메뉴 건너뛰기




Volumn 6, Issue 3, 2016, Pages

Metformin: A hopeful promise in aging research

Author keywords

[No Author keywords available]

Indexed keywords

METFORMIN;

EID: 84959566618     PISSN: None     EISSN: 21571422     Source Type: Journal    
DOI: 10.1101/cshperspect.a025932     Document Type: Article
Times cited : (128)

References (110)
  • 3
    • 84892649479 scopus 로고    scopus 로고
    • Standards of medical care in diabetes—2014
    • American Diabetes Association.
    • American Diabetes Association. 2014 Standards of medical care in diabetes—2014. Diabetes Care 37: S14–S80
    • (2014) Diabetes Care , vol.37
  • 4
    • 85015468073 scopus 로고    scopus 로고
    • Do metformin a real anticarcinogen? A critical reappraisal of experimental data
    • Anisimov VN. 2014 Do metformin a real anticarcinogen? A critical reappraisal of experimental data. Ann Transl Med 2: 60
    • (2014) Ann Transl Med , vol.2
    • Anisimov, V.N.1
  • 15
    • 84905718750 scopus 로고    scopus 로고
    • Control of gluconeogenesis by metformin: Does redox trump energy charge?
    • Baur JA, Birnbaum MJ. 2014 Control of gluconeogenesis by metformin: Does redox trump energy charge? Cell Metab 20: 197–199
    • (2014) Cell Metab , vol.20 , pp. 197-199
    • Baur, J.A.1    Birnbaum, M.J.2
  • 17
    • 84864541430 scopus 로고    scopus 로고
    • Metformin in obesity, cancer and aging: Addressing controversies
    • Berstein LM. 2012.Metformin in obesity, cancer and aging: Addressing controversies. Aging 4: 320–329
    • (2012) Aging , vol.4 , pp. 320-329
    • Berstein, L.M.1
  • 18
    • 84877643626 scopus 로고    scopus 로고
    • Big mice die young but large animals live longer
    • Blagosklonny MV. 2013 Big mice die young but large animals live longer. Aging 5: 227–233
    • (2013) Aging , vol.5 , pp. 227-233
    • Blagosklonny, M.V.1
  • 19
    • 50849124484 scopus 로고    scopus 로고
    • Cancer and aging:More puzzles, more promises?
    • Blagosklonny MV, Campisi J. 2008 Cancer and aging:More puzzles, more promises? Cell Cycle 7: 2615–2618
    • (2008) Cell Cycle , vol.7 , pp. 2615-2618
    • Blagosklonny, M.V.1    Campisi, J.2
  • 20
    • 80054999500 scopus 로고    scopus 로고
    • Metformin as a geroprotector
    • Bulterijs S. 2011 Metformin as a geroprotector. Rejuvenation Res 14: 469–482
    • (2011) Rejuvenation Res , vol.14 , pp. 469-482
    • Bulterijs, S.1
  • 21
    • 84883347483 scopus 로고    scopus 로고
    • Worms need microbes too: Microbiota, health and aging in Caenorhabditis elegans
    • Cabreiro F, Gems D. 2013 Worms need microbes too: Microbiota, health and aging in Caenorhabditis elegans. EMBO Mol Med 5: 1300–1310
    • (2013) EMBO Mol Med , vol.5 , pp. 1300-1310
    • Cabreiro, F.1    Gems, D.2
  • 23
  • 26
    • 78951479936 scopus 로고    scopus 로고
    • New aspects of an old drug: Metformin as a glucagon-like peptide 1 (GLP-1) enhancer and sensitizer
    • Cho YM, Kieffer TJ. 2011 New aspects of an old drug: Metformin as a glucagon-like peptide 1 (GLP-1) enhancer and sensitizer. Diabetologia 54: 219–222
    • (2011) Diabetologia , vol.54 , pp. 219-222
    • Cho, Y.M.1    Kieffer, T.J.2
  • 27
    • 40749106098 scopus 로고    scopus 로고
    • Effects of estrogen on lifespan and motor functions in female hSOD1 G93A transgenic mice
    • Choi CI, Lee YD, Gwag BJ, Cho SI, Kim SS, Suh-Kim H. 2008 Effects of estrogen on lifespan and motor functions in female hSOD1 G93A transgenic mice. J Neurol Sci 268: 40–47
    • (2008) J Neurol Sci , vol.268 , pp. 40-47
    • Choi, C.I.1    Lee, Y.D.2    Gwag, B.J.3    Cho, S.I.4    Kim, S.S.5    Suh-Kim, H.6
  • 28
    • 33745822416 scopus 로고    scopus 로고
    • Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle
