-
1
-
-
50049127672
-
Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6
-
Adachi, Y., Shibai, Y., Mitsushita, J., Shang, W.H., Hirose, K. & Kamata, T. (2008) Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6. Oncogene 27, 4921-4932.
-
(2008)
Oncogene
, vol.27
, pp. 4921-4932
-
-
Adachi, Y.1
Shibai, Y.2
Mitsushita, J.3
Shang, W.H.4
Hirose, K.5
Kamata, T.6
-
3
-
-
0038246249
-
Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a
-
Bulavin, D.V., Kovalsky, O., Hollander, M.C. & Fornace, A.J., Jr (2003) Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a. Mol. Cell. Biol. 23, 3859-3871.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 3859-3871
-
-
Bulavin, D.V.1
Kovalsky, O.2
Hollander, M.C.3
Fornace Jr., A.J.4
-
4
-
-
10344260912
-
Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts
-
Chen, J.H., Stoeber, K., Kingsbury, S., Ozanne, S.E., Williams, G.H. & Hales, C.N. (2004) Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts. J. Biol. Chem. 279, 49439-49446.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 49439-49446
-
-
Chen, J.H.1
Stoeber, K.2
Kingsbury, S.3
Ozanne, S.E.4
Williams, G.H.5
Hales, C.N.6
-
5
-
-
23244447893
-
Tumour biology: senescence in premalignant tumours
-
Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A.J., Barradas, M., Benguria, A., Zaballos, A., Flores, J.M., Barbacid, M., Beach, D. & Serrano, M. (2005) Tumour biology: senescence in premalignant tumours. Nature 436, 642.
-
(2005)
Nature
, vol.436
, pp. 642
-
-
Collado, M.1
Gil, J.2
Efeyan, A.3
Guerra, C.4
Schuhmacher, A.J.5
Barradas, M.6
Benguria, A.7
Zaballos, A.8
Flores, J.M.9
Barbacid, M.10
Beach, D.11
Serrano, M.12
-
6
-
-
0029955128
-
Control of ras activation
-
Downward, J. (1996) Control of ras activation. Cancer Surv. 27, 87-100.
-
(1996)
Cancer Surv.
, vol.27
, pp. 87-100
-
-
Downward, J.1
-
7
-
-
34548217651
-
Maximizing mouse cancer models
-
Frese, K.K. & Tuveson, D.A. (2007) Maximizing mouse cancer models. Nat. Rev. Cancer 7, 645-658.
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 645-658
-
-
Frese, K.K.1
Tuveson, D.A.2
-
8
-
-
0034608934
-
Identification of renox, an NAD(P)H oxidase in kidney
-
Geiszt, M., Kopp, J.B., Varnai, P. & Leto, T.L. (2000) Identification of renox, an NAD(P)H oxidase in kidney. Proc. Natl Acad. Sci. USA 97, 8010-8014.
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 8010-8014
-
-
Geiszt, M.1
Kopp, J.B.2
Varnai, P.3
Leto, T.L.4
-
9
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
Gorgoulis, V.G., Vassiliou, L.V., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., Ditullio, R.A., Jr, Kastrinakis, N.G., Levy, B., Kletsas, D., Yoneta, A., Herlyn, M., Kittas, C. & Halazonetis, T.D. (2005) Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434, 907-913.
-
(2005)
Nature
, vol.434
, pp. 907-913
-
-
Gorgoulis, V.G.1
Vassiliou, L.V.2
Karakaidos, P.3
Zacharatos, P.4
Kotsinas, A.5
Liloglou, T.6
Venere, M.7
Ditullio Jr., R.A.8
Kastrinakis, N.G.9
Levy, B.10
Kletsas, D.11
Yoneta, A.12
Herlyn, M.13
Kittas, C.14
Halazonetis, T.D.15
-
10
-
-
77955493991
-
NADPH oxidase 4 is an oncoprotein localized to mitochondria
-
Graham, K.A., Kulawiec, M., Owens, K.M., Li, X., Desouki, M.M., Chandra, D. & Singh, K.K. (2010) NADPH oxidase 4 is an oncoprotein localized to mitochondria. Cancer Biol. Ther. 10, 223-231.
-
(2010)
Cancer Biol. Ther.
, vol.10
, pp. 223-231
-
-
Graham, K.A.1
Kulawiec, M.2
Owens, K.M.3
Li, X.4
Desouki, M.M.5
Chandra, D.6
Singh, K.K.7
-
11
-
-
0036731380
-
Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence
-
Haq, R., Brenton, J.D., Takahashi, M., Finan, D., Finkielsztein, A., Damaraju, S., Rottapel, R. & Zanke, B. (2002) Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence. Cancer Res. 62, 5076-5082.
