancer Research

Volumn 69, Issue 19, 2009, Pages 7595-7602

  Caja, Laia ^a   Sancho, Patricia ^a   Bertran, Esther ^a   Iglesias Serret, Daniel ^a   Gil, Joan ^a   Fabregat, Isabel ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PROTEIN BCL XL; PROTEIN MCL 1; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN HEPG2; CELL SURVIVAL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIVER CELL; LIVER CELL CARCINOMA; LIVER TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL; TUMOR RESISTANCE; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LIVER NEOPLASMS; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA; NADPH OXIDASE; OXIDATIVE STRESS; PROTEIN KINASE INHIBITORS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 70350212686     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-1482     Document Type: Article

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