    • Collier CA, Bruce CR, Smith AC, Lopaschuk G, Dyck DJ. 2006 Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle. Am J Physiol Endocrinol Metab 291: E182–E189
    • (2006) Am J Physiol Endocrinol Metab , vol.291 , pp. E182-E189
    • Collier, C.A.1    Bruce, C.R.2    Smith, A.C.3    Lopaschuk, G.4    Dyck, D.J.5
  • 29
    • 84890569997 scopus 로고    scopus 로고
    • Effects of neonatal programming on hypothalamic mechanisms controlling energy balance
    • Contreras C, Novelle MG, Leis R, Dieguez C, Skrede S, Lopez M. 2013 Effects of neonatal programming on hypothalamic mechanisms controlling energy balance. Horm Metab Res 45: 935–944.
    • (2013) Horm Metab Res , vol.45 , pp. 935-944
    • Contreras, C.1    Novelle, M.G.2    Leis, R.3    Dieguez, C.4    Skrede, S.5    Lopez, M.6
  • 30
    • 84903158901 scopus 로고    scopus 로고
    • The search for antiaging interventions: From elixirs to fasting regimens
    • de Cabo R, Carmona-Gutierrez D, Bernier M, Hall MN, Madeo F. 2014 The search for antiaging interventions: From elixirs to fasting regimens. Cell 157: 1515–1526
    • (2014) Cell , vol.157 , pp. 1515-1526
    • De Cabo, R.1    Carmona-Gutierrez, D.2    Bernier, M.3    Hall, M.N.4    Madeo, F.5
  • 32
    • 33644787577 scopus 로고    scopus 로고
    • Identification of potential caloric restriction mimetics by microarray profiling
    • Dhahbi JM, Mote PL, Fahy GM, Spindler SR. 2005 Identification of potential caloric restriction mimetics by microarray profiling. Physiol Genomics 23: 343–350
    • (2005) Physiol Genomics , vol.23 , pp. 343-350
    • Dhahbi, J.M.1    Mote, P.L.2    Fahy, G.M.3    Spindler, S.R.4
  • 33
    • 75149162547 scopus 로고    scopus 로고
    • Metformin: An old medication of new fashion: Evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome
    • Diamanti-Kandarakis E, Christakou CD, Kandaraki E, Economou FN. 2010 Metformin: An old medication of new fashion: Evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome. Eur J Endocrinol 162: 193–212
    • (2010) Eur J Endocrinol , vol.162 , pp. 193-212
    • Diamanti-Kandarakis, E.1    Christakou, C.D.2    Kandaraki, E.3    Economou, F.N.4
  • 34
    • 36348950449 scopus 로고    scopus 로고
    • Metformin inhibits mammalian target of rapamycin- dependent translation initiation in breast cancer cells
    • Dowling RJ, Zakikhani M, Fantus IG, Pollak M, Sonenberg N. 2007 Metformin inhibits mammalian target of rapamycin- dependent translation initiation in breast cancer cells. Cancer Res 67: 10804–10812
    • (2007) Cancer Res , vol.67 , pp. 10804-10812
    • Dowling, R.J.1    Zakikhani, M.2    Fantus, I.G.3    Pollak, M.4    Sonenberg, N.5
  • 35
    • 0034614420 scopus 로고    scopus 로고
    • Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
    • El-Mir MY, Nogueira V, Fontaine E, Averet N, Rigoulet M, Leverve X. 2000 Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem 275: 223–228
    • (2000) J Biol Chem , vol.275 , pp. 223-228
    • El-Mir, M.Y.1    Nogueira, V.2    Fontaine, E.3    Averet, N.4    Rigoulet, M.5    Leverve, X.6
  • 36
    • 84879207411 scopus 로고    scopus 로고
    • Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure: Systematic review of observational studies involving 34,000 patients
    • Eurich DT, Weir DL, Majumdar SR, Tsuyuki RT, Johnson JA, Tjosvold L, Vanderloo SE, McAlister FA. 2013 Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure: Systematic review of observational studies involving 34,000 patients. Circ Heart Fail 6: 395–402
    • (2013) Circ Heart Fail , vol.6 , pp. 395-402
    • Eurich, D.T.1    Weir, D.L.2    Majumdar, S.R.3    Tsuyuki, R.T.4    Johnson, J.A.5    Tjosvold, L.6    Vanderloo, S.E.7    McAlister, F.A.8
  • 37
    • 84907808348 scopus 로고    scopus 로고
    • Metformin and respiratory chain complex. I: The last piece of the puzzle?