-
(2002)
Cancer Res.
, vol.62
, pp. 5076-5082
-
-
Haq, R.1
Brenton, J.D.2
Takahashi, M.3
Finan, D.4
Finkielsztein, A.5
Damaraju, S.6
Rottapel, R.7
Zanke, B.8
-
12
-
-
0026303190
-
p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts
-
Harvey, D.M. & Levine, A.J. (1991) p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts. Genes Dev. 5, 2375-2385.
-
(1991)
Genes Dev.
, vol.5
, pp. 2375-2385
-
-
Harvey, D.M.1
Levine, A.J.2
-
13
-
-
0345932931
-
Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway
-
Iwasa, H., Han, J. & Ishikawa, F. (2003) Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 8, 131-144.
-
(2003)
Genes Cells
, vol.8
, pp. 131-144
-
-
Iwasa, H.1
Han, J.2
Ishikawa, F.3
-
14
-
-
77954243065
-
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
-
Jun, J.I. & Lau, L.F. (2010) The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat. Cell Biol. 12, 676-685.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 676-685
-
-
Jun, J.I.1
Lau, L.F.2
-
15
-
-
49149110899
-
NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression
-
Komatsu, D., Kato, M., Nakayama, J., Miyagawa, S. & Kamata, T. (2008) NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression. Oncogene 27, 4724-4732.
-
(2008)
Oncogene
, vol.27
, pp. 4724-4732
-
-
Komatsu, D.1
Kato, M.2
Nakayama, J.3
Miyagawa, S.4
Kamata, T.5
-
16
-
-
34347257042
-
Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy
-
Lambeth, J.D. (2007) Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. Free Radic. Biol. Med. 43, 332-347.
-
(2007)
Free Radic. Biol. Med.
, vol.43
, pp. 332-347
-
-
Lambeth, J.D.1
-
17
-
-
34250888056
-
Regulation of Nox and Duox enzymatic activity and expression
-
Lambeth, J.D., Kawahara, T. & Diebold, B. (2007) Regulation of Nox and Duox enzymatic activity and expression. Free Radic. Biol. Med. 43, 319-331.
-
(2007)
Free Radic. Biol. Med.
, vol.43
, pp. 319-331
-
-
Lambeth, J.D.1
Kawahara, T.2
Diebold, B.3
-
18
-
-
0033583242
-
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
-
Lee, A.C., Fenster, B.E., Ito, H., Takeda, K., Bae, N.S., Hirai, T., Yu, Z.X., Ferrans, V.J., Howard, B.H. & Finkel, T. (1999) Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J. Biol. Chem. 274, 7936-7940.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7936-7940
-
-
Lee, A.C.1
Fenster, B.E.2
Ito, H.3
Takeda, K.4
Bae, N.S.5
Hirai, T.6
Yu, Z.X.7
Ferrans, V.J.8
Howard, B.H.9
Finkel, T.10
-
19
-
-
0032190629
-
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
-
Lin, A.W., Barradas, M., Stone, J.C., van Aelst, L., Serrano, M. & Lowe, S.W. (1998) Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 12, 3008-3019.
-
(1998)
Genes Dev.
, vol.12
, pp. 3008-3019
-
-
Lin, A.W.1
Barradas, M.2
Stone, J.C.3
van Aelst, L.4
Serrano, M.5
Lowe, S.W.6
-
20
-
-
33846128155
-
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
-
Mallette, F.A., Gaumont-Leclerc, M.F. & Ferbeyre, G. (2007) The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. Genes Dev. 21, 43-48.
-
(2007)
Genes Dev.
, vol.21
, pp. 43-48
-
-
Mallette, F.A.1
Gaumont-Leclerc, M.F.2
Ferbeyre, G.3
-
21
-
-
27444441677
-
Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice
-
Matsuno, K., Yamada, H., Iwata, K., Jin, D., Katsuyama, M., Matsuki, M., Takai, S., Yamanishi, K., Miyazaki, M., Matsubara, H. & Yabe-Nishimura, C. (2005) Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice. Circulation 112, 2677-2685.
