Exposure of human skin diploid fibroblasts to repeated subcytotoxic doses of ultraviolet-B induces the overexpression of transforming growth factor-β1 mRNA

Annals of the New York Academy of Sciences

Volumn 973, Issue , 2002, Pages 44-48

  Chainiaux, Florence ^a   Remacle, José ^a   Toussaint, Olivier ^a,b  

^a UNIVERSITY OF NAMUR   (Belgium)

^b NONE   (Belgium)

Author keywords

Human skin diploid fibroblasts; Stress induced premature senescence; Transforming growth factor beta; Ultraviolet B

Indexed keywords

MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

CONFERENCE PAPER; CONTROLLED STUDY; DIPLOIDY; FIBROBLAST; FOLLOW UP; HUMAN; HUMAN CELL; RADIATION DOSE; SENESCENCE; STEADY STATE; ULTRAVIOLET B RADIATION;

EID: 0036964871     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04603.x     Document Type: Conference Paper

References (5)

1. CHAINIAUX, F. et al. 2002. UVB-induced premature senescence of human diploid skin fibroblasts. Int. J. Biochem. Cell Biol. 34: 1331-1339.
2. HOCEVAR, B. et al. 1999. TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J. 18: 1345-1356.
3. SHIBA, H. et al. 1998. Differential effects of various growth factors and cytokines on the syntheses of DNA, type I collagen, laminin, fibronectin, osteonectin/secreted protein, acidic and rich in cysteine (SPARC), and alkaline phosphatase by human pulp cells in culture. J. Cell. Physiol. 174: 194-208.
4. WEGROWSKI, Y., et al. 1999. Transforming growth factor beta-1 up-regulates clusterin synthesis in thyroid epithelial cells. Exp. Cell Res. 247: 475-483.
5. FRIPPIAT, C. et al. 2001. Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J. Biol. Chem. 276: 2531-2537.