    • Fontaine E. 2014 Metformin and respiratory chain complex. I: The last piece of the puzzle? Biochem J 463: e3–e5
    • (2014) Biochem J , vol.463
    • Fontaine, E.1
  • 41
    • 0034914193 scopus 로고    scopus 로고
    • Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30
    • Glueck CJ, Fontaine RN, Wang P, Subbiah MT, Weber K, Illig E, Streicher P, Sieve-Smith L, Tracy TM, Lang JE, et al. 2001 Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30. Metabolism 50: 856–861
    • (2001) Metabolism , vol.50 , pp. 856-861
    • Glueck, C.J.1    Fontaine, R.N.2    Wang, P.3    Subbiah, M.T.4    Weber, K.5    Illig, E.6    Streicher, P.7    Sieve-Smith, L.8    Tracy, T.M.9    Lang, J.E.10
  • 43
    • 84924279764 scopus 로고    scopus 로고
    • Gastric cancer:Metformin improves survival and recurrence rate in patients with diabetes and gastric cancer
    • reenhill C. 2015 Gastric cancer:Metformin improves survival and recurrence rate in patients with diabetes and gastric cancer. Nat Rev Gastroenterol Hepatol 12: 124
    • (2015) Nat Rev Gastroenterol Hepatol , vol.12 , pp. 124
    • Reenhill, C.1
  • 44
    • 38649132337 scopus 로고    scopus 로고
    • Mitochondria—Anexus for aging, calorie restriction, and sirtuins?
    • Guarente L. 2008 Mitochondria—Anexus for aging, calorie restriction, and sirtuins? Cell 132: 171–176
    • (2008) Cell , vol.132 , pp. 171-176
    • Guarente, L.1
  • 45
    • 0037341552 scopus 로고    scopus 로고
    • Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulinreceptor substrate-2
    • Gunton JE, Delhanty PJ, Takahashi S, Baxter RC. 2003 Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulinreceptor substrate-2. J Clin Endocrinol Metab 88: 1323–1332
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 1323-1332
    • Gunton, J.E.1    Delhanty, P.J.2    Takahashi, S.3    Baxter, R.C.4
  • 46
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • Hardie DG, Ross FA, Hawley SA. 2012 AMPK: A nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 13: 251–262
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 47
    • 0036324142 scopus 로고    scopus 로고
    • The antidiabetic drug metformin activates theAMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
    • Hawley SA, Gadalla AE, Olsen GS, Hardie DG. 2002 The antidiabetic drug metformin activates theAMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes 51: 2420–2425
    • (2002) Diabetes , vol.51 , pp. 2420-2425
    • Hawley, S.A.1    Gadalla, A.E.2    Olsen, G.S.3    Hardie, D.G.4
  • 48
    • 84872529696 scopus 로고    scopus 로고
    • Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
    • Hirsch HA, Iliopoulos D, Struhl K. 2013.Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc Natl Acad Sci 110: 972–977
    • (2013) Proc Natl Acad Sci , vol.110 , pp. 972-977
    • Hirsch, H.A.1    Iliopoulos, D.2    Struhl, K.3
  • 49
    • 84874357500 scopus 로고    scopus 로고
    • Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease
    • Hong J, Zhang Y, Lai S, Lv A, Su Q, Dong Y, Zhou Z, Tang W, Zhao J, Cui L, et al. 2013 Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease. Diabetes Care 36: 1304–1311
    • (2013) Diabetes Care , vol.36 , pp. 1304-1311
    • Hong, J.1    Zhang, Y.2    Lai, S.3    Lv, A.4    Su, Q.5    Dong, Y.6    Zhou, Z.7    Tang, W.8    Zhao, J.9    Cui, L.10
  • 52
    • 84872527628 scopus 로고    scopus 로고
    • MTOR is a key modulator of ageing and age-related disease