-
(2005)
Circulation
, vol.112
, pp. 2677-2685
-
-
Matsuno, K.1
Yamada, H.2
Iwata, K.3
Jin, D.4
Katsuyama, M.5
Matsuki, M.6
Takai, S.7
Yamanishi, K.8
Miyazaki, M.9
Matsubara, H.10
Yabe-Nishimura, C.11
-
22
-
-
58949084649
-
Base excision repair of oxidative DNA damage and association with cancer and aging
-
Maynard, S., Schurman, S.H., Harboe, C., de Souza-Pinto, N.C. & Bohr, V.A. (2009) Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis 30, 2-10.
-
(2009)
Carcinogenesis
, vol.30
, pp. 2-10
-
-
Maynard, S.1
Schurman, S.H.2
Harboe, C.3
de Souza-Pinto, N.C.4
Bohr, V.A.5
-
23
-
-
23244447037
-
BRAFE600-associated senescence-like cell cycle arrest of human naevi
-
Michaloglou, C., Vredeveld, L.C., Soengas, M.S., Denoyelle, C., Kuilman, T., van der Horst, C.M., Majoor, D.M., Shay, J.W., Mooi, W.J. & Peeper, D.S. (2005) BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436, 720-724.
-
(2005)
Nature
, vol.436
, pp. 720-724
-
-
Michaloglou, C.1
Vredeveld, L.C.2
Soengas, M.S.3
Denoyelle, C.4
Kuilman, T.5
van der Horst, C.M.6
Majoor, D.M.7
Shay, J.W.8
Mooi, W.J.9
Peeper, D.S.10
-
24
-
-
2442693092
-
The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation
-
Mitsushita, J., Lambeth, J.D. & Kamata, T. (2004) The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation. Cancer Res. 64, 3580-3585.
-
(2004)
Cancer Res.
, vol.64
, pp. 3580-3585
-
-
Mitsushita, J.1
Lambeth, J.D.2
Kamata, T.3
-
25
-
-
24744454582
-
Senescence comes of age
-
Narita, M. & Lowe, S.W. (2005) Senescence comes of age. Nat. Med. 11, 920-922.
-
(2005)
Nat. Med.
, vol.11
, pp. 920-922
-
-
Narita, M.1
Lowe, S.W.2
-
26
-
-
43149114461
-
Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage
-
Noguchi, T., Ishii, K., Fukutomi, H., Naguro, I., Matsuzawa, A., Takeda, K. & Ichijo, H. (2008) Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage. J. Biol. Chem. 283, 7657-7665.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 7657-7665
-
-
Noguchi, T.1
Ishii, K.2
Fukutomi, H.3
Naguro, I.4
Matsuzawa, A.5
Takeda, K.6
Ichijo, H.7
-
27
-
-
35148812601
-
Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression
-
Nuciforo, P.G., Luise, C., Capra, M., Pelosi, G. & d'Adda di Fagagna, F. (2007) Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression. Carcinogenesis 28, 2082-2088.
-
(2007)
Carcinogenesis
, vol.28
, pp. 2082-2088
-
-
Nuciforo, P.G.1
Luise, C.2
Capra, M.3
Pelosi, G.4
d'Adda di Fagagna, F.5
-
28
-
-
0029119852
-
Cloning and characterization of murine p16INK4a and p15INK4b genes
-
Quelle, D.E., Ashmun, R.A., Hannon, G.J., Rehberger, P.A., Trono, D., Richter, K.H., Walker, C., Beach, D., Sherr, C.J. & Serrano, M. (1995) Cloning and characterization of murine p16INK4a and p15INK4b genes. Oncogene 11, 635-645.
-
(1995)
Oncogene
, vol.11
, pp. 635-645
-
-
Quelle, D.E.1
Ashmun, R.A.2
Hannon, G.J.3
Rehberger, P.A.4
Trono, D.5
Richter, K.H.6
Walker, C.7
Beach, D.8
Sherr, C.J.9
Serrano, M.10
-
29
-
-
67349259948
-
NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells
-
Schilder, Y.D., Heiss, E.H., Schachner, D., Ziegler, J., Reznicek, G., Sorescu, D. & Dirsch, V.M. (2009) NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells. Free Radic. Biol. Med. 46, 1598-1606.
-
(2009)
Free Radic. Biol. Med.
, vol.46
, pp. 1598-1606
-
-
Schilder, Y.D.1
Heiss, E.H.2
Schachner, D.3
Ziegler, J.4
Reznicek, G.5
Sorescu, D.6
Dirsch, V.M.7
-
30
-
-
0029993450
-
Role of the INK4a locus in tumor suppression and cell mortality
-
Serrano, M., Lee, H., Chin, L., Cordon-Cardo, C., Beach, D. & DePinho, R.A. (1996) Role of the INK4a locus in tumor suppression and cell mortality. Cell 85, 27-37.