    • Johnson SC, Rabinovitch PS, Kaeberlein M. 2013 mTOR is a key modulator of ageing and age-related disease. Nature 493: 338–345
    • (2013) Nature , vol.493 , pp. 338-345
    • Johnson, S.C.1    Rabinovitch, P.S.2    Kaeberlein, M.3
  • 54
    • 80052364474 scopus 로고    scopus 로고
    • Metformin treatment has no beneficial effect in a doseresponse survival study in the SOD1G93A mouse model of ALS and is harmful in female mice
    • Kaneb HM, Sharp PS, Rahmani-Kondori N, Wells DJ. 2011 Metformin treatment has no beneficial effect in a doseresponse survival study in the SOD1G93A mouse model of ALS and is harmful in female mice. PLoS ONE 6: e24189
    • (2011) Plos ONE , vol.6
    • Kaneb, H.M.1    Sharp, P.S.2    Rahmani-Kondori, N.3    Wells, D.J.4
  • 55
    • 40749116561 scopus 로고    scopus 로고
    • Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP
    • Kim YD, Park KG, Lee YS, Park YY, Kim DK, Nedumaran B, Jang WG, Cho WJ, Ha J, Lee IK, et al. 2008 Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP. Diabetes 57: 306–314
    • (2008) Diabetes , vol.57 , pp. 306-314
    • Kim, Y.D.1    Park, K.G.2    Lee, Y.S.3    Park, Y.Y.4    Kim, D.K.5    Nedumaran, B.6    Jang, W.G.7    Cho, W.J.8    Ha, J.9    Lee, I.K.10
  • 56
    • 84893058002 scopus 로고    scopus 로고
    • Metformin enhances glucagon-like peptide 1 via cooperation between insulin and Wnt signaling
    • Kim MH, Jee JH, Park S, Lee MS, Kim KW, Lee MK. 2014 Metformin enhances glucagon-like peptide 1 via cooperation between insulin and Wnt signaling. J Endocrinol 220: 117–128
    • (2014) J Endocrinol , vol.220 , pp. 117-128
    • Kim, M.H.1    Jee, J.H.2    Park, S.3    Lee, M.S.4    Kim, K.W.5    Lee, M.K.6
  • 60
    • 84869488061 scopus 로고    scopus 로고
    • Lessons from C. Elegans: Signaling pathways for longevity
    • Lapierre LR, Hansen M. 2012 Lessons from C. elegans: Signaling pathways for longevity. Trends Endocrinol Metab 23: 637–644
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 637-644
    • Lapierre, L.R.1    Hansen, M.2
  • 61
    • 79751481650 scopus 로고    scopus 로고
    • Environmental and genetic preconditioning for long-term anoxia responses requires AMPK in Caenorhabditis elegans
    • LaRue BL, Padilla PA. 2011 Environmental and genetic preconditioning for long-term anoxia responses requires AMPK in Caenorhabditis elegans. PLoS ONE 6: e16790
    • (2011) Plos ONE , vol.6
    • Larue, B.L.1    Padilla, P.A.2
  • 62
    • 84908342070 scopus 로고    scopus 로고
    • Anti-diabetic doses of metformin decrease proliferation markers in tumors of patients with endometrial cancer
    • Laskov I, Drudi L, Beauchamp MC, Yasmeen A, Ferenczy A, Pollak M, Gotlieb WH. 2014 Anti-diabetic doses of metformin decrease proliferation markers in tumors of patients with endometrial cancer. Gynecol Oncol 134: 607–614
    • (2014) Gynecol Oncol , vol.134 , pp. 607-614
    • Laskov, I.1    Drudi, L.2    Beauchamp, M.C.3    Yasmeen, A.4    Ferenczy, A.5    Pollak, M.6    Gotlieb, W.H.7
  • 63
    • 44349145008 scopus 로고    scopus 로고
    • Vanfleteren JR. 2008Dietary restriction of Caenorhabditis elegans by axenic culture reflects nutritional requirement for constituents provided by metabolically active microbes
    • Lenaerts I, Walker GA, Van Hoorebeke L, Gems D, Vanfleteren JR. 2008Dietary restriction of Caenorhabditis elegans by axenic culture reflects nutritional requirement for constituents provided by metabolically active microbes. J Gerontol A Biol Sci Med Sci 63: 242–252
    • J Gerontol a Biol Sci Med Sci , vol.63 , pp. 242-252
    • Lenaerts, I.1    Walker, G.A.2    Van Hoorebeke, L.3    Gems, D.4
  • 64
    • 79953755370 scopus 로고    scopus 로고
    • AMPKphosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
    • Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, et al. 2011.AMPKphosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 13: 376–388
    • (2011) Cell Metab , vol.13 , pp. 376-388
    • Li, Y.1    Xu, S.2    Mihaylova, M.M.3    Zheng, B.4    Hou, X.5    Jiang, B.6    Park, O.7    Luo, Z.8    Lefai, E.9    Shyy, J.Y.10
  • 65
    • 84862777219 scopus 로고    scopus 로고
    • Metformin alters the expression profiles of microRNAs in human pancreatic cancer cells
    • Li W, Yuan Y, Huang L, Qiao M, Zhang Y. 2012 Metformin alters the expression profiles of microRNAs in human pancreatic cancer cells. Diabetes Res Clin Pract 96: 187–195
    • (2012) Diabetes Res Clin Pract , vol.96 , pp. 187-195
    • Li, W.1    Yuan, Y.2    Huang, L.3    Qiao, M.4    Zhang, Y.5
  • 71
    • 78951476273 scopus 로고    scopus 로고
    • Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-a in mice
    • Maida A, Lamont BJ, Cao X, Drucker DJ. 2011 Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-a in mice. Diabetologia 54: 339–349
    • (2011) Diabetologia , vol.54 , pp. 339-349
    • Maida, A.1    Lamont, B.J.2    Cao, X.3    Drucker, D.J.4
  • 75
    • 84922359822 scopus 로고    scopus 로고
    • Metformin activates AMP-activated protein kinase by promoting formation of the abg heterotrimeric complex
    • Meng S, Cao J, He Q, Xiong L, Chang E, Radovick S, Wondisford FE, He L. 2014 Metformin activates AMP-activated protein kinase by promoting formation of the abg heterotrimeric complex. J Biol Chem 290: 3793–3802
    • (2014) J Biol Chem , vol.290 , pp. 3793-3802
    • Meng, S.1    Cao, J.2    He, Q.3    Xiong, L.4    Chang, E.5    Radovick, S.6    Wondisford, F.E.7    He, L.8
  • 78
    • 84873707522 scopus 로고    scopus 로고
    • Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
    • Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ. 2013 Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature 494: 256–260
    • (2013) Nature , vol.494 , pp. 256-260
    • Miller, R.A.1    Chu, Q.2    Xie, J.3    Foretz, M.4    Viollet, B.5    Birnbaum, M.J.6
  • 79
    • 84885861971 scopus 로고    scopus 로고
    • Mechanism of metformin: Inhibition of DNA damage and proliferative activity in Drosophila midgut stem cell
    • Na HJ, Park JS, Pyo JH, Lee SH, Jeon HJ, Kim YS, Yoo MA. 2013 Mechanism of metformin: Inhibition of DNA damage and proliferative activity in Drosophila midgut stem cell. Mech Ageing Dev 134: 381–390
    • (2013) Mech Ageing Dev , vol.134 , pp. 381-390
    • Na, H.J.1    Park, J.S.2    Pyo, J.H.3    Lee, S.H.4    Jeon, H.J.5    Kim, Y.S.6    Yoo, M.A.7
  • 80
    • 84902239478 scopus 로고    scopus 로고
    • Long-term metformin usage and cognitive function among older adults with diabetes
    • Ng TP, Feng L, Yap KB, Lee TS, Tan CH, Winblad B. 2014 Long-term metformin usage and cognitive function among older adults with diabetes. J Alzheimers Dis 41: 61–68
    • (2014) J Alzheimers Dis , vol.41 , pp. 61-68
    • Ng, T.P.1    Feng, L.2    Yap, K.B.3    Lee, T.S.4    Tan, C.H.5    Winblad, B.6
  • 81