-
(1996)
Cell
, vol.85
, pp. 27-37
-
-
Serrano, M.1
Lee, H.2
Chin, L.3
Cordon-Cardo, C.4
Beach, D.5
DePinho, R.A.6
-
31
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano, M., Lin, A.W., McCurrach, M.E., Beach, D. & Lowe, S.W. (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
32
-
-
77951191817
-
Reactive oxygen generated by NADPH oxidase 1 (Nox1) contributes to cell invasion by regulating matrix metalloprotease-9 production and cell migration
-
Shinohara, M., Adachi, Y., Mitsushita, J., Kuwabara, M., Nagasawa, A., Harada, S., Furuta, S., Zhang, Y., Seheli, K., Miyazaki, H. & Kamata, T. (2010) Reactive oxygen generated by NADPH oxidase 1 (Nox1) contributes to cell invasion by regulating matrix metalloprotease-9 production and cell migration. J. Biol. Chem. 285, 4481-4488.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 4481-4488
-
-
Shinohara, M.1
Adachi, Y.2
Mitsushita, J.3
Kuwabara, M.4
Nagasawa, A.5
Harada, S.6
Furuta, S.7
Zhang, Y.8
Seheli, K.9
Miyazaki, H.10
Kamata, T.11
-
33
-
-
33750510904
-
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence
-
Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S., Tahara, H., Nakayama, K., Nakayama, K.I., Ide, T., Saya, H. & Hara, E. (2006) Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat. Cell Biol. 8, 1291-1297.
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 1291-1297
-
-
Takahashi, A.1
Ohtani, N.2
Yamakoshi, K.3
Iida, S.4
Tahara, H.5
Nakayama, K.6
Nakayama, K.I.7
Ide, T.8
Saya, H.9
Hara, E.10
-
34
-
-
44449086957
-
Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: role in signaling TPA-induced growth arrest in ML-1 cells
-
Traore, K., Sharma, R., Thimmulappa, R.K., Watson, W.H., Biswal, S. & Trush, M.A. (2008) Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: role in signaling TPA-induced growth arrest in ML-1 cells. J. Cell. Physiol. 216, 276-285.
-
(2008)
J. Cell. Physiol.
, vol.216
, pp. 276-285
-
-
Traore, K.1
Sharma, R.2
Thimmulappa, R.K.3
Watson, W.H.4
Biswal, S.5
Trush, M.A.6
-
35
-
-
0036242247
-
Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence
-
Wang, W., Chen, J.X., Liao, R., Deng, Q., Zhou, J.J., Huang, S. & Sun, P. (2002) Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol. Cell. Biol. 22, 3389-3403.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 3389-3403
-
-
Wang, W.1
Chen, J.X.2
Liao, R.3
Deng, Q.4
Zhou, J.J.5
Huang, S.6
Sun, P.7
-
36
-
-
84857790798
-
ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence
-
Weyemi, U., Lagente-Chevallier, O., Boufraqech, M., Prenois, F., Courtin, F., Caillou, B., Talbot, M., Dardalhon, M., Al Ghuzlan, A., Bidart, J.M., Schlumberger, M. & Dupuy, C. (2012) ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence. Oncogene 31, 1117-1129.
-
(2012)
Oncogene
, vol.31
, pp. 1117-1129
-
-
Weyemi, U.1
Lagente-Chevallier, O.2
Boufraqech, M.3
Prenois, F.4
Courtin, F.5
Caillou, B.6
Talbot, M.7
Dardalhon, M.8
Al Ghuzlan, A.9
Bidart, J.M.10
Schlumberger, M.11
Dupuy, C.12
-
37
-
-
65549114660
-
NADPH oxidase 4 contributes to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression
-
Yamaura, M., Mitsushita, J., Furuta, S., Kiniwa, Y., Ashida, A., Goto, Y., Shang, W.H., Kubodera, M., Kato, M., Takata, M., Saida, T. & Kamata, T. (2009) NADPH oxidase 4 contributes to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression. Cancer Res. 69, 2647-2654.
-
(2009)
Cancer Res.
, vol.69
, pp. 2647-2654
-
-
Yamaura, M.1
Mitsushita, J.2
Furuta, S.3
Kiniwa, Y.4
Ashida, A.5
Goto, Y.6
Shang, W.H.7
Kubodera, M.8
Kato, M.9
Takata, M.10
Saida, T.11
Kamata, T.12
|