    • 33744503150 scopus 로고    scopus 로고
    • Using Caenorhabditis elegans as a model for aging and age-related diseases
    • Olsen A, Vantipalli MC, Lithgow GJ. 2006 Using Caenorhabditis elegans as a model for aging and age-related diseases. Ann NY Acad Sci 1067: 120–128
    • (2006) Ann NY Acad Sci , vol.1067 , pp. 120-128
    • Olsen, A.1    Vantipalli, M.C.2    Lithgow, G.J.3
  • 82
    • 77649311383 scopus 로고    scopus 로고
    • Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. Elegans healthspan via AMPK
    • Onken B, Driscoll M. 2010 Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans healthspan via AMPK, LKB1, and SKN- 1 PLoS ONE 5: e8758
    • (2010) LKB1, and SKN- 1 Plos ONE , vol.5
    • Onken, B.1    Driscoll, M.2
  • 83
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • Owen MR, Doran E, Halestrap AP. 2000 Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 348: 607–614
    • (2000) Biochem J , vol.348 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 84
    • 84895456459 scopus 로고    scopus 로고
    • Diabetes drugs and neurological disorders: New views and therapeutic possibilities
    • Patrone C, Eriksson O, Lindholm D. 2014 Diabetes drugs and neurological disorders: New views and therapeutic possibilities. Lancet Diabetes Endocrinol 2: 256–262
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 256-262
    • Patrone, C.1    Eriksson, O.2    Lindholm, D.3
  • 87
    • 84905757105 scopus 로고    scopus 로고
    • Metformin—Mode of action and clinical implications for diabetes and cancer
    • Pernicova I, Korbonits M. 2014 Metformin—Mode of action and clinical implications for diabetes and cancer. Nat Rev Endocrinol 10: 143–156
    • (2014) Nat Rev Endocrinol , vol.10 , pp. 143-156
    • Pernicova, I.1    Korbonits, M.2
  • 90
    • 70349326296 scopus 로고    scopus 로고
    • Metformin inhibits aromatase via an extracellular signal-regulated kinase-mediated pathway
    • Rice S, Pellatt L, Ramanathan K, Whitehead SA, Mason HD. 2009 Metformin inhibits aromatase via an extracellular signal-regulated kinase-mediated pathway. Endocrinology 150: 4794–4801
    • (2009) Endocrinology , vol.150 , pp. 4794-4801
    • Rice, S.1    Pellatt, L.2    Ramanathan, K.3    Whitehead, S.A.4    Mason, H.D.5
  • 91
    • 18144449490 scopus 로고    scopus 로고
    • Improving survival with metformin:The evidence base today
    • Scarpello JH. 2003 Improving survival with metformin:The evidence base today. DiabetesMetab 29: 6S36–6S43
    • (2003) Diabetesmetab , vol.29
    • Scarpello, J.H.1
  • 92
    • 34748850786 scopus 로고    scopus 로고
    • Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    • Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M. 2007 Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab 6: 280–293
    • (2007) Cell Metab , vol.6 , pp. 280-293
    • Schulz, T.J.1    Zarse, K.2    Voigt, A.3    Urban, N.4    Birringer, M.5    Ristow, M.6
  • 96
    • 84867621125 scopus 로고    scopus 로고
    • Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila
    • Slack C, Foley A, Partridge L. 2012 Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila. PLoS ONE 7: e47699
    • (2012) Plos ONE , vol.7
    • Slack, C.1    Foley, A.2    Partridge, L.3
  • 98
    • 33644809525 scopus 로고    scopus 로고
    • Use of microarray biomarkers to identify longevity therapeutics
    • Spindler SR. 2006 Use of microarray biomarkers to identify longevity therapeutics. Aging Cell 5: 39–50
    • (2006) Aging Cell , vol.5 , pp. 39-50
    • Spindler, S.R.1
  • 99
    • 84872137308 scopus 로고    scopus 로고
    • Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies
    • Stenesen D, Suh JM, Seo J, Yu K, Lee KS, Kim JS, Min KJ, Graff JM. 2013 Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Cell Metab 17: 101–112
    • (2013) Cell Metab , vol.17 , pp. 101-112
    • Stenesen, D.1    Suh, J.M.2    Seo, J.3    Yu, K.4    Lee, K.S.5    Kim, J.S.6    Min, K.J.7    Graff, J.M.8
  • 100
    • 82455209029 scopus 로고    scopus 로고
    • Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
    • Stephenne X, Foretz M, Taleux N, van der Zon GC, Sokal E, Hue L, Viollet B, Guigas B. 2011 Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status. Diabetologia 54: 3101–3110
    • (2011) Diabetologia , vol.54 , pp. 3101-3110
    • Stephenne, X.1    Foretz, M.2    Taleux, N.3    Van Der Zon, G.C.4    Sokal, E.5    Hue, L.6    Viollet, B.7    Guigas, B.8
  • 102
    • 77949872870 scopus 로고    scopus 로고
    • A critical role of SNF1A/ dAMPKa (Drosophila AMP-activated protein kinasea) in muscle on longevity and stress resistance in Drosophila melanogaster
    • Tohyama D, Yamaguchi A. 2010 A critical role of SNF1A/ dAMPKa (Drosophila AMP-activated protein kinasea) in muscle on longevity and stress resistance in Drosophila melanogaster. Biochem Biophys Res Commun 394: 112–118
    • (2010) Biochem Biophys Res Commun , vol.394 , pp. 112-118
    • Tohyama, D.1    Yamaguchi, A.2
  • 103
    • 84937441058 scopus 로고    scopus 로고
    • Frailty attenuates the impact of metformin on reducing mortality in older adults with type 2 diabetes
    • Wang CP, Lorenzo C, Espinoza SE. 2014 Frailty attenuates the impact of metformin on reducing mortality in older adults with type 2 diabetes. J Endocrinol Diabetes Obes 2: 1030
    • (2014) J Endocrinol Diabetes Obes , vol.2 , pp. 1030
    • Wang, C.P.1    Lorenzo, C.2    Espinoza, S.E.3
  • 104
    • 84898619692 scopus 로고    scopus 로고
    • Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity
    • Woo SL, Xu H, Li H, Zhao Y, Hu X, Zhao J, Guo X, Guo T, Botchlett R, Qi T, et al. 2014 Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity. PLoS ONE 9: e91111
    • (2014) Plos ONE , vol.9
    • Woo, S.L.1    Xu, H.2    Li, H.3    Zhao, Y.4    Hu, X.5    Zhao, J.6    Guo, X.7    Guo, T.8    Botchlett, R.9    Qi, T.10
  • 105
    • 84890016628 scopus 로고    scopus 로고
    • Metformin is associated with survival benefit in cancer patients with concurrent type 2 diabetes: A systematic review and meta-analysis
    • Yin M, Zhou J, Gorak EJ, Quddus F. 2013 Metformin is associated with survival benefit in cancer patients with concurrent type 2 diabetes: A systematic review and meta-analysis. Oncologist 18: 1248–1255
    • (2013) Oncologist , vol.18 , pp. 1248-1255
    • Yin, M.1    Zhou, J.2    Gorak, E.J.3    Quddus, F.4
  • 106
    • 0037231053 scopus 로고    scopus 로고
    • Metformin modulates insulin post-receptor signaling transduction in chronically insulin-treated Hep G2 cells
    • Yuan L, Ziegler R, Hamann A. 2003 Metformin modulates insulin post-receptor signaling transduction in chronically insulin-treated Hep G2 cells. Acta Pharmacol Sin 24: 55–60
    • (2003) Acta Pharmacol Sin , vol.24 , pp. 55-60
    • Yuan, L.1    Ziegler, R.2    Hamann, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.